Antiviral therapy in human immunodeficiency virus infections. Current status (Part II).

abstract：:Buflomedil hydrochloride is a vasoactive drug with a variety of pharmacodynamic properties. Importantly, it seems to improve nutritional blood flow in ischaemic tissue of patients with peripheral and/or cerebral vascular disease by a combination of pharmacological effects: inhibition of alpha-adrenoceptors, inhibition...

journal_title：Drugs

authors： Clissold SP,Lynch S,Sorkin EM

更新日期：1987-05-01 00:00:00

abstract：:Our knowledge of the mechanisms of platelet-mediated thrombosis has increased dramatically over the last 40 years. This increased understanding has identified treatment strategies for acute coronary syndromes (ACS) by targeting key mediators of platelet activation and aggregation processes. Aspirin (acetylsalicylic ac...

journal_title：Drugs

authors： Angiolillo DJ

更新日期：2012-11-12 00:00:00

abstract：:Administration of unopposed postmenopausal estrogen therapy protects against coronary heart disease (CHD) in women. This is mediated, in part, through beneficial effects on lipid and lipoprotein metabolism. Fewer data are available with regard to CHD risk reduction when a progesterone is required in addition to estrog...

journal_title：Drugs

authors： Kafonek SD

更新日期：1994-01-01 00:00:00

abstract：:Alteplase is the product of recombinant DNA technology and is chemically identical to endogenous tissue-type plasminogen activator: Plasminogen is converted to plasmin by alteplase, and fibrinolysis of blood thrombi is subsequently stimulated. Alteplase is now firmly established as a treatment of choice in the managem...

journal_title：Drugs

authors： Wagstaff AJ,Gillis JC,Goa KL

更新日期：1995-08-01 00:00:00

abstract：:Pegaspargase (Oncaspar®), a pegylated form of native Escherichia coli-derived L-asparaginase (hereafter referred as E. coliL-asparaginase), is indicated in the USA and EU for the treatment of acute lymphoblastic leukaemia (ALL) as a component of multi-agent chemotherapy in paediatric and adult patients. Relative to E....

journal_title：Drugs

authors： Heo YA,Syed YY,Keam SJ

更新日期：2019-05-01 00:00:00

abstract：:Glucocorticoids (GCs) are often used for improvement of quality of life, particularly in the elderly, but long-term GC use may cause harm; bone loss and fractures are among the most devastating side effects. Fracture risk is particularly high in patients with a severe underlying disease with an urgent need for treatme...

journal_title：Drugs

authors： Raterman HG,Bultink IEM,Lems WF

更新日期：2019-07-01 00:00:00

abstract：:Safety data have been gathered in US clinical trials of nabumetone on 1912 patients from August 1981 to May 1988. Dosing in the double-blind trials was 100 mg at bedtime, but in open-label trials patients could increase the dosage of nabumetone to 1500 or 2000 mg if required. Adverse experiences reported in the double...

journal_title：Drugs

authors： Willkens RF

更新日期：1990-01-01 00:00:00

abstract：:Airway inflammation is central to the pathophysiology of asthma, with treatment directed towards modification of this inflammation and its consequences. The relationship between cigarette smoking and airway inflammation is also well described, but relatively little data are available on the potential influence of smok...

journal_title：Drugs

authors： Livingston E,Thomson NC,Chalmers GW

更新日期：2005-01-01 00:00:00

abstract：:The clonidine transdermal therapeutic system (TTS) is a cutaneous delivery device which provides therapeutically effective doses of clonidine at a constant rate over 7 days. In clinical trials it reduces blood pressure in patients with mild to moderate hypertension as effectively as oral clonidine but with greater sta...

journal_title：Drugs

authors： Langley MS,Heel RC

更新日期：1988-02-01 00:00:00

abstract：:Azacitidine (Vidaza) is a pyrimidine nucleoside analogue of cytidine. Subcutaneous azacitidine was recently approved in the EU for the treatment of adults who are not eligible for haematopoietic stem cell transplantation and who have intermediate-2-risk or high-risk myelodysplastic syndromes (MDS) [according to Intern...

journal_title：Drugs

authors： Keating GM

更新日期：2009-01-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is a leading cause of cancer death in industrialised countries, with an overall 5-year survival rate of less than 10%. Good patient performance status is associated with a significantly improved prognosis, whereas the presence of metastases, particularly to the bone or liver, is asso...

journal_title：Drugs

authors： Faulds D

更新日期：1992-01-01 00:00:00

abstract：:Acarbose delays digestion of complex carbohydrates and disaccharides to absorbable monosaccharides, by reversibly inhibiting alpha-glucosidases within the intestinal brush border, thereby attenuating postprandial blood glucose peaks. Clinical trials have demonstrated that acarbose generally improves glycaemic control ...

journal_title：Drugs

authors： Balfour JA,McTavish D

更新日期：1993-12-01 00:00:00

abstract：:Alopecia areata (AA) is an autoimmune condition that affects up to 2% of the general population. Currently available treatment options for AA are of limited efficacy and can be associated with adverse effects. The advancement in understanding of the genetic and molecular mechanisms of AA has led to the development of ...

journal_title：Drugs

authors： Pourang A,Mesinkovska NA

更新日期：2020-05-01 00:00:00

abstract：:Methotrexate has been approved for the treatment of refractory rheumatoid arthritis by several regulatory agencies, including the Food and Drug Administration. The tendency is now to prescribe it at earlier stages of the disease. Methotrexate is a well known antifolate. Its exact mechanism of action in rheumatoid arth...

journal_title：Drugs

authors： Bannwarth B,Labat L,Moride Y,Schaeverbeke T

更新日期：1994-01-01 00:00:00

abstract：:74 cirrhotic patients with a history of variceal or gastric bleeding were randomly assigned to treatment with propranolol (40 to 360 mg/day) or placebo. The patients were all in good condition and doses of propranolol were titrated until a 25% reduction in heart rate was achieved. After 2 years, the cumulative percent...

journal_title：Drugs

authors： Lebrec D,Poynard T,Bernuau J,Bercoff E,Nouel O,Capron JP,Poupon R,Bouvry M,Rueff B,Benhamou JP

更新日期：1989-01-01 00:00:00

abstract：:The annual incidence of skin and soft tissue infections (SSTIs) has nearly tripled in the US since the early 1990s. Many purulent SSTIs in the community setting are caused by methicillin-resistant Staphylococcus aureus (MRSA). Incision and drainage (I&D) are indicated for most purulent MRSA infections; however, the us...

journal_title：Drugs

authors： Forcade NA,Wiederhold NP,Ryan L,Talbert RL,Frei CR

更新日期：2012-02-12 00:00:00

abstract：:In a double-blind study, the efficacy and tolerability of nimesulide (100mg twice daily) were compared with those of diclofenac (50mg twice daily) when administered orally to 50 patients with acute superficial thrombophlebitis of the lower limbs. Pain relief and amelioration of inflammation were apparent in patients t...

journal_title：Drugs

authors： Ferrari E,Pratesi C,Scaricabarozzi I

更新日期：1993-01-01 00:00:00

abstract：:Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature identified reported herb-drug interactions with clinical significance, many of which are from case reports and limited clinical observations. Cases have been publis...

journal_title：Drugs

authors： Hu Z,Yang X,Ho PC,Chan SY,Heng PW,Chan E,Duan W,Koh HL,Zhou S

更新日期：2005-01-01 00:00:00

abstract：:The effects of enalapril on clinical well-being, treadmill exercise performance, haemodynamic measurements, hormone levels, and plasma biochemistry in patients with moderate heart failure, were assessed in a 12-week placebo-controlled, double-blind study. Maintenance frusemide and digoxin treatment was continued throu...

journal_title：Drugs

authors： Webster MW,Fitzpatrick MA,Hamilton EJ,Nicholls MG,Ikram H,Espiner EA,Wells JE

更新日期：1985-01-01 00:00:00

abstract：:Schizophrenia is a severe mental illness characterised by abnormalities of thought and perception that affects 1-2% of the population. Patients who experience a first episode of schizophrenia should be treated early and optimally with antipsychotic agents to lessen the morbidity of the initial episode and possibly imp...

journal_title：Drugs

authors： Bradford DW,Perkins DO,Lieberman JA

更新日期：2003-01-01 00:00:00

abstract：:Alterations of skin and hair pigmentation are important features that have warranted treatment from ancient history on up to modern time. In some cultures, even today patients with vitiligo are regarded as social outcasts and are affected considerably both emotionally and physically. This article presents current opti...

journal_title：Drugs

authors： Hartmann A,Bröcker EB,Becker JC

更新日期：2004-01-01 00:00:00

abstract：:Several compounds have been claimed to have a faster onset of antidepressant action. However, these trials suffered from lack of appropriate definitions and of standardised and comparable methodology, as far as measurement instruments, dosage strategies and statistical analyses were concerned. This article was underta...

journal_title：Drugs

authors： Soares JC,Gershon S

更新日期：1996-10-01 00:00:00

abstract：:Trimetazidine is a cytoprotective drug whose cardiovascular effectiveness, especially in patients with stable ischemic heart disease, has been the source of much controversy in recent years; some have gone so far as to treat the medication as a 'placebo drug' whose new side effects, such as Parkinsonian symptoms, outw...

journal_title：Drugs

authors： Chrusciel P,Rysz J,Banach M

更新日期：2014-06-01 00:00:00

abstract：:Flecainide is a Class I antiarrhythmic drug of the local anaesthetic type. It can be given either intravenously or orally and its pharmacokinetic properties allow relatively long (12 hours) dosing intervals with oral administration. In several open and a few controlled therapeutic trials, orally administered flecainid...

journal_title：Drugs

authors： Holmes B,Heel RC

更新日期：1985-01-01 00:00:00

abstract：:In this paper, several clinical problems associated with the diagnosis of hypertension are discussed. Blood pressure variability and reactivity are factors underlying the difficulties in the diagnosis of hypertension. These phenomena are interrelated and mixed. White coat hypertension (WCH), referring to the phenomeno...

journal_title：Drugs

authors： Ocón-Pujadas J,Mora-Maciá J

更新日期：1993-01-01 00:00:00

abstract：:The therapeutic efficacy of the new beta-lactam antibiotic, temocillin, was studied in 30 critically ill patients with peritonitis, abscesses, bronchopneumonia, and serious soft tissue infections. Patients were treated with temocillin Ig intravenously twice daily. The isolated pathogens comprised mainly Escherichia co...

journal_title：Drugs

authors： Pfeiffer M,Fock RR

更新日期：1985-01-01 00:00:00

abstract：:Various foods and fluids have been used in traditional treatments for diarrhoeal illnesses in infants and children for centuries. During the last 2 decades, however, with the advent of an improved scientific understanding of oral rehydration, effective treatment of dehydrating diarrhoea has been improved, expanded and...

journal_title：Drugs

authors： Sack DA

更新日期：1991-04-01 00:00:00

abstract：:Restless legs syndrome (RLS) is characterised by an urge to move the legs, uncomfortable sensations in the legs and worsening of these symptoms during rest with at least temporary relief brought on by activity. RLS occurs in 3-15% of the general population and in 10-30% of patients on maintenance dialysis. RLS may lea...

journal_title：Drugs

authors： Molnar MZ,Novak M,Mucsi I

更新日期：2006-01-01 00:00:00

abstract：:Gefitinib (Iressa) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that offers treatment for patients with locally advanced or metastatic non-small cell lung cancer (NSCLC), in particular in those who are harbouring EGFR mutations. In a large phase III trial (IPASS) in chemotherapy-naive Asian ...

journal_title：Drugs

authors： Sanford M,Scott LJ

更新日期：2009-11-12 00:00:00

abstract：:Roxatidine acetate (HOE 760, TZU 0460) is a new H2-receptor antagonist which is more potent than cimetidine and ranitidine. A randomised, double-blind, placebo-controlled study was conducted in healthy men to determine the effects of multiple oral doses of roxatidine acetate on unstimulated gastric acid secretion, and...

journal_title：Drugs

authors： Lassman HB,Ho I,Puri SK,Sabo R,Scheffler MR

更新日期：1988-01-01 00:00:00