Acarbose. An update of its pharmacology and therapeutic use in diabetes mellitus.

abstract：:Schistosomiasis, a grave and debilitating disease of socioeconomic importance, is increasing in incidence despite concerted efforts to control and contain the disease in all the endemic areas. While a multipronged method of control using health education, sanitation and snail control has been used, chemotherapy and ch...

journal_title：Drugs

authors： Shekhar KC

更新日期：1991-09-01 00:00:00

abstract：:Insulin degludec (Tresiba(®)) is an ultra-long-acting insulin analogue that is also available as a coformulation with rapid-acting insulin aspart (insulin degludec/insulin aspart) [Ryzodeg(®)]. Insulin degludec has a flat, stable glucose-lowering profile with a duration of action of >42 h, and less within-patient day-...

journal_title：Drugs

authors： Keating GM

更新日期：2013-05-01 00:00:00

abstract：:Antihistamines are a diverse group of drugs which possess the ability to inhibit various histaminic actions. By and large, they bear a certain structural resemblance to histamine, and act principally to prevent histamine-receptor interaction through competition with histamine for histamine receptors. Consequently, the...

journal_title：Drugs

authors： Pearlman DS

更新日期：1976-01-01 00:00:00

abstract：:This paper reviews the use of the fluoroquinolone antibiotics in the management of sexually transmitted diseases (STD) in Southeast Asia. Numerous clinical trials performed in the region have shown that the quinolones are highly effective for treating uncomplicated gonorrhoea. Norfloxacin 800 mg, ofloxacin 400 mg, cip...

journal_title：Drugs

authors： Sivayathorn A

更新日期：1995-01-01 00:00:00

abstract：:It is well documented that long term treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk of peptic ulcer and that gastroduodenal mucosal erosions can be demonstrated in volunteers within 1 week of treatment initiation. However, long term studies in nonsurgical patients have not documented g...

journal_title：Drugs

authors： Kehlet H,Dahl JB

更新日期：1992-01-01 00:00:00

abstract：:Mantle cell lymphoma is a rare yet well defined subtype of B-cell non-Hodgkin's lymphoma. The correct histological diagnosis of this lymphoma subtype is of the utmost importance; however, it is also a very difficult diagnosis. Clinical management is often complex, and despite the successful introduction of monoclonal ...

journal_title：Drugs

authors： Weigert O,Unterhalt M,Hiddemann W,Dreyling M

更新日期：2007-01-01 00:00:00

abstract：:In a double-blind study, 40 patients scheduled for saphenectomy or inguinal hernioplasty were randomly assigned to treatment with nimesulide (200mg 3 times daily) or diclofenac (100mg 3 times daily) administered rectally. Therapy with either drug resulted in significantly less pain, oedema and hyperaemia, and resoluti...

journal_title：Drugs

authors： Ramella G,Costagli V,Vetere M,Capra C,Casella G,Sogni A,Scaricabarozzi I

更新日期：1993-01-01 00:00:00

abstract：:Sulbactam 1g and ampicillin 2g were administered intravenously to 12 patients, and concentrations of the drugs were determined in the serum and myometrium for up to 120 minutes after infusion. The ratio of sulbactam to ampicillin was about 1:2 in the serum and myometrium. Both drugs penetrated well into the myometrium...

journal_title：Drugs

authors： Schwiersch U,Lang N,Wildfeuer DA

更新日期：1986-01-01 00:00:00

abstract：:Hairy cell leukaemia is an uncommon B cell chronic lymphoproliferative disorder characterised by circulating lymphocytes displaying prominent cytoplasmic projections. Therapy is initiated for severe cytopenias or recurrent infections. Splenectomy, the first standard treatment, is now less commonly used as primary trea...

journal_title：Drugs

authors： Gollard R,Lee TC,Piro LD,Saven A

更新日期：1995-06-01 00:00:00

abstract：:Immunotherapies have shown remarkable success in the treatment of multiple cancer types; however, despite encouraging preclinical activity, registration trials of immunotherapy in prostate cancer have largely been unsuccessful. Sipuleucel-T remains the only approved immunotherapy for the treatment of asymptomatic or m...

journal_title：Drugs

authors： Rathi N,McFarland TR,Nussenzveig R,Agarwal N,Swami U

更新日期：2020-12-28 00:00:00

abstract：:Hypertension in pregnancy has implications for both maternal and fetal welfare. Extrapolation from concepts of mechanisms operating in hypertension in general to pregnancy-related hypertension is not justified. In the latter, the major features are a hyper-adrenergic state, plasma volume reduction and an increased sys...

journal_title：Drugs

authors： Lubbe WF

更新日期：1984-08-01 00:00:00

abstract：:Our knowledge of the mechanisms of platelet-mediated thrombosis has increased dramatically over the last 40 years. This increased understanding has identified treatment strategies for acute coronary syndromes (ACS) by targeting key mediators of platelet activation and aggregation processes. Aspirin (acetylsalicylic ac...

journal_title：Drugs

authors： Angiolillo DJ

更新日期：2012-11-12 00:00:00

abstract：:Involuntary infertility is an increasing problem in this era of delayed childbearing. Fortunately, many advances have been made recently in the medical and surgical treatment of infertility. This article reviews the principal aetiologies of infertility and their treatments, and focuses on the current and future uses o...

journal_title：Drugs

authors： Quigley MM

更新日期：1986-08-01 00:00:00

abstract：:Pinacidil is a newly developed antihypertensive vasodilator, proposed to belong to the new group of smooth muscle relaxants, the K+ channel openers. The in vitro effects of pinacidil on induced tone, smooth muscle membrane potential and 86Rb and 42K efflux from rat resistance vessels (internal diameter about 200 micro...

journal_title：Drugs

authors： Videbaek LM,Aalkjaer C,Mulvany MJ

更新日期：1988-01-01 00:00:00

abstract：:Page 9, Fig. 2, which originally appeared as. ...

journal_title：Drugs

authors： Mathieson S,Maher CG,Ferreira GE,Hamilton M,Jansen J,McLachlan AJ,Underwood M,Lin CC

更新日期：2020-10-01 00:00:00

abstract：:The combined oral contraceptive pill is the most popular method of contraception worldwide, with modern low-dose formulations significantly improving tolerability. Breakthrough bleeding is the most significant adverse event associated with the low-dose combined oral contraceptives. Monophasic, biphasic, triphasic and ...

journal_title：Drugs

authors： Weisberg E

更新日期：1995-02-01 00:00:00

abstract：:Four medicinal cancer biological blockbusters will end their patent lifespan by 2020. It is estimated that the total market for cancer biologicals will reach approximately US$68 billion at that time. Approximately 20 biosimilars have entered the European market since the launch of the original approval guidelines in 2...

journal_title：Drugs

authors： Camacho LH

更新日期：2017-06-01 00:00:00

abstract：:Because of inappropriate signals from the volume-regulation system and a reduction in renal blood flow, the kidney is not able to prevent sodium and water retention in chronic congestive heart failure (CHF). A brief summary of normal renal function and renal involvement in CHF is given and a study of renal function in...

journal_title：Drugs

authors： Ljungman S,Laragh JH,Cody RJ

更新日期：1990-01-01 00:00:00

abstract：:Drug treatment for various anorectal conditions has been known since ancient times. Today, modern as well as traditional drugs are being increasingly used in all grades of symptomatic haemorrhoids. These drugs (oral and local) are used as a part of conservative management or as an adjuvant to invasive outpatient proce...

journal_title：Drugs

authors： Misra MC,Imlitemsu

更新日期：2005-01-01 00:00:00

abstract：:Cytotoxic chemotherapy plays a key role in the treatment of carcinoma for thousands of patients annually who either present with metastatic disease or relapse after surgical excision of apparently localised disease. Unfortunately, there is such a wide range of responsiveness to drug therapy within individual tumour ty...

journal_title：Drugs

authors： Sarosdy MF,Von Hoff DD

更新日期：1983-11-01 00:00:00

abstract：:Buflomedil hydrochloride is a vasoactive drug with a variety of pharmacodynamic properties. Importantly, it seems to improve nutritional blood flow in ischaemic tissue of patients with peripheral and/or cerebral vascular disease by a combination of pharmacological effects: inhibition of alpha-adrenoceptors, inhibition...

journal_title：Drugs

authors： Clissold SP,Lynch S,Sorkin EM

更新日期：1987-05-01 00:00:00

abstract：:Serious hepatotoxicity is uncommon with the proper therapeutic use of non-narcotic analgesics but experience with new non-steroidal anti-inflammatory drugs (NSAIDs) is limited. Drugs such as ibufenac, fenclofenac and benoxaprofen were withdrawn from the market because of hepatotoxicity, and liver damage has been repor...

journal_title：Drugs

authors： Prescott LF

更新日期：1986-01-01 00:00:00

abstract：:Testing for and treating sexually transmitted diseases (STDs) in pregnant women deserves special attention. Treatment possibilities are limited because of potential risks for the developing fetus, and because effects can differ in pregnant compared with non-pregnant women, re-infection may be missed because of the int...

journal_title：Drugs

authors： Donders GG

更新日期：2000-03-01 00:00:00

abstract：:The therapeutic efficacy of the new beta-lactam antibiotic, temocillin, was studied in 30 critically ill patients with peritonitis, abscesses, bronchopneumonia, and serious soft tissue infections. Patients were treated with temocillin Ig intravenously twice daily. The isolated pathogens comprised mainly Escherichia co...

journal_title：Drugs

authors： Pfeiffer M,Fock RR

更新日期：1985-01-01 00:00:00

abstract：:There is now good evidence that T cells play a central role in the inflammatory pathway that leads to the persistent synovitis that causes joint damage in rheumatoid arthritis (RA). T cells require two signals to become activated. The second step in the activation of T cells involves costimulatory pathways, the best d...

journal_title：Drugs

authors： Pollard LC

更新日期：2007-01-01 00:00:00

abstract：:A number of oral and inhaled drugs are available for the long term management of patients with persistent asthma, yet the disease continues to be associated with significant morbidity and mortality. Over the past years, inhaled glucocorticoids have become established as a cornerstone of maintenance therapy because of ...

journal_title：Drugs

authors： Fabbri LM,Piattella M,Caramori G,Ciaccia A

更新日期：1996-01-01 00:00:00

abstract：:As first reported by our group in 1975, severe heart failure due to idiopathic dilated cardiomyopathy could be improved in patients receiving beta-blocker therapy starting at a very low dose and followed by a stepwise increase. Since then, these results have been confirmed by our own group and by others, and similar r...

journal_title：Drugs

authors： Hjalmarson A,Waagstein F

更新日期：1994-01-01 00:00:00

abstract：:Although the incidence of HIV-associated cryptococcosis has decreased in developed countries since the introduction of antiretroviral therapy, this disease continues to cause significant morbidity and mortality in sub-Saharan Africa among patients with AIDS. Important strides have been made in an attempt to decrease t...

journal_title：Drugs

authors： La Hoz RM,Pappas PG

更新日期：2013-05-01 00:00:00

abstract：:The selective sodium hydrogen exchanger 3 (NHE3) inhibitor tenapanor is being developed by Ardelyx Inc. for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) [under the tradename IBSRELA®] and for hyperphosphataemia in patients with chronic kidney disease (CKD) on dialysis or with end stage re...

journal_title：Drugs

authors： Markham A

更新日期：2019-11-01 00:00:00

abstract：:Hypertension is a major risk factor for coronary heart disease (CHD) and is the primary risk factor for stroke. Drug trials lowering blood pressure by pharmacological means have demonstrated impressive reduction in both fatal and nonfatal stroke (33 to 50%) that are virtually identical to the predicted stroke reductio...

journal_title：Drugs

authors： Grimm RH Jr,Flack JM,Byington R,Bond G,Brugger S

更新日期：1990-01-01 00:00:00