Concentration of sulbactam and ampicillin in serum and the myometrium.

abstract：:Clostridium difficile-associated disease (CDAD) is increasingly being reported in many regions throughout the world. The reasons for this are unknown, are likely to be multifactorial, and are the subject of several current investigations. In addition to the upsurge in frequency of CDAD, an increased rate of relapse/re...

journal_title：Drugs

authors： Owens RC

更新日期：2007-01-01 00:00:00

abstract：:Non-insulin-dependent diabetes mellitus (NIDDM, type 2 diabetes) is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. There are various pharmacological approaches to improving glucose homeostasis, but those currently used in clinical practice either d...

journal_title：Drugs

authors： Scheen AJ

更新日期：1997-09-01 00:00:00

abstract：:Gastro-oesophageal reflux disease (GORD or GERD) is a very common disorder, and advancement in drug development over the years has markedly improved disease management. Proton pump inhibitors (PPIs) remain the mainstay of treatment for GERD due to their profound and consistent inhibitory effect on acid secretion. Howe...

journal_title：Drugs

authors： Hershcovici T,Fass R

更新日期：2011-12-24 00:00:00

abstract：:Aflibercept (Eylea(®)) is an anti-vascular endothelial growth factor agent indicated for intravitreal use in the treatment of diabetic macular oedema. In patients with diabetic macular oedema, significantly greater improvements from baseline to week 52 in visual acuity were seen with intravitreal aflibercept versus ma...

journal_title：Drugs

authors： Keating GM

更新日期：2015-07-01 00:00:00

abstract：:Bisoprolol is a beta 1-adrenoceptor antagonist with no partial agonist (intrinsic sympathomimetic) activity or membrane stabilising (local anaesthetic) activity. The oral bioavailability of bisoprolol is high (90%) and the drug has a long elimination half-life which allows once-daily administration; in addition, it is...

journal_title：Drugs

authors： Lancaster SG,Sorkin EM

更新日期：1988-09-01 00:00:00

abstract：:There have been a number of controlled trials of antacids in the treatment of patients with peptic ulcer disease. As a general rule the size of studies has been small and there have been difficulties ensuring adequate binding, because of the formulation and taste of the antacids. Despite these difficulties, antacids a...

journal_title：Drugs

authors： Walt RP,Langman MJ

更新日期：1991-08-01 00:00:00

abstract：:After surgery, patients try to minimise discomfort by various manoeuvres including change of posture, immobilisation of injured areas and use of analgesic drugs. The characteristic finding with drug use, revealed by permitting patients to titrate themselves with analgesic from a machine, is that the interindividual do...

journal_title：Drugs

authors： Bullingham RE

更新日期：1985-04-01 00:00:00

abstract：:The endothelium is involved in both the physiological regulation of vascular tone and the structural transformation of the vessel under pathological conditions. Under physiological conditions, endothelial cells continuously secrete nitric oxide (NO), which relaxes smooth muscle cells and ensures vessel patency. Damage...

journal_title：Drugs

authors： Haller H

更新日期：1997-01-01 00:00:00

abstract：:This paper reviews the evidence that, in patients with hypertension, end-organ damage correlates more closely with blood pressure values obtained by ambulatory blood pressure monitoring than with those obtained by conventional sphygmomanometry. However, ambulatory blood pressure monitoring is not suitable for routine ...

journal_title：Drugs

authors： Mancia G,Omboni S,Ravogli A,Frattola A,Villani A

更新日期：1992-01-01 00:00:00

abstract：:Along with nausea and vomiting, postanaesthetic shivering is one of the leading causes of discomfort for patients recovering from general anaesthesia. The distinguishing factor during electromyogram recordings between patients with postanaesthetic shivering and shivering in fully awake patients is the existence of clo...

journal_title：Drugs

authors： Alfonsi P

更新日期：2001-01-01 00:00:00

abstract：:The rapid spread of human immunodeficiency virus (HIV) infections and the grim outcome of these infections have focused interest on the possibilities for medical intervention. The end-stage of these infections, acquired immune deficiency syndrome (AIDS), was first recognised in 1981, and the causative agent isolated i...

journal_title：Drugs

authors： Sandström EG,Kaplan JC

更新日期：1987-09-01 00:00:00

abstract：:Cenobamate (XCOPRI®) is an oral, small molecule neurotherapeutic azole compound that is being developed by SK Life Science Inc. and Arvelle Therapeutics for the treatment of epilepsy. Based on results of two pivotal phase 2 trials, cenobamate was recently approved in the USA for use in the treatment of partial-onset s...

journal_title：Drugs

authors： Keam SJ

更新日期：2020-01-01 00:00:00

abstract：:For almost half a century, the first-line treatment for ovulation induction in cases of anovulation, unexplained infertility, or mild male factor has been clomifene (clomiphene citrate). Clomifene is an effective and safely used oral agent, but is known to have relatively common antiestrogenic endometrial and cervical...

journal_title：Drugs

authors： Mitwally MF,Casper RF

更新日期：2006-01-01 00:00:00

abstract：:Conventional formulations of metoprolol have become well established in cardiovascular medicine and are particularly useful in the management of hypertension and ischaemic heart disease. Recently developed controlled release metoprolol delivery systems (metoprolol CR/ZOK and metoprolol OROS) were designed to overcome ...

journal_title：Drugs

authors： Plosker GL,Clissold SP

更新日期：1992-03-01 00:00:00

abstract：:Immune checkpoint inhibition of programmed-death receptor 1 (PD-1) or its ligand (PD-L1) has become a standard in the treatment of metastatic non-small cell lung cancer, either as monotherapy or in combination. Recently, it could be shown that immunotherapy works as consolidation after chemoradiotherapy in locally adv...

journal_title：Drugs

authors： Heigener DF,Reck M

更新日期：2019-12-01 00:00:00

abstract：:Bevacizumab is a recombinant, humanized anti-vascular endothelial growth factor (VEGF) monoclonal antibody that neutralizes the biological activity of VEGF and inhibits tumour angiogenesis. In two pivotal, well designed, phase III, clinical trials (GOG-0218 and ICON7) in women with advanced epithelial ovarian, fallopi...

journal_title：Drugs

authors： Dhillon S

更新日期：2012-05-07 00:00:00

abstract：:Hepatic encephalopathy (HE) is a challenging clinical complication of liver dysfunction with a wide spectrum of neuropsychiatric abnormalities that range from mild disturbances in cognitive function and consciousness to coma and death. The pathogenesis of HE in cirrhosis is complex and multifactorial, but a key role i...

journal_title：Drugs

authors： Phongsamran PV,Kim JW,Cupo Abbott J,Rosenblatt A

更新日期：2010-06-18 00:00:00

abstract：:Utilising a modified fixed-dose, 4 x 3 factorial design, the antihypertensive effects of all combinations of 4 doses of pinacidil (0, 12.5, 25 and 37.5 mg bid) with 3 doses of hydrochlorothiazide (0, 12.5 and 25 mg bid) were studied in patients with supine diastolic blood pressure of 95 to 110mm Hg. The decreases in s...

journal_title：Drugs

authors： Goldberg MR,Offen WW

更新日期：1988-01-01 00:00:00

abstract：:Immunotherapeutic approaches have been, and continue to be, aggressively investigated in the treatment of infiltrating gliomas. While the results of late-phase clinical studies have been disappointing in this disease space thus far, the success of immunotherapies in other malignancies as well as the incremental gains ...

journal_title：Drugs

authors： Lukas RV,Wainwright DA,Horbinski CM,Iwamoto FM,Sonabend AM

更新日期：2019-11-01 00:00:00

abstract：:Tocilizumab (RoActemra or Actemra) is a recombinant humanized monoclonal antibody that acts as an interleukin (IL)-6 receptor antagonist. Intravenous tocilizumab 8 mg/kg (and no less than 4.8 mg), in combination with methotrexate, is approved in the EU for the treatment of moderate to severe active rheumatoid arthriti...

journal_title：Drugs

authors： Oldfield V,Dhillon S,Plosker GL

更新日期：2009-01-01 00:00:00

abstract：:Outpatient parenteral antibiotic therapy (OPAT) programmes are effective, well tolerated and economically advantageous in carefully selected patient populations. Inclusion criteria for patient selection for OPAT include good clinical appearance and uncomplicated infection. By virtue of their favourable microbiological...

journal_title：Drugs

authors： Esposito S

更新日期：2000-01-01 00:00:00

abstract：:Stavudine is a nucleoside analogue which undergoes intracellular phosphorylation to its active metabolite, stavudine-5'-triphosphate. At clinically relevant concentrations, the active metabolite restricts HIV replication by inhibiting the inclusion of thymidine-5'-triphosphate into proviral DNA by HIV reverse transcri...

journal_title：Drugs

authors： Lea AP,Faulds D

更新日期：1996-05-01 00:00:00

abstract：:Various foods and fluids have been used in traditional treatments for diarrhoeal illnesses in infants and children for centuries. During the last 2 decades, however, with the advent of an improved scientific understanding of oral rehydration, effective treatment of dehydrating diarrhoea has been improved, expanded and...

journal_title：Drugs

authors： Sack DA

更新日期：1991-04-01 00:00:00

abstract：:It is important to distinguish between therapy used to reduce acute inflammation in gout and therapy used to manage hyperuricaemia in patients with chronic gouty arthritis. This article discusses treatments for acute gout, emphasizing the use of corticotrophin (adrenocorticotropic hormone; ACTH) and the evidence on wh...

journal_title：Drugs

authors： Schlesinger N

更新日期：2008-01-01 00:00:00

abstract：:The objective of surgical prophylaxis is to prevent wound infections associated with surgery. The rates of wound infections vary according to the procedure: less than 3 infections per 100 for clean procedures; up to 4 per 100 for clean-contaminated procedures; and up to 9 per 100 for contaminated procedures. Surgical ...

journal_title：Drugs

authors： Dellamonica P,Bernard E

更新日期：1993-01-01 00:00:00

abstract：:Cilazapril is an orally active angiotensin converting enzyme (ACE) inhibitor which lowers peripheral vascular resistance without affecting heart rate. Like enalapril and ramipril it is a prodrug, and is hydrolysed after absorption to cilazaprilat, which has a long terminal phase elimination half-life permitting once d...

journal_title：Drugs

authors： Deget F,Brogden RN

更新日期：1991-05-01 00:00:00

abstract：:Serum concentrations and pharmacokinetic parameters of ofloxacin were measured in 10 patients on haemodialysis treatment. Serum half-life during the interdialytic interval was 48 hours, and during haemodialysis treatment 10 hours. The decrease in serum concentrations during a 4-hour haemodialysis was 25%. After severa...

journal_title：Drugs

authors： Dörfler A,Schulz W,Burkhardt F,Zichner M

更新日期：1987-01-01 00:00:00

abstract：:Cisatracurium besilate (besylate) is a nondepolarising neuromuscular blocking agent with an intermediate duration of action. It is the R-cis, R'-cis isomer of atracurium besilate and is approximately 3-fold more potent than the mixture of isomers that constitute the parent drug. The ED95 for cisatracurium besilate (do...

journal_title：Drugs

authors： Bryson HM,Faulds D

更新日期：1997-05-01 00:00:00

abstract：:The clinical and bacteriological efficacy and adverse reactions of ofloxacin vs trimethoprim-sulphamethoxazole were investigated in a double-blind, randomised study in 250 female patients (125 in each group) with acute, uncomplicated lower urinary tract infections. The dosages of ofloxacin and trimethoprim-sulphametho...

journal_title：Drugs

authors： Block JM,Walstad RA,Bjertnaes A,Hafstad PE,Holte M,Ottemo I,Svarva PL,Rolstad T,Peterson LE

更新日期：1987-01-01 00:00:00

abstract：:Alteplase is the product of recombinant DNA technology and is chemically identical to endogenous tissue-type plasminogen activator: Plasminogen is converted to plasmin by alteplase, and fibrinolysis of blood thrombi is subsequently stimulated. Alteplase is now firmly established as a treatment of choice in the managem...

journal_title：Drugs

authors： Wagstaff AJ,Gillis JC,Goa KL

更新日期：1995-08-01 00:00:00