Tocilizumab: a review of its use in the management of rheumatoid arthritis.

abstract：:During recent decades, undeniable progress has been made with regard to the management of arterial hypertension. Larger numbers of patients are aware they have hypertension, receive treatment and benefit from this therapy. Furthermore, significant reductions have been observed in morbidity and mortality resulting from...

journal_title：Drugs

authors： Krivitzky A,Nguyen G,Gaudouen Y,Legrand M,Cohen R

更新日期：1998-01-01 00:00:00

abstract：:Emicizumab (Hemlibra®), a recombinant, humanized, bispecific monoclonal antibody, restores the function of missing activated factor VIII (FVIII) by bridging FIXa and FX to facilitate effective haemostasis in patients with haemophilia A. Subcutaneous emicizumab is approved in several countries, including in the USA and...

journal_title：Drugs

authors： Blair HA

更新日期：2019-10-01 00:00:00

abstract：:Interstitial lung disease (ILD) can be associated with all connective tissue diseases and is an important cause of morbidity and mortality. The management of connective tissue disease-interstitial lung disease (CTD-ILD) is challenging due substantial heterogeneity in disease behaviour and paucity of controlled clinica...

journal_title：Drugs

authors： Jee AS,Corte TJ

更新日期：2019-09-01 00:00:00

abstract：:Atenolol and nifedipine have been shown to be effective single agents in angina pectoris, but reports suggest that additional benefits may be conferred by combining the 2 drugs. Therefore, to establish that the combination regimen was at least as effective as either atenolol or nifedipine alone, a multicentre study wa...

journal_title：Drugs

authors： Sandberg M,Foale RA

更新日期：1988-01-01 00:00:00

abstract：:Immunotherapeutic approaches have been, and continue to be, aggressively investigated in the treatment of infiltrating gliomas. While the results of late-phase clinical studies have been disappointing in this disease space thus far, the success of immunotherapies in other malignancies as well as the incremental gains ...

journal_title：Drugs

authors： Lukas RV,Wainwright DA,Horbinski CM,Iwamoto FM,Sonabend AM

更新日期：2019-11-01 00:00:00

abstract：:Terfenadine is a selective histamine H1-receptor antagonist which, in pharmacodynamic studies, is devoid of central nervous system depressant activity. In clinical studies terfenadine is well tolerated and at a dose of 60mg administered twice daily the drug provides effective relief of symptoms in patients with allerg...

journal_title：Drugs

authors： McTavish D,Goa KL,Ferrill M

更新日期：1990-04-01 00:00:00

abstract：UNLABELLED:Enoxaparin (enoxaparin sodium) is a low molecular weight heparin (LMWH) that is widely used in the prevention of deep venous thrombosis and pulmonary embolism in patients undergoing orthopaedic or general surgery. Its efficacy in these indications has led to study of its use in patients with coronary artery ...

journal_title：Drugs

authors： Noble S,Spencer CM

更新日期：1998-08-01 00:00:00

abstract：:Knowledge of the structure, function and distribution of the components of the renin-angiotensin-aldosterone system (RAS) and the integrated physiological role of this hormonal system is rapidly increasing, although many questions remain unanswered. The primary structure and localisation of RAS such as renin, prorenin...

journal_title：Drugs

authors： Johnston CI

更新日期：1990-01-01 00:00:00

abstract：UNLABELLED:Levonorgestrel 6-capsule subdermal implants (Norplant) are an effective form of reversible contraception. When implanted under the skin of the upper arm, they release drug into the circulation at a relatively constant rate over 5 years. Generally, the cumulative pregnancy rate at the end of 5 years' levonorg...

journal_title：Drugs

authors： Coukell AJ,Balfour JA

更新日期：1998-06-01 00:00:00

abstract：:Ciclesonide nasal spray delivers the corticosteroid ciclesonide as a hypotonic spray via a metered-dose manual pump. Systemic exposure to ciclesonide and its active metabolite desisobutyryl-ciclesonide is low after intranasal administration. High protein binding (approximately 99%) and rapid first-pass clearance furth...

journal_title：Drugs

authors： Dhillon S,Wagstaff AJ

更新日期：2008-01-01 00:00:00

abstract：:Numerous intervention studies have clearly demonstrated the value of antihypertensive treatment. By lowering diastolic blood pressure 5 to 6mm Hg in middle-aged hypertensive patients, a 42% reduction in stroke morbidity and a 14% reduction in coronary heart disease morbidity can be obtained. Recently published large i...

journal_title：Drugs

authors： Hansson L

更新日期：1993-01-01 00:00:00

abstract：:Discharge from the ear can be the result of many disease processes. The ear may discharge blood, pus, cerebrospinal fluid (CSF) or wax. Keratosis obturans, stenosis of the external meatus and benign tumours of the external meatus all lead to wax build-up, which may cause recurrent attacks of otitis externa. Malignant ...

journal_title：Drugs

authors： Ruddy J,Bickerton RC

更新日期：1992-02-01 00:00:00

abstract：:Heparin remains the most effective antithrombotic drug. It acts by combining with plasma antithrombin, thereby accelerating the neurtalisation of thrombin and other acitvated coagulation factors. Full-dose intravenous heparin is indicated in all cases of pulmonary embolism and established deep venous thrombosis, unles...

journal_title：Drugs

authors： Deykin D

更新日期：1977-01-01 00:00:00

abstract：:Porcine-derived lung surfactant (PLS; Curosurf) has shown efficacy in neonatal respiratory distress syndrome. PLS consists of phospholipids, mainly dipalmitoylphosphatidylcholine, the primary surface-active agent of natural lung surfactant, and pulmonary surfactant-associated proteins which facilitate spreading and ad...

journal_title：Drugs

authors： Wiseman LR,Bryson HM

更新日期：1994-09-01 00:00:00

abstract：:Developed by Bayer in Germany, nifedipine was shown to be effective in the treatment of patients with angina pectoris by Japanese investigators. Professor Kimura first reported the efficacy of nifedipine in patients with angina pectoris and those findings have been replicated in numerous trials conducted since then. C...

journal_title：Drugs

authors： Hosoda S

更新日期：2006-01-01 00:00:00

abstract：:Cephalosporins have a role in the treatment of gonorrhoea, and especially infections caused by strains that are penicillin-resistant, either because they produce plasmid-mediated beta-lactamase or they have chromosomally mediated diminished permeability or modified penicillin-binding proteins. Although none of the ora...

journal_title：Drugs

authors： Phillips I

更新日期：1987-01-01 00:00:00

abstract：:For almost half a century, the first-line treatment for ovulation induction in cases of anovulation, unexplained infertility, or mild male factor has been clomifene (clomiphene citrate). Clomifene is an effective and safely used oral agent, but is known to have relatively common antiestrogenic endometrial and cervical...

journal_title：Drugs

authors： Mitwally MF,Casper RF

更新日期：2006-01-01 00:00:00

abstract：:The newest (third generation) fluoroquinolones are potentially useful agents in the management of community-acquired respiratory tract infections. This is mainly due to their increased activity against Streptococcuspneumoniae, a pathogen poorly susceptible to the second-generation compounds, and playing a major role i...

journal_title：Drugs

authors： Momméja-Marin H,Carbon C

更新日期：1999-06-01 00:00:00

abstract：:The sensitivity to cefotaxime and amikacin of 14,272 Gram-negative bacilli (Enterobacteriaceae and non-fermenting Gram-negative bacilli) isolated from clinical samples was studied during the period 1980 to 1985. The minimum inhibitory concentration (MIC) was determined by means of diffusion in agar. Strains were consi...

journal_title：Drugs

authors： Dámaso D,Sánchez-Moreno MP,Martínez-Martínez L,Mesa E,Portero F,Mendaza P,Daza RM

更新日期：1988-01-01 00:00:00

abstract：:The treatment of a variety of inflammatory skin diseases was greatly changed by the introduction, in the early 1950s, of corticosteroids for topical use. Topical corticosteroids are still the most widely used drugs in dermatology, and many preparations with quite different potencies are now available. However, attempt...

journal_title：Drugs

authors： Ortonne JP

更新日期：1988-01-01 00:00:00

abstract：:Our knowledge of the mechanisms of platelet-mediated thrombosis has increased dramatically over the last 40 years. This increased understanding has identified treatment strategies for acute coronary syndromes (ACS) by targeting key mediators of platelet activation and aggregation processes. Aspirin (acetylsalicylic ac...

journal_title：Drugs

authors： Angiolillo DJ

更新日期：2012-11-12 00:00:00

abstract：:The link between co-morbid insomnia and depression has been demonstrated in numerous groups. Insomnia has been associated with: (1) an increased risk of developing subsequent depression; (2) an increased duration of established depression; and (3) relapse following treatment for depression. In addition, specific insom...

journal_title：Drugs

authors： Riemann D,Workshop Participants.

更新日期：2009-01-01 00:00:00

abstract：:The Japanese encephalitis vaccine IC-51 (IXIARO) is an inactivated virus (strain SA(14)-14-2) that is manufactured in cultured Vero cells and is currently being developed for preventive vaccination against the Japanese encephalitis virus. black triangle Administration of IXIARO as a two-dose treatment in healthy adult...

journal_title：Drugs

authors： Duggan ST,Plosker GL

更新日期：2009-01-01 00:00:00

abstract：:The use of digitalis in congestive heart failure with normal sinus rhythm is still debated. While older uncontrolled, withdrawal studies from 1969 to 1983 provided incomplete data, with poorly documented clinical status and poor haemodynamic and exercise data, some patients did improve clinically when digitalis treatm...

journal_title：Drugs

authors： Riaz K,Forker AD

更新日期：1998-06-01 00:00:00

abstract：:HIV causes chronic infection and is associated with persistent viral replication and a high viral mutation rate. It is an illusion to think that monotherapy with any antiretroviral agent will have a major and lasting impact on this disease. Monotherapy with antitubercular agents led to dramatic improvements in treatme...

journal_title：Drugs

authors： Lange J

更新日期：1995-01-01 00:00:00

abstract：:Drug-resistant tuberculosis (DR-TB) is an emerging global health threat as treatment involves complex multiple drug regimens, which are longer and more toxic than standard therapy and yet have worse outcomes. In the presence of resistance to one or more first-line drugs, an alternative regimen should be designed. A ma...

journal_title：Drugs

authors： Albanna AS,Menzies D

更新日期：2011-05-07 00:00:00

abstract：:During depression, chronobiological disorders occur, such as disturbances in body temperature and early urinary excretion of a noradrenaline metabolite. Sleep patterns are disturbed in 90% of depressed patients; early REM sleep and shortened slow-wave sleep (stages 3 and 4), resulting in an increase in REM sleep, have...

journal_title：Drugs

authors： Rüther E

更新日期：1989-01-01 00:00:00

abstract：:Eltrombopag (Revolade(®)) is an orally bioavailable, low molecular weight, synthetic nonpeptide thrombopoietin receptor agonist, which selectively binds to the transmembrane and juxtamembrane domains of the thrombopoietin receptor on the surface of platelets, megakaryocytes and megakaryocyte precursor cells, resulting...

journal_title：Drugs

authors： Garnock-Jones KP

更新日期：2011-07-09 00:00:00

abstract：:General anaesthesia is the reversible depression of central nervous system function. There is still no agreement over what constitutes depth of anaesthesia, and the clinical anaesthetist must thus titrate drug input according to clinical signs (heart rate, blood pressure, somatic movement, autonomic responses). The po...

journal_title：Drugs

authors： Sear JW

更新日期：1992-01-01 00:00:00

abstract：:Pimavanserin (Nuplazid™) is a selective and potent serotonin 2A (5-HT2A) receptor inverse agonist and antagonist developed by ACADIA Pharmaceuticals that has been approved in the US as a treatment for patients with hallucinations and delusions associated with Parkinson's disease psychosis. Up to 60 % of patients with ...

journal_title：Drugs

authors： Markham A

更新日期：2016-07-01 00:00:00