Pharmacokinetics of ofloxacin in patients on haemodialysis treatment.

abstract：:There are many current concepts of the pathogenesis of rheumatic diseases which incorporate immunological, infectious and hereditary factors. Rheumatic diseases may sometimes become apparent after trauma, be associated with certain diseases and may be induced by nerve damage and serum sickness. Systemic lupuserythemat...

journal_title：Drugs

authors： Smyth CJ,Bravo JF

更新日期：1975-01-01 00:00:00

abstract：:Cibenzoline is a class I antiarrhythmic drug with limited class III and IV activity which can be administered orally or intravenously. An elimination half-life of about 8 to 12 hours permits twice daily administration, although age and renal function must be considered when determining dosage. Cibenzoline has some act...

journal_title：Drugs

authors： Harron DW,Brogden RN,Faulds D,Fitton A

更新日期：1992-05-01 00:00:00

abstract：:The annual incidence of skin and soft tissue infections (SSTIs) has nearly tripled in the US since the early 1990s. Many purulent SSTIs in the community setting are caused by methicillin-resistant Staphylococcus aureus (MRSA). Incision and drainage (I&D) are indicated for most purulent MRSA infections; however, the us...

journal_title：Drugs

authors： Forcade NA,Wiederhold NP,Ryan L,Talbert RL,Frei CR

更新日期：2012-02-12 00:00:00

abstract：:Methotrexate has been approved for the treatment of refractory rheumatoid arthritis by several regulatory agencies, including the Food and Drug Administration. The tendency is now to prescribe it at earlier stages of the disease. Methotrexate is a well known antifolate. Its exact mechanism of action in rheumatoid arth...

journal_title：Drugs

authors： Bannwarth B,Labat L,Moride Y,Schaeverbeke T

更新日期：1994-01-01 00:00:00

abstract：:Peficitinib [Smyraf® (Astellas Pharma)] is a Janus kinase (JAK)1, JAK2, JAK3 and tyrosine kinase (Tyk)2 (pan-JAK) inhibitor recently approved in Japan for the treatment of rheumatoid arthritis. Inhibition of JAK suppresses the activation of cytokine signalling pathways involved in inflammation and joint destruction in...

journal_title：Drugs

authors： Markham A,Keam SJ

更新日期：2019-06-01 00:00:00

abstract：:Intravenous inotuzumab ozogamicin (Besponsa®; Pfizer) is an anti-CD22 monoclonal antibody-calicheamicin conjugate that binds to CD22-expressing tumour cells. Upon binding, the complex is internalised and the cytotoxic calicheamicin derivative is released inside the cell, inducing double-strand DNA breakage and subsequ...

journal_title：Drugs

authors： Lamb YN

更新日期：2017-09-01 00:00:00

abstract：:Gene rearrangements involving the neurotrophic receptor kinase genes NTRK1, NTRK2, and NTRK3 (referred to as TRK, encoding TRKA, TRKB, and TRKC, respectively) result in highly oncogenic fusions. TRK fusions are rare, with a prevalence of < 1% in solid tumors. Detection of TRK fusions can be based on fluorescence in-si...

journal_title：Drugs

authors： Rohrberg KS,Lassen U

更新日期：2021-01-05 00:00:00

abstract：:Pharmacological treatment of hypertension can, cause clinically significant alterations in endocrine function and glucose homeostasis. The aim of this study was to investigate the antihypertensive efficacy and the influence on carbohydrate metabolism of carvedilol and metoprolol in non-insulin-dependent diabetics with...

journal_title：Drugs

authors： Ehmer B,van der Does R,Rudorf J

更新日期：1988-01-01 00:00:00

abstract：:The occurrence of late side effects of long term levodopa therapy (fluctuations in motor performance, abnormal movements, and symptoms unresponsive to dihydroxyphenylalanine) led to the search for novel anti-Parkinsonian drugs. Dopamine agonists are one of the newer families of anti-Parkinsonian agents, and they inclu...

journal_title：Drugs

authors： Montastruc JL,Rascol O,Senard JM

更新日期：1993-09-01 00:00:00

abstract：:Slowing of nerve conduction, a hallmark of both experimental and human diabetic neuropathy, is improved or corrected by aldose reductase inhibitors such as sorbinil. Animal experiments suggest that a myo-inositol-related defect in nerve sodium-potassium adenosine triphosphatase (ATPase) is responsible for the acute re...

journal_title：Drugs

authors： Greene DA

更新日期：1986-01-01 00:00:00

abstract：:The geminal bisphosphonates are a new class of drugs characterised by a P-C-P bond. Consequently, they are analogues of pyrophosphate, but are resistant to chemical and enzymatic hydrolysis. The bisphosphonates bind strongly to hydroxyapatite crystals and inhibit their formation and dissolution. This physicochemical e...

journal_title：Drugs

authors： Fleisch H

更新日期：1991-12-01 00:00:00

abstract：:Nateglinide is a novel D-phenylalanine derivative that inhibits ATP-sensitive K+ channels in pancreatic beta-cells in the presence of glucose and thereby stimulates the prandial release of insulin. Nateglinide reduces fasting and mealtime blood glucose levels in animals, healthy volunteers, and patients with type 2 (n...

journal_title：Drugs

authors： Dunn CJ,Faulds D

更新日期：2000-09-01 00:00:00

abstract：:Potassium channel openers or agonists represent a novel new class of compounds in the treatment of a range of cardiovascular disorders, particularly angina pectoris and hypertension. Nicorandil is the only clinically available potassium channel opener with antianginal effects, and with comparable efficacy and tolerabi...

journal_title：Drugs

authors： Gomma AH,Purcell HJ,Fox KM

更新日期：2001-01-01 00:00:00

abstract：:Restless legs syndrome (RLS) is characterised by an urge to move the legs, uncomfortable sensations in the legs and worsening of these symptoms during rest with at least temporary relief brought on by activity. RLS occurs in 3-15% of the general population and in 10-30% of patients on maintenance dialysis. RLS may lea...

journal_title：Drugs

authors： Molnar MZ,Novak M,Mucsi I

更新日期：2006-01-01 00:00:00

abstract：:Osteoporosis is a systemic bone disease characterized by low bone mass and bone mineral density, and deterioration of the underlying structure of bone tissue. These changes lead to an increase in bone fragility and an increased risk for fracture, which are the clinical consequences of osteoporosis. The classical triad...

journal_title：Drugs

authors： Reginster JY

更新日期：2011-01-01 00:00:00

abstract：:Lumasiran (Oxlumo™) is a subcutaneously administered small interfering RNA (siRNA) targeting the mRNA for hydroxyacid oxidase 1 gene (HAO1; encodes glycolate oxidase) and was developed by Alnylam Pharmaceuticals for the treatment of primary hyperoxaluria type 1 (PH1). By silencing the gene encoding glycolate oxidase, ...

journal_title：Drugs

authors： Scott LJ,Keam SJ

更新日期：2021-01-06 00:00:00

abstract：:Page 9, Fig. 2, which originally appeared as. ...

journal_title：Drugs

authors： Mathieson S,Maher CG,Ferreira GE,Hamilton M,Jansen J,McLachlan AJ,Underwood M,Lin CC

更新日期：2020-10-01 00:00:00

abstract：:The efficacy of an antiretroviral (ARV) treatment regimen depends on the activity of the regimen's individual ARV drugs and the number of HIV-1 mutations required for the development of resistance to each ARV - the genetic barrier to resistance. ARV resistance impairs the response to therapy in patients with transmitt...

journal_title：Drugs

authors： Tang MW,Shafer RW

更新日期：2012-06-18 00:00:00

abstract：:Glucocorticoids are used for a variety of illnesses. One of their major complications is suppression of the hypothalamic-pituitary-adrenal axis, rendering a patient unable to respond to stress. The risk of this suppression may be minimised by the use of short-acting glucocorticoid preparations, administration of the e...

journal_title：Drugs

authors： Helfer EL,Rose LI

更新日期：1989-11-01 00:00:00

abstract：:Drotrecogin alfa (activated), recombinant human activated protein C, inhibits coagulation and inflammation and promotes fibrinolysis in patients with severe sepsis. 850 patients with severe sepsis treated with intravenous drotrecogin alfa (activated) 24 microg/kg/h for 96 hours had a significantly greater reduction in...

journal_title：Drugs

authors： Lyseng-Williamson KA,Perry CM

更新日期：2002-01-01 00:00:00

abstract：:Inflammatory cells, such as neutrophils and eosinophils, are thought to actively contribute to the pathogenesis of asthma since they infiltrate into the lung tissue and may be activated locally to release bronchoconstrictor mediators. In this study we provide evidence that nedocromil sodium is capable of effectively i...

journal_title：Drugs

authors： Bruijnzeel PL,Warringa RA,Kok PT,Hamelink ML,Kreukniet J

更新日期：1989-01-01 00:00:00

abstract：:The rationale for the use of nifedipine in patients with acute myocardial infarction (MI) is based on the various cardiovascular actions of the compound: reduction of myocardial oxygen consumption by attenuation of cardiac and vascular smooth muscle tension; augmentation of oxygen and substrate supply after increased ...

journal_title：Drugs

authors： Rafflenbeul W,Ebner F

更新日期：1991-01-01 00:00:00

abstract：:Gatifloxacin (Tequin) is an 8-methoxy fluoroquinolone approved in the US for use in the treatment of community-acquired pneumonia (CAP), acute exacerbations of chronic bronchitis (AECB), acute sinusitis, uncomplicated and complicated urinary tract infections (UTIs), pyelonephritis, gonorrhoea and uncomplicated skin an...

journal_title：Drugs

authors： Keam SJ,Croom KF,Keating GM

更新日期：2005-01-01 00:00:00

abstract：:It is well documented that long term treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk of peptic ulcer and that gastroduodenal mucosal erosions can be demonstrated in volunteers within 1 week of treatment initiation. However, long term studies in nonsurgical patients have not documented g...

journal_title：Drugs

authors： Kehlet H,Dahl JB

更新日期：1992-01-01 00:00:00

abstract：:Amorolfine is a structurally unique, topically active antifungal agent, which possesses both fungistatic and fungicidal activity in vitro. Its spectrum of in vitro activity includes dermatophyte, dimorphic, some dematiaceous and filamentous fungi, and some yeasts. In clinical trials, application of amorolfine 5% nail ...

journal_title：Drugs

authors： Haria M,Bryson HM

更新日期：1995-01-01 00:00:00

abstract：:Viral respiratory tract infections (RTIs) are common causes of mild illness in immunocompetent children and adults, with occasional significant morbidity or mortality in the very young, very old or infirm. However, recipients of solid organ transplants (SOT) or haematopoietic stem cell transplants (HSCT) are at marked...

journal_title：Drugs

authors： Lee I,Barton TD

更新日期：2007-01-01 00:00:00

abstract：:This narrative review reports on the pharmacological and pharmacokinetic properties of rotigotine, a non-ergolinic D₃/D₂/D₁ dopamine receptor agonist approved for the treatment of early- and advanced-stage Parkinson's disease (PD) and moderate to severe restless legs syndrome (RLS). Rotigotine is formulated as a trans...

journal_title：Drugs

authors： Elshoff JP,Cawello W,Andreas JO,Mathy FX,Braun M

更新日期：2015-04-01 00:00:00

abstract：UNLABELLED:Oxaliplatin is a platinum compound that inhibits DNA synthesis, primarily by causing intrastrand cross-links in DNA. Oxaliplatin has a broad spectrum of antineoplastic activity and has demonstrated a lack of cross-resistance with other platinum compounds. In patients with metastatic colorectal cancer, intrav...

journal_title：Drugs

authors： Culy CR,Clemett D,Wiseman LR

更新日期：2000-10-01 00:00:00

abstract：:Cenobamate (XCOPRI®) is an oral, small molecule neurotherapeutic azole compound that is being developed by SK Life Science Inc. and Arvelle Therapeutics for the treatment of epilepsy. Based on results of two pivotal phase 2 trials, cenobamate was recently approved in the USA for use in the treatment of partial-onset s...

journal_title：Drugs

authors： Keam SJ

更新日期：2020-01-01 00:00:00

abstract：:MenB-FHbp (bivalent rLP2086; Trumenba®) is a recombinant protein-based vaccine targeting Neisseria meningitidis serogroup B (MenB), which has recently been licensed in the EU for active immunization to prevent invasive disease caused by MenB in individuals ≥ 10 years of age. The vaccine, which contains a variant from ...

journal_title：Drugs

authors： Shirley M,Taha MK

更新日期：2018-02-01 00:00:00