Peficitinib: First Global Approval.

Abstract:

:Peficitinib [Smyraf® (Astellas Pharma)] is a Janus kinase (JAK)1, JAK2, JAK3 and tyrosine kinase (Tyk)2 (pan-JAK) inhibitor recently approved in Japan for the treatment of rheumatoid arthritis. Inhibition of JAK suppresses the activation of cytokine signalling pathways involved in inflammation and joint destruction in rheumatoid arthritis. Peficitinib has been shown to significantly improve ACR20 and other measures of disease severity and to reduce the mean modified total Sharp score change from baseline in clinical trials. This article summarizes the milestones in the development of peficitinib leading to this first approval as a treatment for rheumatoid arthritis in patients who have an inadequate response to conventional therapies.

journal_name

Drugs

journal_title

Drugs

authors

Markham A,Keam SJ

doi

10.1007/s40265-019-01131-y

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

887-891

issue

8

eissn

0012-6667

issn

1179-1950

pii

10.1007/s40265-019-01131-y

journal_volume

79

pub_type

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