Abstract:
:Peficitinib [Smyraf® (Astellas Pharma)] is a Janus kinase (JAK)1, JAK2, JAK3 and tyrosine kinase (Tyk)2 (pan-JAK) inhibitor recently approved in Japan for the treatment of rheumatoid arthritis. Inhibition of JAK suppresses the activation of cytokine signalling pathways involved in inflammation and joint destruction in rheumatoid arthritis. Peficitinib has been shown to significantly improve ACR20 and other measures of disease severity and to reduce the mean modified total Sharp score change from baseline in clinical trials. This article summarizes the milestones in the development of peficitinib leading to this first approval as a treatment for rheumatoid arthritis in patients who have an inadequate response to conventional therapies.
journal_name
Drugsjournal_title
Drugsauthors
Markham A,Keam SJdoi
10.1007/s40265-019-01131-ysubject
Has Abstractpub_date
2019-06-01 00:00:00pages
887-891issue
8eissn
0012-6667issn
1179-1950pii
10.1007/s40265-019-01131-yjournal_volume
79pub_type
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