Abstract:
:Slowing of nerve conduction, a hallmark of both experimental and human diabetic neuropathy, is improved or corrected by aldose reductase inhibitors such as sorbinil. Animal experiments suggest that a myo-inositol-related defect in nerve sodium-potassium adenosine triphosphatase (ATPase) is responsible for the acute reversible slowing of nerve conduction in diabetes mellitus. This myo-inositol-related defect is at present viewed as a cyclic metabolic defect. Aldose reductase inhibitors have been shown to restore to normal both the myo-inositol content and the sodium-potassium ATPase activity of nerve. This suggests that the acute effects of aldose-reductase inhibitors on nerve conduction in both diabetic animals and human patients may be modified by the correction of an underlying myo-inositol-related defect of nerve sodium-potassium ATPase. Furthermore, this myo-inositol-related defect may contribute to other biochemical, functional and structural abnormalities of diabetic peripheral neuropathy.
journal_name
Drugsjournal_title
Drugsauthors
Greene DAdoi
10.2165/00003495-198600322-00004subject
Has Abstractpub_date
1986-01-01 00:00:00pages
6-14eissn
0012-6667issn
1179-1950journal_volume
32 Suppl 2pub_type
杂志文章,评审相关文献
DRUGS文献大全abstract::Nivolumab (Opdivo(®)) is a fully human monoclonal antibody against programmed death receptor-1, a negative regulatory checkpoint molecule with a role in immunosuppression. The drug is administered intravenously and is approved for the treatment of unresectable malignant melanoma in Japan. The potential for intravenous...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0234-4
更新日期:2014-07-01 00:00:00
abstract::25 patients have been included in a randomised trial aimed to compare prehospital and hospital administration of anisoylated plasminogen streptokinase activator complex (AP-SAC). Patients were first seen, at home, by a noncardiologist doctor working in a mobile-care unit and were then evaluated for entry into the stud...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-198700333-00042
更新日期:1987-01-01 00:00:00
abstract::ROS1 gene rearrangements exist in 1-2% of non-small cell lung cancers, typically occurring in younger, never or light smokers with adenocarcinoma. ROS1 gene fusions are potent oncogenic drivers, the presence of which results in the susceptibility of tumours to ROS1-targeted therapy. Crizotinib was the first tyrosine k...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01164-3
更新日期:2019-08-01 00:00:00
abstract::Dementia is commonly diagnosed at a time of major domestic breakdown, when symptoms are severe and family and community patience has been eroded. In order to encourage early referral and identification of patients with treatable conditions, a Memory Clinic is held at the University Hospital in Cardiff. The clinic prov...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198700332-00016
更新日期:1987-01-01 00:00:00
abstract::Ascletis has developed danoprevir (Ganovo®), an orally-administered hepatitis C virus NS3 protease inhibitor, as a treatment for hepatitis C. Based on positive results in phase II and phase III trials in patients with hepatitis C, danoprevir, in combination with ritonavir, peginterferon alfa and ribavirin was recently...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-018-0960-0
更新日期:2018-08-01 00:00:00
abstract::The popularity of antidepressants in the treatment of insomnia is not supported by a large amount of convincing data, but rather by opinions and beliefs of the prescribing physicians on the advantages of these agents compared with drugs acting on the benzodiazepine receptor or other drugs used for the treatment of ins...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/0003495-200868170-00001
更新日期:2008-01-01 00:00:00
abstract:UNLABELLED:5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation [psoralen plus UV (PUVA)] to manage psoriasis and vitiligo. In patients and volunteers, PUVA 5-methoxypsoralen causes a dose-related increase in cutaneous photosensitivi...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199856040-00015
更新日期:1998-10-01 00:00:00
abstract::Results from prevalence, case-control, angiographic and echocardiographic investigations incriminate elevated fibrinogen levels as a strong independent risk factor for the occurrence of initial and recurrent cardiovascular events. Average fibrinogen levels are higher in women and persons with other risk factors includ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199700543-00006
更新日期:1997-01-01 00:00:00
abstract::Saxagliptin (Onglyza™) is a dipeptidyl peptidase 4 inhibitor widely approved for the treatment of type 2 diabetes mellitus. In the EU, saxagliptin is indicated as combination therapy with metformin, a sulfonylurea, a thiazolidinedione, or insulin (with or without metformin) for the treatment of adult patients with typ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11208160-000000000-00000
更新日期:2012-01-22 00:00:00
abstract::Prostaglandin E2 (PGE2) is a potent stimulator of inflammation, and the inhibition of its synthesis is one possible mechanism of action of non-steroidal anti-inflammatory drugs (NSAIDs). We have investigated patients suffering from rheumatoid arthritis to determine how synovial fluid levels of PGE2 are affected by tia...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-198800351-00004
更新日期:1988-01-01 00:00:00
abstract::Pruritus is an unpleasant sensation that provokes an urge to scratch. Many stimuli (notably histamine) are able to induce pruritus. The neural conduction of the itch sensation from the free unmyelinated nerve endings to the central nervous system mainly occurs on unmyelinated C fibres and the anterolateral spinothalam...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199039020-00005
更新日期:1990-02-01 00:00:00
abstract::The fluoroquinolones have been shown to be active in vitro against many mycobacterial species, including most strains of Mycobacterium tuberculosis complex and M. fortuitum, and some strains of M. kansasii, M. avium-intracellulare (MAI) complex and M. leprae. Ciprofloxacin, ofloxacin and sparfloxacin are the best stud...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199958002-00004
更新日期:1999-01-01 00:00:00
abstract::Knowledge of the structure, function and distribution of the components of the renin-angiotensin-aldosterone system (RAS) and the integrated physiological role of this hormonal system is rapidly increasing, although many questions remain unanswered. The primary structure and localisation of RAS such as renin, prorenin...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199000391-00005
更新日期:1990-01-01 00:00:00
abstract::In a double-blind study, 128 patients with essential hypertension, refractory to beta-blocker monotherapy, were randomised to 1 of 4 treatment groups. Felodipine 2.5 mg twice daily, 5mg twice daily, 10mg twice daily or matched placebo twice daily were administered in addition to the beta-blocker for 4 weeks. Mean supi...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-198700343-00023
更新日期:1987-01-01 00:00:00
abstract::Varicella zoster virus (VZV), a member of the herpesvirus family, is responsible for both primary (varicella, chickenpox) as well as reactivation (zoster, shingles) infections. In immunocompetent patients, the course of varicella is generally benign. For varicella zoster, post-herpetic neuralgia is the most common com...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199957020-00005
更新日期:1999-02-01 00:00:00
abstract::The incidence of pulmonary embolism (PE) and venous thromboembolism (VTE) is higher in pregnant patients than in non-pregnant patients. The incidence of thrombosis in all pregnancies is reported to be between 0.05 and 1%, and an incidence as high as 3% may be present in women after caesarean section. Anticoagulant med...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200262030-00004
更新日期:2002-01-01 00:00:00
abstract::Torasemide (torsemide) is a high-ceiling loop diuretic which acts on the thick ascending limb of the loop of Henle to promote rapid and marked excretion of water, sodium and chloride. Like furosemide (frusemide), its major site of action is from the luminal side of the cell. Torasemide is at least twice as potent as f...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199141010-00008
更新日期:1991-01-01 00:00:00
abstract::Drug development offers potential solutions to a number of tropical health diseases, although the expense of pharmaceutical research and lack of return on investment has limited the production of new agents. The greatest successes have been through the development of single dose therapy and mass treatment control prog...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200060050-00002
更新日期:2000-11-01 00:00:00
abstract::Drug-drug interactions (DDIs) occur commonly and may lead to severe adverse drug reactions if not handled appropriately. Considerable information to support clinical decision making regarding potential DDIs is available in the literature and through various systems providing electronic decision support for healthcare ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-017-0729-x
更新日期:2017-05-01 00:00:00
abstract::Pentamidine is an aromatic diamidine derivative which has become one of the standard therapies for Pneumocystis carinii pneumonia (PCP), particularly in patients with acquired immunodeficiency syndrome (AIDS). However, with parenteral administration of the drug there is a high risk of toxicity. Inhaled pentamidine pro...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199039050-00008
更新日期:1990-05-01 00:00:00
abstract::The treatment of a variety of inflammatory skin diseases was greatly changed by the introduction, in the early 1950s, of corticosteroids for topical use. Topical corticosteroids are still the most widely used drugs in dermatology, and many preparations with quite different potencies are now available. However, attempt...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198800365-00008
更新日期:1988-01-01 00:00:00
abstract::Platinum-based doublet chemotherapy with or without bevacizumab is the standard of care for the initial management of advanced and metastatic non-small cell lung cancer (NSCLC) without a targetable molecular abnormality. However, the majority of patients with NSCLC will ultimately develop resistance to initial platinu...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-016-0628-6
更新日期:2016-09-01 00:00:00
abstract::Nausea and vomiting is a common and distressing symptom complex in patients with far-advanced cancer, affecting up to 60% of individuals at some stage of their illness. The current approach to the palliative care of patients with nausea and vomiting is based on identifying the cause, understanding its pathophysiology ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/0003495-200868180-00004
更新日期:2008-01-01 00:00:00
abstract::Developed by Bayer in Germany, nifedipine was shown to be effective in the treatment of patients with angina pectoris by Japanese investigators. Professor Kimura first reported the efficacy of nifedipine in patients with angina pectoris and those findings have been replicated in numerous trials conducted since then. C...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666991-00003
更新日期:2006-01-01 00:00:00
abstract::Kaposi's sarcoma is the most common malignancy associated with HIV infection, and the morbidity and mortality attributable to AIDS-related Kaposi's sarcoma (AIDS-KS) may be increasing. No curative therapy is available for AIDS-KS, but palliative therapy can eliminate or reduce cosmetically unacceptable lesions, reduce...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199448040-00006
更新日期:1994-10-01 00:00:00
abstract::Intravenous susoctocog alfa (Obizur(®)) is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). Intravenous susoctocog alfa was an effective and generally well to...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-016-0576-1
更新日期:2016-05-01 00:00:00
abstract::Immunotherapeutic approaches have been, and continue to be, aggressively investigated in the treatment of infiltrating gliomas. While the results of late-phase clinical studies have been disappointing in this disease space thus far, the success of immunotherapies in other malignancies as well as the incremental gains ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01203-z
更新日期:2019-11-01 00:00:00
abstract::Ovulation induction is the most common medical intervention for the treatment of infertility. Clomifene is generally the first treatment choice for patients with amenorrhoea, unless there is profound hypothalamic deficiency. When clomifene fails to induce ovulation, menotropins (human menopausal gonadotrophin) or gona...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199550030-00006
更新日期:1995-09-01 00:00:00
abstract::Buflomedil hydrochloride is a vasoactive drug with a variety of pharmacodynamic properties. Importantly, it seems to improve nutritional blood flow in ischaemic tissue of patients with peripheral and/or cerebral vascular disease by a combination of pharmacological effects: inhibition of alpha-adrenoceptors, inhibition...
journal_title:Drugs
pub_type: 临床试验,杂志文章,评审
doi:10.2165/00003495-198733050-00002
更新日期:1987-05-01 00:00:00
abstract::Pharmacological treatment of hypertension can, cause clinically significant alterations in endocrine function and glucose homeostasis. The aim of this study was to investigate the antihypertensive efficacy and the influence on carbohydrate metabolism of carvedilol and metoprolol in non-insulin-dependent diabetics with...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-198800366-00023
更新日期:1988-01-01 00:00:00