Abstract:
:In a double-blind study, 40 patients scheduled for saphenectomy or inguinal hernioplasty were randomly assigned to treatment with nimesulide (200mg 3 times daily) or diclofenac (100mg 3 times daily) administered rectally. Therapy with either drug resulted in significantly less pain, oedema and hyperaemia, and resolution of mild fever. No adverse reactions attributable to treatment were observed.
journal_name
Drugsjournal_title
Drugsauthors
Ramella G,Costagli V,Vetere M,Capra C,Casella G,Sogni A,Scaricabarozzi Idoi
10.2165/00003495-199300461-00038subject
Has Abstractpub_date
1993-01-01 00:00:00pages
159-61eissn
0012-6667issn
1179-1950journal_volume
46 Suppl 1pub_type
临床试验,杂志文章,随机对照试验相关文献
DRUGS文献大全abstract::Cisatracurium besilate (besylate) is a nondepolarising neuromuscular blocking agent with an intermediate duration of action. It is the R-cis, R'-cis isomer of atracurium besilate and is approximately 3-fold more potent than the mixture of isomers that constitute the parent drug. The ED95 for cisatracurium besilate (do...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199753050-00012
更新日期:1997-05-01 00:00:00
abstract::Induction of labour, defined as stimulation of uterine contractions before the spontaneous onset of labour, is indicated when the condition of the mother or fetus precludes awaiting the onset of spontaneous labour. In current medical practice, induction of labour comprises 2 phases: cervical priming and induction of c...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199754010-00005
更新日期:1997-07-01 00:00:00
abstract::Janus kinase (JAK) is a signal transducer and activator of a protein transcription system that transduces signals from cell surface cytokine and growth factor receptors to the nucleus. Recently developed JAK inhibitors (JAKinibs) inhibit JAKs non-selectively or selectively and down-regulate the effects of correspondin...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01349-1
更新日期:2020-08-01 00:00:00
abstract::The chronic fatigue syndrome (CFS) was formally defined in 1988 to describe a syndrome of severe and disabling fatigue of uncertain aetiology associated with a variable number of somatic and/or psychological symptoms. CFS has been reported in most industrialised countries and is most prevalent in women aged between 20...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199346040-00005
更新日期:1993-10-01 00:00:00
abstract::This paper reviews the evidence that, in patients with hypertension, end-organ damage correlates more closely with blood pressure values obtained by ambulatory blood pressure monitoring than with those obtained by conventional sphygmomanometry. However, ambulatory blood pressure monitoring is not suitable for routine ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199200441-00004
更新日期:1992-01-01 00:00:00
abstract::Hypertension affects 65 million people in the US, and is a major cause of morbidity and mortality, but less than one-third of patients with hypertension are treated to goal blood pressure. Multiple factors have been cited, and include suboptimal adherence to treatment and lifestyle modifications, limited access to hea...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666090-00006
更新日期:2006-01-01 00:00:00
abstract::The treatment of acute upper gastrointestinal bleeding is becoming more dependent upon early diagnosis. For the majority of patients whose bleeding has stopped when they come to the physician's attention, treatment for peptic disorders remains the mainstay of therapy. For patients who present to the physician actively...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198937010-00007
更新日期:1989-01-01 00:00:00
abstract::Despite advances in the understanding of the mechanism of cerebral injury during focal ischaemia, the best treatment of cerebral ischaemia is still prevention. The pathophysiological mechanisms that contribute to cerebral ischaemia are discussed relative to the many therapeutic interventions that have been attempted. ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198835040-00005
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:Generic drugs are approved on the basis of pharmaceutical equivalence and bioequivalence. Some drug products have unique structural or functional attributes, necessitating modified approaches to bioequivalence determinations. OBJECTIVE:The aim of this systematic review was to identify studies that evaluated...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-015-0382-1
更新日期:2015-04-01 00:00:00
abstract::Dietary measures have achieved mixed results in the management of liver disorders. Although a high energy diet may shorten the course of viral hepatitis by a relatively small amount, dietary restriction is usually of no benefit in compensated cirrhosis. Restriction of sodium intake to 22 to 60 mol/day leads to resolut...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199000403-00005
更新日期:1990-01-01 00:00:00
abstract::Amorolfine is a structurally unique, topically active antifungal agent, which possesses both fungistatic and fungicidal activity in vitro. Its spectrum of in vitro activity includes dermatophyte, dimorphic, some dematiaceous and filamentous fungi, and some yeasts. In clinical trials, application of amorolfine 5% nail ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199549010-00008
更新日期:1995-01-01 00:00:00
abstract::Teneligliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that was approved for the treatment of type 2 diabetes mellitus (T2DM) in Japan and Korea and is being researched in several countries. Teneligliptin is a potent, selective, and long-lasting DPP-4 inhibitor with a t½ of approximately 24 h and unique pharmacok...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01086-0
更新日期:2019-05-01 00:00:00
abstract:SYNOPSIS:Acitretin (etretin), a second generation monoaromatic retinoid for use in the treatment of severe psoriasis and other dermatoses, is the major active metabolite of etretinate and possesses a similar therapeutic index; i.e. a similar ratio of clinical efficacy to adverse effects. When used alone at a maintenanc...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-199243040-00010
更新日期:1992-04-01 00:00:00
abstract::There are several first choices for the treatment of mild and moderate hypertension. The selection of a drug may be influenced by concomitant pathology, with positive indications for particular drugs, e.g. coexistent angina, indicating use of a beta-receptor blocking drug or calcium antagonist; fluid retention indicat...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198800356-00006
更新日期:1988-01-01 00:00:00
abstract::In type 1 and 2 diabetes mellitus patients, hyperglycaemia is independently related to the development of microvascular and macrovascular complications. Glycaemic targets and the benefits of intensive versus conventional glucose control are under debate. The purpose of this review is to provide an overview of the rand...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11585220-000000000-00000
更新日期:2010-12-03 00:00:00
abstract::The antihypertensive effects of the regular immediate release formulation of verapamil (verapamil IR) and the newer sustained release formulation of verapamil (verapamil SR) were compared in Hispanic patients with untreated essential hypertension. Verapamil IR was given in 3 divided doses (80 or 160mg 3 times daily) a...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-199200441-00002
更新日期:1992-01-01 00:00:00
abstract::With its approval more than 15 years ago, subcutaneous etanercept (Enbrel(®)) was the first biological disease-modifying antirheumatic drug (bDMARD) and the first tumour necrosis factor inhibitor to be approved for use in rheumatic diseases. Etanercept remains an important cost-effective treatment option in adult pati...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0258-9
更新日期:2014-08-01 00:00:00
abstract::Subcutaneous dulaglutide (Trulicity®) is a once-weekly glucagon-like peptide-1 receptor agonist that is approved in numerous countries as an adjunct to diet and exercise for the treatment of adults with type 2 diabetes (T2D). In the clinical trial and real-world settings, once-weekly subcutaneous dulaglutide, as monot...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01260-9
更新日期:2020-02-01 00:00:00
abstract::Sitagliptin (Januvia, Glactiv(R), Tesavel(R)) is a dipeptidyl peptidase-4 inhibitor indicated for the treatment of type 2 diabetes mellitus. Oral sitagliptin as monotherapy or combination therapy was generally well tolerated and improved glycaemic control in well designed clinical trials in patients with type 2 diabet...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11203790-000000000-00000
更新日期:2010-03-05 00:00:00
abstract::The clonidine transdermal therapeutic system (TTS) is a cutaneous delivery device which provides therapeutically effective doses of clonidine at a constant rate over 7 days. In clinical trials it reduces blood pressure in patients with mild to moderate hypertension as effectively as oral clonidine but with greater sta...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198835020-00003
更新日期:1988-02-01 00:00:00
abstract::Filgrastim, a recombinant human granulocyte colony-stimulating factor (G-CSF), has identical biological activity to that of endogenous human G-CSF, but differs in that it contains an N-terminal methionine residue and is not glycosylated. It principally stimulates activation, proliferation and differentiation of neutro...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199448050-00007
更新日期:1994-11-01 00:00:00
abstract::The fluoroquinolones have been shown to be active in vitro against many mycobacterial species, including most strains of Mycobacterium tuberculosis complex and M. fortuitum, and some strains of M. kansasii, M. avium-intracellulare (MAI) complex and M. leprae. Ciprofloxacin, ofloxacin and sparfloxacin are the best stud...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199958002-00004
更新日期:1999-01-01 00:00:00
abstract::Delamanid (Deltyba(®)), a nitroimidazo-oxazole derivative, is a new anti-tuberculosis (TB) drug which exhibits potent in vitro and in vivo antitubercular activity against drug-susceptible and -resistant strains of Mycobacterium tuberculosis. It is approved in several countries, including Japan and those of the EU, for...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0331-4
更新日期:2015-01-01 00:00:00
abstract::In general, hepatic encephalopathy (HE) is defined as a brain dysfunction caused by liver insufficiency and/or portal-systemic blood shunting. This article relates to the so-called type C HE: that is, HE in patients with liver cirrhosis. It manifests as a wide spectrum of neurological or psychiatric abnormalities, ran...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-018-1018-z
更新日期:2019-02-01 00:00:00
abstract::Drug development offers potential solutions to a number of tropical health diseases, although the expense of pharmaceutical research and lack of return on investment has limited the production of new agents. The greatest successes have been through the development of single dose therapy and mass treatment control prog...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200060050-00002
更新日期:2000-11-01 00:00:00
abstract::Since an earlier review in the Journal substantial additional data have accumulated, further clarifying the in vitro activity, pharmacokinetic profile, clinical efficacy and tolerability of teicoplanin. Recent therapeutic trials confirm the efficacy of teicoplanin in the treatment of microbiologically confirmed Gram-p...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199447050-00008
更新日期:1994-05-01 00:00:00
abstract::Diabetic gastroparesis is a common and debilitating condition affecting millions of patients with diabetes mellitus worldwide. Although gastroparesis in diabetes has been known clinically for more than 50 years, treatment options remain very limited. Until recently, the scientific literature has offered few clues rega...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200363130-00002
更新日期:2003-01-01 00:00:00
abstract::Cytotoxic chemotherapy plays a key role in the treatment of carcinoma for thousands of patients annually who either present with metastatic disease or relapse after surgical excision of apparently localised disease. Unfortunately, there is such a wide range of responsiveness to drug therapy within individual tumour ty...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198326050-00004
更新日期:1983-11-01 00:00:00
abstract::The management of patients with chronic pain is a common clinical challenge. Indeed, chronic pain is often inadequately controlled in patients with cancer and in those with non-cancer chronic pain. Because of the complex nature of chronic pain, successful long-term treatment is more difficult than for acute pain. Most...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200363010-00002
更新日期:2003-01-01 00:00:00
abstract::Pomalidomide (Imnovid®; Pomalyst®), an analogue of thalidomide, is an immunomodulatory agent, with several mechanisms of action (both direct and indirect) thought to be involved in its anti-myeloma activity. Oral pomalidomide is available in several countries for use in combination with low-dose dexamethasone in adult...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-017-0833-y
更新日期:2017-11-01 00:00:00