The role of beta-blockers in the treatment of cardiomyopathy and ischaemic heart failure.

abstract：:The occurrence of late side effects of long term levodopa therapy (fluctuations in motor performance, abnormal movements, and symptoms unresponsive to dihydroxyphenylalanine) led to the search for novel anti-Parkinsonian drugs. Dopamine agonists are one of the newer families of anti-Parkinsonian agents, and they inclu...

journal_title：Drugs

authors： Montastruc JL,Rascol O,Senard JM

更新日期：1993-09-01 00:00:00

abstract：:Capecitabine is an orally administered fluoropyrimidine carbamate used for the treatment of paclitaxel- or anthracycline-refractory breast cancer. Capecitabine is metabolised via a 3-step process to the active agent fluorouracil. The final step of this process occurs preferentially in malignant tissue. In patients wit...

journal_title：Drugs

authors： Dooley M,Goa KL

更新日期：1999-07-01 00:00:00

abstract：:As a consequence of disparities in access to and utilization of preventative healthcare, the incidence and death rates from cervical cancer remain substantial in the face of indisputable evidence that screening saves lives. While disparities persist, there will be an urgent need for research into the treatment of adva...

journal_title：Drugs

authors： Longoria TC,Tewari KS

更新日期：2015-11-01 00:00:00

abstract：:Accumulating evidence suggests the involvement of estrogen in depression. Estrogen can modulate neurotransmitter turnover, enhancing the levels of serotonin and noradrenaline (norepinephrine), and it is involved in the regulation of serotonin receptor number and function. Across the female reproductive life, fluctuati...

journal_title：Drugs

authors： Ryan J,Ancelin ML

更新日期：2012-09-10 00:00:00

abstract：:Cancer-related anorexia/cachexia (CAC) is a complex phenomenon in which metabolic abnormalities, proinflammatory cytokines produced by the host immune system, circulating tumour-derived catabolic factors, decreased food intake, and probably additional unknown factors, all play different roles. This review examines the...

journal_title：Drugs

authors： Mantovani G,Macciò A,Massa E,Madeddu C

更新日期：2001-01-01 00:00:00

abstract：:Epizoonoses such as scabies, lice and cimicosis are common, vexing disorders that occur worldwide. Historically, many treatment modalities have been employed in the management of these disorders, and most of the drugs described in this review are of historical interest and no longer recommended or in widespread use be...

journal_title：Drugs

authors： Roos TC,Alam M,Roos S,Merk HF,Bickers DR

更新日期：2001-01-01 00:00:00

abstract：:The effects of enalapril on clinical well-being, treadmill exercise performance, haemodynamic measurements, hormone levels, and plasma biochemistry in patients with moderate heart failure, were assessed in a 12-week placebo-controlled, double-blind study. Maintenance frusemide and digoxin treatment was continued throu...

journal_title：Drugs

authors： Webster MW,Fitzpatrick MA,Hamilton EJ,Nicholls MG,Ikram H,Espiner EA,Wells JE

更新日期：1985-01-01 00:00:00

abstract：:The pharmacokinetics of different formulations of glyceryl trinitrate, isosorbide dinitrate, isosorbide 5-mononitrate and isosorbide 2-mononitrate are reviewed. ...

journal_title：Drugs

authors： Kampmann JP

更新日期：1987-01-01 00:00:00

abstract：:Pharmacotherapy for the management of obesity is primarily aimed at weight loss, weight loss maintenance and risk reduction, and has included thyroid hormone, amphetamines, phentermine, amfepramone (diethylpropion), phenylpropanolamine, mazindol, fenfluramines and, more recently, sibutramine and orlistat. These agents...

journal_title：Drugs

authors： Ioannides-Demos LL,Proietto J,McNeil JJ

更新日期：2005-01-01 00:00:00

abstract：:Antihistamines are a diverse group of drugs which possess the ability to inhibit various histaminic actions. By and large, they bear a certain structural resemblance to histamine, and act principally to prevent histamine-receptor interaction through competition with histamine for histamine receptors. Consequently, the...

journal_title：Drugs

authors： Pearlman DS

更新日期：1976-01-01 00:00:00

abstract：:Through years of evolutionary selection pressures, organisms have developed potent toxins that coincidentally have marked antineoplastic activity. These natural products have been vital for the development of multiagent treatment regimens currently employed in cancer chemotherapy, and are used in the treatment of a va...

journal_title：Drugs

authors： Trendowski M

更新日期：2015-11-01 00:00:00

abstract：:Eight patients about to have the whole or part of a lung resected were given a 2g bolus dose of temocillin. A series of serum samples and a piece of peripheral lung tissue were collected and assayed for temocillin concentration. 30 minutes after drug administration, the mean serum and tissue concentrations were 172 mg...

journal_title：Drugs

authors： Cowan W,Baird A,Sleigh JD,Gray JM,Leiper JM,Lawson DH

更新日期：1985-01-01 00:00:00

abstract：:The increased understanding of the mechanisms which underlie rheumatoid disease has been accompanied by a more appropriate use of the limited repertoire of therapeutic agents. Conventional second-line drugs still have a role in everyday practice. The efficacy of these agents in reducing the severity of clinical signs ...

journal_title：Drugs

authors： Luqmani R,Gordon C,Bacon P

更新日期：1994-02-01 00:00:00

abstract：:Influenza vaccines form the mainstay of public health and personal protection against infection with seasonal influenza viruses. These vaccines are designed to protect people against infection with the currently circulating influenza viruses. Since the late 1970s, this has required the use of a trivalent vaccine consi...

journal_title：Drugs

authors： Barr IG,Jelley LL

更新日期：2012-12-03 00:00:00

abstract：:Preclinical studies indicate that angiogenic growth factors can stimulate the development of collateral arteries in animal models of peripheral or myocardial ischaemia, a concept termed 'therapeutic angiogenesis'. The goal of this review is to provide a brief overview of the advantages and disadvantages of gene versus...

journal_title：Drugs

authors： Amant C,Berthou L,Walsh K

更新日期：1999-01-01 00:00:00

abstract：:Valsartan/hydrochlorothiazide (HCTZ) combines an angiotensin II AT1 receptor blocker with a thiazide diuretic to produce additive blood pressure reductions without major effects on heart rate. HCTZ did not significantly alter valsartan pharmacokinetics; during combination therapy, HCTZ pharmacokinetics differed from t...

journal_title：Drugs

authors： Langtry HD,McClellan KJ

更新日期：1999-05-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) is a potent stimulator of inflammation, and the inhibition of its synthesis is one possible mechanism of action of non-steroidal anti-inflammatory drugs (NSAIDs). We have investigated patients suffering from rheumatoid arthritis to determine how synovial fluid levels of PGE2 are affected by tia...

journal_title：Drugs

authors： Daymond TJ,Rowell FJ

更新日期：1988-01-01 00:00:00

abstract：:Since their introduction 15 years ago, retinoids have been increasingly used for topical and systemic treatment of psoriasis and other hyperkeratotic and parakeratotic skin disorders, keratotic genodermatoses, severe acne and acne-related dermatoses, and also for therapy and/or chemoprevention of skin cancer and other...

journal_title：Drugs

authors： Orfanos CE,Zouboulis CC,Almond-Roesler B,Geilen CC

更新日期：1997-03-01 00:00:00

abstract：:Our knowledge of the mechanisms of platelet-mediated thrombosis has increased dramatically over the last 40 years. This increased understanding has identified treatment strategies for acute coronary syndromes (ACS) by targeting key mediators of platelet activation and aggregation processes. Aspirin (acetylsalicylic ac...

journal_title：Drugs

authors： Angiolillo DJ

更新日期：2012-11-12 00:00:00

abstract：:Recent developments in diagnosis and therapy of cytomegalovirus (CMV) infection have helped to reduce CMV-associated mortality following organ transplantation. However, CMV is still associated with significant morbidity in recipients of an allogeneic stem cell or solid-organ transplant. The clinical symptoms of active...

journal_title：Drugs

authors： Hebart H,Kanz L,Jahn G,Einsele H

更新日期：1998-01-01 00:00:00

abstract：:Avapritinib (AYVAKIT™) is a potent and selective tyrosine kinase inhibitor of platelet-derived growth factor receptor alpha (PDGFRA) and KIT activation loop mutants. It is being developed by Blueprint Medicines for the treatment of gastrointestinal stromal tumours (GIST), solid tumours and systemic mastocytosis. Avapr...

journal_title：Drugs

authors： Dhillon S

更新日期：2020-03-01 00:00:00

abstract：:Patient compliance refers to the willingness and ability of an individual to follow health-related advice, to take medication as prescribed, to attend scheduled clinic appointments and to complete recommended investigations. It is a major health issue, with outcomes related to levels of morbidity, mortality and cost u...

journal_title：Drugs

authors： Murphy J,Coster G

更新日期：1997-12-01 00:00:00

abstract：SYNOPSIS:Acitretin (etretin), a second generation monoaromatic retinoid for use in the treatment of severe psoriasis and other dermatoses, is the major active metabolite of etretinate and possesses a similar therapeutic index; i.e. a similar ratio of clinical efficacy to adverse effects. When used alone at a maintenanc...

journal_title：Drugs

authors： Pilkington T,Brogden RN

更新日期：1992-04-01 00:00:00

abstract：:Dopamine agonists (DAs) represent an excellent treatment option for patients with Parkinson's disease, in both the early and advanced stages of the disease, improving motor symptoms, lowering the incidence of motor complications, and addressing several non-motor symptoms. Indeed, each of these compounds have different...

journal_title：Drugs

authors： Torti M,Bravi D,Vacca L,Stocchi F

更新日期：2019-05-01 00:00:00

abstract：:The clinical and bacteriological efficacy and adverse reactions of ofloxacin vs trimethoprim-sulphamethoxazole were investigated in a double-blind, randomised study in 250 female patients (125 in each group) with acute, uncomplicated lower urinary tract infections. The dosages of ofloxacin and trimethoprim-sulphametho...

journal_title：Drugs

authors： Block JM,Walstad RA,Bjertnaes A,Hafstad PE,Holte M,Ottemo I,Svarva PL,Rolstad T,Peterson LE

更新日期：1987-01-01 00:00:00

abstract：:Intravenous dalbavancin (Dalvance®, Xydalba®), first approved as a two-dose regimen for the treatment of acute bacterial skin and skin structure infections (ABSSSI), has now been additionally approved as a single-dose regimen. This narrative review discusses the pharmacological properties of intravenous dalbavancin an...

journal_title：Drugs

authors： Garnock-Jones KP

更新日期：2017-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is characterised by insidiously progressive airflow limitation. The necessarily multifactorial management programme should include smoking cessation, prevention of infections, bronchodilator and steroid therapy, supplemental oxygen, physical therapy, pulmonary rehabilitatio...

journal_title：Drugs

authors： Kesten S,Rebuck AS

更新日期：1989-07-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic and progressive inflammatory disease that ultimately leads to disability and functional decline. Because patients usually develop RA in mid-life, they may experience its consequences for 20-30 years or longer. Proinflammatory cytokines, notably interleukin (IL)-1 and tumour necro...

journal_title：Drugs

authors： Schiff MH

更新日期：2004-01-01 00:00:00

abstract：:Aliskiren/hydrochlorothiazide is a single-pill combination of the first in the new class of non-peptide direct renin inhibitors (aliskiren) and a thiazide diuretic (hydrochlorothiazide [HCTZ]) that achieves blood pressure (BP) reductions greater than those seen with either component alone. In double-blind, 8-week clin...

journal_title：Drugs

authors： Baldwin CM,Plosker GL

更新日期：2009-01-01 00:00:00

abstract：UNLABELLED:Gatifloxacin is an 8-methoxy fluoroquinolone antibacterial agent. The drug has a broader spectrum of antibacterial activity than the older fluoroquinolones (e.g. ciprofloxacin) and shows good activity against many Gram-positive and Gram-negative pathogens, atypical organisms and some anaerobes. Notably, gati...

journal_title：Drugs

authors： Perry CM,Ormrod D,Hurst M,Onrust SV

更新日期：2002-01-01 00:00:00