Abstract:
:Administration of unopposed postmenopausal estrogen therapy protects against coronary heart disease (CHD) in women. This is mediated, in part, through beneficial effects on lipid and lipoprotein metabolism. Fewer data are available with regard to CHD risk reduction when a progesterone is required in addition to estrogen. Administration of continuous, rather than cyclic, estrogen-progesterone therapy may maintain the beneficial effects of estrogen and yet protect against the increase in endometrial cancer observed with estrogen therapy alone. Clinical guidelines for hormone replacement therapy await the completion of adequate controlled clinical trials.
journal_name
Drugsjournal_title
Drugsauthors
Kafonek SDdoi
10.2165/00003495-199400472-00005subject
Has Abstractpub_date
1994-01-01 00:00:00pages
16-24eissn
0012-6667issn
1179-1950journal_volume
47 Suppl 2pub_type
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