Abstract:
:In a noncomparative trial, 73 adults with acute sinusitis confirmed by x-ray received cefixime 400mg once daily for approximately 10 days. At the end of treatment, 60 patients (82%) were cured, 2 (2.7%) had improved and 7 (9.6%) had failed therapy; 4 patients were not evaluable. No relapses were observed at follow-up. Haemophilus influenzae, Streptococcus pneumoniae and Branhamella (Moraxella) catarrhalis were the main pretreatment pathogens, accounting for 65% of all bacterial isolates. Overall, 84% of pathogens were eradicated after treatment. Cefixime was well tolerated, moderate gastrointestinal disturbances being the most frequent adverse effects noted (3 of 4 patients with adverse effects). These results are comparable to those obtained with cefixime 400mg administered orally in 2 divided doses.
journal_name
Drugsjournal_title
Drugsauthors
Gehanno P,Boucot I,Berche P,Uhlrich Jdoi
10.2165/00003495-199100424-00007subject
Has Abstractpub_date
1991-01-01 00:00:00pages
19-24eissn
0012-6667issn
1179-1950journal_volume
42 Suppl 4pub_type
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