The Treatment of Advanced Thyroid Cancer in the Age of Novel Targeted Therapies.

abstract：:Proton Pump Inhibitors (PPIs) are widely used in the treatment of acid-peptic diseases. Their mechanism of action involves inhibition of the H-K-adenosine triphosphatase enzyme present in the parietal cells of the gastric mucosa. Because PPIs are the most potent inhibitors of gastric acid secretion available, they eff...

journal_title：Drugs

authors： Boparai V,Rajagopalan J,Triadafilopoulos G

更新日期：2008-01-01 00:00:00

abstract：:Advances over the past 2 decades in our understanding of the biology of panic disorder have paralleled a remarkable increase in the development of new pharmacological agents with antipanic effects. Although we can not presently use biological tests to help with our choice of therapeutic agent for individual patients, ...

journal_title：Drugs

authors： Johnson MR,Lydiard RB,Ballenger JC

更新日期：1995-03-01 00:00:00

abstract：:Telavancin is the first available lipoglycopeptide antibacterial agent. It is active against Gram-positive bacteria, including meticillin/oxacillin-resistant Staphylococcus aureus (MRSA) strains associated with complicated skin and skin structure infections (cSSSIs). In randomized, double-blind trials, intravenous tel...

journal_title：Drugs

authors： Lyseng-Williamson KA,Blick SK

更新日期：2009-01-01 00:00:00

abstract：:Iodixanol is an iso-osmolal nonionic dimeric hydrophilic contrast agent. It has similar diagnostic efficacy to that of other iodinated contrast media. Because of its physical properties, iodixanol would be expected to produce a lower incidence of adverse events than other nondimeric contrast media. Indeed, pharmacodyn...

journal_title：Drugs

authors： Spencer CM,Goa KL

更新日期：1996-12-01 00:00:00

abstract：:On the basis of well documented biochemical and pharmacological data about the influence of drug mediated enzyme induction on the biotransformation of natural and synthetic sex steroids, practical consequences for hormonal steroid contraception are described and discussed. Clinical reports dealing with this problem ar...

journal_title：Drugs

authors： Hempel E,Klinger W

更新日期：1976-12-01 00:00:00

abstract：:A meta-analysis of 20 short term comparative studies of 5 selective serotonin reuptake inhibitors (SSRIs; citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline) has shown no difference in efficacy between individual compounds but a slower onset of action of fluoxetine. There were suggestions that fluoxetine c...

journal_title：Drugs

authors： Edwards JG,Anderson I

更新日期：1999-04-01 00:00:00

abstract：:Endothelial dysfunction and increased arterial stiffness occur early in the pathogenesis of diabetic vasculopathy. They are both powerful independent predictors of cardiovascular risk. Advances in non-invasive methodologies have led to widespread clinical investigation of these abnormalities in diabetes mellitus, gene...

journal_title：Drugs

authors： Woodman RJ,Chew GT,Watts GF

更新日期：2005-01-01 00:00:00

abstract：:This paper reviews the theoretical concepts and methods utilised with isolated tissues to characterise drugs and drug receptors. Specifically the impact, on the in vitro measurement of agonist affinity and relative efficacy, of the idea that receptors bind to transduction proteins in the lipid bilayer of the cell memb...

journal_title：Drugs

authors： Kenakin T

更新日期：1990-11-01 00:00:00

abstract：:Lumasiran (Oxlumo™) is a subcutaneously administered small interfering RNA (siRNA) targeting the mRNA for hydroxyacid oxidase 1 gene (HAO1; encodes glycolate oxidase) and was developed by Alnylam Pharmaceuticals for the treatment of primary hyperoxaluria type 1 (PH1). By silencing the gene encoding glycolate oxidase, ...

journal_title：Drugs

authors： Scott LJ,Keam SJ

更新日期：2021-01-06 00:00:00

abstract：:Trifluridine (trifluorothymidine) is an antiviral agent for topical use in the eye, and is structurally related to idoxuridine. In vitro studies have shown that it effectively inhibits the replication of herpes simplex virus type 1, which causes primary keratoconjunctivitis and recurrent epithelial keratitis in man. I...

journal_title：Drugs

authors： Carmine AA,Brogden RN,Heel RC,Speight TM,Avery GS

更新日期：1982-05-01 00:00:00

abstract：:Schistosomiasis, a grave and debilitating disease of socioeconomic importance, is increasing in incidence despite concerted efforts to control and contain the disease in all the endemic areas. While a multipronged method of control using health education, sanitation and snail control has been used, chemotherapy and ch...

journal_title：Drugs

authors： Shekhar KC

更新日期：1991-09-01 00:00:00

abstract：:In a double-blind study, 128 patients with essential hypertension, refractory to beta-blocker monotherapy, were randomised to 1 of 4 treatment groups. Felodipine 2.5 mg twice daily, 5mg twice daily, 10mg twice daily or matched placebo twice daily were administered in addition to the beta-blocker for 4 weeks. Mean supi...

journal_title：Drugs

authors： Sluiter HE

更新日期：1987-01-01 00:00:00

abstract：:Pomalidomide (Imnovid®; Pomalyst®), an analogue of thalidomide, is an immunomodulatory agent, with several mechanisms of action (both direct and indirect) thought to be involved in its anti-myeloma activity. Oral pomalidomide is available in several countries for use in combination with low-dose dexamethasone in adult...

journal_title：Drugs

authors： Hoy SM

更新日期：2017-11-01 00:00:00

abstract：:Pruritus is a common complication of end-stage renal disease (ESRD), affecting about one-third of dialysis patients. It is a chronic, unpleasant symptom with a strong negative impact on patients' quality of life, often inducing sleeplessness and mood disorders. Recent data show that it is also associated with increase...

journal_title：Drugs

authors： Manenti L,Tansinda P,Vaglio A

更新日期：2009-01-01 00:00:00

abstract：:During depression, chronobiological disorders occur, such as disturbances in body temperature and early urinary excretion of a noradrenaline metabolite. Sleep patterns are disturbed in 90% of depressed patients; early REM sleep and shortened slow-wave sleep (stages 3 and 4), resulting in an increase in REM sleep, have...

journal_title：Drugs

authors： Rüther E

更新日期：1989-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a common medical disorder, which causes considerable morbidity and mortality. Given the chronic and symptomatic nature of the disease, the patient is often seen in the physician's office with complaints of dyspnea. However, more than 50% of COPD patients also have sleep ...

journal_title：Drugs

authors： George CF,Bayliff CD

更新日期：2003-01-01 00:00:00

abstract：:Zimelidine is a new antidepressant, which is structurally unrelated to the tricyclic and tetracyclic antidepressants. The pharmacological profile of zimelidine is different to that of other antidepressants in that it appears to owe the major part of its activity to the inhibition of serotonin uptake within the central...

journal_title：Drugs

authors： Heel RC,Morley PA,Brogden RN,Carmine AA,Speight TM,Avery GS

更新日期：1982-09-01 00:00:00

abstract：:Therapy for Gram-negative sepsis remains unsatisfactory despite a concerted effort to develop new treatments for this common, life-threatening syndrome. Current research continues on several fronts to improve the treatment options available to clinicians in the management of these critically ill patients. Recently, a ...

journal_title：Drugs

authors： Opal SM,Yu RL Jr

更新日期：1998-04-01 00:00:00

abstract：:The antihypertensive and vasodilator effects of felodipine, a new calcium antagonist of the dihydropyridine group, were examined in 15 patients with moderate to severe hypertension. Flow was measured simultaneously at the calf and finger using a venous occlusion ECG-triggered plethysmograph. Measurements were made at ...

journal_title：Drugs

authors： Clement DL,De Pue NY

更新日期：1985-01-01 00:00:00

abstract：:Restless legs syndrome (RLS) is characterised by an urge to move the legs, uncomfortable sensations in the legs and worsening of these symptoms during rest with at least temporary relief brought on by activity. RLS occurs in 3-15% of the general population and in 10-30% of patients on maintenance dialysis. RLS may lea...

journal_title：Drugs

authors： Molnar MZ,Novak M,Mucsi I

更新日期：2006-01-01 00:00:00

abstract：:Mantle cell lymphoma is a rare yet well defined subtype of B-cell non-Hodgkin's lymphoma. The correct histological diagnosis of this lymphoma subtype is of the utmost importance; however, it is also a very difficult diagnosis. Clinical management is often complex, and despite the successful introduction of monoclonal ...

journal_title：Drugs

authors： Weigert O,Unterhalt M,Hiddemann W,Dreyling M

更新日期：2007-01-01 00:00:00

abstract：:Patients with oncogene-driven lung cancer have limited therapeutic options after progressing on their targeted tyrosine kinase inhibitor (TKI) therapy. Given the growing role of immune checkpoint inhibitor (ICI) therapy in the treatment of lung cancer, oncogene-driven cancer has warranted further evaluation regarding ...

journal_title：Drugs

authors： Somasundaram A,Socinski MA,Villaruz LC

更新日期：2020-06-01 00:00:00

abstract：:In the 30 years since the rabbit antithymocyte globulin (rATG) Thymoglobulin(®) was first licensed, its use in solid organ transplantation and hematology has expanded progressively. Although the evidence base is incomplete, specific roles for rATG in organ transplant recipients using contemporary dosing strategies are...

journal_title：Drugs

authors： Mohty M,Bacigalupo A,Saliba F,Zuckermann A,Morelon E,Lebranchu Y

更新日期：2014-09-01 00:00:00

abstract：:Alopecia areata (AA) is an autoimmune condition that affects up to 2% of the general population. Currently available treatment options for AA are of limited efficacy and can be associated with adverse effects. The advancement in understanding of the genetic and molecular mechanisms of AA has led to the development of ...

journal_title：Drugs

authors： Pourang A,Mesinkovska NA

更新日期：2020-05-01 00:00:00

abstract：:This article is intended to stimulate thought and focus on those areas where we feel advances in drug therapy for inflammatory bowel disease may occur. It is not an extensive review of current practice, although this is considered where it is thought to be pertinent to future developments. There are several excellent ...

journal_title：Drugs

authors： Rhodes J,Thomas G,Evans BK

更新日期：1997-02-01 00:00:00

abstract：:The treatment of a variety of inflammatory skin diseases was greatly changed by the introduction, in the early 1950s, of corticosteroids for topical use. Topical corticosteroids are still the most widely used drugs in dermatology, and many preparations with quite different potencies are now available. However, attempt...

journal_title：Drugs

authors： Ortonne JP

更新日期：1988-01-01 00:00:00

abstract：:Levetiracetam (Keppra®, E Keppra®) is an established second-generation antiepileptic drug (AED). Worldwide, levetiracetam is most commonly approved as adjunctive treatment of partial onset seizures with or without secondary generalization; other approved indications include monotherapy treatment of partial onset seizu...

journal_title：Drugs

authors： Lyseng-Williamson KA

更新日期：2011-03-05 00:00:00

abstract：:This article reviews the development and pharmacokinetics of a number of new dosage formulations (e.g. transdermal patches and buccal tablets) and new active substances (e.g. isosorbide 5-mononitrate) which have recently been introduced to overcome some of the problems inherent in conventional formulations of organic ...

journal_title：Drugs

authors： Jonsson UE

更新日期：1987-01-01 00:00:00

abstract：:Along with nausea and vomiting, postanaesthetic shivering is one of the leading causes of discomfort for patients recovering from general anaesthesia. The distinguishing factor during electromyogram recordings between patients with postanaesthetic shivering and shivering in fully awake patients is the existence of clo...

journal_title：Drugs

authors： Alfonsi P

更新日期：2001-01-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is implicated in the pathogenesis of lymphoma. Deeper understanding of the diversity and biological impact of this pathway has led to the development of specific inhibitors to this pathway. Preclinical data in cell lines, patient samples and disease models have bro...

journal_title：Drugs

authors： Seiler T,Hutter G,Dreyling M

更新日期：2016-04-01 00:00:00