Abstract:
:The phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is implicated in the pathogenesis of lymphoma. Deeper understanding of the diversity and biological impact of this pathway has led to the development of specific inhibitors to this pathway. Preclinical data in cell lines, patient samples and disease models have broadened our understanding of PI3K inhibition. Several PI3K inhibitors are currently in advanced stages of clinical development. Idelalisib is the first agent of this new substance class to be approved in chronic lymphocytic leukemia and follicular lymphoma. Other agents specifically target different PI3K isoforms and show promising clinical efficacy.
journal_name
Drugsjournal_title
Drugsauthors
Seiler T,Hutter G,Dreyling Mdoi
10.1007/s40265-016-0565-4subject
Has Abstractpub_date
2016-04-01 00:00:00pages
639-46issue
6eissn
0012-6667issn
1179-1950pii
10.1007/s40265-016-0565-4journal_volume
76pub_type
杂志文章,评审相关文献
DRUGS文献大全abstract::Kaposi's sarcoma is the most common malignancy associated with HIV infection, and the morbidity and mortality attributable to AIDS-related Kaposi's sarcoma (AIDS-KS) may be increasing. No curative therapy is available for AIDS-KS, but palliative therapy can eliminate or reduce cosmetically unacceptable lesions, reduce...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199448040-00006
更新日期:1994-10-01 00:00:00
abstract::The treatment of acute upper gastrointestinal bleeding is becoming more dependent upon early diagnosis. For the majority of patients whose bleeding has stopped when they come to the physician's attention, treatment for peptic disorders remains the mainstay of therapy. For patients who present to the physician actively...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198937010-00007
更新日期:1989-01-01 00:00:00
abstract::Mantle cell lymphoma is a rare yet well defined subtype of B-cell non-Hodgkin's lymphoma. The correct histological diagnosis of this lymphoma subtype is of the utmost importance; however, it is also a very difficult diagnosis. Clinical management is often complex, and despite the successful introduction of monoclonal ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200767120-00004
更新日期:2007-01-01 00:00:00
abstract::In recent years, there have been major advances in the management of rheumatoid arthritis (RA), leading to the development of tumour necrosis factor (TNF) antagonists. With these agents, it is possible to arrest joint damage and, by treating early in the disease course, to prevent joint damage. It is also now thought ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666140-00001
更新日期:2006-01-01 00:00:00
abstract::The disposition of many drugs in cystic fibrosis is abnormal. In general, changes in pharmacokinetics include: increased volume of distribution, decreased plasma concentration, and enhanced renal and sometimes non-renal elimination of drugs. Pathophysiology of the disease important for drug disposition includes: (a) h...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198835050-00004
更新日期:1988-05-01 00:00:00
abstract::Eight patients about to have the whole or part of a lung resected were given a 2g bolus dose of temocillin. A series of serum samples and a piece of peripheral lung tissue were collected and assayed for temocillin concentration. 30 minutes after drug administration, the mean serum and tissue concentrations were 172 mg...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198500295-00031
更新日期:1985-01-01 00:00:00
abstract::Teneligliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that was approved for the treatment of type 2 diabetes mellitus (T2DM) in Japan and Korea and is being researched in several countries. Teneligliptin is a potent, selective, and long-lasting DPP-4 inhibitor with a t½ of approximately 24 h and unique pharmacok...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01086-0
更新日期:2019-05-01 00:00:00
abstract::Various foods and fluids have been used in traditional treatments for diarrhoeal illnesses in infants and children for centuries. During the last 2 decades, however, with the advent of an improved scientific understanding of oral rehydration, effective treatment of dehydrating diarrhoea has been improved, expanded and...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199141040-00005
更新日期:1991-04-01 00:00:00
abstract::Serious hepatotoxicity is uncommon with the proper therapeutic use of non-narcotic analgesics but experience with new non-steroidal anti-inflammatory drugs (NSAIDs) is limited. Drugs such as ibufenac, fenclofenac and benoxaprofen were withdrawn from the market because of hepatotoxicity, and liver damage has been repor...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198600324-00010
更新日期:1986-01-01 00:00:00
abstract::Pruritus is a common complication of end-stage renal disease (ESRD), affecting about one-third of dialysis patients. It is a chronic, unpleasant symptom with a strong negative impact on patients' quality of life, often inducing sleeplessness and mood disorders. Recent data show that it is also associated with increase...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200969030-00002
更新日期:2009-01-01 00:00:00
abstract::Rupatadine (Rupafin, Rinialer, Rupax, Alergoliber) is a selective oral histamine H(1)-receptor antagonist that has also been shown to have platelet-activating factor (PAF) antagonist activity in vitro. It is indicated for use in seasonal allergic rhinitis (SAR), perennial allergic rhinitis (PAR) and chronic idiopathic...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200767030-00008
更新日期:2007-01-01 00:00:00
abstract::Lanthanum carbonate is a novel, non-aluminium, non-calcium phosphate binding agent that forms a water-insoluble compound, lanthanum phosphate, in the gut. Lanthanum carbonate (elemental lanthanum 375-3000 mg/day) reduced serum phosphorus levels compared with placebo in two randomised, double-blind, multicentre 4-week ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200464090-00008
更新日期:2004-01-01 00:00:00
abstract:INTRODUCTION:Several pharmacological treatments aiming at a better symptomatic control of osteoarthritis (OA) are used in daily practice but their efficacy is often disputed. The purpose of this network meta-analysis (NMA) is to assess the efficacy on pain and function of the drugs that are most widely prescribed again...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01423-8
更新日期:2020-12-01 00:00:00
abstract::Results from the United Kingdom Prospective Diabetes Study showed that intensive treatment of type 2 (non-insulin-dependent) diabetes mellitus, with sulphonylureas or insulin, significantly reduced microvascular complications but did not have a significant effect on macrovascular complications after 10 years. Insulin ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200060050-00004
更新日期:2000-11-01 00:00:00
abstract::Sore throats are most commonly due to infections, many of which are viral and do not require specific treatment. Symptoms and signs of the common cold, influenza or croup, the occurrence of conjunctivitis in some adenoviral infections, generalised lymphadenopathy and splenomegaly in glandular fever or the presence of ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199040060-00007
更新日期:1990-12-01 00:00:00
abstract::Drug-drug interactions (DDIs) occur commonly and may lead to severe adverse drug reactions if not handled appropriately. Considerable information to support clinical decision making regarding potential DDIs is available in the literature and through various systems providing electronic decision support for healthcare ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-017-0729-x
更新日期:2017-05-01 00:00:00
abstract::Cephalosporins have a role in the treatment of gonorrhoea, and especially infections caused by strains that are penicillin-resistant, either because they produce plasmid-mediated beta-lactamase or they have chromosomally mediated diminished permeability or modified penicillin-binding proteins. Although none of the ora...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198700342-00013
更新日期:1987-01-01 00:00:00
abstract::The development of chronic heart failure (CHF) includes phenotypic changes in a host of homeostatic systems so that, as the disease advances, CHF may be seen as a multi-system disorder with its origins in the heart but embracing many extra-cardiac manifestations. Immunological abnormalities are recognised in this cont...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200060060-00002
更新日期:2000-12-01 00:00:00
abstract::Pomalidomide (Imnovid®; Pomalyst®), an analogue of thalidomide, is an immunomodulatory agent, with several mechanisms of action (both direct and indirect) thought to be involved in its anti-myeloma activity. Oral pomalidomide is available in several countries for use in combination with low-dose dexamethasone in adult...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-017-0833-y
更新日期:2017-11-01 00:00:00
abstract::Outpatient parenteral antibiotic therapy (OPAT) programmes are effective, well tolerated and economically advantageous in carefully selected patient populations. Inclusion criteria for patient selection for OPAT include good clinical appearance and uncomplicated infection. By virtue of their favourable microbiological...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200059003-00003
更新日期:2000-01-01 00:00:00
abstract::The rationale for the use of vasodilating agents in the treatment of congestive heart failure is to reverse the systemic vasoconstriction that characterises patients with this disorder, and which may further limit cardiac performance. Nitrates were the first vasodilators used, followed by arterial vasodilators (hydral...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198600325-00003
更新日期:1986-01-01 00:00:00
abstract::Acute renal failure (ARF) occurs frequently in hospitalised patients, and is associated with significant morbidity and mortality. The most common and generalised forms of acute renal failure are pre-renal conditions and intra-renal acute tubular necrosis (ATN). Pre-renal ARF in its pure state should be entirely revers...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200059010-00005
更新日期:2000-01-01 00:00:00
abstract::Bipolar disorder is a common and severe condition, and has a clinical outcome that is frequently sub-optimal. Only a small number of therapeutic options are currently available for the disorder. A growing range of novel therapeutic options for the treatment of bipolar disorder are under investigation. These include th...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200161100-00004
更新日期:2001-01-01 00:00:00
abstract::Many drugs alter the anticoagulant effect of oral coumarins. It is essential that physicians be aware of interactions leading to increased or decreased anticoagulation or to erratic control. Interacting drugs can be classified as influencing the pharmacodynamics (pharmacological actions) or the pharmacokinetics (absor...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-197611060-00006
更新日期:1976-01-01 00:00:00
abstract::Aflibercept (Eylea(®)) is an anti-vascular endothelial growth factor agent indicated for intravitreal use in the treatment of diabetic macular oedema. In patients with diabetic macular oedema, significantly greater improvements from baseline to week 52 in visual acuity were seen with intravitreal aflibercept versus ma...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-015-0421-y
更新日期:2015-07-01 00:00:00
abstract::During the intervening years since metoprolol was first reviewed in the Journal (1977), it has become widely used in the treatment of mild to moderate hypertension and angina pectoris. Although much data have accumulated, its precise mechanisms of action in these diseases remain largely uncertain. Optimum treatment of...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198631050-00002
更新日期:1986-05-01 00:00:00
abstract::An acute thrombus at the site of an atherosclerotic obstruction is the usual cause of myocardial infarction. Thrombolytic therapy is an exciting new therapy for reducing the extent of myocardial infarction by lysing intracoronary clots. Such therapy has now been widely applied by: prolonged intravenous infusion of str...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198428050-00004
更新日期:1984-11-01 00:00:00
abstract::The objective of this study was to evaluate the haemodynamic and antiarrhythmic effects of flecainide acetate in patients with heart failure. Flecainide acetate, a class Ic antiarrhythmic agent, was given intravenously to 9 patients with congestive heart failure and frequent ventricular arrhythmias with nonsustained v...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198500294-00012
更新日期:1985-01-01 00:00:00
abstract::Arachidonic acid is normally stored in membrane-bound phospholipids and released by the action of phospholipases. Enzymatic conversion of released arachidonic acid into biologically active derivatives proceeds through one of several routes. Cyclo-oxygenase converts arachidonic acid to unstable cyclic endoperoxides fro...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198700331-00003
更新日期:1987-01-01 00:00:00
abstract::Oral fidaxomicin (Dificid(®); Dificlir(®)) is a first-in-class macrocyclic antibacterial that is approved in several countries for the treatment of adult patients with Clostridium difficile-associated diarrhoea. Fidaxomicin 200 mg twice daily for 10 days was an effective and generally well tolerated treatment in adult...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-013-0134-z
更新日期:2013-10-01 00:00:00