Abstract:
:The antihypertensive and vasodilator effects of felodipine, a new calcium antagonist of the dihydropyridine group, were examined in 15 patients with moderate to severe hypertension. Flow was measured simultaneously at the calf and finger using a venous occlusion ECG-triggered plethysmograph. Measurements were made at rest, during handgrip and during reactive hyperaemia. Felodipine (12.5 mg, orally) was given after placebo treatment and after 3 weeks' treatment with metoprolol. It was also given for 3 weeks in combination with metoprolol. Felodipine caused a significant decrease in blood pressure which was similar in the supine, sitting and standing positions without causing any orthostatic reaction. The antihypertensive effect was accompanied by an increase in heart rate, dilatation of calf arteries and, to a lesser degree, dilatation of finger arteries. However, the degree of vasodilatation diminished with long term treatment. Metoprolol prevented the increase in heart rate but not vasodilatation. Felodipine decreased the potential for further dilatation in certain situations, as shown during reactive hyperaemia, although vasoconstrictor responses during the handgrip test remained unimpaired.
journal_name
Drugsjournal_title
Drugsauthors
Clement DL,De Pue NYdoi
10.2165/00003495-198500292-00024subject
Has Abstractpub_date
1985-01-01 00:00:00pages
137-43eissn
0012-6667issn
1179-1950journal_volume
29 Suppl 2pub_type
杂志文章相关文献
DRUGS文献大全abstract::Damoctocog alfa pegol (Jivi®) is approved in the USA, EU, Japan and Canada for the treatment and prophylaxis of previously treated patients aged ≥ 12 years with haemophilia A. Formulated with a 60 kDa polyethylene glycol (PEG) moiety, damoctocog alfa pegol is an intravenously (IV) administered recombinant factor VIII ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01152-7
更新日期:2019-07-01 00:00:00
abstract::Alopecia areata (AA) is an autoimmune condition that affects up to 2% of the general population. Currently available treatment options for AA are of limited efficacy and can be associated with adverse effects. The advancement in understanding of the genetic and molecular mechanisms of AA has led to the development of ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01293-0
更新日期:2020-05-01 00:00:00
abstract::Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2), is now a global pandemic. This virus primarily affects the respiratory tract and causes lung injury characterized by acute respiratory distress syndrome. Although the pathophysiology of COVID-19 is not yet clea...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01377-x
更新日期:2020-10-01 00:00:00
abstract::Dietary measures have achieved mixed results in the management of liver disorders. Although a high energy diet may shorten the course of viral hepatitis by a relatively small amount, dietary restriction is usually of no benefit in compensated cirrhosis. Restriction of sodium intake to 22 to 60 mol/day leads to resolut...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199000403-00005
更新日期:1990-01-01 00:00:00
abstract::Remifentanil (Ultiva), a fentanyl derivative, is an ultra-short acting, nonspecific esterase-metabolised, selective mu-opioid receptor agonist, with a pharmacodynamic profile typical of opioid analgesic agents. Notably, the esterase linkage in remifentanil results in a unique and favourable pharmacokinetic profile for...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200565130-00007
更新日期:2005-01-01 00:00:00
abstract::The efficacy of an antiretroviral (ARV) treatment regimen depends on the activity of the regimen's individual ARV drugs and the number of HIV-1 mutations required for the development of resistance to each ARV - the genetic barrier to resistance. ARV resistance impairs the response to therapy in patients with transmitt...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11633630-000000000-00000
更新日期:2012-06-18 00:00:00
abstract::Alzheimer's disease (AD) is the most common age-related neurodegenerative disease and has become an urgent public health problem in most areas of the world. Substantial progress has been made in understanding the basic neurobiology of AD and, as a result, new drugs for its treatment have become available. Cholinestera...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200161010-00005
更新日期:2001-01-01 00:00:00
abstract::Inflammatory cells, such as neutrophils and eosinophils, are thought to actively contribute to the pathogenesis of asthma since they infiltrate into the lung tissue and may be activated locally to release bronchoconstrictor mediators. In this study we provide evidence that nedocromil sodium is capable of effectively i...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198900371-00004
更新日期:1989-01-01 00:00:00
abstract::Effective control of variceal rebleeding (secondary prophylaxis) or prevention of the initial bleeding (primary prophylaxis) are the main objectives of the treatment of portal hypertension. Endoscopic sclerotherapy is the treatment of choice for secondary prophylaxis, since it significantly decreases rebleeding and, t...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199200442-00007
更新日期:1992-01-01 00:00:00
abstract::Antiviral therapy has in the past met with limited success and only a few antiviral drugs have been available. The human immunodeficiency virus (HIV) epidemic has created an urgent need for the development of antiviral therapy against this infection. HIV replication offers several targets for inhibitory compounds, the...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199345040-00002
更新日期:1993-04-01 00:00:00
abstract::Coronary artery disease and acute myocardial infarction still represent the leading cause of mortality in developed countries. Therefore, great efforts have been made in the last decades to improve reperfusion strategies and adjunctive antithrombotic therapies. In fact, despite optimal epicardial recanalisation, a lar...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-015-0425-7
更新日期:2015-07-01 00:00:00
abstract::Capecitabine is an orally administered fluoropyrimidine carbamate used for the treatment of paclitaxel- or anthracycline-refractory breast cancer. Capecitabine is metabolised via a 3-step process to the active agent fluorouracil. The final step of this process occurs preferentially in malignant tissue. In patients wit...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199958010-00006
更新日期:1999-07-01 00:00:00
abstract::Intravenous dalbavancin (Dalvance®, Xydalba®), first approved as a two-dose regimen for the treatment of acute bacterial skin and skin structure infections (ABSSSI), has now been additionally approved as a single-dose regimen. This narrative review discusses the pharmacological properties of intravenous dalbavancin an...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-016-0666-0
更新日期:2017-01-01 00:00:00
abstract::The treatment of acute upper gastrointestinal bleeding is becoming more dependent upon early diagnosis. For the majority of patients whose bleeding has stopped when they come to the physician's attention, treatment for peptic disorders remains the mainstay of therapy. For patients who present to the physician actively...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198937010-00007
更新日期:1989-01-01 00:00:00
abstract::Globally, tuberculosis (TB) and HIV interact in deadly synergy. The high burden of TB among HIV-infected individuals underlies the importance of TB diagnosis, treatment and prevention for clinicians involved in HIV care. Despite expanding access to antiretroviral therapy (ART) to treat HIV infection in resource-limite...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11591360-000000000-00000
更新日期:2011-06-18 00:00:00
abstract::In a double-blind, crossover study we have investigated the effect of nedocromil sodium on neurokinin A (NKA)-induced bronchoconstriction in asthmatics. 12 patients with mild asthma inhaled either nedocromil sodium 4mg or placebo, on 2 separate days, as 2 puffs from a metered-dose aerosol 30 minutes before challenge w...
journal_title:Drugs
pub_type: 临床试验,杂志文章
doi:10.2165/00003495-198900371-00019
更新日期:1989-01-01 00:00:00
abstract::A new formulation of paclitaxel, 130-nanometre albumin-bound paclitaxel (nab-paclitaxel), solubilises hydrophobic paclitaxel and may increase paclitaxel delivery to tumour cells. Intravenous nab-paclitaxel 260 mg/m(2) had a higher maximum whole-blood concentration, shorter time to peak concentration, larger distributi...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-200666070-00007
更新日期:2006-01-01 00:00:00
abstract::Resistance to the metabolic actions of insulin is thought to play a determining role in the aetiology of a great variety of disorders, including essential hypertension, accelerated atherosclerosis and cardiomyopathies. ACE inhibitors are recognised as being highly effective therapy for hypertension and cardiac insuffi...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200262090-00002
更新日期:2002-01-01 00:00:00
abstract::Heparin remains the most effective antithrombotic drug. It acts by combining with plasma antithrombin, thereby accelerating the neurtalisation of thrombin and other acitvated coagulation factors. Full-dose intravenous heparin is indicated in all cases of pulmonary embolism and established deep venous thrombosis, unles...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-197713010-00005
更新日期:1977-01-01 00:00:00
abstract::Suvorexant (Belsomra(®)), a first-in-class, orally active dual orexin-1 receptor and orexin-2 receptor antagonist, has been developed by Merck for the treatment of insomnia. Variations in the levels of the neuropeptides orexin A and orexin B have been linked to circadian rhythms and wakefulness. Orexin-producing neuro...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0294-5
更新日期:2014-10-01 00:00:00
abstract::Patients with viral infections of the central nervous system (CNS) may present with a variety of neurological symptoms, most commonly dominated by either encephalitis or meningitis. The aetiological panorama varies in different parts of the world as well as over time. Thus, virological first-line diagnostics must be a...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-013-0007-5
更新日期:2013-02-01 00:00:00
abstract::Methylnaltrexone is a selective mu-opioid receptor antagonist that has restricted ability to cross the blood-brain barrier, thus enabling reversal of opioid-induced peripheral effects, such as constipation, without affecting the central effects, such as pain relief. Treatment with subcutaneous methylnaltrexone 0.15-0....
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11204520-000000000-00000
更新日期:2010-05-07 00:00:00
abstract::Methotrexate has been approved for the treatment of refractory rheumatoid arthritis by several regulatory agencies, including the Food and Drug Administration. The tendency is now to prescribe it at earlier stages of the disease. Methotrexate is a well known antifolate. Its exact mechanism of action in rheumatoid arth...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199447010-00003
更新日期:1994-01-01 00:00:00
abstract::Acamprosate (calcium acetylhomotaurinate), a synthetic compound with a similar chemical structure to that of gamma-aminobutyric acid, is thought to act via several mechanisms affecting multiple neurotransmitter systems; inhibition of neuronal hyperexcitability by antagonism of excitatory amino acid activity and reduct...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199753060-00008
更新日期:1997-06-01 00:00:00
abstract::Inhaled mometasone furoate (Asmanex) is a synthetic corticosteroid indicated for the first-line maintenance prophylactic therapy of persistent asthma in adults and adolescents. It is formulated for delivery via a breath-actuated dry powder inhaler (DPI) [Twisthaler].Inhaled mometasone furoate delivered by DPI is effec...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666080-00011
更新日期:2006-01-01 00:00:00
abstract::Sodium-glucose co-transporter 2 (SGLT2) inhibitors are glucose-lowering drugs that reduce plasma glucose levels by inhibiting glucose and sodium reabsorption in the kidneys, thus resulting in glucosuria. Their effects consequently include reductions in HbA1c, blood glucose levels, and blood pressure, but also reductio...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-1057-0
更新日期:2019-02-01 00:00:00
abstract::Losartan/hydrochlorothiazide (HCTZ) [Hyzaar(R)] is a fixed-dose combination of the angiotensin II receptor antagonist (angiotensin receptor blocker [ARB]) losartan and the thiazide diuretic HCTZ. It is indicated for the treatment of hypertension (including as initial therapy in severe hypertension) and for stroke risk...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200969090-00008
更新日期:2009-06-18 00:00:00
abstract::Vitamin A acid (retinoic acid: tretinoin) is a vitamin A derivative used in the topical treatment of acne. It acts by 'unseating' comedones, improvement developing slowly over a period of 2 to 3 or more months, and is also said to prevent the formation of new lesions. About three-quarters of patients with acne vulgari...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-197714060-00001
更新日期:1977-12-01 00:00:00
abstract::Valsartan/hydrochlorothiazide (HCTZ) combines an angiotensin II AT1 receptor blocker with a thiazide diuretic to produce additive blood pressure reductions without major effects on heart rate. HCTZ did not significantly alter valsartan pharmacokinetics; during combination therapy, HCTZ pharmacokinetics differed from t...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199957050-00008
更新日期:1999-05-01 00:00:00
abstract::Mortality and morbidity in gastroenteritis in children is the result of fluid loss, acid-base and electrolyte imbalance. Hence therapy should be aimed at preventing or correcting this imbalance. The use of intestinal antibiotics to treat the condition should not be a routine, but parenteral antibiotic therapy in the p...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-197611040-00004
更新日期:1976-01-01 00:00:00