Suvorexant: first global approval.

abstract：:In hospitals, oral quinolone therapy has lower daily associated costs (acquisition and administration) than most intravenous regimens. In addition, oral switch therapy shortens the duration of hospital stay for most patients. However, randomised trials are required to measure the economic impact of the switch to oral ...

journal_title：Drugs

authors： Davey P

更新日期：1999-01-01 00:00:00

abstract：:Acyclovir (aciclovir) is a nucleoside antiviral drug with antiviral activity in vitro against members of the herpes group of DNA viruses. As an established treatment of herpes simplex infection, intravenous, oral and to a lesser extent topical formulations of acyclovir provide significant therapeutic benefit in genita...

journal_title：Drugs

authors： O'Brien JJ,Campoli-Richards DM

更新日期：1989-03-01 00:00:00

abstract：:The European Commission and the European Parliament have acknowledged the specific need for a proper evaluation of new drugs in children. The evaluation of the antiepileptic drugs (AEDs) available on the market illustrates the deficit in therapeutic trials for childhood epilepsy syndromes. Currently, the development o...

journal_title：Drugs

authors： Chiron C,Dulac O,Pons G

更新日期：2008-01-01 00:00:00

abstract：:Pharmacological treatment of hypertension can, cause clinically significant alterations in endocrine function and glucose homeostasis. The aim of this study was to investigate the antihypertensive efficacy and the influence on carbohydrate metabolism of carvedilol and metoprolol in non-insulin-dependent diabetics with...

journal_title：Drugs

authors： Ehmer B,van der Does R,Rudorf J

更新日期：1988-01-01 00:00:00

abstract：:Accumulating evidence suggests the involvement of estrogen in depression. Estrogen can modulate neurotransmitter turnover, enhancing the levels of serotonin and noradrenaline (norepinephrine), and it is involved in the regulation of serotonin receptor number and function. Across the female reproductive life, fluctuati...

journal_title：Drugs

authors： Ryan J,Ancelin ML

更新日期：2012-09-10 00:00:00

abstract：:When to treat the patient who presents with ocular hypertension has been a question that has 'stumped' the ophthalmic community for decades. Population-based studies and intervention trials have provided the basis for understanding why we consider treating such patients. Although the EGPS (European Glaucoma Prevention...

journal_title：Drugs

authors： Higginbotham EJ

更新日期：2006-01-01 00:00:00

abstract：:Estrogenic compounds are the most important group of drugs that can induce hypertension. Studies have shown an incidence of significant hypertension amounting to less than 1% after 1 year of taking oral contraceptives and about 2% after 5 years. The ratio of the incidence of hypertension among ''takers'' to that of ...

journal_title：Drugs

authors： Stokes GS

更新日期：1976-01-01 00:00:00

abstract：:In the table 'Key clinical trials of isatuximab (Sanofi)', in the left-hand column. ...

journal_title：Drugs

authors： Dhillon S

更新日期：2020-06-01 00:00:00

abstract：:204 individuals from a rural community were given a single dose of oxantel-pyrantel at 15mg/kg bodyweight and if still infected, 20mg/kg bodyweight, with cure rates of 100%, 53% and 71% for ascariasis, trichuriasis and hookworm infection, respectively. From an urban community, 124 patients were given the same drug eit...

journal_title：Drugs

authors： Cabrera BD,Sy FS

更新日期：1978-01-01 00:00:00

abstract：:The number of effective cytotoxic agents for the treatment of patients with metastatic adult soft tissue sarcoma is limited, especially when patients have failed anthracycline- and ifosfamide-based chemotherapy. For the subgroup of patients with inoperable gastrointestinal stromal tumour (GIST), progress has been made...

journal_title：Drugs

authors： Hartmann JT,Patel S

更新日期：2005-01-01 00:00:00

abstract：:Brodalumab (Lumicef(®)) is a human monoclonal immunoglobulin G antibody that is being developed by Kyowa Hakko Kirin in Japan, where it has been approved for the treatment of psoriasis vulgaris, psoriatic arthritis, pustular psoriasis and psoriatic erythroderma. Brodalumab binds with high affinity to interleukin (IL)-...

journal_title：Drugs

authors： Greig SL

更新日期：2016-09-01 00:00:00

abstract：:For many years now a treatment mitigating the debilitating effects of jet lag has been sought. Rapid travel across time zones leads, in most people, to temporary symptoms, in particular poor sleep, daytime alertness and poor performance. Mis-timed circadian rhythms are considered to be the main factor underlying jet-l...

journal_title：Drugs

authors： Arendt J

更新日期：2018-09-01 00:00:00

abstract：:The article Trifluridine/Tipiracil: A Review in Metastatic Gastric Cancer, written by Connie Kang, Sohita Dhillon and Emma D. Deeks, was originally published Online First without open access. ...

journal_title：Drugs

authors： Kang C,Dhillon S,Deeks ED

更新日期：2019-10-01 00:00:00

abstract：:There is now good evidence that T cells play a central role in the inflammatory pathway that leads to the persistent synovitis that causes joint damage in rheumatoid arthritis (RA). T cells require two signals to become activated. The second step in the activation of T cells involves costimulatory pathways, the best d...

journal_title：Drugs

authors： Pollard LC

更新日期：2007-01-01 00:00:00

abstract：:Cefpodoxime, the active de-esterified molecule of the orally absorbable cephalosporin cefpodoxime proxetil, inhibits streptococci, Neisseria spp., and most Enterobacteriaceae, with MIC50 and/or MIC90 values of less than or equal to 2 mg/L; with regard to the latter family of bacteria, the MIC50 and/or MIC90 values of ...

journal_title：Drugs

authors： Wiedemann B,Luhmer E,Zühlsdorf MT

更新日期：1991-01-01 00:00:00

abstract：:Alterations of skin and hair pigmentation are important features that have warranted treatment from ancient history on up to modern time. In some cultures, even today patients with vitiligo are regarded as social outcasts and are affected considerably both emotionally and physically. This article presents current opti...

journal_title：Drugs

authors： Hartmann A,Bröcker EB,Becker JC

更新日期：2004-01-01 00:00:00

abstract：:On the basis of well documented biochemical and pharmacological data about the influence of drug mediated enzyme induction on the biotransformation of natural and synthetic sex steroids, practical consequences for hormonal steroid contraception are described and discussed. Clinical reports dealing with this problem ar...

journal_title：Drugs

authors： Hempel E,Klinger W

更新日期：1976-12-01 00:00:00

abstract：:Etoposide is one of the most active agents for the therapy of lymphomas. Oral etoposide has proven to be active in and clearly beneficial for patients with previously treated lymphomas. The optimal dose and schedule of oral etoposide for use in combination chemotherapy are still uncertain, but low daily doses (50 to 1...

journal_title：Drugs

authors： Greco FA

更新日期：1999-01-01 00:00:00

abstract：:In ten large, well-controlled, randomised trials (n = 203 to 1089), valdecoxib, a selective inhibitor of cyclo-oxygenase-2, was significantly more effective than placebo in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with primary dysmenorrhoea, and for postsurgical analgesia. Valdecoxib 1...

journal_title：Drugs

authors： Ormrod D,Wellington K,Wagstaff AJ

更新日期：2002-01-01 00:00:00

abstract：:The original article can be found online. ...

journal_title：Drugs

authors： Scott LJ

更新日期：2020-09-01 00:00:00

abstract：:Dopamine agonists (DAs) represent an excellent treatment option for patients with Parkinson's disease, in both the early and advanced stages of the disease, improving motor symptoms, lowering the incidence of motor complications, and addressing several non-motor symptoms. Indeed, each of these compounds have different...

journal_title：Drugs

authors： Torti M,Bravi D,Vacca L,Stocchi F

更新日期：2019-05-01 00:00:00

abstract：:Alipogene tiparvovec (Glybera®; AMT-011, AAV1-LPL(S447X)) is an adeno-associated virus serotype 1-based gene therapy for adult patients with familial lipoprotein lipase (LPL) deficiency (LPLD) and suffering from severe or multiple pancreatitis attacks despite dietary fat restrictions. It is administered as a one-time ...

journal_title：Drugs

authors： Scott LJ

更新日期：2015-02-01 00:00:00

abstract：:This paper reviews the theoretical concepts and methods utilised with isolated tissues to characterise drugs and drug receptors. Specifically the impact, on the in vitro measurement of agonist affinity and relative efficacy, of the idea that receptors bind to transduction proteins in the lipid bilayer of the cell memb...

journal_title：Drugs

authors： Kenakin T

更新日期：1990-11-01 00:00:00

abstract：:The common clinical problem of recurrent symptomatic urinary tract infections (UTI) in young women may be inconvenient and distressing to both the patient and her family, particularly if the infections are not managed in a rational manner. A suggested approach is included in table 1. ...

journal_title：Drugs

authors： Bailey RR

更新日期：1977-02-01 00:00:00

abstract：:Amorolfine is a structurally unique, topically active antifungal agent, which possesses both fungistatic and fungicidal activity in vitro. Its spectrum of in vitro activity includes dermatophyte, dimorphic, some dematiaceous and filamentous fungi, and some yeasts. In clinical trials, application of amorolfine 5% nail ...

journal_title：Drugs

authors： Haria M,Bryson HM

更新日期：1995-01-01 00:00:00

abstract：UNLABELLED:Tranexamic acid is a synthetic derivative of the amino acid lysine that exerts its antifibrinolytic effect through the reversible blockade of lysine binding sites on plasminogen molecules. Intravenously administered tranexamic acid (most commonly 10 mg/kg followed by infusion of 1 mg/kg/hour) caused reductio...

journal_title：Drugs

authors： Dunn CJ,Goa KL

更新日期：1999-06-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway is implicated in the pathogenesis of lymphoma. Deeper understanding of the diversity and biological impact of this pathway has led to the development of specific inhibitors to this pathway. Preclinical data in cell lines, patient samples and disease models have bro...

journal_title：Drugs

authors： Seiler T,Hutter G,Dreyling M

更新日期：2016-04-01 00:00:00

abstract：:Lapatinib (Tyverb, Tykerb) is an orally active, small molecule, reversible, dual tyrosine kinase inhibitor of human epidermal growth factor receptor type 1 (HER1) and type 2 (HER2). In the EU, lapatinib in combination with capecitabine is indicated for the treatment of women with HER2-overexpressing, advanced or metas...

journal_title：Drugs

authors： Frampton JE

更新日期：2009-10-22 00:00:00

abstract：:Although antiangiogenic treatments have produced milestone advances in the treatment of several diseases, and have significantly extended the median survival of cancer patients, these agents share some weaknesses, including a limited impact on the overall cure rate, a fleeting effect because of redundant pathways or e...

journal_title：Drugs

authors： Aprile G,Bonotto M,Ongaro E,Pozzo C,Giuliani F

更新日期：2013-12-01 00:00:00

abstract：:Rilpivirine is an orally administered, non-nucleoside reverse transcriptase inhibitor that is a component drug in combination therapy for antiretroviral-naive patients with HIV-1 infection. The randomized, double-blind, double-dummy, multinational ECHO and THRIVE trials in antiretroviral-naive adult patients with HIV-...

journal_title：Drugs

authors： Sanford M

更新日期：2012-03-05 00:00:00