Abstract:
:Inhaled mometasone furoate (Asmanex) is a synthetic corticosteroid indicated for the first-line maintenance prophylactic therapy of persistent asthma in adults and adolescents. It is formulated for delivery via a breath-actuated dry powder inhaler (DPI) [Twisthaler].Inhaled mometasone furoate delivered by DPI is effective in treating patients with persistent asthma. It improves pulmonary function and health-related quality of life, reduces symptoms and decreases oral corticosteroid requirements in severe disease. It is a potent anti-inflammatory agent and is at least as clinically effective as other inhaled corticosteroids. Inhaled mometasone furoate is equally effective in controlling asthma when administered in two divided doses or as a single daily dose. Once-daily administration of mometasone furoate 200 microg in the evening was more effective than administration of the same dosage in the morning. The drug is well tolerated, with low systemic bioavailability and minimal systemic activity. Therefore, it is an effective and convenient option for controller therapy of persistent asthma in adults and adolescents.
journal_name
Drugsjournal_title
Drugsauthors
McCormack PL,Plosker GLdoi
10.2165/00003495-200666080-00011subject
Has Abstractpub_date
2006-01-01 00:00:00pages
1151-68issue
8eissn
0012-6667issn
1179-1950pii
66811journal_volume
66pub_type
杂志文章,评审相关文献
DRUGS文献大全abstract::The treatment of a variety of inflammatory skin diseases was greatly changed by the introduction, in the early 1950s, of corticosteroids for topical use. Topical corticosteroids are still the most widely used drugs in dermatology, and many preparations with quite different potencies are now available. However, attempt...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198800365-00008
更新日期:1988-01-01 00:00:00
abstract::Opioid dependence, manifesting as addiction to heroin and pharmaceutical opioids is increasing. Internationally, there are an estimated 15.6 million illicit opioid users. The global economic burden of opioid dependence is profound both in terms of HIV and hepatitis C virus transmission, direct healthcare costs, and in...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11597520-000000000-00000
更新日期:2012-01-22 00:00:00
abstract::Chronic hand eczema is a common but frequently disabling skin condition which poses a significant social and economic burden. Although skin protection measures and topical therapies are fundamental in its management, some patients are refractory to first-line therapy with topical corticosteroids and require systemic t...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-016-0621-0
更新日期:2016-09-01 00:00:00
abstract::Bevacizumab is a recombinant, humanized anti-vascular endothelial growth factor (VEGF) monoclonal antibody that neutralizes the biological activity of VEGF and inhibits tumour angiogenesis. In two pivotal, well designed, phase III, clinical trials (GOG-0218 and ICON7) in women with advanced epithelial ovarian, fallopi...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11208940-000000000-00000
更新日期:2012-05-07 00:00:00
abstract::Since their introduction 15 years ago, retinoids have been increasingly used for topical and systemic treatment of psoriasis and other hyperkeratotic and parakeratotic skin disorders, keratotic genodermatoses, severe acne and acne-related dermatoses, and also for therapy and/or chemoprevention of skin cancer and other...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199753030-00003
更新日期:1997-03-01 00:00:00
abstract::74 cirrhotic patients with a history of variceal or gastric bleeding were randomly assigned to treatment with propranolol (40 to 360 mg/day) or placebo. The patients were all in good condition and doses of propranolol were titrated until a 25% reduction in heart rate was achieved. After 2 years, the cumulative percent...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-198900372-00006
更新日期:1989-01-01 00:00:00
abstract::The endothelium is involved in both the physiological regulation of vascular tone and the structural transformation of the vessel under pathological conditions. Under physiological conditions, endothelial cells continuously secrete nitric oxide (NO), which relaxes smooth muscle cells and ensures vessel patency. Damage...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199700531-00003
更新日期:1997-01-01 00:00:00
abstract::Stroke is the third most common cause of death in the US. Primary prevention of stroke can be achieved by control of risk factors including hypertension, diabetes mellitus, elevated cholesterol levels and smoking. Approximately one-third of all ischaemic strokes occur in patients with a history of stroke or transient ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200565040-00003
更新日期:2005-01-01 00:00:00
abstract::Azacitidine (Vidaza) is a pyrimidine nucleoside analogue of cytidine. Subcutaneous azacitidine was recently approved in the EU for the treatment of adults who are not eligible for haematopoietic stem cell transplantation and who have intermediate-2-risk or high-risk myelodysplastic syndromes (MDS) [according to Intern...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11202840-000000000-00000
更新日期:2009-01-01 00:00:00
abstract::The article Latanoprostene Bunod Ophthalmic Solution 0.024%: A Review in Open-Angle Glaucoma and Ocular Hypertension, written by Sheridan Hoy, was originally published Online First without open access. ...
journal_title:Drugs
pub_type: 杂志文章,已发布勘误
doi:10.1007/s40265-018-0925-3
更新日期:2018-06-01 00:00:00
abstract::Colloid solutions have been developed and used over the past 70 years as expanders of the intravascular space, based on an understanding of Starling's law. Increasing osmotic pressure with colloidal products has remained an attractive theoretical premise for volume resuscitation. Indeed, colloids have been shown to in...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199855050-00002
更新日期:1998-05-01 00:00:00
abstract::An association between low serum potassium concentrations and ventricular arrhythmias has been observed by a number of investigators in patients with both acute myocardial infarction and symptomatic angina. The increased frequency of ventricular fibrillation in patients with low serum potassium concentrations has not ...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198600314-00014
更新日期:1986-01-01 00:00:00
abstract::The studies reported here were designed to ascertain whether or not the new beta-lactam antibiotic, temocillin, would produce antibiotic-associated colitis in the hamster. The experiments were controlled with clindamycin and cefoxitin, which are known to induce antibiotic-associated colitis experimentally and clinical...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198500295-00012
更新日期:1985-01-01 00:00:00
abstract::Acyclovir (aciclovir) is a nucleoside antiviral drug with antiviral activity in vitro against members of the herpes group of DNA viruses. As an established treatment of herpes simplex infection, intravenous, oral and to a lesser extent topical formulations of acyclovir provide significant therapeutic benefit in genita...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198937030-00002
更新日期:1989-03-01 00:00:00
abstract::Miconazole is an imidazole antifungal drug which has recently become available for systemic use. Its antifungal activity has been well studied and it is active in vitro against a wide range of fungi. Published and unpublished reports of the use of miconazole in conditions such as systemic or mucocutaneous candidosis, ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198019010-00002
更新日期:1980-01-01 00:00:00
abstract::Trifluridine/tipiracil (Lonsurf(®)) is a novel, orally active, antimetabolite agent comprised of trifluridine, a thymidine-based nucleoside analogue, and tipiracil, a potent thymidine phosphorylase inhibitor. Trifluridine is incorporated into DNA via phosphorylation, ultimately inhibiting cell proliferation. Tipiracil...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-016-0633-9
更新日期:2016-09-01 00:00:00
abstract::Recent clinical trials have demonstrated beyond doubt that statins are effective in the prevention of acute coronary events. Critical analysis of these studies suggests that the benefits of statin therapy cannot be fully explained on the basis of reductions in plasma cholesterol levels. Accumulating knowledge of the a...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199856040-00001
更新日期:1998-10-01 00:00:00
abstract::Increases in cancer diagnosis have tremendous negative impacts on patients and their families, and major societal and economic costs. The beneficial effect of chemotherapeutic agents on tumor suppression comes with major unwanted side effects such as weight and hair loss, nausea and vomiting, and neuropathic pain. Che...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01132-x
更新日期:2019-06-01 00:00:00
abstract::In hospitals, oral quinolone therapy has lower daily associated costs (acquisition and administration) than most intravenous regimens. In addition, oral switch therapy shortens the duration of hospital stay for most patients. However, randomised trials are required to measure the economic impact of the switch to oral ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199958002-00014
更新日期:1999-01-01 00:00:00
abstract::Numerous studies report the relationship between aspirin and other nonsteroidal anti-inflammatories (NSAIDs) and cancer incidence, in particular for colorectal cancer. This paper systematically reviews the evidence of the effect of aspirin and other NSAIDs on the primary prevention of colorectal and other gastrointest...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200262060-00006
更新日期:2002-01-01 00:00:00
abstract::Discharge from the ear can be the result of many disease processes. The ear may discharge blood, pus, cerebrospinal fluid (CSF) or wax. Keratosis obturans, stenosis of the external meatus and benign tumours of the external meatus all lead to wax build-up, which may cause recurrent attacks of otitis externa. Malignant ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199243020-00008
更新日期:1992-02-01 00:00:00
abstract::Marijuana has been used for over 2 centuries. Its major psychoactive constituent, delta-9-tetrahydrocannabinol (THC) was isolated in 1964 and first used to control nausea and vomiting during chemotherapy in the 1970s. THC has cardiovascular, pulmonary and endocrinological effects as well as actions on the central nerv...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198300251-00006
更新日期:1983-02-01 00:00:00
abstract::Airway inflammation is central to the pathophysiology of asthma, with treatment directed towards modification of this inflammation and its consequences. The relationship between cigarette smoking and airway inflammation is also well described, but relatively little data are available on the potential influence of smok...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200565110-00005
更新日期:2005-01-01 00:00:00
abstract::Venous thromboembolism (VTE) is a major cause of morbidity, mortality, and healthcare expenditure. In the United States, approximately 0.1 % of the population experiences an initial VTE event each year. Anticoagulation therapy is the cornerstone of acute VTE treatment and for prevention of recurrent VTE events. Conven...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0301-x
更新日期:2014-11-01 00:00:00
abstract::The increasing incidence of systemic fungal infections and rising medical costs have highlighted the need for an economic appraisal of antifungal agents to determine the most cost-effective therapeutic option. Cost savings derived from the prophylactic or empirical use of antifungal agents have been difficult to estim...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200161001-00005
更新日期:2001-01-01 00:00:00
abstract::The effect of cefotaxime and ceftriaxone on faecal flora was investigated in women undergoing routine vaginal or abdominal hysterectomy. Three groups of 9 patients received, in a double-blind fashion and just before surgery, cefotaxime 2g intravenously, ceftriaxone 2g intravenously or no antibiotic (controls). Stools ...
journal_title:Drugs
pub_type: 临床试验,杂志文章
doi:10.2165/00003495-198800352-00004
更新日期:1988-01-01 00:00:00
abstract::The hyperkinetic syndrome is a symptom complex of hyperactivity, short attention span, distractibility, impulsivity, learning difficulties, other behaviour problems and 'equivocal' neurological signs. However, none of these terms has ever been objectively defined and at present diagnosis is largely a matter of clinica...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-197611020-00001
更新日期:1976-01-01 00:00:00
abstract:UNLABELLED:Patients with beta-thalassaemia and other transfusion-dependent diseases develop iron overload from chronic blood transfusions and require regular iron chelation to prevent potentially fatal iron-related complications. The only iron chelator currently widely available is deferoxamine, which is expensive and ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199958030-00021
更新日期:1999-09-01 00:00:00
abstract::Pain represents a major clinical, social and economic problem, with estimates of its prevalence ranging from 8% to more than 60%, depending on the population. The impact of pain on economies is enormous, with the cost of back pain alone equivalent to more than one-fifth of one country's total health expenditure and 1....
journal_title:Drugs
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:The aim of this article is to review data on the efficacy and safety of montelukast in the treatment of children with asthma. METHODOLOGY:Available published literature, including published abstracts, is reviewed. RESULTS:In patients aged 6 to 14 years with asthma (n = 27), montelukast 5mg demonstrated a si...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200059001-00005
更新日期:2000-01-01 00:00:00