Abstract:
:An association between low serum potassium concentrations and ventricular arrhythmias has been observed by a number of investigators in patients with both acute myocardial infarction and symptomatic angina. The increased frequency of ventricular fibrillation in patients with low serum potassium concentrations has not been attributable to differences in the size or location of the infarct or concomitant digitalis administration. Although prior diuretic usage is frequently associated with a low serum potassium concentration, diuretic usage in the absence of significant changes in serum electrolytes is not associated with an increase in malignant ventricular arrhythmias. It is not clear whether the alterations in serum potassium are important in the pathogenesis of the arrhythmias or merely a marker for other arrhythmogenic factors. To the extent that changes in serum potassium contribute to the production of serious ventricular arrhythmias, efforts should be directed at the correction of such electrolyte disturbances. Attempts to increase the serum potassium in acute cases do not appear to be successful in preventing ventricular arrhythmias in this setting. Primary prevention of electrolyte disturbances would seem to offer more effective protection against serious arrhythmias. Long term studies with beta-blockers support this premise.
journal_name
Drugsjournal_title
Drugsauthors
Solomon RJdoi
10.2165/00003495-198600314-00014subject
Has Abstractpub_date
1986-01-01 00:00:00pages
112-20eissn
0012-6667issn
1179-1950journal_volume
31 Suppl 4pub_type
杂志文章相关文献
DRUGS文献大全abstract::Alteplase is the product of recombinant DNA technology and is chemically identical to endogenous tissue-type plasminogen activator: Plasminogen is converted to plasmin by alteplase, and fibrinolysis of blood thrombi is subsequently stimulated. Alteplase is now firmly established as a treatment of choice in the managem...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199550020-00007
更新日期:1995-08-01 00:00:00
abstract::Drug treatment for various anorectal conditions has been known since ancient times. Today, modern as well as traditional drugs are being increasingly used in all grades of symptomatic haemorrhoids. These drugs (oral and local) are used as a part of conservative management or as an adjuvant to invasive outpatient proce...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200565110-00003
更新日期:2005-01-01 00:00:00
abstract::Since their introduction 15 years ago, retinoids have been increasingly used for topical and systemic treatment of psoriasis and other hyperkeratotic and parakeratotic skin disorders, keratotic genodermatoses, severe acne and acne-related dermatoses, and also for therapy and/or chemoprevention of skin cancer and other...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199753030-00003
更新日期:1997-03-01 00:00:00
abstract::The fluoroquinolones have been shown to be active in vitro against many mycobacterial species, including most strains of Mycobacterium tuberculosis complex and M. fortuitum, and some strains of M. kansasii, M. avium-intracellulare (MAI) complex and M. leprae. Ciprofloxacin, ofloxacin and sparfloxacin are the best stud...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199958002-00004
更新日期:1999-01-01 00:00:00
abstract::Insulin glargine is a human insulin analogue prepared by recombinant DNA technology. Modification of the human insulin molecule at position A21 and at the C-terminus of the B-chain results in the formation of a stable compound that is soluble at pH 4.0, but forms amorphous microprecipitates in subcutaneous tissue from...
journal_title:Drugs
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验,评审
doi:10.2165/00003495-200363160-00007
更新日期:2003-01-01 00:00:00
abstract::Bevacizumab is a recombinant, humanized anti-vascular endothelial growth factor (VEGF) monoclonal antibody that neutralizes the biological activity of VEGF and inhibits tumour angiogenesis. In two pivotal, well designed, phase III, clinical trials (GOG-0218 and ICON7) in women with advanced epithelial ovarian, fallopi...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11208940-000000000-00000
更新日期:2012-05-07 00:00:00
abstract::Entecavir (Baraclude) is a novel nucleoside analogue of 2'-deoxyguanosine whose intracellular triphosphate form inhibits replication of the hepatitis B virus (HBV). In large, randomised, double-blind, phase III clinical trials in patients with chronic HBV infection, oral entecavir 0.5 or 1.0mg once daily for up to 96 ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666120-00009
更新日期:2006-01-01 00:00:00
abstract::Rabeprazole is an inhibitor of the gastric proton pump. It causes dose-dependent inhibition of acid secretion and has a more rapid onset of action than omeprazole. Duodenal ulcers healed faster after treatment with rabeprazole 20 or 40 mg/day than placebo or ranitidine 150 mg 4 times daily and at a generally similar r...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199958040-00014
更新日期:1999-10-01 00:00:00
abstract::All 27 EU member states and another seven countries participate in the European Surveillance of Antimicrobial Consumption (ESAC) project. ESAC carried out three hospital point-prevalence surveys on antimicrobial use. Point-prevalence surveys linked antimicrobial use to indication and also assessed dosing using a stand...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/11591180-000000000-00000
更新日期:2011-04-16 00:00:00
abstract::Evidence suggests that arterial hypertension, in addition to being a cardiovascular and renal risk factor, may also be associated with an impairment of male sexual function. Since other cardiovascular risk factors, especially diabetes mellitus, have also been shown to correlate with impaired sexual function it has bee...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200565060-00005
更新日期:2005-01-01 00:00:00
abstract::Immunotherapeutic approaches have been, and continue to be, aggressively investigated in the treatment of infiltrating gliomas. While the results of late-phase clinical studies have been disappointing in this disease space thus far, the success of immunotherapies in other malignancies as well as the incremental gains ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01203-z
更新日期:2019-11-01 00:00:00
abstract::Insulin glargine 300 U/mL (Toujeo(®)) is a long-acting basal insulin analogue approved for the treatment of diabetes mellitus. Insulin glargine 300 U/mL has a more stable and prolonged pharmacokinetic/pharmacodynamic profile than insulin glargine 100 U/mL (Lantus(®)), with a duration of glucose-lowering activity excee...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-016-0541-z
更新日期:2016-03-01 00:00:00
abstract::The most positive results in this area have been those of the second Danish Study Group on Verapamil in Myocardial Infarction (1990) which assessed the benefit of treatment with verapamil from the second week after myocardial infarction. Verapamil produced a significant reduction in both mortality and reinfarction rat...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199100421-00005
更新日期:1991-01-01 00:00:00
abstract::The use of digitalis in congestive heart failure with normal sinus rhythm is still debated. While older uncontrolled, withdrawal studies from 1969 to 1983 provided incomplete data, with poorly documented clinical status and poor haemodynamic and exercise data, some patients did improve clinically when digitalis treatm...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199855060-00002
更新日期:1998-06-01 00:00:00
abstract::Serum concentrations and pharmacokinetic parameters of ofloxacin were measured in 10 patients on haemodialysis treatment. Serum half-life during the interdialytic interval was 48 hours, and during haemodialysis treatment 10 hours. The decrease in serum concentrations during a 4-hour haemodialysis was 25%. After severa...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198700341-00014
更新日期:1987-01-01 00:00:00
abstract::During the intervening years since metoprolol was first reviewed in the Journal (1977), it has become widely used in the treatment of mild to moderate hypertension and angina pectoris. Although much data have accumulated, its precise mechanisms of action in these diseases remain largely uncertain. Optimum treatment of...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198631050-00002
更新日期:1986-05-01 00:00:00
abstract::Numerous studies report the relationship between aspirin and other nonsteroidal anti-inflammatories (NSAIDs) and cancer incidence, in particular for colorectal cancer. This paper systematically reviews the evidence of the effect of aspirin and other NSAIDs on the primary prevention of colorectal and other gastrointest...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200262060-00006
更新日期:2002-01-01 00:00:00
abstract::Influenza vaccines form the mainstay of public health and personal protection against infection with seasonal influenza viruses. These vaccines are designed to protect people against infection with the currently circulating influenza viruses. Since the late 1970s, this has required the use of a trivalent vaccine consi...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/11641110-000000000-00000
更新日期:2012-12-03 00:00:00
abstract::Lefamulin is a novel oral and intravenous (IV) pleuromutilin developed as a twice-daily treatment for community-acquired bacterial pneumonia (CABP). It is a semi-synthetic pleuromutilin with a chemical structure that contains a tricyclic core of five-, six-, and eight-membered rings and a 2-(4-amino-2-hydroxycyclohexy...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01443-4
更新日期:2020-11-28 00:00:00
abstract::Lumasiran (Oxlumo™) is a subcutaneously administered small interfering RNA (siRNA) targeting the mRNA for hydroxyacid oxidase 1 gene (HAO1; encodes glycolate oxidase) and was developed by Alnylam Pharmaceuticals for the treatment of primary hyperoxaluria type 1 (PH1). By silencing the gene encoding glycolate oxidase, ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01463-0
更新日期:2021-01-06 00:00:00
abstract::The newest (third generation) fluoroquinolones are potentially useful agents in the management of community-acquired respiratory tract infections. This is mainly due to their increased activity against Streptococcuspneumoniae, a pathogen poorly susceptible to the second-generation compounds, and playing a major role i...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199957060-00002
更新日期:1999-06-01 00:00:00
abstract::Insulin degludec (Tresiba(®)) is an ultra-long-acting insulin analogue that is also available as a coformulation with rapid-acting insulin aspart (insulin degludec/insulin aspart) [Ryzodeg(®)]. Insulin degludec has a flat, stable glucose-lowering profile with a duration of action of >42 h, and less within-patient day-...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-013-0051-1
更新日期:2013-05-01 00:00:00
abstract::Mantle cell lymphoma is a rare yet well defined subtype of B-cell non-Hodgkin's lymphoma. The correct histological diagnosis of this lymphoma subtype is of the utmost importance; however, it is also a very difficult diagnosis. Clinical management is often complex, and despite the successful introduction of monoclonal ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200767120-00004
更新日期:2007-01-01 00:00:00
abstract::The benefits of the treatment of hypertension currently consist of a substantially reduced incidence of premature stroke, left ventricular failure and malignant hypertension. The benefits for the individual are most clearcut in those who have already had severe or symptomatic hypertension. Older subjects who have a hi...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198800366-00003
更新日期:1988-01-01 00:00:00
abstract::Acamprosate (calcium acetylhomotaurinate), a synthetic compound with a similar chemical structure to that of gamma-aminobutyric acid, is thought to act via several mechanisms affecting multiple neurotransmitter systems; inhibition of neuronal hyperexcitability by antagonism of excitatory amino acid activity and reduct...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199753060-00008
更新日期:1997-06-01 00:00:00
abstract::Chronic spontaneous urticaria (CSU) is characterized by the presence of wheals, angioedema, or both for at least 6 weeks. It may persist for a long time-up to 50% of the patients have been reported to be symptomatic 5 years after the onset. Some patients can suffer more than one episode of CSU during their lifetime. C...
journal_title:Drugs
pub_type: 杂志文章
doi:10.1007/s40265-020-01387-9
更新日期:2020-11-01 00:00:00
abstract::Administration of unopposed postmenopausal estrogen therapy protects against coronary heart disease (CHD) in women. This is mediated, in part, through beneficial effects on lipid and lipoprotein metabolism. Fewer data are available with regard to CHD risk reduction when a progesterone is required in addition to estrog...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199400472-00005
更新日期:1994-01-01 00:00:00
abstract::Acyclovir (aciclovir) is a nucleoside antiviral drug with antiviral activity in vitro against members of the herpes group of DNA viruses. As an established treatment of herpes simplex infection, intravenous, oral and to a lesser extent topical formulations of acyclovir provide significant therapeutic benefit in genita...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198937030-00002
更新日期:1989-03-01 00:00:00
abstract::Intravenous dalbavancin (Dalvance®, Xydalba®), first approved as a two-dose regimen for the treatment of acute bacterial skin and skin structure infections (ABSSSI), has now been additionally approved as a single-dose regimen. This narrative review discusses the pharmacological properties of intravenous dalbavancin an...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-016-0666-0
更新日期:2017-01-01 00:00:00
abstract::Voriconazole (VFEND), a synthetic second-generation, broad-spectrum triazole derivative of fluconazole, inhibits the cytochrome P450 (CYP)-dependent enzyme 14-alpha-sterol demethylase, thereby disrupting the cell membrane and halting fungal growth. In the US, intravenous and/or oral voriconazole is recommended in adul...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200767020-00009
更新日期:2007-01-01 00:00:00