Protective effects of calcium antagonists against ischaemia and reperfusion damage.

abstract：UNLABELLED:Dofetilide is a 'pure' class III antiarrhythmic agent which has demonstrated efficacy in the conversion of atrial fibrillation or flutter to sinus rhythm and the maintenance of sinus rhythm. By blocking the rapid component of the cardiac delayed rectifier potassium current (I(Kr)), dofetilide prolongs the ca...

journal_title：Drugs

authors： McClellan KJ,Markham A

更新日期：1999-12-01 00:00:00

abstract：:The incidence of pulmonary embolism (PE) and venous thromboembolism (VTE) is higher in pregnant patients than in non-pregnant patients. The incidence of thrombosis in all pregnancies is reported to be between 0.05 and 1%, and an incidence as high as 3% may be present in women after caesarean section. Anticoagulant med...

journal_title：Drugs

authors： Laurent P,Dussarat GV,Bonal J,Jego C,Talard P,Bouchiat C,Cellarier G

更新日期：2002-01-01 00:00:00

abstract：:Certolizumab pegol (Cimzia(®)) is a recombinant, polyethylene glycolylated, antigen-binding fragment of a humanized monoclonal antibody that selectively targets and neutralizes tumour necrosis factor (TNF)-α. The drug is indicated for subcutaneous use every 2 or 4 weeks (q2w or q4w) for the treatment of adults with mo...

journal_title：Drugs

authors： Deeks ED

更新日期：2013-01-01 00:00:00

abstract：:Page 9, Fig. 2, which originally appeared as. ...

journal_title：Drugs

authors： Mathieson S,Maher CG,Ferreira GE,Hamilton M,Jansen J,McLachlan AJ,Underwood M,Lin CC

更新日期：2020-10-01 00:00:00

abstract：:Mild to moderate hypertension still remains poorly controlled. This relates to multiple factors including low antihypertensive efficacy of single drug therapies reluctance of primary care physicians to modify/titrate initially chosen therapy to obtain target blood pressure, and poor compliance with medication. Several...

journal_title：Drugs

authors： Ruzicka M,Leenen FH

更新日期：2001-01-01 00:00:00

abstract：:Cefpodoxime, the active de-esterified molecule of the orally absorbable cephalosporin cefpodoxime proxetil, inhibits streptococci, Neisseria spp., and most Enterobacteriaceae, with MIC50 and/or MIC90 values of less than or equal to 2 mg/L; with regard to the latter family of bacteria, the MIC50 and/or MIC90 values of ...

journal_title：Drugs

authors： Wiedemann B,Luhmer E,Zühlsdorf MT

更新日期：1991-01-01 00:00:00

abstract：:Vemurafenib is the first molecularly targeted therapy to be licensed in the US and Europe for treatment of advanced melanoma. Its mechanism of action involves selective inhibition of the mutated BRAF V600E kinase that leads to reduced signalling through the aberrant mitogen-activated protein kinase (MAPK) pathway. Its...

journal_title：Drugs

authors： Sharma A,Shah SR,Illum H,Dowell J

更新日期：2012-12-03 00:00:00

abstract：:Budesonide MMX(®) (Cortiment(®); Uceris(®)) is a novel once-daily oral formulation of budesonide using Multi Matrix (MMX(®)) colonic delivery technology to permit the release of budesonide at a controlled rate throughout the colon. It is available in the USA for the induction of remission in patients with active, mild...

journal_title：Drugs

authors： Hoy SM

更新日期：2015-05-01 00:00:00

abstract：:The discovery of immune inhibitory checkpoints has revolutionized the approach to the systemic treatment of cancer. The programmed death 1 (PD-1) inhibitory checkpoint, in particular, has played a key role in understanding how certain cancers can evade immune surveillance. Blocking the interaction between the PD-1 rec...

journal_title：Drugs

authors： Tsai KK,Daud AI

更新日期：2015-04-01 00:00:00

abstract：:An increase in serum digoxin concentration occurs in 90% of patients given quinidine. On average, the serum digoxin doubles during treatment with therapeutic doses of quinidine. Almost every patient treated with quinidine will have a decrease in the renal clearance of digoxin and many will have a decrease in the volum...

journal_title：Drugs

authors： Bigger JT Jr,Leahey EB Jr

更新日期：1982-09-01 00:00:00

abstract：:Influenza vaccines form the mainstay of public health and personal protection against infection with seasonal influenza viruses. These vaccines are designed to protect people against infection with the currently circulating influenza viruses. Since the late 1970s, this has required the use of a trivalent vaccine consi...

journal_title：Drugs

authors： Barr IG,Jelley LL

更新日期：2012-12-03 00:00:00

abstract：:Pinacidil is a newly developed antihypertensive vasodilator, proposed to belong to the new group of smooth muscle relaxants, the K+ channel openers. The in vitro effects of pinacidil on induced tone, smooth muscle membrane potential and 86Rb and 42K efflux from rat resistance vessels (internal diameter about 200 micro...

journal_title：Drugs

authors： Videbaek LM,Aalkjaer C,Mulvany MJ

更新日期：1988-01-01 00:00:00

abstract：:The effects of enalapril on clinical well-being, treadmill exercise performance, haemodynamic measurements, hormone levels, and plasma biochemistry in patients with moderate heart failure, were assessed in a 12-week placebo-controlled, double-blind study. Maintenance frusemide and digoxin treatment was continued throu...

journal_title：Drugs

authors： Webster MW,Fitzpatrick MA,Hamilton EJ,Nicholls MG,Ikram H,Espiner EA,Wells JE

更新日期：1985-01-01 00:00:00

abstract：:Azacitidine (Vidaza) is a pyrimidine nucleoside analogue of cytidine. Subcutaneous azacitidine was recently approved in the EU for the treatment of adults who are not eligible for haematopoietic stem cell transplantation and who have intermediate-2-risk or high-risk myelodysplastic syndromes (MDS) [according to Intern...

journal_title：Drugs

authors： Keating GM

更新日期：2009-01-01 00:00:00

abstract：:Immunotherapeutic approaches have been, and continue to be, aggressively investigated in the treatment of infiltrating gliomas. While the results of late-phase clinical studies have been disappointing in this disease space thus far, the success of immunotherapies in other malignancies as well as the incremental gains ...

journal_title：Drugs

authors： Lukas RV,Wainwright DA,Horbinski CM,Iwamoto FM,Sonabend AM

更新日期：2019-11-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a challenging clinical complication of liver dysfunction with a wide spectrum of neuropsychiatric abnormalities that range from mild disturbances in cognitive function and consciousness to coma and death. The pathogenesis of HE in cirrhosis is complex and multifactorial, but a key role i...

journal_title：Drugs

authors： Phongsamran PV,Kim JW,Cupo Abbott J,Rosenblatt A

更新日期：2010-06-18 00:00:00

abstract：:Antibacterial activities of cefotaxime and its major metabolite, desacetylcefotaxime, against 178 strains (of 10 species) were assessed in terms of minimum inhibitory concentrations (MIC50 and MIC80), and were compared with those of cefoperazone and ceftazidime. The activity of desacetylcefotaxime was several times le...

journal_title：Drugs

authors： Oizumi K,Hayashi I,Aonuma S,Konno K

更新日期：1988-01-01 00:00:00

abstract：:67 samples of 15 different tissues were obtained from 26 patients who were given an intravenous bolus dose of temocillin approximately 3 to 4 hours prior to surgery. 50 tissue samples were obtained from 19 patients who received 1g temocillin and 17 tissue samples were obtained from 7 patients who received 2g temocilli...

journal_title：Drugs

authors： Gould JG,Meikle G,Cooper DL,Horton R

更新日期：1985-01-01 00:00:00

abstract：:Anthracyclines are among the most active drugs for the treatment of advanced breast cancer. Epirubicin has been found to be as effective as doxorubicin at equimolar doses but significantly better tolerated, especially in terms of alopecia, leucopenia, and cardiac toxicity. The role of anthracycline-containing regimens...

journal_title：Drugs

authors： Fumoleau P,Devaux Y,Vo Van ML,Kerbrat P,Fargeot P,Schraub S,Mihura J,Namer M,Mercier M

更新日期：1993-01-01 00:00:00

abstract：:In general, hepatic encephalopathy (HE) is defined as a brain dysfunction caused by liver insufficiency and/or portal-systemic blood shunting. This article relates to the so-called type C HE: that is, HE in patients with liver cirrhosis. It manifests as a wide spectrum of neurological or psychiatric abnormalities, ran...

journal_title：Drugs

authors： Weissenborn K

更新日期：2019-02-01 00:00:00

abstract：:Antiviral therapy has in the past met with limited success and only a few antiviral drugs have been available. The human immunodeficiency virus (HIV) epidemic has created an urgent need for the development of antiviral therapy against this infection. HIV replication offers several targets for inhibitory compounds, the...

journal_title：Drugs

authors： Sandström E,Oberg B

更新日期：1993-04-01 00:00:00

abstract：:Ondansetron is a selective 5-HT3 receptor antagonist which has previously been reported in the Journal to be a promising new agent for use as prophylaxis against nausea and vomiting caused by chemotherapy and radiotherapy. Since the publication of this original review, further studies have been published that show ond...

journal_title：Drugs

authors： Markham A,Sorkin EM

更新日期：1993-06-01 00:00:00

abstract：:The management of mediastinitis involves directing appropriate antibacterial therapy against the potential bacterial pathogens. The increased recovery of anaerobic bacteria from mediastinal infections has led to a greater appreciation of their role in this condition and to re-evaluation of the proper treatment of this...

journal_title：Drugs

authors： Brook I

更新日期：2006-01-01 00:00:00

abstract：:Saxagliptin (Onglyza™) is a dipeptidyl peptidase 4 inhibitor widely approved for the treatment of type 2 diabetes mellitus. In the EU, saxagliptin is indicated as combination therapy with metformin, a sulfonylurea, a thiazolidinedione, or insulin (with or without metformin) for the treatment of adult patients with typ...

journal_title：Drugs

authors： Yang LP

更新日期：2012-01-22 00:00:00

abstract：:In hospitals, oral quinolone therapy has lower daily associated costs (acquisition and administration) than most intravenous regimens. In addition, oral switch therapy shortens the duration of hospital stay for most patients. However, randomised trials are required to measure the economic impact of the switch to oral ...

journal_title：Drugs

authors： Davey P

更新日期：1999-01-01 00:00:00

abstract：:Teneligliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that was approved for the treatment of type 2 diabetes mellitus (T2DM) in Japan and Korea and is being researched in several countries. Teneligliptin is a potent, selective, and long-lasting DPP-4 inhibitor with a t½ of approximately 24 h and unique pharmacok...

journal_title：Drugs

authors： Ceriello A,De Nigris V,Iijima H,Matsui T,Gouda M

更新日期：2019-05-01 00:00:00

abstract：:Zaleplon is a pyrazolopyrimidine hypnotic agent which is indicated for the short term (2 to 4 weeks) management of insomnia. Zaleplon 5 and 10 mg at bedtime (usual recommended doses) significantly reduced sleep latency compared with placebo in clinical trials in nonelderly and elderly patients with insomnia. In genera...

journal_title：Drugs

authors： Dooley M,Plosker GL

更新日期：2000-08-01 00:00:00

abstract：:Hirsuties and androgenic alopecia are the patterns of hair growth in women which develop in a similar manner to that normally seen in men. This process is mediated by androgens. It may be due to increased hormone production or increased target organ sensitivity. The majority of patients with hirsuties may be adequatel...

journal_title：Drugs

authors： Barth JH

更新日期：1988-01-01 00:00:00

abstract：:This article reviews the development and pharmacokinetics of a number of new dosage formulations (e.g. transdermal patches and buccal tablets) and new active substances (e.g. isosorbide 5-mononitrate) which have recently been introduced to overcome some of the problems inherent in conventional formulations of organic ...

journal_title：Drugs

authors： Jonsson UE

更新日期：1987-01-01 00:00:00

abstract：:Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature identified reported herb-drug interactions with clinical significance, many of which are from case reports and limited clinical observations. Cases have been publis...

journal_title：Drugs

authors： Hu Z,Yang X,Ho PC,Chan SY,Heng PW,Chan E,Duan W,Koh HL,Zhou S

更新日期：2005-01-01 00:00:00