Abstract:
:In human lung tissue in vitro, nedocromil sodium inhibited the release of histamine and leukotrienes induced by anti-IgE, as well as the contraction of isolated bronchi which followed this challenge. In the hamster cheek pouch in vivo, nedocromil sodium inhibited the inflammatory response induced by challenge with either antigen or the individual inflammatory mediators, histamine and leukotriene B4. The findings thus indicate that nedocromil sodium has a dual anti-inflammatory action: inhibition of mediator secretion and antagonism of mediator action.
journal_name
Drugsjournal_title
Drugsauthors
Dahlén SE,Björck T,Kumlin M,Sydbom A,Raud J,Palmertz U,Franzén L,Grönneberg R,Hedqvist Pdoi
10.2165/00003495-198900371-00013subject
Has Abstractpub_date
1989-01-01 00:00:00pages
63-8; discussion 69-77eissn
0012-6667issn
1179-1950journal_volume
37 Suppl 1pub_type
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