Abstract:
:Enasidenib (Idhifa®) is an oral isocitrate dehydrogenase-2 (IDH2) inhibitor developed by Celgene Corporation under a global, exclusive license from Agios Pharmaceuticals. Enasidenib has been approved in the USA for the treatment of adults with relapsed or refractory acute myeloid leukaemia (AML) and an IDH2 mutation as detected by an FDA-approved test. It is at various stages of development in other countries for AML, myelodysplastic syndromes and solid tumours. This article summarizes the milestones in the development of enasidenib leading to this first global approval in the USA for the treatment of adults with relapsed or refractory IDH2-mutated AML.
journal_name
Drugsjournal_title
Drugsauthors
Kim ESdoi
10.1007/s40265-017-0813-2subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1705-1711issue
15eissn
0012-6667issn
1179-1950pii
10.1007/s40265-017-0813-2journal_volume
77pub_type
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