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[Evaluation of the impact of peripheral obliterative arteriopathy on quality of life].

Abstract：

:Peripheral arterial occlusive disease is a common condition with possible serious consequences. It is usually diagnosed at the intermittent claudication stage. There are 2 objectives of treatment: to prevent ischaemic attacks and to improve quality of life. Treatment efficacy is, however, usually evaluated only in terms of walking distance. When making medical decisions, it is now generally accepted that patients are as much concerned by quality of life as by life expectancy, particularly with regard to chronic diseases for which the aim of therapy is not only to treat the disease but also to relieve pain or restore function. Quality-of-life evaluation is therefore necessary to assess treatment efficacy, guiding clinicians in their choice of therapy and manufacturers in their choice of new molecules for development. Three types of instruments can be used to evaluate quality of life. Currently, those most often used are health status and health-related quality-of-life scales. These scales can be nonspecific, giving information on both health status and quality of life independently of any particular condition [the Medical Outcomes Study (MOS) Short Form-36 items (SF-36), for example], or they may be relevant to one disease. Specific scales are usually more sensitive than nonspecific ones. When the ARTEMIS scale, which is specific to peripheral arterial occlusive disease, was developed in 1993, there were 400 scales in existence. However, none were specific to peripheral arterial occlusive disease. The ARTEMIS scale is a self-administered questionnaire, composed of a general (SF-36) and a specific instrument. It comprises 64 items covering the 8 dimensions of the SF-36, 5 specific dimensions and 2 differential dimensions (perception of health status evolution and perception of the future). The ARTEMIS questionnaire was validated in 177 patients with intermittent claudication (phases IIa and IIb of the Leriche and Fontaine classification). Results obtained with the ARTEMIS questionnaire are presented and compared with those obtained by other authors using nonspecific or specific scales for quality-of-life evaluation. All results showed that intermittent claudication has a significant effect on the various dimensions of quality of life (except in one study). Nevertheless, the relationship between walking distance (or other functional measures) and quality of life did not prove to be as close as had been expected, indicating that functional measures do not reflect the patient's overall perception of the disease. The ARTEMIS questionnaire showed that quality-of-life scores were significantly higher (better quality of life) in patients with walking distances greater than 500 metres than in those with shorter walking distances (less than 500 metres). Moreover, quality-of-life scores were both high and similar in patients with walking distances greater than 500 metres, while in patients with shorter walking distances quality-of-life scores ranged from high (good quality of life) to low (bad quality of life). In the absence of curative treatment, the patient's perception of quality of life must therefore be evaluated prior to any treatment. Treatment will help to prevent ischaemic attacks in patients with walking distances greater than 500 metres, and will have a preventive effect and improve functional measures in patients with low quality-of-life scores, regardless of walking distance. The ARTEMIS questionnaire can therefore assist clinicians in their choice of therapeutic strategy and in the evaluation of treatment efficacy.

journal_name

Drugs

journal_title

Drugs

authors

Marquis P

doi

10.2165/00003495-199856003-00004

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

25-35

eissn

0012-6667

issn

1179-1950

journal_volume

56 Suppl 3

pub_type

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[Evaluation of the impact of peripheral obliterative arteriopathy on quality of life].