Abstract:
:This review focuses on the biochemical and clinical aspects of methylation in neuropsychiatric disorders and the clinical potential of their treatment with ademetionine (S-adenosylmethionine; SAMe). SAMe is required in numerous transmethylation reactions involving nucleic acids, proteins, phospholipids, amines and other neurotransmitters. The synthesis of SAMe is intimately linked with folate and vitamin B12 (cyanocobalamin) metabolism, and deficiencies of both these vitamins have been found to reduce CNS SAMe concentrations. Both folate and vitamin B12 deficiency may cause similar neurological and psychiatric disturbances including depression, dementia, myelopathy and peripheral neuropathy. SAMe has a variety of pharmacological effects in the CNS, especially on monoamine neurotransmitter metabolism and receptor systems. SAMe has antidepressant properties, and preliminary studies indicate that it may improve cognitive function in patients with dementia. Treatment with methyl donors (betaine, methionine and SAMe) is associated with remyelination in patients with inborn errors of folate and C-1 (one-carbon) metabolism. These studies support a current theory that impaired methylation may occur by different mechanisms in several neurological and psychiatric disorders.
journal_name
Drugsjournal_title
Drugsauthors
Bottiglieri T,Hyland K,Reynolds EHdoi
10.2165/00003495-199448020-00002subject
Has Abstractpub_date
1994-08-01 00:00:00pages
137-52issue
2eissn
0012-6667issn
1179-1950journal_volume
48pub_type
杂志文章,评审相关文献
DRUGS文献大全abstract::Glaucoma, a group of progressive optic neuropathies with similar patterns of tissue loss, is primarily treated with medical therapy, followed by laser therapy and, later, incisional surgery. Aside from the introduction of prostaglandin analogs, topical carbonic anhydrase inhibitors, and topical alpha-agonists in the 1...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01130-z
更新日期:2019-07-01 00:00:00
abstract::Terfenadine is a selective histamine H1-receptor antagonist which, in pharmacodynamic studies, is devoid of central nervous system depressant activity. In clinical studies terfenadine is well tolerated and at a dose of 60mg administered twice daily the drug provides effective relief of symptoms in patients with allerg...
journal_title:Drugs
pub_type: 临床试验,杂志文章,评审
doi:10.2165/00003495-199039040-00006
更新日期:1990-04-01 00:00:00
abstract::Entecavir (Baraclude) is a novel nucleoside analogue of 2'-deoxyguanosine whose intracellular triphosphate form inhibits replication of the hepatitis B virus (HBV). In large, randomised, double-blind, phase III clinical trials in patients with chronic HBV infection, oral entecavir 0.5 or 1.0mg once daily for up to 96 ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666120-00009
更新日期:2006-01-01 00:00:00
abstract::Bevacizumab is a recombinant, humanized anti-vascular endothelial growth factor (VEGF) monoclonal antibody that neutralizes the biological activity of VEGF and inhibits tumour angiogenesis. In two pivotal, well designed, phase III, clinical trials (GOG-0218 and ICON7) in women with advanced epithelial ovarian, fallopi...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11208940-000000000-00000
更新日期:2012-05-07 00:00:00
abstract::Administration of unopposed postmenopausal estrogen therapy protects against coronary heart disease (CHD) in women. This is mediated, in part, through beneficial effects on lipid and lipoprotein metabolism. Fewer data are available with regard to CHD risk reduction when a progesterone is required in addition to estrog...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199400472-00005
更新日期:1994-01-01 00:00:00
abstract::Pruritus is a common complication of end-stage renal disease (ESRD), affecting about one-third of dialysis patients. It is a chronic, unpleasant symptom with a strong negative impact on patients' quality of life, often inducing sleeplessness and mood disorders. Recent data show that it is also associated with increase...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200969030-00002
更新日期:2009-01-01 00:00:00
abstract::Rupatadine (Rupafin, Rinialer, Rupax, Alergoliber) is a selective oral histamine H(1)-receptor antagonist that has also been shown to have platelet-activating factor (PAF) antagonist activity in vitro. It is indicated for use in seasonal allergic rhinitis (SAR), perennial allergic rhinitis (PAR) and chronic idiopathic...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200767030-00008
更新日期:2007-01-01 00:00:00
abstract::Pharmacotherapy for the management of obesity is primarily aimed at weight loss, weight loss maintenance and risk reduction, and has included thyroid hormone, amphetamines, phentermine, amfepramone (diethylpropion), phenylpropanolamine, mazindol, fenfluramines and, more recently, sibutramine and orlistat. These agents...
journal_title:Drugs
pub_type: 杂志文章,meta分析,评审
doi:10.2165/00003495-200565100-00006
更新日期:2005-01-01 00:00:00
abstract::Atenolol and nifedipine have been shown to be effective single agents in angina pectoris, but reports suggest that additional benefits may be conferred by combining the 2 drugs. Therefore, to establish that the combination regimen was at least as effective as either atenolol or nifedipine alone, a multicentre study wa...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-198800354-00012
更新日期:1988-01-01 00:00:00
abstract::Healthcare systems are in flux throughout the world. Traditional structures and attitudes are changing. The balance of power between political bodies, payers, providers and patients is being destabilised. New approaches by governments and forward integration by drug companies and payers into care management are all ma...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-199600522-00014
更新日期:1996-01-01 00:00:00
abstract::Trimetazidine is a cytoprotective drug whose cardiovascular effectiveness, especially in patients with stable ischemic heart disease, has been the source of much controversy in recent years; some have gone so far as to treat the medication as a 'placebo drug' whose new side effects, such as Parkinsonian symptoms, outw...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0233-5
更新日期:2014-06-01 00:00:00
abstract::Childhood obesity has become the most common paediatric disorder in the developed world. Treatment of obesity in children may include lifestyle interventions, pharmacotherapy and weight-loss supplements. The outcome of lifestyle interventions, which classically include dietary modifications, increased activity and beh...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11319210-000000000-00000
更新日期:2010-02-12 00:00:00
abstract::Many drugs have a site of action within the inner ear. The list includes therapeutic, diagnostic and ototoxic agents. Therapeutic agents are most useful in cases of infections, endolymphatic hydrops, vascular insufficiency, vertigo of peripheral origin, autoimmune disease, otosclerosis (otospongiosis), sudden hearing ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198836060-00005
更新日期:1988-12-01 00:00:00
abstract::Gatifloxacin (Tequin) is an 8-methoxy fluoroquinolone approved in the US for use in the treatment of community-acquired pneumonia (CAP), acute exacerbations of chronic bronchitis (AECB), acute sinusitis, uncomplicated and complicated urinary tract infections (UTIs), pyelonephritis, gonorrhoea and uncomplicated skin an...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200565050-00007
更新日期:2005-01-01 00:00:00
abstract::Valsartan/hydrochlorothiazide (HCTZ) combines an angiotensin II AT1 receptor blocker with a thiazide diuretic to produce additive blood pressure reductions without major effects on heart rate. HCTZ did not significantly alter valsartan pharmacokinetics; during combination therapy, HCTZ pharmacokinetics differed from t...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199957050-00008
更新日期:1999-05-01 00:00:00
abstract::Nausea and vomiting continue to be critical problems in cancer chemotherapy, although considerable progress has been made toward understanding the neuropharmacological mechanisms of vomiting and how chemotherapeutic agents and antiemetics affect these mechanisms. The principles of behavioural psychology have also been...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198734010-00005
更新日期:1987-07-01 00:00:00
abstract::Aliskiren/hydrochlorothiazide is a single-pill combination of the first in the new class of non-peptide direct renin inhibitors (aliskiren) and a thiazide diuretic (hydrochlorothiazide [HCTZ]) that achieves blood pressure (BP) reductions greater than those seen with either component alone. In double-blind, 8-week clin...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-200969070-00004
更新日期:2009-01-01 00:00:00
abstract::The rationale for the use of vasodilating agents in the treatment of congestive heart failure is to reverse the systemic vasoconstriction that characterises patients with this disorder, and which may further limit cardiac performance. Nitrates were the first vasodilators used, followed by arterial vasodilators (hydral...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198600325-00003
更新日期:1986-01-01 00:00:00
abstract::Transdermal nicotine delivery systems are a cigarette smoking cessation aid designed to deliver nicotine into the systemic circulation via the skin. The partial replacement of plasma nicotine, which would have otherwise been obtained from cigarettes, reduces the severity of nicotine withdrawal symptoms, and so allows ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199244030-00011
更新日期:1992-09-01 00:00:00
abstract::In a double-blind study, the efficacy and tolerability of nimesulide (100mg twice daily) were compared with those of diclofenac (50mg twice daily) when administered orally to 50 patients with acute superficial thrombophlebitis of the lower limbs. Pain relief and amelioration of inflammation were apparent in patients t...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-199300461-00050
更新日期:1993-01-01 00:00:00
abstract::Budesonide is a glucocorticoid with high topical activity, but low systemic bio-availability which results in reduced systemic effects in comparison with other glucocorticoids. To date, it has been evaluated for use in patients with inflammatory bowel disease when administered either orally as a controlled ileal relea...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199550050-00006
更新日期:1995-11-01 00:00:00
abstract::Treatment of idiopathic membranous nephropathy is based on a 'symptomatic' therapy that includes ACE inhibitors or angiotensin II receptor antagonists, and on an 'aetiological' therapy aimed at modulating underlying immunological mechanisms. The role of the latter is still debated given the usually indolent course of ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200969100-00002
更新日期:2009-07-09 00:00:00
abstract::Developed by Bayer in Germany, nifedipine was shown to be effective in the treatment of patients with angina pectoris by Japanese investigators. Professor Kimura first reported the efficacy of nifedipine in patients with angina pectoris and those findings have been replicated in numerous trials conducted since then. C...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666991-00003
更新日期:2006-01-01 00:00:00
abstract::The potential beneficial effects of antihypertensive drugs on cardiovascular morbidity and mortality may be compromised by their adverse effects on serum lipid levels. In our study we compared verapamil and captopril and evaluated their effects on blood pressure and on serum lipid and lipoprotein levels, with particul...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-199200441-00016
更新日期:1992-01-01 00:00:00
abstract::Sitagliptin (Januvia, Glactiv(R), Tesavel(R)) is a dipeptidyl peptidase-4 inhibitor indicated for the treatment of type 2 diabetes mellitus. Oral sitagliptin as monotherapy or combination therapy was generally well tolerated and improved glycaemic control in well designed clinical trials in patients with type 2 diabet...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11203790-000000000-00000
更新日期:2010-03-05 00:00:00
abstract::The increased understanding of the mechanisms which underlie rheumatoid disease has been accompanied by a more appropriate use of the limited repertoire of therapeutic agents. Conventional second-line drugs still have a role in everyday practice. The efficacy of these agents in reducing the severity of clinical signs ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199447020-00003
更新日期:1994-02-01 00:00:00
abstract::Delamanid (Deltyba(®)), a nitroimidazo-oxazole derivative, is a new anti-tuberculosis (TB) drug which exhibits potent in vitro and in vivo antitubercular activity against drug-susceptible and -resistant strains of Mycobacterium tuberculosis. It is approved in several countries, including Japan and those of the EU, for...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0331-4
更新日期:2015-01-01 00:00:00
abstract::Pegaspargase (Oncaspar®), a pegylated form of native Escherichia coli-derived L-asparaginase (hereafter referred as E. coliL-asparaginase), is indicated in the USA and EU for the treatment of acute lymphoblastic leukaemia (ALL) as a component of multi-agent chemotherapy in paediatric and adult patients. Relative to E....
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-01120-1
更新日期:2019-05-01 00:00:00
abstract::Despite the availability of effective pharmacological treatments to aid the control of blood pressure, the global rate of uncontrolled blood pressure remains high. As such, further measures are required to improve blood pressure control. Recently, several national and international guidelines for the management of hyp...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0306-5
更新日期:2014-11-01 00:00:00
abstract::Acitretin (etretin), a second generation monoaromatic retinoid for use in the treatment of severe psoriasis and other dermatoses, is the major active metabolite of etretinate and possesses a similar therapeutic index; i.e. a similar ratio of clinical efficacy to adverse effects. When used alone at a maintenance dosage...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199243040-00010
更新日期:1992-04-01 00:00:00