Abstract:
:In a double-blind, parallel-group randomised trial of 3 months' duration, the efficacy of cyclandelate 800 mg twice daily in migraine prophylaxis was compared with that of flunarizine 5mg daily in 40 patients. In comparison with placebo and baseline values, both drugs significantly relieved symptoms of migraine as assessed by indices of pain total index, headache index, analgesic consumption and number of migraine days. Patients taking flunarizine experienced side effects such as drowsiness, weight gain and asthenia, while the most common complaint reported with cyclandelate was gastric upset. These results suggest that cyclandelate may be a useful alternative in migraine prophylaxis.
journal_name
Drugsjournal_title
Drugsauthors
Nappi G,Sandrini G,Savoini G,Cavallini A,de Rysky C,Micieli Gdoi
10.2165/00003495-198700332-00019subject
Has Abstractpub_date
1987-01-01 00:00:00pages
103-9eissn
0012-6667issn
1179-1950journal_volume
33 Suppl 2pub_type
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