Sotagliflozin: A Review in Type 1 Diabetes.

Abstract:

:Sotagliflozin (Zynquista™) is the first dual inhibitor of sodium-glucose co-transporter-1 and -2 (SGLT1 and 2). In the phase 3, inTANDEM 1-3 trials, adjunctive use of oral sotagliflozin (200 mg or 400 mg once daily) improved glycaemic control and reduced bodyweight and insulin requirements relative to placebo over 24 weeks of treatment in adults whose type 1 diabetes (T1D) was inadequately controlled by insulin therapy. Similar benefits were seen with the drug in patients who were overweight/obese [i.e. body mass index (BMI) ≥ 27 kg/m2] in inTANDEM 1 and 2 (pooled). The benefits of sotagliflozin were largely maintained over 52 weeks of treatment. Overall, use of sotagliflozin in this setting is generally well tolerated and reduces, or at least does not increase, the likelihood of hypoglycaemia; however, as with other SGLT inhibitors, sotagliflozin carries a risk of diabetic ketoacidosis (DKA). On the basis of its risk/benefit profile, sotagliflozin is indicated in the EU as an adjunct to insulin in adults with T1D with a BMI ≥ 27 kg/m2 who have failed to achieve adequate glycaemic control despite optimal insulin therapy, thus expanding the currently limited adjunctive oral treatment options available for use in this population.

journal_name

Drugs

journal_title

Drugs

authors

Deeks ED

doi

10.1007/s40265-019-01230-w

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

1977-1987

issue

18

eissn

0012-6667

issn

1179-1950

pii

10.1007/s40265-019-01230-w

journal_volume

79

pub_type

杂志文章,评审

相关文献

DRUGS文献大全
  • Avapritinib: First Approval.

    abstract::Avapritinib (AYVAKIT™) is a potent and selective tyrosine kinase inhibitor of platelet-derived growth factor receptor alpha (PDGFRA) and KIT activation loop mutants. It is being developed by Blueprint Medicines for the treatment of gastrointestinal stromal tumours (GIST), solid tumours and systemic mastocytosis. Avapr...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.1007/s40265-020-01275-2

    authors: Dhillon S

    更新日期:2020-03-01 00:00:00

  • Effect of a single dose of cefotaxime or ceftriaxone on human faecal flora. A double-blind study.

    abstract::The effect of cefotaxime and ceftriaxone on faecal flora was investigated in women undergoing routine vaginal or abdominal hysterectomy. Three groups of 9 patients received, in a double-blind fashion and just before surgery, cefotaxime 2g intravenously, ceftriaxone 2g intravenously or no antibiotic (controls). Stools ...

    journal_title:Drugs

    pub_type: 临床试验,杂志文章

    doi:10.2165/00003495-198800352-00004

    authors: Michéa-Hamzehpour M,Auckenthaler R,Kunz J,Pechère JC

    更新日期:1988-01-01 00:00:00

  • Insulin Glargine 300 U/mL: A Review in Diabetes Mellitus.

    abstract::Insulin glargine 300 U/mL (Toujeo(®)) is a long-acting basal insulin analogue approved for the treatment of diabetes mellitus. Insulin glargine 300 U/mL has a more stable and prolonged pharmacokinetic/pharmacodynamic profile than insulin glargine 100 U/mL (Lantus(®)), with a duration of glucose-lowering activity excee...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.1007/s40265-016-0541-z

    authors: Blair HA,Keating GM

    更新日期:2016-03-01 00:00:00

  • Drug-induced hypertension: pathogenesis and management.

    abstract::Estrogenic compounds are the most important group of drugs that can induce hypertension. Studies have shown an incidence of significant hypertension amounting to less than 1% after 1 year of taking oral contraceptives and about 2% after 5 years. The ratio of the incidence of hypertension among ''takers'' to that of ...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-197612030-00005

    authors: Stokes GS

    更新日期:1976-01-01 00:00:00

  • Gastro-oesophageal reflux disease: beyond proton pump inhibitor therapy.

    abstract::Gastro-oesophageal reflux disease (GORD or GERD) is a very common disorder, and advancement in drug development over the years has markedly improved disease management. Proton pump inhibitors (PPIs) remain the mainstay of treatment for GERD due to their profound and consistent inhibitory effect on acid secretion. Howe...

    journal_title:Drugs

    pub_type: 杂志文章

    doi:10.2165/11597300-000000000-00000

    authors: Hershcovici T,Fass R

    更新日期:2011-12-24 00:00:00

  • Anidulafungin, a new echinocandin: in vitro activity.

    abstract::Anidulafungin is an antifungal drug belonging to the echinocandin class with a potent in vitro fungicidal activity against a wide range of Candida species, including C. glabrata and C. krusei. Anidulafungin is also active in vitro against moulds belonging to the genus Aspergillus and some dematiaceous genera. Furtherm...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/11315560-000000000-00000

    authors: Morace G,Borghi E,Iatta R,Montagna MT

    更新日期:2009-01-01 00:00:00

  • Vasodilatation with pinacidil. Mode of action in rat resistance vessels.

    abstract::Pinacidil is a newly developed antihypertensive vasodilator, proposed to belong to the new group of smooth muscle relaxants, the K+ channel openers. The in vitro effects of pinacidil on induced tone, smooth muscle membrane potential and 86Rb and 42K efflux from rat resistance vessels (internal diameter about 200 micro...

    journal_title:Drugs

    pub_type: 杂志文章

    doi:10.2165/00003495-198800367-00006

    authors: Videbaek LM,Aalkjaer C,Mulvany MJ

    更新日期:1988-01-01 00:00:00

  • Pharmacotherapy and weight-loss supplements for treatment of paediatric obesity.

    abstract::Childhood obesity has become the most common paediatric disorder in the developed world. Treatment of obesity in children may include lifestyle interventions, pharmacotherapy and weight-loss supplements. The outcome of lifestyle interventions, which classically include dietary modifications, increased activity and beh...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/11319210-000000000-00000

    authors: Rogovik AL,Chanoine JP,Goldman RD

    更新日期:2010-02-12 00:00:00

  • Mechanisms, significance and treatment of vascular dysfunction in type 2 diabetes mellitus: focus on lipid-regulating therapy.

    abstract::Endothelial dysfunction and increased arterial stiffness occur early in the pathogenesis of diabetic vasculopathy. They are both powerful independent predictors of cardiovascular risk. Advances in non-invasive methodologies have led to widespread clinical investigation of these abnormalities in diabetes mellitus, gene...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-200565010-00003

    authors: Woodman RJ,Chew GT,Watts GF

    更新日期:2005-01-01 00:00:00

  • Epidemiology and therapy of Chlamydia trachomatis infections.

    abstract::Chlamydia trachomatis infections are exceedingly prevalent, and can be associated with significant sequelae. The major infections are urethritis, cervicitis, salpingitis, and ocular infection. Chlamydial genital infections present as syndromes, where C. trachomatis is one of the causes of the syndrome. Because specifi...

    journal_title:Drugs

    pub_type: 杂志文章

    doi:10.2165/00003495-198427050-00005

    authors: Bowie WR

    更新日期:1984-05-01 00:00:00

  • Overview of the worldwide problem of diarrhoea.

    abstract::Acute infectious diarrhoea is the major killer of children in the Third World. It is also the principal cause of malnutrition in children under 5 years of age. More than 4 million children die each year of diarrhoea and its complications. Acute diarrhoea kills by causing dehydration, which leads to hypovolaemia and me...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-198800364-00003

    authors: Gold R

    更新日期:1988-01-01 00:00:00

  • Botulinum neurotoxin type A free of complexing proteins (XEOMIN) in focal dystonia.

    abstract::Botulinum neurotoxin type A (BTX-A) weakens voluntary muscle strength and is an effective therapy for focal dystonia, including cervical dystonia (CD) and benign essential blepharospasm (BEB). It is also known to relieve hemifacial spasm and focal spasticity in children and adults. In addition, BTX-A has been shown to...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-200767050-00003

    authors: Jost WH,Blümel J,Grafe S

    更新日期:2007-01-01 00:00:00

  • Lefamulin: A Novel Oral and Intravenous Pleuromutilin for the Treatment of Community-Acquired Bacterial Pneumonia.

    abstract::Lefamulin is a novel oral and intravenous (IV) pleuromutilin developed as a twice-daily treatment for community-acquired bacterial pneumonia (CABP). It is a semi-synthetic pleuromutilin with a chemical structure that contains a tricyclic core of five-, six-, and eight-membered rings and a 2-(4-amino-2-hydroxycyclohexy...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.1007/s40265-020-01443-4

    authors: Zhanel GG,Deng C,Zelenitsky S,Lawrence CK,Adam HJ,Golden A,Berry L,Schweizer F,Zhanel MA,Irfan N,Bay D,Lagacé-Wiens P,Walkty A,Mandell L,Lynch JP 3rd,Karlowsky JA

    更新日期:2020-11-28 00:00:00

  • Controlled release metoprolol formulations. A review of their pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and ischaemic heart disease.

    abstract::Conventional formulations of metoprolol have become well established in cardiovascular medicine and are particularly useful in the management of hypertension and ischaemic heart disease. Recently developed controlled release metoprolol delivery systems (metoprolol CR/ZOK and metoprolol OROS) were designed to overcome ...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-199243030-00006

    authors: Plosker GL,Clissold SP

    更新日期:1992-03-01 00:00:00

  • Current concepts in diabetic gastroparesis.

    abstract::Diabetic gastroparesis is a common and debilitating condition affecting millions of patients with diabetes mellitus worldwide. Although gastroparesis in diabetes has been known clinically for more than 50 years, treatment options remain very limited. Until recently, the scientific literature has offered few clues rega...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-200363130-00002

    authors: Smith DS,Ferris CD

    更新日期:2003-01-01 00:00:00

  • Oxatomide. A review of its pharmacodynamic properties and therapeutic efficacy.

    abstract::Oxatomide is an orally active H1-histamine receptor antagonist which, as appears to occur with some other antihistamines, also inhibits mast cell degranulation. Oxatomide has demonstrated response rates similar to those with other more established members of its drug class in a few studies of chronic urticaria and all...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-198427030-00003

    authors: Richards DM,Brogden RN,Heel RC,Speight TM,Avery GS

    更新日期:1984-03-01 00:00:00

  • Heparin Therapy: regimens and management.

    abstract::Heparin remains the most effective antithrombotic drug. It acts by combining with plasma antithrombin, thereby accelerating the neurtalisation of thrombin and other acitvated coagulation factors. Full-dose intravenous heparin is indicated in all cases of pulmonary embolism and established deep venous thrombosis, unles...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-197713010-00005

    authors: Deykin D

    更新日期:1977-01-01 00:00:00

  • Statins and menopause.

    abstract::During the reproductive period, women generally have lower low-density lipoprotein (LDL) cholesterol and higher high-density lipoprotein cholesterol than age- and diet-matched men. However, these possibly antiatherogenic characteristics of lipoproteins are changed to a potentially atherogenic profile after menopause. ...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-200262170-00002

    authors: Moghadasian MH

    更新日期:2002-01-01 00:00:00

  • Antiendotoxin strategies for the prevention and treatment of septic shock. New approaches and future directions.

    abstract::Therapy for Gram-negative sepsis remains unsatisfactory despite a concerted effort to develop new treatments for this common, life-threatening syndrome. Current research continues on several fronts to improve the treatment options available to clinicians in the management of these critically ill patients. Recently, a ...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-199855040-00002

    authors: Opal SM,Yu RL Jr

    更新日期:1998-04-01 00:00:00

  • Herb-drug interactions: a literature review.

    abstract::Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature identified reported herb-drug interactions with clinical significance, many of which are from case reports and limited clinical observations. Cases have been publis...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-200565090-00005

    authors: Hu Z,Yang X,Ho PC,Chan SY,Heng PW,Chan E,Duan W,Koh HL,Zhou S

    更新日期:2005-01-01 00:00:00

  • Clinical aspects of invasive candidiasis in critically ill patients.

    abstract::Invasive candidiasis has emerged as an important cause of morbidity and mortality in intensive care unit patients. This short review focuses on many aspects of Candida infection in critically ill patients including epidemiology, impact on mortality, problems related to diagnosis, strategies to identify patients at ris...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/11315590-000000000-00000

    authors: Pennisi M,Antonelli M

    更新日期:2009-01-01 00:00:00

  • Second-Line Treatment of Non-Small Cell Lung Cancer: New Developments for Tumours Not Harbouring Targetable Oncogenic Driver Mutations.

    abstract::Platinum-based doublet chemotherapy with or without bevacizumab is the standard of care for the initial management of advanced and metastatic non-small cell lung cancer (NSCLC) without a targetable molecular abnormality. However, the majority of patients with NSCLC will ultimately develop resistance to initial platinu...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.1007/s40265-016-0628-6

    authors: Barnfield PC,Ellis PM

    更新日期:2016-09-01 00:00:00

  • Transdermal fentanyl: an updated review of its pharmacological properties and therapeutic efficacy in chronic cancer pain control.

    abstract:UNLABELLED:Fentanyl is a synthetic opioid agonist which interacts primarily with the mu-opioid receptor. The low molecular weight, high potency and lipid solubility of fentanyl make it suitable for delivery by the transdermal therapeutic system. These patches are designed to deliver fentanyl at a constant rate (25, 50,...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-200161150-00014

    authors: Muijsers RB,Wagstaff AJ

    更新日期:2001-01-01 00:00:00

  • Acute upper gastrointestinal bleeding.

    abstract::The treatment of acute upper gastrointestinal bleeding is becoming more dependent upon early diagnosis. For the majority of patients whose bleeding has stopped when they come to the physician's attention, treatment for peptic disorders remains the mainstay of therapy. For patients who present to the physician actively...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-198937010-00007

    authors: Schaffner JA

    更新日期:1989-01-01 00:00:00

  • The Multifactor Primary Prevention Trial in Göteborg, Sweden. Comparison with a previously untreated population sample.

    abstract::All male inhabitants of the city of Göteborg, who were born between 1915-1922 and 1924-1925 were included in the trial, and were 47 to 55 years of age on entry to the study in 1970 to 1973. One-third of these men were randomly allocated to an intervention group, whilst the other two-thirds acted as controls. Men of al...

    journal_title:Drugs

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.2165/00003495-198600311-00009

    authors: Wilhelmsen L,Berglund G,Elmfeldt D,Samuelsson O,Svardsudd K

    更新日期:1986-01-01 00:00:00

  • Cardioprotective mechanisms of ACE inhibition. The angiotensin II-nitric oxide balance.

    abstract::The current challenge facing clinicians is to develop pharmacotherapies that move beyond the treatment of symptoms towards a new agenda in cardiovascular therapeutics that includes interventions to actually prevent the development of end-stage coronary heart disease. The development of new strategies to alter the natu...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-199700545-00003

    authors: Gibbons GH

    更新日期:1997-01-01 00:00:00

  • Albumin-bound Paclitaxel: in metastatic breast cancer.

    abstract::A new formulation of paclitaxel, 130-nanometre albumin-bound paclitaxel (nab-paclitaxel), solubilises hydrophobic paclitaxel and may increase paclitaxel delivery to tumour cells. Intravenous nab-paclitaxel 260 mg/m(2) had a higher maximum whole-blood concentration, shorter time to peak concentration, larger distributi...

    journal_title:Drugs

    pub_type: 杂志文章

    doi:10.2165/00003495-200666070-00007

    authors: Robinson DM,Keating GM

    更新日期:2006-01-01 00:00:00

  • Gefitinib: a review of its use in the treatment of locally advanced/metastatic non-small cell lung cancer.

    abstract::Gefitinib (Iressa) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that offers treatment for patients with locally advanced or metastatic non-small cell lung cancer (NSCLC), in particular in those who are harbouring EGFR mutations. In a large phase III trial (IPASS) in chemotherapy-naive Asian ...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/10489100-000000000-00000

    authors: Sanford M,Scott LJ

    更新日期:2009-11-12 00:00:00

  • Drug treatment of hypertension.

    abstract::There are several first choices for the treatment of mild and moderate hypertension. The selection of a drug may be influenced by concomitant pathology, with positive indications for particular drugs, e.g. coexistent angina, indicating use of a beta-receptor blocking drug or calcium antagonist; fluid retention indicat...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-198800356-00006

    authors: Prichard BN

    更新日期:1988-01-01 00:00:00

  • Candesartan cilexetil: an update of its use in essential hypertension.

    abstract:UNLABELLED:Candesartan cilexetil is converted to the angiotensin II receptor antagonist candesartan during absorption from the gastrointestinal tract. The selective and competitive binding of candesartan to the angiotensin II type 1 (AT(1)) receptor prevents binding of angiotensin II, a key mediator in the renin-angiot...

    journal_title:Drugs

    pub_type: 杂志文章,评审

    doi:10.2165/00003495-200262080-00016

    authors: Easthope SE,Jarvis B

    更新日期:2002-01-01 00:00:00