Abstract:
:Alprazolam is a triazolobenzodiazepine which is related to diazepam and other 1,4-benzodiazepines, and has a similar pharmacological profile. Relative to the newer benzodiazepines, alprazolam has an intermediate half-life of 10 to 12 hours in healthy young subjects. In placebo-controlled and double-blind comparative trials in patients with anxiety, alprazolam was of comparable efficacy to diazepam and generally caused a lower incidence of drowsiness. Alprazolam has antidepressant activity and has been shown to be similar in efficacy to imipramine in the treatment of unipolar depression. Thus, alprazolam may be particularly useful in patients with mixed anxiety/depression. However, its general acceptance as an antidepressant awaits further studies.
journal_name
Drugsjournal_title
Drugsauthors
Dawson GW,Jue SG,Brogden RNdoi
10.2165/00003495-198427020-00002subject
Has Abstractpub_date
1984-02-01 00:00:00pages
132-47issue
2eissn
0012-6667issn
1179-1950journal_volume
27pub_type
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