Use of economic evaluation in decision making: evidence and recommendations for improvement.

abstract：:The hyperkinetic syndrome is a symptom complex of hyperactivity, short attention span, distractibility, impulsivity, learning difficulties, other behaviour problems and 'equivocal' neurological signs. However, none of these terms has ever been objectively defined and at present diagnosis is largely a matter of clinica...

journal_title：Drugs

authors： Werry JS

更新日期：1976-01-01 00:00:00

abstract：:Sotagliflozin (Zynquista™) is the first dual inhibitor of sodium-glucose co-transporter-1 and -2 (SGLT1 and 2). In the phase 3, inTANDEM 1-3 trials, adjunctive use of oral sotagliflozin (200 mg or 400 mg once daily) improved glycaemic control and reduced bodyweight and insulin requirements relative to placebo over 24 ...

journal_title：Drugs

authors： Deeks ED

更新日期：2019-12-01 00:00:00

abstract：:Hypertension is common in chronic renal disease and is a risk factor for the faster progression of renal damage, and reduction of blood pressure (BP) is an efficient way of preventing or slowing the progression of this damage. International guidelines recommend lowering BP to 140/90 mm Hg or less in patients with unco...

journal_title：Drugs

authors： Wenzel RR

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Authorization of orphan medicinal products (OMPs) is often based on studies with several methodological shortcomings. Hence, data are difficult to interpret and efficacy does not always correspond to real-world effectiveness. We investigated to what extent an efficacy-effectiveness gap exists for OMPs for ...

journal_title：Drugs

authors： Schuller Y,Hollak CEM,Gispen-de Wied CC,Stoyanova-Beninska V,Biegstraaten M

更新日期：2017-09-01 00:00:00

abstract：:Hepatitis E accounts for the major part of enterally transmitted non-A, non-B hepatitis worldwide. Its agent, the hepatitis E virus (HEV), is a small, single-stranded RNA virus. Only one serotype of HEV is recognised. Infection results in protective immunity with long-lived neutralising antibodies. In developing count...

journal_title：Drugs

authors： Worm HC,Wirnsberger G

更新日期：2004-01-01 00:00:00

abstract：:Zimelidine is a new antidepressant, which is structurally unrelated to the tricyclic and tetracyclic antidepressants. The pharmacological profile of zimelidine is different to that of other antidepressants in that it appears to owe the major part of its activity to the inhibition of serotonin uptake within the central...

journal_title：Drugs

authors： Heel RC,Morley PA,Brogden RN,Carmine AA,Speight TM,Avery GS

更新日期：1982-09-01 00:00:00

abstract：:An unexpected precipitous fall in peripheral leucocyte count may occur during treatment of certain sensitised individuals with drugs usually well tolerated by most people. Three basic mechanisms for drug sensitivity have been found. One is characterised by sudden destruction of large numbers of leucocytes in periphera...

journal_title：Drugs

authors： Pisciotta V

更新日期：1978-02-01 00:00:00

abstract：:The optimal treatment of pain requires an understanding of the mechanisms involved. Pain is a sensory end-point that can be generated by a number of dissimilar processes. Consequently, the concept of treating pain as a unitary symptom is obsolete. The mechanisms responsible for specific types of pain need to be unders...

journal_title：Drugs

authors： Woolf CJ

更新日期：1994-01-01 00:00:00

abstract：:For many years now a treatment mitigating the debilitating effects of jet lag has been sought. Rapid travel across time zones leads, in most people, to temporary symptoms, in particular poor sleep, daytime alertness and poor performance. Mis-timed circadian rhythms are considered to be the main factor underlying jet-l...

journal_title：Drugs

authors： Arendt J

更新日期：2018-09-01 00:00:00

abstract：:Tipranavir is a non-peptidic HIV-1 protease inhibitor. It binds strongly and selectively, has a favourable resistance profile, and is administered orally twice daily with a subtherapeutic dosage of ritonavir in a 'boosted' regimen (TPV/r) in order to increase its bioavailability. Analysis of clinical isolates from tre...

journal_title：Drugs

authors： Croom KF,Keam SJ

更新日期：2005-01-01 00:00:00

abstract：:Lumasiran (Oxlumo™) is a subcutaneously administered small interfering RNA (siRNA) targeting the mRNA for hydroxyacid oxidase 1 gene (HAO1; encodes glycolate oxidase) and was developed by Alnylam Pharmaceuticals for the treatment of primary hyperoxaluria type 1 (PH1). By silencing the gene encoding glycolate oxidase, ...

journal_title：Drugs

authors： Scott LJ,Keam SJ

更新日期：2021-01-06 00:00:00

abstract：UNLABELLED:Candesartan cilexetil is converted to the angiotensin II receptor antagonist candesartan during absorption from the gastrointestinal tract. The selective and competitive binding of candesartan to the angiotensin II type 1 (AT(1)) receptor prevents binding of angiotensin II, a key mediator in the renin-angiot...

journal_title：Drugs

authors： Easthope SE,Jarvis B

更新日期：2002-01-01 00:00:00

abstract：:Valsartan/hydrochlorothiazide is a fixed-dose (valsartan 80, 160 or 320mg plus hydrochlorothiazide 12.5 or 25mg) angiotensin II receptor blocker/diuretic drug combination indicated for the treatment of patients with essential hypertension not adequately controlled by monotherapy.There is ample evidence that valsartan/...

journal_title：Drugs

authors： Wagstaff AJ

更新日期：2006-01-01 00:00:00

abstract：:Oxatomide is an orally active H1-histamine receptor antagonist which, as appears to occur with some other antihistamines, also inhibits mast cell degranulation. Oxatomide has demonstrated response rates similar to those with other more established members of its drug class in a few studies of chronic urticaria and all...

journal_title：Drugs

authors： Richards DM,Brogden RN,Heel RC,Speight TM,Avery GS

更新日期：1984-03-01 00:00:00

abstract：:Transdermal nicotine delivery systems are a cigarette smoking cessation aid designed to deliver nicotine into the systemic circulation via the skin. The partial replacement of plasma nicotine, which would have otherwise been obtained from cigarettes, reduces the severity of nicotine withdrawal symptoms, and so allows ...

journal_title：Drugs

authors： Palmer KJ,Buckley MM,Faulds D

更新日期：1992-09-01 00:00:00

abstract：:This article is intended to stimulate thought and focus on those areas where we feel advances in drug therapy for inflammatory bowel disease may occur. It is not an extensive review of current practice, although this is considered where it is thought to be pertinent to future developments. There are several excellent ...

journal_title：Drugs

authors： Rhodes J,Thomas G,Evans BK

更新日期：1997-02-01 00:00:00

abstract：:Several compounds have been claimed to have a faster onset of antidepressant action. However, these trials suffered from lack of appropriate definitions and of standardised and comparable methodology, as far as measurement instruments, dosage strategies and statistical analyses were concerned. This article was underta...

journal_title：Drugs

authors： Soares JC,Gershon S

更新日期：1996-10-01 00:00:00

abstract：:Ascletis has developed danoprevir (Ganovo®), an orally-administered hepatitis C virus NS3 protease inhibitor, as a treatment for hepatitis C. Based on positive results in phase II and phase III trials in patients with hepatitis C, danoprevir, in combination with ritonavir, peginterferon alfa and ribavirin was recently...

journal_title：Drugs

authors： Markham A,Keam SJ

更新日期：2018-08-01 00:00:00

abstract：:Varicella zoster virus (VZV), a member of the herpesvirus family, is responsible for both primary (varicella, chickenpox) as well as reactivation (zoster, shingles) infections. In immunocompetent patients, the course of varicella is generally benign. For varicella zoster, post-herpetic neuralgia is the most common com...

journal_title：Drugs

authors： Snoeck R,Andrei G,De Clercq E

更新日期：1999-02-01 00:00:00

abstract：UNLABELLED:Joint pain is the main complaint in patients affected by osteoarthritis (OA), and NSAIDs are commonly used to treat pain associated with OA. Over the past few years, cyclo-oxygenase (COX)-2-selective inhibitors have been proved to have certain advantages over non-selective NSAIDs and have been increasingly u...

journal_title：Drugs

authors： Bianchi M,Broggini M

更新日期：2003-01-01 00:00:00

abstract：:The cardinal haemodynamic disturbance in established hypertension is an increased total peripheral resistance and a subnormal blood flow, particularly during exercise. The spontaneously occurring changes in central haemodynamics have been followed in young males with essential hypertension over a 17-year period: a gra...

journal_title：Drugs

authors： Lund-Johansen P

更新日期：1984-01-01 00:00:00

abstract：:Growth hormone deficiency (GHD) in the adult has now been fully recognised as a clinical entity characterised by abnormal body composition, osteopenia, impaired quality of life, cardiac dysfunction and an adverse lipid profile. While short-term studies of GH replacement have demonstrated irrefutably a favourable effec...

journal_title：Drugs

authors： Verhelst J,Abs R

更新日期：2002-01-01 00:00:00

abstract：:A somatropin preparation (Zorbtive) produced by recombinant DNA technology has been evaluated in patients with short bowel syndrome. Somatropin is thought to enhance intestinal adaptation in this condition through direct or indirect effects on the intestine. In a randomised, double-blind study in patients with short b...

journal_title：Drugs

authors： Keating GM,Wellington K

更新日期：2004-01-01 00:00:00

abstract：:The potential beneficial effects of antihypertensive drugs on cardiovascular morbidity and mortality may be compromised by their adverse effects on serum lipid levels. In our study we compared verapamil and captopril and evaluated their effects on blood pressure and on serum lipid and lipoprotein levels, with particul...

journal_title：Drugs

authors： Catalano M,Cislaghi C,Carzaniga G,Aronica A,Seregni R,Libretti A

更新日期：1992-01-01 00:00:00

abstract：:Nizatidine is an H2-receptor antagonist which in animal studies was more active on a weight-for-weight basis than cimetidine in inhibiting basal and stimulated gastric acid secretion. Similarly, studies in humans have confirmed that nizatidine is a potent inhibitor of basal, nocturnal and stimulated gastric acid secre...

journal_title：Drugs

authors： Price AH,Brogden RN

更新日期：1988-11-01 00:00:00

abstract：:In a double-blind study, 40 patients scheduled for saphenectomy or inguinal hernioplasty were randomly assigned to treatment with nimesulide (200mg 3 times daily) or diclofenac (100mg 3 times daily) administered rectally. Therapy with either drug resulted in significantly less pain, oedema and hyperaemia, and resoluti...

journal_title：Drugs

authors： Ramella G,Costagli V,Vetere M,Capra C,Casella G,Sogni A,Scaricabarozzi I

更新日期：1993-01-01 00:00:00

abstract：:Acamprosate (Campral(®), Aotal(®), Regtect(®)) is one of a limited number of pharmacological treatment options approved as an adjunct to psychosocial interventions to facilitate the maintenance of abstinence in alcohol-dependent patients. It has been used in Europe, the USA and other countries for many years and was r...

journal_title：Drugs

authors： Plosker GL

更新日期：2015-07-01 00:00:00

abstract：:The new therapeutic options available to clinicians treating dyslipidaemia in the last decade have enabled effective treatment for many patients. The development of the HMG-CoA reductase inhibitors (statins) have been a major advance in that they possess multiple pharmacological effects (pleiotropic effects) resulting...

journal_title：Drugs

authors： Chong PH,Bachenheimer BS

更新日期：2000-07-01 00:00:00

abstract：:Torasemide (torsemide) is a high-ceiling loop diuretic which acts on the thick ascending limb of the loop of Henle to promote rapid and marked excretion of water, sodium and chloride. Like furosemide (frusemide), its major site of action is from the luminal side of the cell. Torasemide is at least twice as potent as f...

journal_title：Drugs

authors： Friedel HA,Buckley MM

更新日期：1991-01-01 00:00:00

abstract：:74 cirrhotic patients with a history of variceal or gastric bleeding were randomly assigned to treatment with propranolol (40 to 360 mg/day) or placebo. The patients were all in good condition and doses of propranolol were titrated until a 25% reduction in heart rate was achieved. After 2 years, the cumulative percent...

journal_title：Drugs

authors： Lebrec D,Poynard T,Bernuau J,Bercoff E,Nouel O,Capron JP,Poupon R,Bouvry M,Rueff B,Benhamou JP

更新日期：1989-01-01 00:00:00