Abstract:
:86 patients with a first myocardial infarction presenting within 6 hours of the onset of symptoms were randomly allocated to treatment with intravenous streptokinase or anisoylated plasminogen streptokinase activator complex (APSAC). Plasma concentrations of fibrinogen, plasminogen, alpha 2-antiplasmin and fibrinogen degradation products and thrombin and prothrombin times, were measured before the injection of the thrombolytic drug and every 3 hours during the first 24 hours. APSAC and streptokinase produced identical and important systemic effects. APSAC produced a slightly smaller decrease in fibrinogen concentrations. The duration of this systemic activity was about the same for the 2 drugs (congruent to 24 hours).
journal_name
Drugsjournal_title
Drugsauthors
Monassier JP,Hanssen Mdoi
10.2165/00003495-198700333-00046subject
Has Abstractpub_date
1987-01-01 00:00:00pages
247-52eissn
0012-6667issn
1179-1950journal_volume
33 Suppl 3pub_type
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