Abstract:
:The comprehensive treatment of schizophrenia requires the full resources of a clinical team that is able to offer treatment for the acute psychotic state in a hospital environment, and appropriate rehabilitation following resolution of the florid symptoms. Following a second or subsequent relapse, maintenance therapy with long-acting injections of depot antipsychotics will be required for an unknown period. Although drugs form an essential part of all treatments, it is essential to examine the environment for precipitating factors and to involve the patient's family in the rehabilitation. Recent studies have reported that some patients still have a relatively poor prognosis; although this proportion may be in the minority, the strain on the whole family of an even moderately handicapped patient can be enormous, and it is important to examine the needs of the whole family in evaluating care within the community. The effect of antipsychotic drugs is much wider that the mere control of acute symptoms and can influence the patterns of social behaviour and rehabilitation, in addition to offering protection against stress. The proper use of depot injections requires that they be kept under constant review. The current widespread practice of prescribing anti-cholinergic drugs on a prophylactic basis, or even as the inital treatment of extrapyramidal side-effects, needs revision.
journal_name
Drugsjournal_title
Drugsauthors
Johnson DAdoi
10.2165/00003495-197714040-00004subject
Has Abstractpub_date
1977-10-01 00:00:00pages
291-9issue
4eissn
0012-6667issn
1179-1950journal_volume
14pub_type
杂志文章相关文献
DRUGS文献大全abstract::We have analysed the published literature on eptacog alfa (recombinant factor VIIa; rFVIIa) for nonhaemophiliac conditions with the aim of determining its current place in therapy. Initial surgical and/or medical management is required for any patient with life-threatening bleeding. In those with continued life-threat...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200868120-00005
更新日期:2008-01-01 00:00:00
abstract::Cilazapril is an orally active angiotensin converting enzyme (ACE) inhibitor which lowers peripheral vascular resistance without affecting heart rate. Like enalapril and ramipril it is a prodrug, and is hydrolysed after absorption to cilazaprilat, which has a long terminal phase elimination half-life permitting once d...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199141050-00008
更新日期:1991-05-01 00:00:00
abstract::A number of new agents for the management of chronic obstructive pulmonary disease (COPD) are at different stages of development, including several inhaled long-acting antimuscarinics (LAMA). Long-acting bronchodilators are considered to be central to the management of COPD due to the evidence supporting their efficac...
journal_title:Drugs
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s40265-015-0532-5
更新日期:2016-03-01 00:00:00
abstract::Levetiracetam (Keppra®, E Keppra®) is an established second-generation antiepileptic drug (AED). Worldwide, levetiracetam is most commonly approved as adjunctive treatment of partial onset seizures with or without secondary generalization; other approved indications include monotherapy treatment of partial onset seizu...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11204490-000000000-00000
更新日期:2011-03-05 00:00:00
abstract::The incidence of infection in clean surgery (i.e. surgery with no major contamination of the operative site) should be less than 2%, although the incidence of postoperative infections can be higher in patients with various risk factors (namely insertion of foreign bodies, a compromised immune status or prolonged durat...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199700546-00008
更新日期:1997-01-01 00:00:00
abstract::Cardiovascular disease continues to be the principal cause of death in Western countries. Epidemiological studies have repeatedly demonstrated a striking relationship between blood pressure and the risk of cardiovascular disease in that those with the highest levels of blood pressure are at the greatest risk for subse...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198600314-00003
更新日期:1986-01-01 00:00:00
abstract::Alteplase is the product of recombinant DNA technology and is chemically identical to endogenous tissue-type plasminogen activator: Plasminogen is converted to plasmin by alteplase, and fibrinolysis of blood thrombi is subsequently stimulated. Alteplase is now firmly established as a treatment of choice in the managem...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199550020-00007
更新日期:1995-08-01 00:00:00
abstract::86 patients with a first myocardial infarction presenting within 6 hours of the onset of symptoms were randomly allocated to treatment with intravenous streptokinase or anisoylated plasminogen streptokinase activator complex (APSAC). Plasma concentrations of fibrinogen, plasminogen, alpha 2-antiplasmin and fibrinogen ...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-198700333-00046
更新日期:1987-01-01 00:00:00
abstract::With its approval more than 15 years ago, subcutaneous etanercept (Enbrel(®)) was the first biological disease-modifying antirheumatic drug (bDMARD) and the first tumour necrosis factor inhibitor to be approved for use in rheumatic diseases. Etanercept remains an important cost-effective treatment option in adult pati...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0258-9
更新日期:2014-08-01 00:00:00
abstract::Sodium-glucose co-transporter 2 (SGLT2) inhibitors are glucose-lowering drugs that reduce plasma glucose levels by inhibiting glucose and sodium reabsorption in the kidneys, thus resulting in glucosuria. Their effects consequently include reductions in HbA1c, blood glucose levels, and blood pressure, but also reductio...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-019-1057-0
更新日期:2019-02-01 00:00:00
abstract::Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV‑2), is now a global pandemic. This virus primarily affects the respiratory tract and causes lung injury characterized by acute respiratory distress syndrome. Although the pathophysiology of COVID-19 is not yet clea...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01377-x
更新日期:2020-10-01 00:00:00
abstract::There is now good evidence that T cells play a central role in the inflammatory pathway that leads to the persistent synovitis that causes joint damage in rheumatoid arthritis (RA). T cells require two signals to become activated. The second step in the activation of T cells involves costimulatory pathways, the best d...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200767010-00001
更新日期:2007-01-01 00:00:00
abstract::Evidence suggests that arterial hypertension, in addition to being a cardiovascular and renal risk factor, may also be associated with an impairment of male sexual function. Since other cardiovascular risk factors, especially diabetes mellitus, have also been shown to correlate with impaired sexual function it has bee...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200565060-00005
更新日期:2005-01-01 00:00:00
abstract::Alprazolam is a triazolobenzodiazepine which is related to diazepam and other 1,4-benzodiazepines, and has a similar pharmacological profile. Relative to the newer benzodiazepines, alprazolam has an intermediate half-life of 10 to 12 hours in healthy young subjects. In placebo-controlled and double-blind comparative t...
journal_title:Drugs
pub_type: 临床试验,杂志文章,评审
doi:10.2165/00003495-198427020-00002
更新日期:1984-02-01 00:00:00
abstract::Heparin remains the most effective antithrombotic drug. It acts by combining with plasma antithrombin, thereby accelerating the neurtalisation of thrombin and other acitvated coagulation factors. Full-dose intravenous heparin is indicated in all cases of pulmonary embolism and established deep venous thrombosis, unles...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-197713010-00005
更新日期:1977-01-01 00:00:00
abstract::Schistosomiasis, a grave and debilitating disease of socioeconomic importance, is increasing in incidence despite concerted efforts to control and contain the disease in all the endemic areas. While a multipronged method of control using health education, sanitation and snail control has been used, chemotherapy and ch...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199142030-00004
更新日期:1991-09-01 00:00:00
abstract::Hepatitis E accounts for the major part of enterally transmitted non-A, non-B hepatitis worldwide. Its agent, the hepatitis E virus (HEV), is a small, single-stranded RNA virus. Only one serotype of HEV is recognised. Infection results in protective immunity with long-lived neutralising antibodies. In developing count...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200464140-00002
更新日期:2004-01-01 00:00:00
abstract::Flecainide is a Class I antiarrhythmic drug of the local anaesthetic type. It can be given either intravenously or orally and its pharmacokinetic properties allow relatively long (12 hours) dosing intervals with oral administration. In several open and a few controlled therapeutic trials, orally administered flecainid...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198529010-00001
更新日期:1985-01-01 00:00:00
abstract::Despite the availability of effective pharmacological treatments to aid the control of blood pressure, the global rate of uncontrolled blood pressure remains high. As such, further measures are required to improve blood pressure control. Recently, several national and international guidelines for the management of hyp...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-014-0306-5
更新日期:2014-11-01 00:00:00
abstract::The geminal bisphosphonates are a new class of drugs characterised by a P-C-P bond. Consequently, they are analogues of pyrophosphate, but are resistant to chemical and enzymatic hydrolysis. The bisphosphonates bind strongly to hydroxyapatite crystals and inhibit their formation and dissolution. This physicochemical e...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199142060-00003
更新日期:1991-12-01 00:00:00
abstract::Cenegermin (Oxervate™), an ophthalmic solution containing 20 µg/mL of recombinant human nerve growth factor (rhNGF), is the first drug to be approved for the treatment of neurotrophic keratitis (NK; also referred to as neurotrophic keratopathy). In the registration trials, the majority of adults with moderate or sever...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-020-01289-w
更新日期:2020-04-01 00:00:00
abstract::Lifestyle interventions constitute the initial strategy for the primary and secondary prevention of cardiovascular disease in women. However, pharmacotherapy is often indicated for control of major cardiovascular risk factors, and abundant clinical trial data support the morbidity and mortality benefit of a number of ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200868030-00006
更新日期:2008-01-01 00:00:00
abstract::Alfuzosin, a new quinazoline derivative, acts as a selective and competitive antagonist of alpha 1-adrenoceptor-mediated contraction of prostatic, prostatic capsule, bladder base and proximal urethral smooth muscle, thereby reducing the tone of these structures. Consequently, urethral pressure and resistance, bladder ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199345030-00008
更新日期:1993-03-01 00:00:00
abstract::Purine nucleoside analogues are a new class of drugs with activity against nondividing lymphocytes; thus, they should play a major role in the treatment of low grade lymphoid malignancies. As these drugs are active against resting lymphocytes, harmful effects related to this action were expected and have been reported...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199400476-00009
更新日期:1994-01-01 00:00:00
abstract::Eplerenone (Inspra) is a selective aldosterone blocker. Oral eplerenone is approved for use in patients with left ventricular (LV) systolic dysfunction and clinical evidence of heart failure following acute myocardial infarction (MI) in the US and in European countries (e.g. the UK and The Netherlands). The addition o...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200464230-00005
更新日期:2004-01-01 00:00:00
abstract::The selective once-daily prandial glucagon-like peptide-1 (GLP-1) receptor agonist lixisenatide (Lyxumia(®)) is under development with Sanofi for the treatment of type 2 diabetes mellitus. Lixisenatide belongs to a class of GLP-1 compounds designed to mimic the endogenous hormone GLP-1. Native GLP-1 stimulates insulin...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-013-0033-3
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Opioid pharmacotherapies play an important role in the treatment of opioid-dependent women; however, very little is known about the safety of naltrexone in pregnant patients. OBJECTIVE:This study examined the obstetric health of opioid-dependent women who were treated with implant naltrexone during pregnanc...
journal_title:Drugs
pub_type: 杂志文章,meta分析
doi:10.1007/s40265-017-0762-9
更新日期:2017-07-01 00:00:00
abstract::Testing for and treating sexually transmitted diseases (STDs) in pregnant women deserves special attention. Treatment possibilities are limited because of potential risks for the developing fetus, and because effects can differ in pregnant compared with non-pregnant women, re-infection may be missed because of the int...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200059030-00005
更新日期:2000-03-01 00:00:00
abstract::Because of inappropriate signals from the volume-regulation system and a reduction in renal blood flow, the kidney is not able to prevent sodium and water retention in chronic congestive heart failure (CHF). A brief summary of normal renal function and renal involvement in CHF is given and a study of renal function in...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-199000394-00004
更新日期:1990-01-01 00:00:00
abstract::In type 1 and 2 diabetes mellitus patients, hyperglycaemia is independently related to the development of microvascular and macrovascular complications. Glycaemic targets and the benefits of intensive versus conventional glucose control are under debate. The purpose of this review is to provide an overview of the rand...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11585220-000000000-00000
更新日期:2010-12-03 00:00:00