Semaglutide: First Global Approval.

abstract：:Significant progress has been made in the battle against transmission of HIV-1 from mother to infant. Antiretroviral regimens covering the later part of gestation, labour and the first few weeks of neonatal life have shown great efficacy in reducing such transmission. With the advent of combination antiretroviral ther...

journal_title：Drugs

authors： Kourtis AP

更新日期：2002-01-01 00:00:00

abstract：:Asthmatic patients during sympton-free periods almost invariably have abnormalities in lung mechanics and gas exchange. Tentacious secretions and mucosal thickening exaggerate maldistribution of ventilation and cause flow limitation in small airways. Hence, the maximal expiratory flow volume loop in these patients wil...

journal_title：Drugs

authors： Goldstein RS,Slutsky AS,Rebuck AS

更新日期：1978-09-01 00:00:00

abstract：:The new therapeutic options available to clinicians treating dyslipidaemia in the last decade have enabled effective treatment for many patients. The development of the HMG-CoA reductase inhibitors (statins) have been a major advance in that they possess multiple pharmacological effects (pleiotropic effects) resulting...

journal_title：Drugs

authors： Chong PH,Bachenheimer BS

更新日期：2000-07-01 00:00:00

abstract：:Trigeminal neuralgia is a representative neuropathic facial pain condition, characterised by unilateral paroxysmal pain in the distribution territory of one or more divisions of the trigeminal nerve, triggered by innocuous stimuli. A subgroup of patients with trigeminal neuralgia [TN (previously defined as atypical TN...

journal_title：Drugs

authors： Di Stefano G,Truini A,Cruccu G

更新日期：2018-09-01 00:00:00

abstract：:25 years have elapsed since the introduction of the first effective oral diuretic, chlorothiazide. Diuretics are now amongst the most widely prescribed drugs in clinical practice worldwide. Availability of these drugs has not only brought therapeutic benefit to countless numbers of patients but it has at the same time...

journal_title：Drugs

authors： Lant A

更新日期：1985-02-01 00:00:00

abstract：:Vitamin A acid (retinoic acid: tretinoin) is a vitamin A derivative used in the topical treatment of acne. It acts by 'unseating' comedones, improvement developing slowly over a period of 2 to 3 or more months, and is also said to prevent the formation of new lesions. About three-quarters of patients with acne vulgari...

journal_title：Drugs

authors： Heel RC,Brogden RN,Speight TM,Avery GS

更新日期：1977-12-01 00:00:00

abstract：:Patients frequently come to the emergency department for pain. For decades, ketamine has been used in the emergency department for procedural sedation but is now receiving attention as a potential alternative to opioids because of its unique analgesic effects. Additionally, ketamine's dissociative properties have made...

journal_title：Drugs

authors： Sheikh S,Hendry P

更新日期：2018-05-01 00:00:00

abstract：:The efficacy of tropisetron in the prevention of nausea and vomiting induced by chemotherapy of varying emetogenic potential was evaluated in 545 patients with a variety of malignancies who had either proved refractory to antiemetic treatment during previous chemotherapy courses or who were considered to be at high ri...

journal_title：Drugs

authors： Bleiberg H,Van Belle S,Paridaens R,De Wasch G,Dirix LY,Tjean M

更新日期：1992-01-01 00:00:00

abstract：:Sitagliptin (Januvia, Glactiv(R), Tesavel(R)) is a dipeptidyl peptidase-4 inhibitor indicated for the treatment of type 2 diabetes mellitus. Oral sitagliptin as monotherapy or combination therapy was generally well tolerated and improved glycaemic control in well designed clinical trials in patients with type 2 diabet...

journal_title：Drugs

authors： Dhillon S

更新日期：2010-03-05 00:00:00

abstract：:Acyclovir (aciclovir) is a nucleoside antiviral drug with antiviral activity in vitro against members of the herpes group of DNA viruses. As an established treatment of herpes simplex infection, intravenous, oral and to a lesser extent topical formulations of acyclovir provide significant therapeutic benefit in genita...

journal_title：Drugs

authors： O'Brien JJ,Campoli-Richards DM

更新日期：1989-03-01 00:00:00

abstract：:Grapefruit juice and grapefruit product consumption have potential health benefits; however, their intake is also associated with interactions with certain drugs, including calcium channel blockers, immunosuppressants and antihistamines. The primary mechanism through which interactions are mediated is mechanism-based ...

journal_title：Drugs

authors： Seden K,Dickinson L,Khoo S,Back D

更新日期：2010-12-24 00:00:00

abstract：:This paper reviews the use of the fluoroquinolone antibiotics in the management of sexually transmitted diseases (STD) in Southeast Asia. Numerous clinical trials performed in the region have shown that the quinolones are highly effective for treating uncomplicated gonorrhoea. Norfloxacin 800 mg, ofloxacin 400 mg, cip...

journal_title：Drugs

authors： Sivayathorn A

更新日期：1995-01-01 00:00:00

abstract：:Pain is an unpleasant sensation that originates from ongoing or impending tissue damage. Management of different types of pain (acute, postoperative, inflammatory, neuropathic or cancer) is the most frequent issue encountered by clinicians and pharmacological therapy is the first line of approach for the treatment of ...

journal_title：Drugs

authors： Guindon J,Walczak JS,Beaulieu P

更新日期：2007-01-01 00:00:00

abstract：:Accumulating evidence suggests the involvement of estrogen in depression. Estrogen can modulate neurotransmitter turnover, enhancing the levels of serotonin and noradrenaline (norepinephrine), and it is involved in the regulation of serotonin receptor number and function. Across the female reproductive life, fluctuati...

journal_title：Drugs

authors： Ryan J,Ancelin ML

更新日期：2012-09-10 00:00:00

abstract：:Ovulation induction is the most common medical intervention for the treatment of infertility. Clomifene is generally the first treatment choice for patients with amenorrhoea, unless there is profound hypothalamic deficiency. When clomifene fails to induce ovulation, menotropins (human menopausal gonadotrophin) or gona...

journal_title：Drugs

authors： Collins JA,Hughes EG

更新日期：1995-09-01 00:00:00

abstract：:The rationale for an arginine vasopressin (argipressin) infusion was put forward after it was discovered that patients in shock states might have an endogenous arginine vasopressin deficiency. Subsequently, several investigations impressively demonstrated that arginine vasopressin can successfully stabilise haemodynam...

journal_title：Drugs

authors： Dunser MW,Wenzel V,Mayr AJ,Hasibeder WR

更新日期：2003-01-01 00:00:00

abstract：:Crizotinib (Xalkori(®)) is an orally active, small molecule inhibitor of multiple receptor tyrosine kinases, including anaplastic lymphoma kinase (ALK), c-Met/hepatocyte growth factor receptor and c-ros oncogene 1. In the EU, crizotinib has been conditionally approved for the treatment of adults with previously treate...

journal_title：Drugs

authors： Frampton JE

更新日期：2013-12-01 00:00:00

abstract：:The popularity of antidepressants in the treatment of insomnia is not supported by a large amount of convincing data, but rather by opinions and beliefs of the prescribing physicians on the advantages of these agents compared with drugs acting on the benzodiazepine receptor or other drugs used for the treatment of ins...

journal_title：Drugs

authors： Wiegand MH

更新日期：2008-01-01 00:00:00

abstract：:Treatment of idiopathic membranous nephropathy is based on a 'symptomatic' therapy that includes ACE inhibitors or angiotensin II receptor antagonists, and on an 'aetiological' therapy aimed at modulating underlying immunological mechanisms. The role of the latter is still debated given the usually indolent course of ...

journal_title：Drugs

authors： Quaglia M,Stratta P

更新日期：2009-07-09 00:00:00

abstract：:The role of serotonin in the pathogenesis of hypertension is not clear. Serotonin is produced by the enterochromaffin cells of the gut; the greater part of this is metabolised in the liver and lungs and nearly all of the remainder is taken up by the platelets. Consequently, circulating levels of serotonin are extremel...

journal_title：Drugs

authors： Doyle AE

更新日期：1988-01-01 00:00:00

abstract：:The studies reported here were designed to ascertain whether or not the new beta-lactam antibiotic, temocillin, would produce antibiotic-associated colitis in the hamster. The experiments were controlled with clindamycin and cefoxitin, which are known to induce antibiotic-associated colitis experimentally and clinical...

journal_title：Drugs

authors： Boon RJ,Beale AS

更新日期：1985-01-01 00:00:00

abstract：:Insulin glargine 300 U/mL (Toujeo(®)) is a long-acting basal insulin analogue approved for the treatment of diabetes mellitus. Insulin glargine 300 U/mL has a more stable and prolonged pharmacokinetic/pharmacodynamic profile than insulin glargine 100 U/mL (Lantus(®)), with a duration of glucose-lowering activity excee...

journal_title：Drugs

authors： Blair HA,Keating GM

更新日期：2016-03-01 00:00:00

abstract：:Therapy for Gram-negative sepsis remains unsatisfactory despite a concerted effort to develop new treatments for this common, life-threatening syndrome. Current research continues on several fronts to improve the treatment options available to clinicians in the management of these critically ill patients. Recently, a ...

journal_title：Drugs

authors： Opal SM,Yu RL Jr

更新日期：1998-04-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a common medical disorder, which causes considerable morbidity and mortality. Given the chronic and symptomatic nature of the disease, the patient is often seen in the physician's office with complaints of dyspnea. However, more than 50% of COPD patients also have sleep ...

journal_title：Drugs

authors： George CF,Bayliff CD

更新日期：2003-01-01 00:00:00

abstract：:Hypopituitarism is a rare disorder, but its prevalence has increased as a result of an increase in secondary causes of hypopituitarism such as traumatic brain injury and cranial irradiation. Estrogen with or without progestogen (progestin) treatment is conventional therapy in women with hypopituitarism. Recent data de...

journal_title：Drugs

authors： Zang H,Davis SR

更新日期：2008-01-01 00:00:00

abstract：:Everolimus is an immunosuppressant that blocks growth factor-mediated proliferation of haematopoietic and nonhaematopoietic cells. Oral everolimus 0.75 or 1.5mg twice daily significantly reduced the incidence of the primary composite endpoint, efficacy failure 6 months after transplantation, compared with azathioprine...

journal_title：Drugs

authors： Chapman TM,Perry CM

更新日期：2004-01-01 00:00:00

abstract：:A new formulation of paclitaxel, 130-nanometre albumin-bound paclitaxel (nab-paclitaxel), solubilises hydrophobic paclitaxel and may increase paclitaxel delivery to tumour cells. Intravenous nab-paclitaxel 260 mg/m(2) had a higher maximum whole-blood concentration, shorter time to peak concentration, larger distributi...

journal_title：Drugs

authors： Robinson DM,Keating GM

更新日期：2006-01-01 00:00:00

abstract：:The prevalence of use of long-term systemic glucocorticoid therapy in the general adult population is 1 %. This figure increases to up to 3 % in elderly women. Metabolic (i.e. diabetes mellitus, dyslipidemia, weight gain, lipodystrophy) and cardiovascular (i.e. hypertension, cardiovascular events) adverse events are c...

journal_title：Drugs

authors： Fardet L,Fève B

更新日期：2014-10-01 00:00:00

abstract：:Macitentan (Opsumit(®)) is an orally active, dual endothelin receptor antagonist (ERA) with tissue targeting properties. Macitentan was approved recently in the EU (as monotherapy or combination therapy) for the long-term treatment of pulmonary arterial hypertension (PAH) in adults of WHO functional class II or III, a...

journal_title：Drugs

authors： Dhillon S

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Opioid pharmacotherapies play an important role in the treatment of opioid-dependent women; however, very little is known about the safety of naltrexone in pregnant patients. OBJECTIVE:This study examined the obstetric health of opioid-dependent women who were treated with implant naltrexone during pregnanc...

journal_title：Drugs

authors： Kelty E,Hulse G

更新日期：2017-07-01 00:00:00