A clinical assessment of the potential for pharmacological interaction between nimesulide and digoxin in patients with heart failure.

Abstract:

:The potential interaction between nimesulide, a nonsteroidal anti-inflammatory drug, and digoxin was studied in 9 patients [6 males, 3 females; mean age 67 (range 57 to 70) years] with mild heart failure. All patients were receiving maintenance therapy with digoxin (0.25 mg/day, orally) and were treated with oral nimesulide 100mg twice daily for 7 days. Blood samples were collected at 8am and 6pm for 4 days before and throughout the nimesulide treatment period for determination of serum digoxin concentrations. Physical health, electrocardiographic recordings and blood and urine samples were also monitored. Mean serum digoxin concentrations remained within the normal therapeutic range throughout the study despite large interindividual variation. Furthermore, there were no significant differences between the morning and afternoon serum digoxin concentrations and there was no major change in the clinical condition of any patient. These results indicate that short term administration (7 days) of conventional therapeutic doses of nimesulide (100mg twice daily) does not modify the serum digoxin profile in patients with low class heart failure treated with a maintenance dose (0.25 mg/day) of this cardiac glycoside.

journal_name

Drugs

journal_title

Drugs

authors

Baggio E,Maraffi F,Montalto C,Nava ML,Torti L,Casciarri I

doi

10.2165/00003495-199300461-00017

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

91-4

eissn

0012-6667

issn

1179-1950

journal_volume

46 Suppl 1

pub_type

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