Chenodeoxycholic acid: a review of its pharmacological properties and therapeutic use.

abstract：:Infections in burn patients continue to be the primary source of morbidity and mortality. Topical antimicrobial therapy remains the single most important component of wound care in hospitalised burn patients. The goal of prophylactic topical antimicrobial therapy is to control microbial colonisation and prevent burn w...

journal_title：Drugs

authors： Monafo WW,West MA

更新日期：1990-09-01 00:00:00

abstract：:Page 9, Fig. 2, which originally appeared as. ...

journal_title：Drugs

authors： Mathieson S,Maher CG,Ferreira GE,Hamilton M,Jansen J,McLachlan AJ,Underwood M,Lin CC

更新日期：2020-10-01 00:00:00

abstract：:Levetiracetam (Keppra®, E Keppra®) is an established second-generation antiepileptic drug (AED). Worldwide, levetiracetam is most commonly approved as adjunctive treatment of partial onset seizures with or without secondary generalization; other approved indications include monotherapy treatment of partial onset seizu...

journal_title：Drugs

authors： Lyseng-Williamson KA

更新日期：2011-03-05 00:00:00

abstract：:Aspirin is currently the most widely prescribed treatment in the prevention of cardiovascular complications. The indications for the use of aspirin during pregnancy are, however, the subject of much controversy. Since the first evidence of the obstetric efficacy of aspirin in 1985, numerous studies have tried to deter...

journal_title：Drugs

authors： Atallah A,Lecarpentier E,Goffinet F,Doret-Dion M,Gaucherand P,Tsatsaris V

更新日期：2017-11-01 00:00:00

abstract：:Chronic spontaneous urticaria (CSU) is characterized by the presence of wheals, angioedema, or both for at least 6 weeks. It may persist for a long time-up to 50% of the patients have been reported to be symptomatic 5 years after the onset. Some patients can suffer more than one episode of CSU during their lifetime. C...

journal_title：Drugs

authors： Giménez-Arnau AM,Salman A

更新日期：2020-11-01 00:00:00

abstract：:Significant progress has been made in the battle against transmission of HIV-1 from mother to infant. Antiretroviral regimens covering the later part of gestation, labour and the first few weeks of neonatal life have shown great efficacy in reducing such transmission. With the advent of combination antiretroviral ther...

journal_title：Drugs

authors： Kourtis AP

更新日期：2002-01-01 00:00:00

abstract：:Globally, tuberculosis (TB) and HIV interact in deadly synergy. The high burden of TB among HIV-infected individuals underlies the importance of TB diagnosis, treatment and prevention for clinicians involved in HIV care. Despite expanding access to antiretroviral therapy (ART) to treat HIV infection in resource-limite...

journal_title：Drugs

authors： Venkatesh KK,Swaminathan S,Andrews JR,Mayer KH

更新日期：2011-06-18 00:00:00

abstract：:Several compounds have been claimed to have a faster onset of antidepressant action. However, these trials suffered from lack of appropriate definitions and of standardised and comparable methodology, as far as measurement instruments, dosage strategies and statistical analyses were concerned. This article was underta...

journal_title：Drugs

authors： Soares JC,Gershon S

更新日期：1996-10-01 00:00:00

abstract：:The incidence of infection in clean surgery (i.e. surgery with no major contamination of the operative site) should be less than 2%, although the incidence of postoperative infections can be higher in patients with various risk factors (namely insertion of foreign bodies, a compromised immune status or prolonged durat...

journal_title：Drugs

authors： Mini E,Nobili S,Periti P

更新日期：1997-01-01 00:00:00

abstract：:Dapoxetine, a selective serotonin reuptake inhibitor, is the first oral pharmacological agent indicated for the treatment of men aged 18-64 years with premature ejaculation. In four randomized, double-blind, placebo-controlled, multicentre studies of 12-24 weeks' duration, oral dapoxetine 30 or 60 mg (administered as ...

journal_title：Drugs

authors： Hoy SM,Scott LJ

更新日期：2010-07-30 00:00:00

abstract：:Involuntary infertility is an increasing problem in this era of delayed childbearing. Fortunately, many advances have been made recently in the medical and surgical treatment of infertility. This article reviews the principal aetiologies of infertility and their treatments, and focuses on the current and future uses o...

journal_title：Drugs

authors： Quigley MM

更新日期：1986-08-01 00:00:00

abstract：:Botulinum neurotoxin type A (BTX-A) weakens voluntary muscle strength and is an effective therapy for focal dystonia, including cervical dystonia (CD) and benign essential blepharospasm (BEB). It is also known to relieve hemifacial spasm and focal spasticity in children and adults. In addition, BTX-A has been shown to...

journal_title：Drugs

authors： Jost WH,Blümel J,Grafe S

更新日期：2007-01-01 00:00:00

abstract：:The disposition of many drugs in cystic fibrosis is abnormal. In general, changes in pharmacokinetics include: increased volume of distribution, decreased plasma concentration, and enhanced renal and sometimes non-renal elimination of drugs. Pathophysiology of the disease important for drug disposition includes: (a) h...

journal_title：Drugs

authors： Prandota J

更新日期：1988-05-01 00:00:00

abstract：:Various foods and fluids have been used in traditional treatments for diarrhoeal illnesses in infants and children for centuries. During the last 2 decades, however, with the advent of an improved scientific understanding of oral rehydration, effective treatment of dehydrating diarrhoea has been improved, expanded and...

journal_title：Drugs

authors： Sack DA

更新日期：1991-04-01 00:00:00

abstract：:General anaesthesia is the reversible depression of central nervous system function. There is still no agreement over what constitutes depth of anaesthesia, and the clinical anaesthetist must thus titrate drug input according to clinical signs (heart rate, blood pressure, somatic movement, autonomic responses). The po...

journal_title：Drugs

authors： Sear JW

更新日期：1992-01-01 00:00:00

abstract：:The incidence of multiresistance in Gram-positive cocci causing infections in critically ill patients admitted to the intensive care unit (ICU) has increased notably in recent years. Thus, therapeutic proposals have been modified according to the emergence of multiresistant cocci and adapted to epidemiological markers...

journal_title：Drugs

authors： Alvarez-Lerma F,Grau S,Gracia-Arnillas MP

更新日期：2006-01-01 00:00:00

abstract：:Despite remarkable advances in cardiovascular therapeutics, sudden cardiac death remains a significant problem. In this review, data from clinical trials and other studies on antiarrhythmic therapies have been evaluated in order to determine effective strategies for the prevention of sudden cardiac death in high risk ...

journal_title：Drugs

authors： McAlister FA,Teo KK

更新日期：1997-08-01 00:00:00

abstract：:Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature identified reported herb-drug interactions with clinical significance, many of which are from case reports and limited clinical observations. Cases have been publis...

journal_title：Drugs

authors： Hu Z,Yang X,Ho PC,Chan SY,Heng PW,Chan E,Duan W,Koh HL,Zhou S

更新日期：2005-01-01 00:00:00

abstract：:Through years of evolutionary selection pressures, organisms have developed potent toxins that coincidentally have marked antineoplastic activity. These natural products have been vital for the development of multiagent treatment regimens currently employed in cancer chemotherapy, and are used in the treatment of a va...

journal_title：Drugs

authors： Trendowski M

更新日期：2015-11-01 00:00:00

abstract：:Despite the availability of effective pharmacological treatments to aid the control of blood pressure, the global rate of uncontrolled blood pressure remains high. As such, further measures are required to improve blood pressure control. Recently, several national and international guidelines for the management of hyp...

journal_title：Drugs

authors： Kjeldsen S,Feldman RD,Lisheng L,Mourad JJ,Chiang CE,Zhang W,Wu Z,Li W,Williams B

更新日期：2014-11-01 00:00:00

abstract：:The endothelin family of peptides are extremely potent endogenous vasoconstrictor and pressor agents. Of the 3 isoforms, endothelin-1 is the major isoform produced by the vascular endothelium and is, therefore, likely to be of most importance for regulation of vascular function. Two endothelin receptor subtypes have s...

journal_title：Drugs

authors： Ferro CJ,Webb DJ

更新日期：1996-01-01 00:00:00

abstract：:This article is intended to stimulate thought and focus on those areas where we feel advances in drug therapy for inflammatory bowel disease may occur. It is not an extensive review of current practice, although this is considered where it is thought to be pertinent to future developments. There are several excellent ...

journal_title：Drugs

authors： Rhodes J,Thomas G,Evans BK

更新日期：1997-02-01 00:00:00

abstract：UNLABELLED:Gatifloxacin is an 8-methoxy fluoroquinolone antibacterial agent. The drug has a broader spectrum of antibacterial activity than the older fluoroquinolones (e.g. ciprofloxacin) and shows good activity against many Gram-positive and Gram-negative pathogens, atypical organisms and some anaerobes. Notably, gati...

journal_title：Drugs

authors： Perry CM,Ormrod D,Hurst M,Onrust SV

更新日期：2002-01-01 00:00:00

abstract：:Results from prevalence, case-control, angiographic and echocardiographic investigations incriminate elevated fibrinogen levels as a strong independent risk factor for the occurrence of initial and recurrent cardiovascular events. Average fibrinogen levels are higher in women and persons with other risk factors includ...

journal_title：Drugs

authors： Kannel WB

更新日期：1997-01-01 00:00:00

abstract：:Immune checkpoint inhibition of programmed-death receptor 1 (PD-1) or its ligand (PD-L1) has become a standard in the treatment of metastatic non-small cell lung cancer, either as monotherapy or in combination. Recently, it could be shown that immunotherapy works as consolidation after chemoradiotherapy in locally adv...

journal_title：Drugs

authors： Heigener DF,Reck M

更新日期：2019-12-01 00:00:00

abstract：:Because platelets are so important in thrombus formation, drugs which inhibit platelet function (the 'antiplatelet drugs') have considerable potential as antithrombotic agents. Among the antiplatelet drugs, only aspirin, sulphinpyrazone, dipyridamole, hydroxychloroquine, and clofibrate have had wide clinical trial. Th...

journal_title：Drugs

authors： Gallus AS

更新日期：1979-12-01 00:00:00

abstract：:Amiodarone is a class III antiarrhythmic drug with sympatholytic properties, which prolongs the refractory period of all cardiac tissues, depresses sinus node automaticity and atrioventricular nodal conduction. It is active on all cardiac arrhythmias, its use being limited by the risk of side effects, mainly extracard...

journal_title：Drugs

authors： Puech P

更新日期：1991-01-01 00:00:00

abstract：:Patient compliance refers to the willingness and ability of an individual to follow health-related advice, to take medication as prescribed, to attend scheduled clinic appointments and to complete recommended investigations. It is a major health issue, with outcomes related to levels of morbidity, mortality and cost u...

journal_title：Drugs

authors： Murphy J,Coster G

更新日期：1997-12-01 00:00:00

abstract：:Dietary measures have achieved mixed results in the management of liver disorders. Although a high energy diet may shorten the course of viral hepatitis by a relatively small amount, dietary restriction is usually of no benefit in compensated cirrhosis. Restriction of sodium intake to 22 to 60 mol/day leads to resolut...

journal_title：Drugs

authors： Messner M,Brissot P

更新日期：1990-01-01 00:00:00

abstract：:Preclinical studies indicate that angiogenic growth factors can stimulate the development of collateral arteries in animal models of peripheral or myocardial ischaemia, a concept termed 'therapeutic angiogenesis'. The goal of this review is to provide a brief overview of the advantages and disadvantages of gene versus...

journal_title：Drugs

authors： Amant C,Berthou L,Walsh K

更新日期：1999-01-01 00:00:00