Antiarrhythmic therapies for the prevention of sudden cardiac death.

abstract：:Management of renal cell carcinoma (RCC) has made considerable progress in recent years, and new emerging strategies are being developed. On the basis of the results of two randomised studies in the early 2000s, nephrectomy has now become the standard as cytoreductive surgery before embarking on systemic treatment wit...

journal_title：Drugs

authors： Escudier B

更新日期：2007-01-01 00:00:00

abstract：:Novo Nordisk has developed a subcutaneous formulation of semaglutide (Ozempic®), a modified human glucagon-like peptide-1 (GLP-1) analogue, for the treatment of type 2 diabetes mellitus. It has been developed using Novo Nordisk's proprietary protein-acylation technology, and is administered using an injection device. ...

journal_title：Drugs

authors： Dhillon S

更新日期：2018-02-01 00:00:00

abstract：:In this paper the different aspects of the role played by alpha-adrenoceptors in the control of renin secretion from the juxtaglomerular apparatus and renal sodium and water reabsorption, and the effects of alpha-adrenoceptor antagonists on systemic haemodynamics, will be investigated. Animal experiments suggest that ...

journal_title：Drugs

authors： Leonetti G

更新日期：1988-01-01 00:00:00

abstract：:Acamprosate (calcium acetylhomotaurinate), a synthetic compound with a similar chemical structure to that of gamma-aminobutyric acid, is thought to act via several mechanisms affecting multiple neurotransmitter systems; inhibition of neuronal hyperexcitability by antagonism of excitatory amino acid activity and reduct...

journal_title：Drugs

authors： Wilde MI,Wagstaff AJ

更新日期：1997-06-01 00:00:00

abstract：UNLABELLED:Enoxaparin (enoxaparin sodium) is a low molecular weight heparin (LMWH) that is widely used in the prevention of deep venous thrombosis and pulmonary embolism in patients undergoing orthopaedic or general surgery. Its efficacy in these indications has led to study of its use in patients with coronary artery ...

journal_title：Drugs

authors： Noble S,Spencer CM

更新日期：1998-08-01 00:00:00

abstract：:Results from prevalence, case-control, angiographic and echocardiographic investigations incriminate elevated fibrinogen levels as a strong independent risk factor for the occurrence of initial and recurrent cardiovascular events. Average fibrinogen levels are higher in women and persons with other risk factors includ...

journal_title：Drugs

authors： Kannel WB

更新日期：1997-01-01 00:00:00

abstract：:Empagliflozin/linagliptin (Glyxambi(®)) is a once-daily sodium glucose co-transporter type 2 (SGLT2) inhibitor and dipeptidyl peptidase (DPP)-4 inhibitor fixed-dose combination product that is approved in the USA as an adjunct to diet and exercise in adults with type 2 diabetes (T2D) when treatment with both empaglifl...

journal_title：Drugs

authors： Kim ES,Deeks ED

更新日期：2015-09-01 00:00:00

abstract：:The increased understanding of the mechanisms which underlie rheumatoid disease has been accompanied by a more appropriate use of the limited repertoire of therapeutic agents. Conventional second-line drugs still have a role in everyday practice. The efficacy of these agents in reducing the severity of clinical signs ...

journal_title：Drugs

authors： Luqmani R,Gordon C,Bacon P

更新日期：1994-02-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is a leading cause of cancer death in industrialised countries, with an overall 5-year survival rate of less than 10%. Good patient performance status is associated with a significantly improved prognosis, whereas the presence of metastases, particularly to the bone or liver, is asso...

journal_title：Drugs

authors： Faulds D

更新日期：1992-01-01 00:00:00

abstract：:There is now good evidence that T cells play a central role in the inflammatory pathway that leads to the persistent synovitis that causes joint damage in rheumatoid arthritis (RA). T cells require two signals to become activated. The second step in the activation of T cells involves costimulatory pathways, the best d...

journal_title：Drugs

authors： Pollard LC

更新日期：2007-01-01 00:00:00

abstract：:The occurrence of late side effects of long term levodopa therapy (fluctuations in motor performance, abnormal movements, and symptoms unresponsive to dihydroxyphenylalanine) led to the search for novel anti-Parkinsonian drugs. Dopamine agonists are one of the newer families of anti-Parkinsonian agents, and they inclu...

journal_title：Drugs

authors： Montastruc JL,Rascol O,Senard JM

更新日期：1993-09-01 00:00:00

abstract：:Airway inflammation is central to the pathophysiology of asthma, with treatment directed towards modification of this inflammation and its consequences. The relationship between cigarette smoking and airway inflammation is also well described, but relatively little data are available on the potential influence of smok...

journal_title：Drugs

authors： Livingston E,Thomson NC,Chalmers GW

更新日期：2005-01-01 00:00:00

abstract：:Intravenous minocycline (Minocin®) is approved in the USA for use in patients with infections due to susceptible strains of Gram-positive and Gram-negative pathogens, including infections due to Acinetobacter spp. Minocycline is a synthetic tetracycline derivative that was originally introduced in the 1960s. A new int...

journal_title：Drugs

authors： Greig SL,Scott LJ

更新日期：2016-10-01 00:00:00

abstract：:Scleroderma or systemic sclerosis is a rare condition with many clinical manifestations including Raynaud's phenomenon. As with many other rarely encountered diseases, drug therapy for scleroderma is often empirical with little evidence in the form of randomised controlled trials to aid drug choice. Raynaud's phenomen...

journal_title：Drugs

authors： Leighton C

更新日期：2001-01-01 00:00:00

abstract：:Olaratumab (Lartruvo™) is a fully human IgG1 monoclonal antibody targeted against the human platelet-derived growth factor (PDGF) receptor α (PDGFRα). It was developed by Eli Lilly and Co. (previously ImClone Systems) after PDGFRα was identified as a potential therapeutic target in a variety of cancers. Olaratumab act...

journal_title：Drugs

authors： Shirley M

更新日期：2017-01-01 00:00:00

abstract：:The discovery of at least 2 cyclo-oxygenase (COX) isoenzymes, referred to as COX-1 and COX-2, has updated our knowledge of nonsteroidal anti-inflammatory drugs (NSAIDs). This has lead investigators to reconsider what can be awaited from this class of drugs. The 2 COX isoenzymes share structural and enzymatic similarit...

journal_title：Drugs

authors： Jouzeau JY,Terlain B,Abid A,Nédélec E,Netter P

更新日期：1997-04-01 00:00:00

abstract：:Arrhythmia treatment has always been difficult, particularly as there are no good indicators of the optimal management strategy. The introduction of new antiarrhythmic agents has forced reappraisal of how these drugs are used. Dynamic electrocardiography and invasive electrophysiological studies are important tools fo...

journal_title：Drugs

authors： Campbell RW

更新日期：1988-11-01 00:00:00

abstract：:Patients with viral infections of the central nervous system (CNS) may present with a variety of neurological symptoms, most commonly dominated by either encephalitis or meningitis. The aetiological panorama varies in different parts of the world as well as over time. Thus, virological first-line diagnostics must be a...

journal_title：Drugs

authors： Studahl M,Lindquist L,Eriksson BM,Günther G,Bengner M,Franzen-Röhl E,Fohlman J,Bergström T,Aurelius E

更新日期：2013-02-01 00:00:00

abstract：:On the basis of well documented biochemical and pharmacological data about the influence of drug mediated enzyme induction on the biotransformation of natural and synthetic sex steroids, practical consequences for hormonal steroid contraception are described and discussed. Clinical reports dealing with this problem ar...

journal_title：Drugs

authors： Hempel E,Klinger W

更新日期：1976-12-01 00:00:00

abstract：:Glucocorticoids (GCs) are often used for improvement of quality of life, particularly in the elderly, but long-term GC use may cause harm; bone loss and fractures are among the most devastating side effects. Fracture risk is particularly high in patients with a severe underlying disease with an urgent need for treatme...

journal_title：Drugs

authors： Raterman HG,Bultink IEM,Lems WF

更新日期：2019-07-01 00:00:00

abstract：:Alterations of skin and hair pigmentation are important features that have warranted treatment from ancient history on up to modern time. In some cultures, even today patients with vitiligo are regarded as social outcasts and are affected considerably both emotionally and physically. This article presents current opti...

journal_title：Drugs

authors： Hartmann A,Bröcker EB,Becker JC

更新日期：2004-01-01 00:00:00

abstract：:Nivolumab (Opdivo(®)) is a fully human monoclonal antibody against programmed death receptor-1, a negative regulatory checkpoint molecule with a role in immunosuppression. The drug is administered intravenously and is approved for the treatment of unresectable malignant melanoma in Japan. The potential for intravenous...

journal_title：Drugs

authors： Deeks ED

更新日期：2014-07-01 00:00:00

abstract：:Stavudine is a nucleoside analogue which undergoes intracellular phosphorylation to its active metabolite, stavudine-5'-triphosphate. At clinically relevant concentrations, the active metabolite restricts HIV replication by inhibiting the inclusion of thymidine-5'-triphosphate into proviral DNA by HIV reverse transcri...

journal_title：Drugs

authors： Lea AP,Faulds D

更新日期：1996-05-01 00:00:00

abstract：:Many drugs alter the anticoagulant effect of oral coumarins. It is essential that physicians be aware of interactions leading to increased or decreased anticoagulation or to erratic control. Interacting drugs can be classified as influencing the pharmacodynamics (pharmacological actions) or the pharmacokinetics (absor...

journal_title：Drugs

authors： MacLeod SM,Sellers EM

更新日期：1976-01-01 00:00:00

abstract：:Conventional formulations of metoprolol have become well established in cardiovascular medicine and are particularly useful in the management of hypertension and ischaemic heart disease. Recently developed controlled release metoprolol delivery systems (metoprolol CR/ZOK and metoprolol OROS) were designed to overcome ...

journal_title：Drugs

authors： Plosker GL,Clissold SP

更新日期：1992-03-01 00:00:00

abstract：:Safety data have been gathered in US clinical trials of nabumetone on 1912 patients from August 1981 to May 1988. Dosing in the double-blind trials was 100 mg at bedtime, but in open-label trials patients could increase the dosage of nabumetone to 1500 or 2000 mg if required. Adverse experiences reported in the double...

journal_title：Drugs

authors： Willkens RF

更新日期：1990-01-01 00:00:00

abstract：:Increases in cancer diagnosis have tremendous negative impacts on patients and their families, and major societal and economic costs. The beneficial effect of chemotherapeutic agents on tumor suppression comes with major unwanted side effects such as weight and hair loss, nausea and vomiting, and neuropathic pain. Che...

journal_title：Drugs

authors： Blanton HL,Brelsfoard J,DeTurk N,Pruitt K,Narasimhan M,Morgan DJ,Guindon J

更新日期：2019-06-01 00:00:00

abstract：:Rilpivirine is an orally administered, non-nucleoside reverse transcriptase inhibitor that is a component drug in combination therapy for antiretroviral-naive patients with HIV-1 infection. The randomized, double-blind, double-dummy, multinational ECHO and THRIVE trials in antiretroviral-naive adult patients with HIV-...

journal_title：Drugs

authors： Sanford M

更新日期：2012-03-05 00:00:00

abstract：:Purine nucleoside analogues are a new class of drugs with activity against nondividing lymphocytes; thus, they should play a major role in the treatment of low grade lymphoid malignancies. As these drugs are active against resting lymphocytes, harmful effects related to this action were expected and have been reported...

journal_title：Drugs

authors： Dighiero G

更新日期：1994-01-01 00:00:00

abstract：:Pain is an unpleasant sensation that originates from ongoing or impending tissue damage. Management of different types of pain (acute, postoperative, inflammatory, neuropathic or cancer) is the most frequent issue encountered by clinicians and pharmacological therapy is the first line of approach for the treatment of ...

journal_title：Drugs

authors： Guindon J,Walczak JS,Beaulieu P

更新日期：2007-01-01 00:00:00