Abstract:
:ZD1839 ('Iressa') is an orally active, selective epidermal growth factor receptor-tyrosine kinase inhibitor which blocks signal transduction pathways implicated in the proliferation and survival of cancer cells and other host-dependent processes promoting cancer growth. In preclinical studies, ZD1839 produced reversible growth inhibition and growth delay in a wide range of tumour cell lines and human tumour xenografts. Moreover, this activity was enhanced when ZD1839 was coadministered with cytotoxic agents. Preliminary results from phase I trials in patients with advanced disease and a wide variety of tumour types suggest that ZD1839 has an acceptable tolerability profile and promising clinical efficacy, particularly in non-small cell lung cancer (NSCLC). ZD1839 is currently in phase III clinical development for the treatment of advanced NSCLC. In addition, further trials are ongoing or planned in a number of other tumour types.
journal_name
Drugsjournal_title
Drugsauthors
Baselga J,Averbuch SDdoi
10.2165/00003495-200060001-00004subject
Has Abstractpub_date
2000-01-01 00:00:00pages
33-40; discussion 41-2eissn
0012-6667issn
1179-1950journal_volume
60 Suppl 1pub_type
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