Abstract:
:Azimilide is a potassium channel antagonist that, in contrast to existing class III antiarrhythmic agents, blocks both the rapidly (I(Kr)) and slowly (I(Ks)) activating components of the delayed rectifier potassium current. In animal and clinical studies, azimilide prolonged repolarisation by increasing the action potential duration and effective refractory period. In animal models, azimilide was effective in terminating both atrial and ventricular arrhythmias. Azimilide also demonstrated antifibrillatory efficacy in a canine model of sudden cardiac death. In patients with a history of atrial fibrillation/flutter, oral azimilide controlled arrhythmias more effectively than placebo in a 6-month randomised double-blind study. At a dosage of 125 mg once daily, azimilide significantly increased the time to first symptomatic recurrence of atrial fibrillation/flutter. However, no significant difference between placebo and azimilide was found in another study. Oral azimilide 100 mg once daily demonstrated clinically significant treatment effects in patients with paroxysmal supraventricular tachycardia. In clinical trials, azimilide was generally well tolerated and headache was the most commonly occurring adverse event. Azimilide is associated with a low incidence of proarrhythmic events, such as torsades de pointes, and few serious adverse events have been reported.
journal_name
Drugsjournal_title
Drugsauthors
Clemett D,Markham Adoi
10.2165/00003495-200059020-00016subject
Has Abstractpub_date
2000-02-01 00:00:00pages
271-7; discussion 278-9issue
2eissn
0012-6667issn
1179-1950journal_volume
59pub_type
杂志文章相关文献
DRUGS文献大全abstract::Chronic spontaneous urticaria (CSU) is characterized by the presence of wheals, angioedema, or both for at least 6 weeks. It may persist for a long time-up to 50% of the patients have been reported to be symptomatic 5 years after the onset. Some patients can suffer more than one episode of CSU during their lifetime. C...
journal_title:Drugs
pub_type: 杂志文章
doi:10.1007/s40265-020-01387-9
更新日期:2020-11-01 00:00:00
abstract::Atenolol and nifedipine have been shown to be effective single agents in angina pectoris, but reports suggest that additional benefits may be conferred by combining the 2 drugs. Therefore, to establish that the combination regimen was at least as effective as either atenolol or nifedipine alone, a multicentre study wa...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-198800354-00012
更新日期:1988-01-01 00:00:00
abstract::Alfuzosin, a new quinazoline derivative, acts as a selective and competitive antagonist of alpha 1-adrenoceptor-mediated contraction of prostatic, prostatic capsule, bladder base and proximal urethral smooth muscle, thereby reducing the tone of these structures. Consequently, urethral pressure and resistance, bladder ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199345030-00008
更新日期:1993-03-01 00:00:00
abstract::Acitretin (etretin), a second generation monoaromatic retinoid for use in the treatment of severe psoriasis and other dermatoses, is the major active metabolite of etretinate and possesses a similar therapeutic index; i.e. a similar ratio of clinical efficacy to adverse effects. When used alone at a maintenance dosage...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199243040-00010
更新日期:1992-04-01 00:00:00
abstract::Bisoprolol is a beta 1-adrenoceptor antagonist with no partial agonist (intrinsic sympathomimetic) activity or membrane stabilising (local anaesthetic) activity. The oral bioavailability of bisoprolol is high (90%) and the drug has a long elimination half-life which allows once-daily administration; in addition, it is...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-198836030-00002
更新日期:1988-09-01 00:00:00
abstract:UNLABELLED:Candesartan cilexetil is converted to the angiotensin II receptor antagonist candesartan during absorption from the gastrointestinal tract. The selective and competitive binding of candesartan to the angiotensin II type 1 (AT(1)) receptor prevents binding of angiotensin II, a key mediator in the renin-angiot...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200262080-00016
更新日期:2002-01-01 00:00:00
abstract::The efficacy and safety of rectally administered nimesulide 200mg and paracetamol 500mg were assessed in a double-blind study. The study was conducted in 39 elderly inpatients with infections of the upper or lower respiratory tract associated with fever; 18 patients received nimesulide and 21 received paracetamol. Bot...
journal_title:Drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2165/00003495-199300461-00026
更新日期:1993-01-01 00:00:00
abstract::Peripheral arterial occlusive disease is a common condition with possible serious consequences. It is usually diagnosed at the intermittent claudication stage. There are 2 objectives of treatment: to prevent ischaemic attacks and to improve quality of life. Treatment efficacy is, however, usually evaluated only in ter...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199856003-00004
更新日期:1998-01-01 00:00:00
abstract::Hepatitis E accounts for the major part of enterally transmitted non-A, non-B hepatitis worldwide. Its agent, the hepatitis E virus (HEV), is a small, single-stranded RNA virus. Only one serotype of HEV is recognised. Infection results in protective immunity with long-lived neutralising antibodies. In developing count...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200464140-00002
更新日期:2004-01-01 00:00:00
abstract::Stavudine is a nucleoside analogue which undergoes intracellular phosphorylation to its active metabolite, stavudine-5'-triphosphate. At clinically relevant concentrations, the active metabolite restricts HIV replication by inhibiting the inclusion of thymidine-5'-triphosphate into proviral DNA by HIV reverse transcri...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199651050-00009
更新日期:1996-05-01 00:00:00
abstract::Valsartan/hydrochlorothiazide (HCTZ) combines an angiotensin II AT1 receptor blocker with a thiazide diuretic to produce additive blood pressure reductions without major effects on heart rate. HCTZ did not significantly alter valsartan pharmacokinetics; during combination therapy, HCTZ pharmacokinetics differed from t...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199957050-00008
更新日期:1999-05-01 00:00:00
abstract::Eltrombopag (Revolade(®)) is an orally bioavailable, low molecular weight, synthetic nonpeptide thrombopoietin receptor agonist, which selectively binds to the transmembrane and juxtamembrane domains of the thrombopoietin receptor on the surface of platelets, megakaryocytes and megakaryocyte precursor cells, resulting...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/11207390-000000000-00000
更新日期:2011-07-09 00:00:00
abstract::Intravenous inotuzumab ozogamicin (Besponsa®; Pfizer) is an anti-CD22 monoclonal antibody-calicheamicin conjugate that binds to CD22-expressing tumour cells. Upon binding, the complex is internalised and the cytotoxic calicheamicin derivative is released inside the cell, inducing double-strand DNA breakage and subsequ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.1007/s40265-017-0802-5
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:Authorization of orphan medicinal products (OMPs) is often based on studies with several methodological shortcomings. Hence, data are difficult to interpret and efficacy does not always correspond to real-world effectiveness. We investigated to what extent an efficacy-effectiveness gap exists for OMPs for ...
journal_title:Drugs
pub_type: 杂志文章
doi:10.1007/s40265-017-0788-z
更新日期:2017-09-01 00:00:00
abstract::Gastro-oesophageal reflux disease (GORD or GERD) is a very common disorder, and advancement in drug development over the years has markedly improved disease management. Proton pump inhibitors (PPIs) remain the mainstay of treatment for GERD due to their profound and consistent inhibitory effect on acid secretion. Howe...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/11597300-000000000-00000
更新日期:2011-12-24 00:00:00
abstract::A study was made of the clinical features and therapeutic response of 144 patients from whose sputum Branhamella catarrhalis was isolated. Typically, features of bronchopulmonary infection with cough productive of moderate amounts of purulent sputum, fever and dyspnoea were present. Of 74 patients who were infected in...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198600313-00023
更新日期:1986-01-01 00:00:00
abstract::In a noncomparative trial, 73 adults with acute sinusitis confirmed by x-ray received cefixime 400mg once daily for approximately 10 days. At the end of treatment, 60 patients (82%) were cured, 2 (2.7%) had improved and 7 (9.6%) had failed therapy; 4 patients were not evaluable. No relapses were observed at follow-up....
journal_title:Drugs
pub_type: 临床试验,杂志文章
doi:10.2165/00003495-199100424-00007
更新日期:1991-01-01 00:00:00
abstract::Transdermal nicotine delivery systems are a cigarette smoking cessation aid designed to deliver nicotine into the systemic circulation via the skin. The partial replacement of plasma nicotine, which would have otherwise been obtained from cigarettes, reduces the severity of nicotine withdrawal symptoms, and so allows ...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199244030-00011
更新日期:1992-09-01 00:00:00
abstract::Alteplase is the product of recombinant DNA technology and is chemically identical to endogenous tissue-type plasminogen activator: Plasminogen is converted to plasmin by alteplase, and fibrinolysis of blood thrombi is subsequently stimulated. Alteplase is now firmly established as a treatment of choice in the managem...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199550020-00007
更新日期:1995-08-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is a leading cause of cancer death in industrialised countries, with an overall 5-year survival rate of less than 10%. Good patient performance status is associated with a significantly improved prognosis, whereas the presence of metastases, particularly to the bone or liver, is asso...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199200444-00006
更新日期:1992-01-01 00:00:00
abstract::Growth hormone deficiency (GHD) in the adult has now been fully recognised as a clinical entity characterised by abnormal body composition, osteopenia, impaired quality of life, cardiac dysfunction and an adverse lipid profile. While short-term studies of GH replacement have demonstrated irrefutably a favourable effec...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200262160-00006
更新日期:2002-01-01 00:00:00
abstract::Irinotecan (CPT-II) is a semisynthetic derivative of camptothecin. It and other camptothecin analogues/derivatives appear to exert their antitumour activity by binding to topoisomerase I. The active metabolite of irinotecan, 7-ethyl-10-hydroxycamptothecin (SN-38), has demonstrated potent growth inhibition of human col...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199652040-00013
更新日期:1996-10-01 00:00:00
abstract::Varicella zoster virus (VZV), a member of the herpesvirus family, is responsible for both primary (varicella, chickenpox) as well as reactivation (zoster, shingles) infections. In immunocompetent patients, the course of varicella is generally benign. For varicella zoster, post-herpetic neuralgia is the most common com...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199957020-00005
更新日期:1999-02-01 00:00:00
abstract::For almost half a century, the first-line treatment for ovulation induction in cases of anovulation, unexplained infertility, or mild male factor has been clomifene (clomiphene citrate). Clomifene is an effective and safely used oral agent, but is known to have relatively common antiestrogenic endometrial and cervical...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200666170-00001
更新日期:2006-01-01 00:00:00
abstract::Temocillin is a novel injectable beta-lactam antibiotic designed for parenteral use. It is active against the majority of Gram-negative bacteria and is stable to a wide range of beta-lactamases. Disposition and metabolic studies on temocillin in animals and man demonstrate that the drug is well distributed throughout ...
journal_title:Drugs
pub_type: 杂志文章
doi:10.2165/00003495-198500295-00021
更新日期:1985-01-01 00:00:00
abstract::Because platelets are so important in thrombus formation, drugs which inhibit platelet function (the 'antiplatelet drugs') have considerable potential as antithrombotic agents. Among the antiplatelet drugs, only aspirin, sulphinpyrazone, dipyridamole, hydroxychloroquine, and clofibrate have had wide clinical trial. Th...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-197918060-00002
更新日期:1979-12-01 00:00:00
abstract::Diabetic gastroparesis is a common and debilitating condition affecting millions of patients with diabetes mellitus worldwide. Although gastroparesis in diabetes has been known clinically for more than 50 years, treatment options remain very limited. Until recently, the scientific literature has offered few clues rega...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200363130-00002
更新日期:2003-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common age-related neurodegenerative disease and has become an urgent public health problem in most areas of the world. Substantial progress has been made in understanding the basic neurobiology of AD and, as a result, new drugs for its treatment have become available. Cholinestera...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200161010-00005
更新日期:2001-01-01 00:00:00
abstract::Aspirin (acetylsalicylic acid)-induced asthma (AIA) consists of the clinical triad of asthma, chronic rhinosinusitis with nasal polyps, and precipitation of asthma and rhinitis attacks in response to aspirin and other NSAIDs. The prevalence of the syndrome in the adult asthmatic populations is approximately 4-10%. Res...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-200464210-00004
更新日期:2004-01-01 00:00:00
abstract::The concept of balanced analgesia was introduced to improve analgesic efficacy and reduce adverse effects. A large amount of clinical data has documented improved analgesia by combining different analgesics, but data on reducing adverse effects are inconclusive. Balanced analgesia should be used whenever possible, and...
journal_title:Drugs
pub_type: 杂志文章,评审
doi:10.2165/00003495-199958050-00002
更新日期:1999-11-01 00:00:00