Abstract：
:Flurbiprofen is a propionic acid-derived non-steroidal anti-inflammatory drug (NSAID) used widely in the treatment of rheumatism and non-arthritic pain. The pharmacokinetics of topically and orally administered flurbiprofen were compared in a two-part, open study involving healthy adult volunteers. In the first (cross-over) part of the study, 12 Caucasians were randomized to receive either a single oral dose of 50 mg flurbiprofen or a single topical application of a novel 40 mg flurbiprofen-containing patch on the right wrist for 12 h. In the second part of the study, each subject applied a flurbiprofen-containing patch twice daily to the same wrist for 7 days. Plasma concentrations of flurbiprofen and urinary concentrations of the NSAID and its metabolites were measured by high-performance liquid chromatography assay, to enable comparison of the pharmacokinetic parameters for delivery of the drug by both routes. Maximum concentrations of the NSAID in plasma (Cmax) were much lower after a single application of the topical 40 mg flurbiprofen patch than after a single oral dose of 50 mg of the NSAID (mean +/- SD: 43 +/- 16 ng/ml versus 5999 +/- 1300 ng/ml, respectively). After repeated application of the topical patch, Cmax increased only slightly to 103 +/- 57 ng/ml. The mean relative bioavailability of flurbiprofen from the patch was 3.5 +/- 1.7%, calculated from plasma area under the curve data and 4.4 +/- 2.8% from urinary excretion data.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
J Clin Pharm Therjournal_title
Journal of clinical pharmacy and therapeuticsauthors
Taburet AM,Singlas E,Glass RC,Thomas F,Leutenegger Edoi
10.1111/j.1365-2710.1995.tb00636.xsubject
Has Abstractpub_date
1995-04-01 00:00:00pages
101-7issue
2eissn
0269-4727issn
1365-2710journal_volume
20pub_type
临床试验,杂志文章,随机对照试验abstract：:A stability-indicating reversed phase high-performance liquid chromatographic assay for prazosin was developed to investigate the feasibility of a transdermal dosage form. The assay enabled detection of drug concentrations down to 0.05 microgram/ml and the quantification of the drug in both permeation fluids and in ex...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.1992.tb01262.x
更新日期：1992-02-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Low-dose methotrexate (LDMTX) has been widely used for many decades in clinical settings, with good safety profiles compared with those of high-dose methotrexate. LDMTX is also used as one of the off-label conservative therapies in treating placenta accreta (PA). Until now, only a few mild a...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.13050
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:In our original study based on five monozygotic twin pairs and seven same-sex sib pairs, we previously showed that genetic factors contribute to body weight gain induced by the atypical antipsychotic clozapine. We aim to study this further by including patients treated with the atypical antipsy...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2009.01084.x
更新日期：2010-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Computerized physician order entry (CPOE) systems reduce medical errors (MEs). Nevertheless, a CPOE system may also lead to new types of errors, especially when it is first implemented. The objectives of this study were to determine the impact of a CPOE on the number of MEs and to identify t...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12305
更新日期：2015-10-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Anti-tuberculosis drug-induced liver injury (ATLI) is one of the most significant adverse reactions for this line of therapy. N-acetyltransferase 2 (NAT2) is an important metabolic enzyme involved in drug metabolism and detoxification. Genetic polymorphism and DNA methylation have been prove...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.13097
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Personal imports of unapproved drugs are made by physicians and patients in Japan. Such imports require submission of a request for an import certificate from the Regional Bureau of Health and Welfare (RBHW). So far, there have been few reports on personal imports of drugs in Japan. OBJECTIVE:To assess the ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2008.00941.x
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:Epilepsy is a disease requiring chronic therapy with antiepileptic drugs (AEDs). Many conventional AEDs currently available have either too rapid an absorption or elimination, requiring the patient to take multiple doses per day, which may adversely impact adherence or cause peak-related side-effects. Conseq...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2009.01117.x
更新日期：2010-08-01 00:00:00
abstract：:The literature indicates that the relative nephrotoxicities of the three drugs used in this investigation are gentamicin > tobramycin > or = netilmicin. Serum creatinine levels over time were used in an attempt to elucidate the situation. They varied widely in all three groups and in controls in theatre. No definite t...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2710.1993.tb00607.x
更新日期：1993-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Based on spontaneous reports from Spain, it is claimed that the British, Irish and Scandinavians are at a greater risk of dipyrone-induced agranulocytosis. This report examines the evidence. COMMENT:Although interethnic differences in drug response are well known, there are no reliable epid...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12768
更新日期：2019-02-01 00:00:00
abstract：:The primary aim of this study was to assess patterns of prescribing of analgesic medications in a primary care setting in South Africa. Medication records of 47,103 patients for the year 1995 were retrospectively reviewed. Analgesic agents represented 12.3% of the total number and 14.2% of the total cost of all the pr...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2710.1997.96175961.x
更新日期：1997-02-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Ceftriaxone is a third-generation cephalosporin with broad-spectrum antibacterial activity. Ceftriaxone-associated urolithiasis and post-renal acute renal failure (PARF) in adults is exceedingly rare and perhaps underappreciated. We report one such case to increase appreciation of this risk ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.12358
更新日期：2016-06-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Low levels of serum triiodothyronine (T3) are a strong predictor of mortality and poor prognosis in critical care patients. Few reports, however, have focused on neurocritical patients. The application of hormone replacement therapy (HRT) in the treatment of neurocritical patients with low T...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.13162
更新日期：2020-08-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Serum sialic acid is a recently investigated potential risk-marker for cardiovascular complications. There is a known association between sialic acid and cardiovascular complications in diabetes mellitus. We aimed to investigate the effect of antidiabetic drugs on the serum concentration of ...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2009.01145.x
更新日期：2010-12-01 00:00:00
abstract：OBJECTIVES:Assessment of mean 24 h oestradiol (E2) and oestrone (E1) concentration and basic FSH secretion in postmenopausal asthmatic women, before and after HRT use, and to identify any connections between changes in hormone concentrations and patients' clinical state. SUBJECTS:Postmenopausal women (55 asthmatic and...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2710.2000.00310.x
更新日期：2000-12-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Metronidazole is one of the drugs with a well-recognized potential to rarely cause acute pancreatitis. The relation of other drugs of the 5-aminoimidazole group (e.g. tinidazole) to acute pancreatitis remains unknown. For the treatment of protozoal infections, tinidazole may be considered as...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type：
doi：10.1111/jcpt.12307
更新日期：2015-10-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Alzheimer's disease (AD) is the most common cause of dementia among the elderly. The exact cause of the disease is not clearly known, and no existing therapies are able to prevent disease progression. Identification of the possible "impaired brain insulin signalling in AD" enriched the scope...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,评审
doi：10.1111/jcpt.12808
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:The quality of 33 formulations of essential antimicrobial and antimalarial drugs (amoxicillin capsules, metronidazole tablets, sulfamethoxazole/trimethoprim tablets, quinine tablets and sulphadoxine/pyrimethamine tablets) marketed in Rwanda and Tanzania was assessed and the influence of tropical storage condi...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2004.00568.x
更新日期：2004-08-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:There is increasing evidence that epigenetics plays a major role in the pathogenesis of the idiopathic mental disorders. This article comments on the role of epigenetics in the pharmacotherapy, psychotherapy and nutritional management of these disorders. COMMENT:There are two classes of epi...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2012.01346.x
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Morphine is one of the most widely used opioid analgesics for controlling pain in cancer and post-operative patients. OBJECTIVE:This study aimed at finding a sensitive method for measuring morphine. METHOD:A one-step solid phase extraction was developed for extracting morphine from various samples, and mor...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2008.00933.x
更新日期：2008-08-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:CYP2C19*17 allele increases the metabolic activity of CYP2C19 resulting in decreased therapeutic levels of CYP2C19 substrates. There exist inter-ethnic differences in the distribution of this allele. The present study was aimed at establishing the allele and genotype frequencies of CYP2C19*1...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2011.01294.x
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Ropivacaine hydrochloride (HCl) ('Naropin') is a long-acting local anaesthetic agent, administered epidurally to patients undergoing various surgical procedures. A combination of local anaesthetic and opioid is often administered for the management of severe pain to ensure that a minimal dose of each is used...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2710.2002.00386.x
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Moxifloxacin is a new fluorquinolone with broad-spectrum activity. It is suitable for treating peritonitis in peritoneal dialysis (PD) patients. The objective of this study was to test stability of moxifloxacin in PD solutions stored at different temperatures. METHODS:Dialysis solution bags we...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2710.2006.00758.x
更新日期：2006-12-01 00:00:00
abstract：OBJECTIVE:To assess the usefulness of dynamic laser scattering for monitoring the stability of ampicillin after reconstitution from commercially available vials with respect to the polymer formation and potency. METHODS:Polymer formation and the remaining potency of the reconstituted ampicillin solution were estimated...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2710.2002.00397.x
更新日期：2002-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:Lactic acidosis (LA) is a rare but potentially lethal side effect of linezolid (LZD). However, limited by the study population, the number of patients with LA is insufficient to summarize all the clinical characteristics and risk factors. METHODS:We evaluated the association between LZD and...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.13245
更新日期：2020-12-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:The most appropriate sedative agent for conscious sedation in minor hysteroscopic surgeries is still unclear. Dexmedetomidine a sedative and analgesic agent, may be appropriate for outpatient procedures. The aim of our study was to compare the sedative, analgesic and hemodynamic effects of d...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1111/jcpt.12793
更新日期：2019-04-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:The development of rapid diagnostics has revolutionized antimicrobial stewardship with efforts targeting earlier de-escalation or discontinuation of antibiotics. The respiratory viral panel (RVP) is one tool quickly able to detect common viral and bacterial pathogens using polymerase chain r...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,评审
doi：10.1111/jcpt.13326
更新日期：2020-12-05 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:There are various reasons why antiepileptic treatment can fail. One is drug-resistant epilepsies, but non-adherence, or poor adherence, to treatment may make some patients' treatment ineffective. The consequences of poor adherence include treatment failure or introduction of more complex tre...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12615
更新日期：2018-02-01 00:00:00
abstract：:The objectives of this study were: (a) to develop a drug serum level-based compliance measure which incorporated pharmacokinetic analysis of patient and drug parameters and to compare it to refill records, an indirect measure, and (b) to use that measure to determine whether pharmacist consultation increased complianc...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1987-02-01 00:00:00
abstract：WHAT IS KNOWN:The increased risk of cardiovascular events in diabetic patients has been related to numerous metabolic and haemoreological factors. Some of these factors appear to be particularly evident during the post-prandial phases and to be related to peak plasma glucose level. AIM:To compare the effect of additio...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1365-2710.2009.01132.x
更新日期：2010-10-01 00:00:00
abstract：WHAT IS KNOWN AND OBJECTIVE:In order to improve public health, it is necessary to facilitate patients' easy access to affordable high-quality primary health care, and one enhanced approach to do so may be to provide primary healthcare services in the community pharmacy setting. Discrete choice experiments to evaluate p...
journal_title：Journal of clinical pharmacy and therapeutics
pub_type： 杂志文章
doi：10.1111/jcpt.12574
更新日期：2017-12-01 00:00:00
