Abstract:
WHAT IS KNOWN AND OBJECTIVE:There are various reasons why antiepileptic treatment can fail. One is drug-resistant epilepsies, but non-adherence, or poor adherence, to treatment may make some patients' treatment ineffective. The consequences of poor adherence include treatment failure or introduction of more complex treatments involving greater toxicity with uncertain prognosis. This study contributes to a critical research area focused on antiepileptic drug adherence and aims to assess the main factors limiting adherence, as well as psychosocial factors influencing on risk of non-adherence. METHODS:An opinion survey was conducted among patients and parents of children treated for epilepsy and members of a French online support group. RESULTS AND DISCUSSION:A total of 263 questionnaires were collected. Of the patients, 79% said they never forget their medication, whereas 21% admitted occasional or frequent omissions. The main treatment-related factors that can limit adherence were adverse effects (limiting factors reported for 70% of patients) and number of tablets or number of intake per day (limiting factors reported for 32% of patients). Galenic (liquid) formulation (18%), drug taste (18%), tablet size (14%) and concern about the perception of others (17%) were cited in roughly equivalent terms as limiting adherence to treatment. Among the 55 patients who were genuinely non-adherent to their treatment, the occupational difficulties induced by following the treatment were a main cause of non-adherence. WHAT IS NEW AND CONCLUSION:Improving adherence in patients with epilepsy is a difficult and complex problem. Community pharmacists could play a major role in the determination of patients' adherence and should be aware of the risk of non-adherence.
journal_name
J Clin Pharm Therjournal_title
Journal of clinical pharmacy and therapeuticsauthors
Laville F,Montana M,Roux N,Rathelot P,Giorgi R,Vanelle Pdoi
10.1111/jcpt.12615subject
Has Abstractpub_date
2018-02-01 00:00:00pages
73-79issue
1eissn
0269-4727issn
1365-2710journal_volume
43pub_type
杂志文章abstract:WHAT IS KNOWN AND OBJECTIVE:CYP2C19*17 allele increases the metabolic activity of CYP2C19 resulting in decreased therapeutic levels of CYP2C19 substrates. There exist inter-ethnic differences in the distribution of this allele. The present study was aimed at establishing the allele and genotype frequencies of CYP2C19*1...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/j.1365-2710.2011.01294.x
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Epilepsy is a disease requiring chronic therapy with antiepileptic drugs (AEDs). Many conventional AEDs currently available have either too rapid an absorption or elimination, requiring the patient to take multiple doses per day, which may adversely impact adherence or cause peak-related side-effects. Conseq...
journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章
doi:10.1046/j.1365-2710.2002.00434.x
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pub_type: 杂志文章
doi:10.1111/j.1365-2710.2004.00555.x
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journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
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journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
doi:10.1111/j.1365-2710.2005.00661.x
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2013-06-01 00:00:00
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journal_title:Journal of clinical pharmacy and therapeutics
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更新日期:1987-08-01 00:00:00
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journal_title:Journal of clinical pharmacy and therapeutics
pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
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abstract:BACKGROUND AND OBJECTIVE:Enteric-coated, delayed-release divalproex sodium requires multiple daily administrations and high adherence rate to prevent breakthrough seizures and control adverse effects. We evaluated the effect of missing one or two doses of divalproex for up to 24 h, followed by replacement and resumptio...
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pub_type: 杂志文章
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