Abstract:
:The aim of the present study was to examine to what extent pH affects human fibroblast repopulation of an experimental wound in vitro laying special emphasis on cell migration, DNA synthesis, and alterations in cell morphology. Wounds were simulated in vitro by partially scraping off monolayers of human embryonic diploid lung fibroblast and human periodontal ligament fibroblast-like cells respectively. The wounded monolayers were cultured at pHs ranging from 7.2 to 8.4. The experiments were evaluated by autoradiography as well as light and scanning electron microscopic techniques. A significant, approximately linear, decrease was noted both in cell migration into and DNA synthesis in the experimental wounds as a result of pH increase. The surviving cells in the wounds showed cytoplasmatic vacuoles and blebbing at pH levels above 7.8. Clinical implications of these results for endodontic calcium hydroxide treatment are that hydroxyl ions, diffusing through root dentin, may interfere with vital cell functions necessary for healing on the root surface.
journal_name
Eur J Oral Scijournal_title
European journal of oral sciencesauthors
Lengheden A,Jansson Ldoi
10.1111/j.1600-0722.1995.tb00016.xsubject
Has Abstractpub_date
1995-06-01 00:00:00pages
148-55issue
3eissn
0909-8836issn
1600-0722journal_volume
103pub_type
杂志文章abstract::The aim of this study was to explore the prevalence and possible explanatory factors of dental avoidance due to dental anxiety among 12 to 18 year olds treated within the Norwegian Public Dental Service. A total of 754 20-yr-olds completed a questionnaire and three psychometric scales, the Dental Fear Scale (DFS), the...
journal_title:European journal of oral sciences
pub_type: 杂志文章
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abstract::Treatment programs to prevent perinatal and postnatal HIV-1 transmission have become available in sub-Saharan Africa, leading to an emerging population of HIV-1 exposed uninfected (HEU) children. Exposure to HIV-1 in utero and during breastfeeding may increase the risk of morbidity and mortality in HEU children. This ...
journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
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abstract::Salivary tissue kallikrein is stored in an active form in human salivary glands. Pre-kallikrein has been demonstrated in mixed saliva, but it is not clear if the various salivary glands contribute equally. This study set out to determine if pre-kallikrein is present in human parotid and submandibular salivas at rest, ...
journal_title:European journal of oral sciences
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更新日期:2001-10-01 00:00:00
abstract::The effect of the dentifrice ingredient triclosan (2,4,4'-trichloro-2'-hydroxyldiphenyl ether) on the production of interleukin (IL)-1beta and IL-6 was studied in human gingival fibroblasts challenged with tumor necrosis factor alpha (TNFalpha) in vitro. When gingival fibroblasts were treated simultaneously with tricl...
journal_title:European journal of oral sciences
pub_type: 杂志文章
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更新日期:1998-04-01 00:00:00
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journal_title:European journal of oral sciences
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更新日期:2014-02-01 00:00:00
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journal_title:European journal of oral sciences
pub_type: 杂志文章
doi:10.1111/eos.12400
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
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doi:10.1111/eos.12022
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abstract::It has been suggested that occlusal interferences may lead to pain and tenderness of the masticatory muscles. Tender jaw muscles are more sensitive to pressure pain, as assessed by means of pressure algometry. We tested the effects of occlusal interferences on the pressure pain threshold of the jaw muscles by means of...
journal_title:European journal of oral sciences
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0722.2006.00298.x
更新日期:2006-04-01 00:00:00
abstract::Fluid and ion secretion from the submandibular gland (SMG) is mainly regulated by parasympathetic nerves. This study evaluated the effect of parasympathectomy on salivary secretion from normal and irradiated rat SMGs from 1 to 24 wk after denervation. Although stimulated salivary secretion was significantly lower in d...
journal_title:European journal of oral sciences
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doi:10.1111/eos.12330
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abstract::Enamelysin is a matrix metalloproteinase (MMP-20) secreted by ameloblasts, previously shown to hydrolyze recombinant amelogenin. The purpose of this study was to use recombinant MMP-20 to further investigate the specific hydrolysis of peptide fragments containing cleavage sites for tyrosine-rich amelogenin peptide (TR...
journal_title:European journal of oral sciences
pub_type: 杂志文章
doi:10.1046/j.0909-8836.1999.eos107506.x
更新日期:1999-10-01 00:00:00
abstract::Prostaglandins, especially prostaglandin E2 (PGE2), play a crucial role in the pathogenesis of periodontal disease. We have previously reported that inflammatory mediators interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFalpha) increase the production of PGE2 in human gingival fibroblasts. In this study, we in...
journal_title:European journal of oral sciences
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doi:10.1034/j.1600-0722.2001.00999.x
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abstract::Mutation of the dihydroorotate dehydrogenase (DHODH) gene is responsible for Miller syndrome, which is characterized by craniofacial malformations with limb abnormalities. We previously demonstrated that DHODH was involved in forming a mitochondrial supercomplex and that mutated DHODH led to protein instability, loss ...
journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1600-0722.2008.00559.x
更新日期:2008-10-01 00:00:00
abstract::Human dentin mineral has been investigated by using micro-Raman spectroscopy. Fluorescence and thermal problems were largely avoided by preparing dentin samples by grinding and ultrasonic agitation in acetone. The Raman spectral features were consistent with those of impure hydroxyapatite containing CO3 and HPO4. Whil...
journal_title:European journal of oral sciences
pub_type: 杂志文章
doi:10.1111/j.1600-0722.1996.tb00056.x
更新日期:1996-04-01 00:00:00
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
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journal_title:European journal of oral sciences
pub_type: 杂志文章
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journal_title:European journal of oral sciences
pub_type: 杂志文章
doi:10.1111/j.1600-0722.1995.tb00010.x
更新日期:1995-02-01 00:00:00
abstract::Tooth development is regulated through a series of reciprocal interactions between the dental epithelium and mesenchyme and requires protein products of a number of genes. It has been reported that selective tooth agenesis is associated with mutations in human MSX and PAX9 genes. Mutational analysis of the two genes w...
journal_title:European journal of oral sciences
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abstract::The aim was to investigate risk indicators associated with dental erosive wear among 18-yr-old subjects in Oslo, Norway. Of 3,206 adolescents invited to participate in a screening examination for erosive wear, 1,456 were examined (giving a response rate of 45%). As part of the examination all participants completed a ...
journal_title:European journal of oral sciences
pub_type: 杂志文章
doi:10.1111/j.1600-0722.2012.00997.x
更新日期:2012-12-01 00:00:00
abstract::The effect of the addition 0.3% triclosan to a non-fluoride and fluoride toothpaste was tested in an in vitro demineralisation model. This model comprised bovine dentin specimens overlaid with acidogenic Streptococcus mutans suspensions in agarose at two different concentrations of cells. Before the experiments, subsu...
journal_title:European journal of oral sciences
pub_type: 杂志文章
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更新日期:1999-04-01 00:00:00
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journal_title:European journal of oral sciences
pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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journal_title:European journal of oral sciences
pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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journal_title:European journal of oral sciences
pub_type: 杂志文章
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journal_title:European journal of oral sciences
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:European journal of oral sciences
pub_type: 杂志文章
doi:10.1111/eos.12167
更新日期:2015-02-01 00:00:00
abstract::The expression of HLA Class II antigens on the surfaces of immunocompetent cells and the presence of CD1a+ cells (Langerhans cells) are important components of antigen presentation. Quantitative variations in HLA class II expression on antigen-presenting cells play a role in immune regulation. An indirect immunofluore...
journal_title:European journal of oral sciences
pub_type: 杂志文章
doi:10.1111/j.1600-0722.1995.tb00161.x
更新日期:1995-08-01 00:00:00