Protection against procarbazine-induced testicular damage by GnRH-agonist and antiandrogen treatment in the rat.

abstract：:The adipose conversion of 3T3-L1 fibroblasts depends on serum factors, one of which has been identified as GH. Human serum extracts obtained by heat treatment do not contain intact GH, as shown by RIA, but still support adipose conversion. After organic solvent extraction followed by reversed phase HPLC, two adipogeni...

journal_title：Endocrinology

authors： Schiwek DR,Löffler G

更新日期：1987-02-01 00:00:00

abstract：:Prolonged exposure to elevated FFA levels has been shown to induce peripheral insulin resistance and to alter the beta-cell secretory response to glucose. To investigate the effects of FFAs on preproinsulin gene expression, we measured insulin release, cell content, and messenger RNA (mRNA) levels in rat islets after ...

journal_title：Endocrinology

authors： Ritz-Laser B,Meda P,Constant I,Klages N,Charollais A,Morales A,Magnan C,Ktorza A,Philippe J

更新日期：1999-09-01 00:00:00

abstract：:Subclinical inflammation is a recently discovered phenomenon in type 2 diabetes. Elevated cytokines impair beta-cell function and survival. A recent clinical trial shows that blocking IL-1beta signaling by IL-1 receptor antagonist (IL-1Ra) improves beta-cell secretory function in patients with type 2 diabetes. In the ...

journal_title：Endocrinology

authors： Sauter NS,Schulthess FT,Galasso R,Castellani LW,Maedler K

更新日期：2008-05-01 00:00:00

abstract：:The effects of several compounds which interfere with cellular microfilaments and microtubules on the conversion of proparathyroid hormone (ProPTH) to parathyroid hormone (PTH) were examined in slices of bovine parathyroid slices incubated in vitro with 3H-leucine. Inhibitors of microtubular function, vinblastine and ...

journal_title：Endocrinology

authors： Kemper B,Habener JF,Rich A,Potts JT Jr

更新日期：1975-04-01 00:00:00

abstract：:The intraislet insulin hypothesis has been proposed to explain absent glucagon responses to hypoglycemia. Recently we directly confirmed this hypothesis by restoring glucagon secretion via provision of a pancreatic artery insulin infusion, which was switched off at the time of hypoglycemia in Wistar rats made diabetic...

journal_title：Endocrinology

authors： Zhou H,Zhang T,Oseid E,Harmon J,Tonooka N,Robertson RP

更新日期：2007-06-01 00:00:00

abstract：:A new perfusion system of isolated rat femora was established, and the effect of PTH or calcitonin (CT) on cAMP release from the adult bone was examined. Stimulation of cAMP release from the isolated perfused bone peaked rapidly between 5 and 10 min after human PTH (hPTH)-(1-34) or eel CT injection, respectively, and ...

journal_title：Endocrinology

authors： Sugimoto T,Fukase M,Tsutsumi M,Imai Y,Hishikawa R,Yoshimoto Y,Fujita T

更新日期：1985-11-01 00:00:00

abstract：:The Pax6 transcription factor is crucial for pancreatic α-cells. Indeed, Pax6-deficient mouse models are characterized by markedly altered α-cell differentiation. Our objective was to investigate the role of Pax6 in glucagon secretion process. We used a Pax6-deficient model in rat primary enriched-α cells with specifi...

journal_title：Endocrinology

authors： Gosmain Y,Cheyssac C,Masson MH,Guérardel A,Poisson C,Philippe J

更新日期：2012-09-01 00:00:00

abstract：:The relationship between progesterone and prostaglandin (PG) secretion in the pseudopregnant rabbit corpus luteum was investigated using isolated in vitro perfused ovaries. Progesterone and PG secretion were measured on days 1, 11, and 18 of hCG-induced pseudopregnancy. The mean progesterone secretion increased signif...

journal_title：Endocrinology

authors： Dharmarajan AM,Sueoka K,Miyazaki T,Atlas SJ,Ghodgaonkar RB,Dubin NH,Zirkin BR,Wallach EE

更新日期：1989-03-01 00:00:00

abstract：:Stimulation of rat granulosa cell aromatase activity by FSH has recently been used as a sensitive biological end point to develop an in vitro FSH bioassay. The present report provides a detailed validation and application of this assay. In the presence of androstenedione and diethylstilbestrol, FSH stimulated estrogen...

journal_title：Endocrinology

authors： Jia XC,Hsueh AJ

更新日期：1986-10-01 00:00:00

abstract：:Maternal and fetal metabolism of vitamin D was examined in term pregnant rabbits fed a normal diet and in those supplemented with a large amount of vitamin D3. Term pregnant rabbits (27--30 days of gestation) fed the normal diet showed lower levels of plasma calcium, 25-hydroxyvitamin D3 (250HD3), and 24,25-dihydroxyv...

journal_title：Endocrinology

authors： Kubota M,Ohno J,Shiina Y,Suda T

更新日期：1982-06-01 00:00:00

abstract：:IGF-binding protein-3 (IGFBP-3) is the major circulating carrier protein for IGF, and also acts as a potent antiproliferative agent in various cell types. Recently, IGFBP-3 was reported to mediate high glucose-induced apoptosis in mesangial cells and podocytes. In this study, we investigated the role of IGFBP-3 in hig...

journal_title：Endocrinology

authors： Yoo EG,Lee WJ,Kim JH,Chae HW,Hyun SE,Kim DH,Kim HS,Oh Y

更新日期：2011-08-01 00:00:00

abstract：:Androgen regulation of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) activities and accumulation of the mRNAs encoding these two enzymes in rodent kidney and accessory sex organs were studied. The ODC mRNA concentration and enzyme activity were increased by androgens in kidney, prosta...

journal_title：Endocrinology

authors： Crozat A,Palvimo JJ,Julkunen M,Jänne OA

更新日期：1992-03-01 00:00:00

abstract：:Four different GnRHs and one GnRH receptor are reported to be expressed in various mammals, whereas 13 GnRHs and numerous GnRH receptors have been identified in various nonmammalian vertebrates. The nucleotide sequencing of the human genome provided the opportunity to determine which of these peptides and receptors mi...

journal_title：Endocrinology

authors： Neill JD

更新日期：2002-03-01 00:00:00

abstract：:The dissociation kinetics of uterine estradiol receptor (UER) from young, middle-aged, and old mice have been studied in vitro and correlated with interactions of the steroid receptor with nuclear suspensions in a cell-free system. Furthermore, we have determined in these various age groups of mice the concentration o...

journal_title：Endocrinology

authors： Belisle S,Bellabarba D,Lehoux JG,Robel P,Baulieu EE

更新日期：1986-02-01 00:00:00

abstract：:Protein kinase-C (PKC) has been suggested as a possible mediator of the antigonadotropic action of prostaglandin F2 alpha (PGF2 alpha) in luteal cells. To examine this possibility, we evaluated the effects of phorbol ester [12-O-tetradecanoylphorbol-13-acetate (TPA)] in relation to those of PGF2 alpha on cAMP accumula...

journal_title：Endocrinology

authors： Musicki B,Aten RF,Behrman HR

更新日期：1990-03-01 00:00:00

abstract：:Testicular LH receptor occupancy and steroidogenic responses were measured in adult male rats after intracardiac injections of [125I]iodo-hCG (0.5--5 x 10(6) cpm) mixed with known amounts of nonradioactive hCG to yield doses ranging from 10 ng to 300 micrograms. Uptake of the hormone by the testis was measured in the ...

journal_title：Endocrinology

authors： Huhtaniemi IT,Clayton RN,Catt KJ

更新日期：1982-09-01 00:00:00

abstract：:Otsuka Long-Evans Tokushima fatty (OLETF) rats lacking cholecystokinin-A receptors are hyperphagic, obese, and diabetic. Although exercise attenuates OLETF rats' obesity, the mechanisms underlying the effects of exercise are unclear. In this study, we determined the effects of running wheel activity on patterns of bod...

journal_title：Endocrinology

authors： Bi S,Scott KA,Hyun J,Ladenheim EE,Moran TH

更新日期：2005-04-01 00:00:00

abstract：:Regulation of the lactogen specific binding sites of rat liver was studied in several different high lactogen states. The specific binding of [125I]iodo-hGH was determined as a measure of these sites. Hypophysectomy of pregnant rats produced a much smaller decrease in hepatic binding of [125I]iodo-hGH than was seen in...

journal_title：Endocrinology

authors： Posner BI

更新日期：1976-11-01 00:00:00

abstract：:The steady state concentration of dopamine (DA), norepinephrine (NE), and serotonin (5HT) was determined and turnover estimated in several brain regions of young (3-4 months) and old (21 months) male Wistar rats. An estimate of DA and NE turnover was obtained by determining their depletion rates after treatment with a...

journal_title：Endocrinology

authors： Simpkins JW,Mueller GP,Huang HH,Meites J

更新日期：1977-06-01 00:00:00

abstract：:A cell-free system was used to characterize the binding reaction between the progesterone receptor and nuclear acceptor sites prepared from rat placenta. Two forms of receptor-acceptor complex were examined. One was extracted from nuclei by exposure to 0.6 M KCl; the other type was resistant to salt extraction. Kineti...

journal_title：Endocrinology

authors： Ogle TF

更新日期：1987-07-01 00:00:00

abstract：:Maternal immune tolerance is required for extravillous trophoblasts (EVTs) to invade the decidua without rejection. Endoplasmic reticulum aminopeptidase-1 (ERAP1) generates human leukocyte antigen (HLA) class I-adapted antigenic peptides, but its function in trophoblasts lacking classical HLA class I molecules remains...

journal_title：Endocrinology

authors： Shido F,Ito T,Nomura S,Yamamoto E,Sumigama S,Ino K,Itakura A,Hattori A,Tsujimoto M,Mizutani S,Kikkawa F

更新日期：2006-04-01 00:00:00

abstract：:This study analyzes the role of the autonomic nervous system, the pituitary gland, ACTH, dexamethasone (DEX), and thyroid hormones in the regulation of 5'deiodinase (5'D) in the hypothalamus (HP) and adrenal gland (AG) of the rat. 5'D activity was analyzed in rats under basal conditions (22 C) and during cold exposure...

journal_title：Endocrinology

authors： Anguiano B,Quintanar A,Luna M,Navarro L,Ramírez del Angel A,Pacheco P,Valverde C

更新日期：1995-08-01 00:00:00

abstract：:In the pituitary, GABA regulates the release of several hormones via different receptors. GABA(C) receptors are heterooligomers that differ from GABA(A) receptors in that they contain p-subunits and are insensitive to bicuculline. However, molecular and functional evidence for the presence of GABA(C) receptors outside...

journal_title：Endocrinology

authors： Boue-Grabot E,Taupignon A,Tramu G,Garret M

更新日期：2000-05-01 00:00:00

abstract：:GnRH regulates the secretion of LH and FSH, which stimulate the secretion of testicular hormones. Acting in a reciprocal fashion, these hormones, including testosterone and inhibin, exert a negative feedback effect on GnRH and gonadotropin secretion. Endogenous opioid peptides (EOPs) have been implicated to play a rol...

journal_title：Endocrinology

authors： Chowen-Breed J,Fraser HM,Vician L,Damassa DA,Clifton DK,Steiner RA

更新日期：1989-04-01 00:00:00

abstract：:Addition of somatostatin-14 (SRIF) inhibits corticotropin releasing factor (CRF) and forskolin-stimulated cyclic AMP formation and ACTH release from tumor cells of the mouse anterior pituitary (AtT-20/D16-16). After long-term pretreatment of these cells with SRIF, the ability of SRIF to inhibit CRF and forskolin-stimu...

journal_title：Endocrinology

authors： Reisine T,Axelrod J

更新日期：1983-08-01 00:00:00

abstract：:Deciduomal reactions in response to artificial stimuli were induced on the tube-ligated uterine horns of unilateral pregnant hamsters. Serum progesterone levels were determined, and the changes of estrogen and progesterone receptors (ER and PR, respectively) were simultaneously studied in the deciduoma. After stimulat...

journal_title：Endocrinology

authors： Chen TJ,Hwang TC,Huang CC,Jow GM,Yu JY

更新日期：1989-07-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF) blocks LH-stimulated androstenedione production by immature rat theca-interstitial cells (TIC) in vitro. The mechanism for TNF inhibition of LH-induced androstenedione is unknown and was investigated. LH stimulation of androstenedione synthesis in TIC is mediated via a cAMP-dependent ...

journal_title：Endocrinology

authors： Zachow RJ,Tash JS,Terranova PF

更新日期：1993-11-01 00:00:00

abstract：:Human myometrium contains hCG/LH receptors. There are fewer of these receptors during labor compared to no labor at preterm or term deliveries. Exogenous hCG can directly inhibit oxytocin-stimulated human myometrial contractions. These findings suggest that hCG may directly maintain myometrial quiescence during pregna...

journal_title：Endocrinology

authors： Ambrus G,Rao CV

更新日期：1994-12-01 00:00:00

abstract：:In rodents, kisspeptin-expressing neurons are localized in 2 hypothalamic brain nuclei (anteroventral periventricular nucleus/periventricular nucleus continuum [AVPv/PeN] and arcuate nucleus [ARC]) and modulated by sex steroids. By using wild-type (WT) and aromatase knockout (ArKO) mice (which cannot convert testoster...

journal_title：Endocrinology

authors： Brock O,Bakker J

更新日期：2013-08-01 00:00:00

abstract：:Selenoproteins contain the essential trace element selenium whose deficiency leads to major disorders including cancer, male reproductive system failure, or autoimmune thyroid disease. Up to now, 25 selenoprotein-encoding genes were identified in mammals, but the spatiotemporal distribution, regulation, and function o...

journal_title：Endocrinology

authors： Tanguy Y,Falluel-Morel A,Arthaud S,Boukhzar L,Manecka DL,Chagraoui A,Prevost G,Elias S,Dorval-Coiffec I,Lesage J,Vieau D,Lihrmann I,Jégou B,Anouar Y

更新日期：2011-11-01 00:00:00