Abstract：
:The potential doubling time (Tpot) is defined as the time necessary to double the number of proliferating tumor cells in the absence of spontaneous cell loss. Tpot is thought to be a better index of tumor proliferation than clinically observed tumour volume doubling time. The in vivo measurement of Tpot is a possible way to detect fast growing tumours which would be better controlled by accelerated radiotherapy. The published data demonstrate the feasibility and the safety of the technique. Large variations in Tpot values were observed in tumors with similar histology, indicating an accelerated proliferation rate in some tumors. There are technical difficulties related to intra-tumor heterogeneity, sample contamination by normal cells, and inter-laboratory variability, which question the biological interpretation of Tpot. Further studies are ongoing to establish whether the in vivo measurement of Tpot 1) provides information that is independent of the "classical" prognostic factors, and 2) allows the early recognition of the patients likely to benefit from accelerated treatment.
journal_name
Bull Cancerjournal_title
Bulletin du cancerauthors
Dubray B,Maciorowsky Z,Cosset JM,Terry NHsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
331-8issue
5eissn
0007-4551issn
1769-6917journal_volume
82pub_type
杂志文章,评审abstract：:The study of cases treated between 1970 and 1984 at the Institut Curie, in women aged 40 years and under, was undertaken in order to determine the influence of age on prognosis. The incidence of these cases was stable throughout the 15 years study period as was the very high incidence of earlier cases: 84.5%. Earlier ...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Targeted therapies, especially monoclonal antibodies, have reached an increasing importance in oncology. High-throughput techniques have allowed the identification of numerous transcripts, proteins, or non-protein antigens, which have generated the concept of immunome. This epitope library constitutes a huge reservoir...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:The retrospective evaluation of the dose after an irradiation accident is of paramount importance; it allows an adequate selection of patients and the most appropriate treatment can then be proposed. Classical physical dosimetry often lacks precision for dose assessment in such accidents. Cytogenetics, usually more re...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Colorectal cancer occurs after the age of 75 in 50% of the case, but elderly patients are under-treated and far from an optimal management of their disease. Principles of colorectal cancer management after the age of 75 are theoretically the same than for younger patients, but physiological age, comorbidities and pati...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1684/bdc.2007.0545
更新日期：2008-05-28 00:00:00
abstract：:Cardiac neoplasms are a rare occurrence in clinical practice. The various frequencies of primary and secondary malignant tumors vary from report to report, approximately 1% in most autopsy series and 4% in cancer patient's autopsies. Cardiac malignancies account for less 1% of cardiac surgery and about for 0.1% of car...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2004-11-01 00:00:00
abstract：:The network of cancer care units in Lorraine area (Oncolor) developed management training for people working in chemotherapy units, and cytotoxic drug preparation. The programme was framed both for staff of executives (pharmacists), and technicians. Firstly, comparison between practices and theoretical recommendations...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
abstract：INTRODUCTION:Cancers of adolescents and young adults have particular epidemiological specificities. The improvement in their survival should be accompanied by an increased consideration of the treatments' side effects, among which the potential decrease in fertility. The objective of the study was to describe the acces...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2020.03.013
更新日期：2020-01-01 00:00:00
abstract：:Since January 1981, 58 patients with postoperative recurrences or inoperable rectal cancer have been included in a trial featuring a neutron boost after an initial series of irradiation given by the classical high energy photon procedure. This group irradiated at the Neutrontherapy Unit in Orléans was compared to a hi...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:In response to the evolution of the information-seeking behaviour of patients and concerns from health professionals regarding cancer patient information, the French National Federation of Comprehensive Cancer Centres (FNCLCC) introduced, in 1998, an information and education program dedicated to patients and relative...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2006-12-01 00:00:00
abstract：:This study is devoted to the analysis of the surgical treatment of cancer of the uterine cervix, stage III. Three circumstances are evaluated: - Stage III with urinary disease the purpose of the surgical treatment is most often to save the renal function;--Recurrences after radiotherapy where surgery is the only poss...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1980-01-01 00:00:00
abstract：:A retrospective review was made of 1 400 cases of cancer of the esophagus treated at the Centre "Francois Baclesse" between 1964 and 1975. The disease appeared at an earlier age and more frequently in men (95%) than in women. The lesions were located predominantly in the middle third of the esophagus. There was a high...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:In chemosensitive tumors, cancer chemotherapy is active as drug combinations. During the development of new anticancer drugs, preclinical experimental models may help to design drug combinations. Indeed, in vitro models are able to define drug interactions in terms of synergism, additivity or antagonism, while in vivo...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:Two operational subdivisions of hereditary colorectal cancer susceptibility are those with and those without premalignant adenomatous colonic polyp expression. In both of these subdivisions, reliable biomarkers of gene carriage would be of value in patient management as we have previously emphasized. Consideration mus...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Cancer growth and metastasis require the coordinate change in gene expression of different sets of genes. While genetic alterations can account for some of these changes, many of the changes in gene expression observed in cancer are caused by epigenetic modifications. The epigenome consists of the chromatin and its mo...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:Adhesion molecules play a major role in the regulation of normal hematopoiesis. Precursor/cell matrix/endothelial interactions determine retainment or release of hematopoietic cells from the bone marrow microenvironment. Consequently, changes in the affinity or quantitative expression of adhesion molecules on either t...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-01 00:00:00
abstract：:From July 1987 to July 1988, 35 patients with non small cell lung cancer, stage IV, were included in a phase II trial (GLOT NPC 87/01). The treatment was as follows: cisplatin 50 mg/m2 day 1, vindesin 3 mg/m2 day 1, mitomycin 6 mg/m2 day 2, and bleomycin 15 mg/day, day 1 + 2 by continuous infusion. The evaluation for ...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-01-01 00:00:00
abstract：:To have a better understanding of the poor participation rate among general practitioners (GPs) in cervical cancer screening, we have conducted a survey in the department of Bas-Rhin on a small sample of GPs. This helped to explain how they perceived this technical act, the problems or barriers related to it: rate, fu...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:Integrins are a family of heterodimeric transmembrane receptors that mediate cell-cell and cell-extracellular matrix adhesion. Integrin-mediated signaling is essential for the regulation of fundamental cellular functions, including proliferation and survival, and for tumor development. According to in vitro studies, i...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2002-11-01 00:00:00
abstract：:Sentinel lymph node (SLN) biopsy is fast becoming the standard for testing lymph node involvement in many institutions. However questions remain as to stage underestimation. The aim of this study was to analyse this specific risk in a retrospective study. Between 1975 to 1999, 1,636 patients underwent a breast cancer ...
journal_title：Bulletin du cancer
pub_type： 临床试验,杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:In Europe, renal tumours are 7th in frequency of men cancers. They are rare tumours in 10 to 15% of cases. Collecting ducts carcinomas or Bellini tumours, described for the first time in 1949, are a distinct clinical and pathological entity. They represented 1% of epithelial cancers. Nephrectomy is the treatment of lo...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2011.1462
更新日期：2011-10-01 00:00:00
abstract：:Seventy five human breast cancers were examined in order to search for the presence of thymidine kinase of the fetal-type (TK-F). The presence of TK-F was evidenced in all tumors. Its activity varied from one to another tumor, but it was evident that the increased TK activity observed in mammary cancers could exclusiv...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Treatment of soft-tissue sarcomas has to deal simultaneously with three goals: 1) to obtain the control of the primary tumor, 2) to preserve the function, and 3) to treat the micrometastatic disease. For local control, surgery remains the most efficient treatment, but the extent of the resection of macroscopically non...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:The standard treatment in first line of advanced or metastatic urothelial bladder cancer (MBC) is the association of Gemcitabine and Cisplatin (GC). Avelumab, an anti-PD-L1 agent, has recently demonstrated efficacy. The objective is to evaluate the combination of these 3 agents. METHODS:This phase II random...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/S0007-4551(20)30280-0
更新日期：2020-06-01 00:00:00
abstract：:Information takes a large part of patient's perceptions of the procedure. If the information is adapted, patients tolerate the procedure well. We point out indications and explain the different types of procedure. For infraclinical masses, sonographically guided automated core needle biopsy removes samples. Sonographi...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2005-03-01 00:00:00
abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice of hematologic malignancies. Acute graft versus host disease (GvHD) is common after HSCT and directly related to graft versus leukemia effect. Little progress has been done in the treatment of acute GvHD. The first line treatment is u...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：10.1684/bdc.2011.1410
更新日期：2011-08-01 00:00:00
abstract：:Malnutrition is common in oncology. However, it is often detected too late and nutritional support is sub-optimal. The patient's opinion, although often sought in therapeutic decisions in oncology, does not appear to be frequently taken into account in dietetic management. In NutriCancer2012 study, we interviewed pati...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2017.09.014
更新日期：2017-11-01 00:00:00
abstract：:The anticancer drug technical commission (COTECH) of the Auvergne OMEDIT has set up a region-wide professional practice evaluation (PPE) with regards to antiemetic prescription practices in chemotherapy-induced nausea and vomiting (CINV), in order to evaluate their compliance with OMEDIT's guidelines. Are not included...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2016.03.009
更新日期：2016-07-01 00:00:00
abstract：:Laparoscopy for malignancy resection has been followed by description of metastatic laparoscopic port sites. Recently published clinical, experimental studies and case reports related to this problem are reviewed. Frequency of port-site metastases for gallbladder, colorectal and ovarian cancers seem to differ. Ascites...
journal_title：Bulletin du cancer
pub_type： 杂志文章,评审
doi：
更新日期：2000-12-01 00:00:00
abstract：INTRODUCTION:Few studies have explored the long-term occupational situation after cancer. The aim of our study were to study the employment status among long-term cancer survivors and to compare it to cancer-free controls from the general population at 5, 10 or 15 years after cancer diagnosis. METHODS:From data of a r...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：10.1016/j.bulcan.2020.06.004
更新日期：2020-09-01 00:00:00
abstract：:To show the nature and magnitude of EKG anomalies subsequent to 5-fluorouracil (5FU) administration and determine whether the onset is dependent on a pre-existing cardiovascular pathological condition. 1,350 patients were treated by 5FU between 1995 and 2000. EKG were recorded in all patients before each administratio...
journal_title：Bulletin du cancer
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
