[Clinical value of the potential doubling time (Tpot) measured by flow cytometry].

Abstract:

:The potential doubling time (Tpot) is defined as the time necessary to double the number of proliferating tumor cells in the absence of spontaneous cell loss. Tpot is thought to be a better index of tumor proliferation than clinically observed tumour volume doubling time. The in vivo measurement of Tpot is a possible way to detect fast growing tumours which would be better controlled by accelerated radiotherapy. The published data demonstrate the feasibility and the safety of the technique. Large variations in Tpot values were observed in tumors with similar histology, indicating an accelerated proliferation rate in some tumors. There are technical difficulties related to intra-tumor heterogeneity, sample contamination by normal cells, and inter-laboratory variability, which question the biological interpretation of Tpot. Further studies are ongoing to establish whether the in vivo measurement of Tpot 1) provides information that is independent of the "classical" prognostic factors, and 2) allows the early recognition of the patients likely to benefit from accelerated treatment.

journal_name

Bull Cancer

journal_title

Bulletin du cancer

authors

Dubray B,Maciorowsky Z,Cosset JM,Terry NH

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

331-8

issue

5

eissn

0007-4551

issn

1769-6917

journal_volume

82

pub_type

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  • [Importance of a multidisciplinary approach to metastatic cancer of the rectum].

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  • [Surgery after chemotherapy: gastric cancer].

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    abstract::Since premedication of patients with an H1 antihistamine is recommended before the start of the intravenous infusion of temsirolimus, temsirolimus is to be used with caution in cases where there is a history of hypersensitivity to this class of antihistamines, or medical contra-indication for treatment with antihistam...

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  • [Colorectal cancer in the elderly].

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    更新日期:2008-05-28 00:00:00

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    doi:

    authors: Devita VT Jr

    更新日期:1988-01-01 00:00:00

  • [Changes in methylation of tumor cells: a new in situ quantitative approach on interphase nuclei and chromosomes].

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    pub_type: 杂志文章

    doi:

    authors: Veilleux C,Bernardino J,Gibaud A,Niveleau A,Malfoy B,Dutrillaux B,Bourgeois CA

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  • [Small cell carcinoma. Incidence, histopathology and anatomical features. Analysis of 465 autopsied bronchopulmonary carcinomas (author's transl)].

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    doi:

    authors: Chomette G,Auriol M,Tranbaloc P,Esperandieu O,Guettier C

    更新日期:1982-01-01 00:00:00

  • [Role of [18F]-FDG PET-CT in the management of the head and neck cancers].

    abstract:OBJECTIVES:To evaluate the impact of [(18)F]-FDG PET/CT image fusion in the management of carcinomas of the upper aero-digestive tract. METHODS:This retrospective study included 169 patients with squamous cell cacinoma of the upper aerodigestive tract who underwent a PET/CT for : initial staging (n = 47), cervical lym...

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    authors: Fakhry N,Barberet M,Lussato D,Cammilleri S,Mundler O,Giovanni A,Zanaret M

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  • [Esophageal cancer in Western France. Retrospective analysis of 1400 cases].

    abstract::A retrospective review was made of 1 400 cases of cancer of the esophagus treated at the Centre "Francois Baclesse" between 1964 and 1975. The disease appeared at an earlier age and more frequently in men (95%) than in women. The lesions were located predominantly in the middle third of the esophagus. There was a high...

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    pub_type: 杂志文章

    doi:

    authors: Roussel A,Gignoux M,Verwaerde JC,Segol P,Abbatucci JS,Valla A

    更新日期:1977-01-01 00:00:00

  • [Place of autologous and allogeneic hematopoietic stem cell transplantation in ovarian cancer].

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    authors: Nayl B,Cabrespine-Faugeras A,Maliki Y,Bay JO

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  • [Value of thymidine kinase in the prediction of response to treatment by chemotherapy or hormone therapy in breast cancer].

    abstract::Thymidine kinase (TK) was assayed in the cytosol of 210 primary breast cancers to assess its predictive value for response to first line chemotherapy and hormonotherapy. We performed correlations between TK and the other prognosis factors of breast cancer. TK activity is correlated with SBR grading and estrogen recept...

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    authors: Bennini N,Mauriac L,Wafflart J,Bonichon F,Durand M

    更新日期:1992-01-01 00:00:00

  • Chemoresistance in the clinic: overview 1994.

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    doi:

    authors: Bates SE,Regis JI,Robey RW,Zhan Z,Scala S,Meadows BJ

    更新日期:1994-12-01 00:00:00

  • [Signal transduction from the membrane to the nucleus: variations on common themes].

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    doi:

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    更新日期:1998-06-01 00:00:00

  • [Rare cancers and new radiotherapy techniques].

    abstract::Rare cancers represent about a quarter of all cancers diagnosed in Europe, and their incidence is increasing. Meanwhile, scientific advances provide techniques, which become more and more sophisticated in the domain of radiotherapy. Treatment options for radiotherapy rare cancers are increasing, but are not yet evalua...

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  • [Can we enhance the one-day part in breast conservative surgery?].

    abstract:INTRODUCTION:French national guidelines lead us to increase the part of one-day breast cancer conservative surgery. Our objective was to check if we can enhance our outpatient part and to identify solutions to improve our practices. METHODS:From 01/01/2013 to 31/12/2014, we conducted a monocentric and retrospective re...

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    authors: Gachon B,Nadeau C,Fritel X

    更新日期:2015-12-01 00:00:00

  • [Treatment of chronic myeloid leukemia in 2007].

    abstract::The treatment of chronic myeloid leukemia (CML) has considerably evolved since imatinib mesylate has been introduced as a new therapeutic weapon for this disease. The 5-year updated results of the IRIS study confirmed that imatinib mesylate is the best first line therapy for chronic phase CML with an overall survival ...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Labussière H,Hayette S,Tigaud I,Michallet M,Nicolini FE

    更新日期:2007-10-01 00:00:00

  • [Acute lymphoblastic leukemia and pregnancy. Apropos of a case].

    abstract::The authors report on a case of a woman with acute lymphoblastic leukemia treated with cortisone therapy during pregnancy. No problems were encountered during the gestational period or at parturition; and no maternal or neonatal complications were observed. ...

    journal_title:Bulletin du cancer

    pub_type: 信件

    doi:

    authors: Hamdoun L,Zeineb NB,Ferchiou M,Zhioua F,Meriah S

    更新日期:1992-01-01 00:00:00

  • [Fertility and the progeny of children surviving cancer treatment (author's transl)].

    abstract::Little is known about the late effects of damage to the gonads in children treated for cancer. This investigation requires a prolonged surveillance. Radiotherapy sterilizes the ovaries above a dose of about 500 rads in an adult. Therefore, to protect at least one ovary in partial irradiation of a child's abdomen in ma...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Flamant F,Schweisguth O

    更新日期:1979-01-01 00:00:00

  • [Radioimmunotherapy of follicular lymphoma: a step towards cure?].

    abstract::Advanced stage follicular lymphoma is incurable by conventional treatment. Important progress has been observed with the development of new therapies based on monoclonal antibodies and on the use of radioimmunotherapy (RIT) in the treatment of non-Hodgkin lymphomas (NHL). Rituximab in combination with chemotherapy in ...

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    pub_type: 杂志文章,评审

    doi:

    authors: Ketterer N,Bischof Delaloye A,Helg C,Luthi F,Buchegger F

    更新日期:2007-09-01 00:00:00

  • [Adjuvant chemotherapy in cancers of the stomach, pancreas and intestine].

    abstract::Adjuvant chemotherapy after apparently complete resection of gastrointestinal cancer may be theoretically justified by the high rate of local and metastatic recurrences. However, the results of controlled trials are generally disappointing, even if some of them have recently suggested some hope, chiefly for adjuvant t...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Martin F

    更新日期:1984-01-01 00:00:00

  • [Cancers of the corpus uteri on the Côte-d'Or 1982-1990. Incidence, clinical stage and survival].

    abstract::In the French administrative "departement" of Côte-d'Or, between 1982 and 1990, the crude incidence rate and the age-adjusted world standardised incidence rate (ASR) for corpus uteri cancer were respectively 16.0 +/- 0.8 and 10.7 +/- 0.6 per 100,000 women per year. The incidence increased after 50 years of age, reachi...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Chaplain G,Cuisenier J,Milan C,Smail M,Janoray P,Collin F,Déchelotte D,Michiels-Marzais D,Jahier J,Michiels R

    更新日期:1994-08-01 00:00:00

  • [Target antigens for therapeutic antibodies in oncology: many candidates, few successes].

    abstract::Targeted therapies, especially monoclonal antibodies, have reached an increasing importance in oncology. High-throughput techniques have allowed the identification of numerous transcripts, proteins, or non-protein antigens, which have generated the concept of immunome. This epitope library constitutes a huge reservoir...

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    doi:

    authors: Ceze N,Probst A,Lecomte T,Ohresser M,Paintaud G,Watier H

    更新日期:2007-01-01 00:00:00

  • [Adjuvant treatment of colon cancer MOSAIC study's main results].

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    pub_type: 杂志文章

    doi:

    authors: André T,Tournigand C,Achille E,Tubiana-Mathieu N,Lledo G,Raoul Y,Carola E,Flesch M,Muron T,Boutan-Laroze A,Guérin Meyer V,Boaziz C,Maigre M,Ganem G,Mousseau M,Mounedji-Boudiaf L,de Gramont A

    更新日期:2006-02-01 00:00:00

  • [Training of pharmacy personnel in the management of a centralized unit: the Oncolor network experience].

    abstract::The network of cancer care units in Lorraine area (Oncolor) developed management training for people working in chemotherapy units, and cytotoxic drug preparation. The programme was framed both for staff of executives (pharmacists), and technicians. Firstly, comparison between practices and theoretical recommendations...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Henn-Ménétré S,Noirez V,Husson J,Vallance C,Lestreit JM,Llorens AM,May I,Grandhaye JP,Bey P

    更新日期:2003-10-01 00:00:00

  • [Cervical cancer screening for high risk women: is it possible? Results of a cervical cancer screening program in three suburban districts of Lyon].

    abstract::Between november 1993 and october 1996, a cervical screening program was proposed for women 25-65-year-old who tend to have little or no medical supervision, in three suburban districts of Lyon. The data and results of the two last Pap-smears have been collected together with details of gynecological follow-up. Both g...

    journal_title:Bulletin du cancer

    pub_type: 杂志文章

    doi:

    authors: Mignotte H,Perol D,Fontanière B,Nachury LP,Blanc-Jouvand A,Fouillat V,Chauvin F,Lasset C

    更新日期:1999-06-01 00:00:00

  • [Histological and immunohistochemical diagnosis of bone marrow metastases of neuroblastomas].

    abstract::A retrospective, morphological and immunochemical study was performed on 60 bone marrow biopsies (BOM) and 12 tumor specimens surgically excised, from 9 patients with neuroblastoma (NB). Immunochemistry concerned "neuron-specific enolase" (NSE), chromogranin A (CGA) and synaptophysin (SP). The results of immunochemica...

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    doi:

    authors: Boman F,Chastagner P,Floquet J,Sommelet D,Aymard B,Palau R,Kleinclaus I

    更新日期:1991-01-01 00:00:00

  • [Angiogenesis and hematologic malignancy].

    abstract::Angiogenesis plays an important role in the progression of tumors. This relationship has been described in several hematologic malignancies. Vascular endothelial growth factor and basic fibroblast growth factor are predictors of poor prognosis in leukemia and non Hodgkin's lymphoma. Bone marrow microvessels were found...

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    pub_type: 杂志文章,评审

    doi:

    authors: Zini JM,Tobelem G

    更新日期:2007-07-01 00:00:00

  • [Hodgkin disease: should high-risk patients be selected and chemotherapy be intensified?].

    abstract::Death still occurs in Hodgkin's disease (HD) patients with advanced stages, but also in early stages. Therefore, the identification of the population of HD patients who would best benefit from an intensification of treatment is a prerequisite in all stages. The best known prognostic factors are bulky mediastinum, B sy...

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    pub_type: 杂志文章,评审

    doi:

    authors: Carde P

    更新日期:1995-08-01 00:00:00

  • [Attachment and caregivers' life course facing cancer].

    abstract:INTRODUCTION:Since the last cancer plan 2014-2019, the assessment of the impact of the disease on caregivers became essential. The quality of caregiving represents an important part of the patient's quality of life. The main objective was to describe the evolution of caregiver's attachment style during the first three ...

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