Acidic pH rapidly increases immunoreactivity of glial fibrillary acidic protein in cultured astrocytes.

abstract：:The nervous system of echinoderms has long been considered too unique to be directly comparable to the nervous system of other Deuterostomia. Using two novel monoclonal antibodies in combination with epifluorescence, confocal, and electron microscopy, we demonstrate here that the central nervous system of the sea cucu...

journal_title：Glia

authors： Mashanov VS,Zueva OR,Garcia-Arraras JE

更新日期：2010-10-01 00:00:00

abstract：:We have analysed in detail the properties of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells derived from the spinal cords of adult rats to gain further insights into the mechanisms that control the generation of oligodendrocytes in the healthy and demyelinated adult central nervous systems (CNS). When O-2A p...

journal_title：Glia

authors： Engel U,Wolswijk G

更新日期：1996-01-01 00:00:00

abstract：:Mechanisms that regulate the amount of releasable Ca2+ in intracellular stores of cultured mouse astrocytes were investigated using digital imaging of fura-2 loaded cells. At rest, the cytoplasmic Ca2+ concentration, [Ca2+]cyt, was about 110 nM. In the absence of extracellular Ca2+, cyclopiazonic acid (CPA), an inhibi...

journal_title：Glia

authors： Golovina VA,Bambrick LL,Yarowsky PJ,Krueger BK,Blaustein MP

更新日期：1996-04-01 00:00:00

abstract：:Painful neuropathy is one of the most common complications of diabetes, one hallmark of which is tactile allodynia (pain hypersensitivity to innocuous stimulation). The underlying mechanisms of tactile allodynia are, however, poorly understood. Emerging evidence indicates that, following nerve injury, activated microg...

journal_title：Glia

authors： Tsuda M,Ueno H,Kataoka A,Tozaki-Saitoh H,Inoue K

更新日期：2008-03-01 00:00:00

abstract：:Isolated acellular nerve segments protected from migration of Schwann cells and the acellular nerve segments joined with the distal nerve stumps were prepared by a repeated freeze-thaw procedure in the rat sciatic nerves. The presence of laminin-1 and -2, as well as alpha6 and beta1 integrin chains, was detected by in...

journal_title：Glia

authors： Dubový P,Svízenská I,Klusáková I,Zítková A,Houst'Ava L,Haninec P

更新日期：2001-01-01 00:00:00

abstract：:Spinal cord injury (SCI) is a cause of major neurological disability, and no satisfactory treatment is currently available. Traumatic SCI directly damages the cell bodies and/or processes of neurons and triggers a series of endogenous processes, including neuroinflammatory response and reactive astrogliosis. In this s...

journal_title：Glia

authors： Su Z,Yuan Y,Cao L,Zhu Y,Gao L,Qiu Y,He C

更新日期：2010-06-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) represents a family of related peptides originally isolated from cardiac atria that have potent natriuretic, diuretic, and vasorelaxant properties. ANP has previously been localized in neurons of the rat brain in regions subserving cardiovascular functions and fluid/electrolyte balance...

journal_title：Glia

authors： McKenzie JC,Berman NE,Thomas CR,Young JK,Compton LY,Cothran LN,Liu WL,Klein RM

更新日期：1994-11-01 00:00:00

abstract：:In the last decade, microRNAs have been increasingly recognized as key modulators of glial development. Recently, we identified miR-125a-3p as a new player in oligodendrocyte physiology, regulating in vitro differentiation of oligodendrocyte precursor cells (OPCs). Here, we show that miR-125a-3p is upregulated in acti...

journal_title：Glia

authors： Marangon D,Boda E,Parolisi R,Negri C,Giorgi C,Montarolo F,Perga S,Bertolotto A,Buffo A,Abbracchio MP,Lecca D

更新日期：2020-10-01 00:00:00

abstract：:Pax-3 is a paired domain transcription factor that plays many roles during vertebrate development. In the Schwann cell lineage, Pax-3 is expressed at an early stage in Schwann cells precursors of the embryonic nerve, is maintained in the nonmyelinating cells of the adult nerve, and is upregulated in Schwann cells afte...

journal_title：Glia

authors： Doddrell RD,Dun XP,Moate RM,Jessen KR,Mirsky R,Parkinson DB

更新日期：2012-09-01 00:00:00

abstract：:Mouse sciatic nerves from the degeneration-resistant strain C57BL/6/Wld (Ola) were surgically injected with lysolecithin to induce focal demyelination. Three days later they were transected adjacent to the spinal cord to eliminate contact of the axons with their cell bodies. The Na+ channel distribution was assessed b...

journal_title：Glia

authors： Tzoumaka EE,Novaković SD,Levinson SR,Shrager P

更新日期：1995-10-01 00:00:00

abstract：:Measurements of extracellular space volume and imaging of intrinsic optical signals (IOSs) have shown that neuronal activity increases light transmittance by causing cellular swelling. However, the cellular mechanisms underlying these volume changes and the contribution of astrocyte swelling to the changes in tissue v...

journal_title：Glia

authors： MacVicar BA,Feighan D,Brown A,Ransom B

更新日期：2002-02-01 00:00:00

abstract：:Astrocytes are the gatekeepers of neuronal energy supply. In neurodegenerative diseases, bioenergetics demand increases and becomes reliant upon fatty acid oxidation as a source of energy. Defective fatty acid oxidation and mitochondrial dysfunctions correlate with hippocampal neurodegeneration and memory deficits in ...

journal_title：Glia

authors： Konttinen H,Gureviciene I,Oksanen M,Grubman A,Loppi S,Huuskonen MT,Korhonen P,Lampinen R,Keuters M,Belaya I,Tanila H,Kanninen KM,Goldsteins G,Landreth G,Koistinaho J,Malm T

更新日期：2019-01-01 00:00:00

abstract：:Activated microglia, astrogliosis, expression of pro-inflammatory cytokines, blood brain barrier (BBB) leakage and peripheral immune cell infiltration are features of mesial temporal lobe epilepsy. Numerous studies correlated the expression of pro-inflammatory cytokines with the activated morphology of microglia, attr...

journal_title：Glia

authors： Vinet J,Vainchtein ID,Spano C,Giordano C,Bordini D,Curia G,Dominici M,Boddeke HW,Eggen BJ,Biagini G

更新日期：2016-08-01 00:00:00

abstract：:The relationship between radial glia and neurons migrating tangentially from the ganglionic eminence (GE) has been suggested but not firmly established. To study this relationship we used a ferret model of cortical dysplasia where radial glia are highly disorganized. To produce this, an antimitotic, methylazoxy methan...

journal_title：Glia

authors： Poluch S,Juliano SL

更新日期：2007-06-01 00:00:00

abstract：:We evaluated the intracellular and extracellular biological role of S100B protein with respect to microglia. S100B, which belongs to the multigenic family of Ca2+-binding proteins, is abundant in astrocytes where it is found diffusely in the cytoplasm and is associated with membranes and cytoskeleton constituents. S10...

journal_title：Glia

authors： Adami C,Sorci G,Blasi E,Agneletti AL,Bistoni F,Donato R

更新日期：2001-02-01 00:00:00

abstract：:Spinocerebellar ataxia type 1 (SCA1) is a fatal, dominantly inherited neurodegenerative disease caused by the expansion of CAG repeats in the Ataxin-1 (ATXN1) gene. SCA1 is characterized by balance and coordination deficits due to the predominant loss of Purkinje neurons in the cerebellum. We previously demonstrated t...

journal_title：Glia

authors： Kim JH,Lukowicz A,Qu W,Johnson A,Cvetanovic M

更新日期：2018-09-01 00:00:00

abstract：:The endocannabinoid system exhibits anti-inflammatory properties by regulating cytokine production. Anandamide (AEA) down-regulates proinflammatory cytokines in a viral model of multiple sclerosis (MS). However, little is known about the mechanisms by which AEA exerts these effects. Microglial cells are the main sourc...

journal_title：Glia

authors： Correa F,Hernangómez M,Mestre L,Loría F,Spagnolo A,Docagne F,Di Marzo V,Guaza C

更新日期：2010-01-15 00:00:00

abstract：:The mechanisms that control microglial activation are of interest, since neuroinflammation, which involves reactive microglia, may be an additional target in the search for therapeutic strategies to treat neurodegenerative diseases. Neuron-microglia interaction through contact-dependent or independent mechanisms is in...

journal_title：Glia

authors： Dentesano G,Serratosa J,Tusell JM,Ramón P,Valente T,Saura J,Solà C

更新日期：2014-06-01 00:00:00

abstract：:Apart from dedicated oligodendroglial progenitor cells, adult neural stem cells (aNSCs) can also give rise to new oligodendrocytes in the adult central nervous system (CNS). This process mainly confers myelinating glial cell replacement in pathological situations and can hence contribute to glial heterogeneity. Our pr...

journal_title：Glia

authors： Beyer F,Jadasz J,Samper Agrelo I,Schira-Heinen J,Groh J,Manousi A,Bütermann C,Estrada V,Reiche L,Cantone M,Vera J,Viganò F,Dimou L,Müller HW,Hartung HP,Küry P

更新日期：2020-02-01 00:00:00

abstract：:Microglia are considered the only cell population of mesodermal origin in the brain, although their role is not fully understood. The present study demonstrated that rat primary microglial cells expressed nestin, A2B5, and O4 antigens, which are markers for oligodendrocyte precursor cells. Based on these findings, we ...

journal_title：Glia

authors： Yokoyama A,Yang L,Itoh S,Mori K,Tanaka J

更新日期：2004-01-01 00:00:00

abstract：:In the course of adult hippocampal neurogenesis, new cells go through a series of stages associated with proliferative activity. The most highly proliferative cell type is an intermediate precursor cell, called type-2 cell. We here report that on the level of type-2 cells a transition takes place between features asso...

journal_title：Glia

authors： Steiner B,Klempin F,Wang L,Kott M,Kettenmann H,Kempermann G

更新日期：2006-12-01 00:00:00

abstract：:Neuropsin and protease M/neurosin are serine proteases expressed by neurons and glial cells, and serve a variety of functions in the central nervous system (CNS). The current study demonstrates changes in the expression of these proteases following hemisection of the mouse spinal cord. Within unlesioned spinal cord, n...

journal_title：Glia

authors： Terayama R,Bando Y,Takahashi T,Yoshida S

更新日期：2004-11-01 00:00:00

abstract：:We have identified a developmentally regulated, oligodendrocyte-specific protein, designated microtubule-associated protein-2 expressing exon 13 (MAP-2+13), in the human central nervous system (CNS). Monoclonal antibodies directed against MAP-2+13 labeled oligodendrocytes in the white matter of human fetal spinal cord...

journal_title：Glia

authors： Shafit-Zagardo B,Davies P,Rockwood J,Kress Y,Lee SC

更新日期：2000-02-01 00:00:00

abstract：:Poly(ADP-ribose) polymerase-1 (PARP-1) is a ubiquitous nuclear enzyme involved in genomic stability. Excessive oxidative DNA strand breaks lead to PARP-1-induced depletion of cellular NAD(+), glycolytic rate, ATP levels, and eventual cell death. Glutamate neurotransmission is tightly controlled by ATP-dependent astroc...

journal_title：Glia

authors： Tang KS,Suh SW,Alano CC,Shao Z,Hunt WT,Swanson RA,Anderson CM

更新日期：2010-03-01 00:00:00

abstract：:Within the last few years, the expression of voltage-dependent, TTX-sensitive Na+ channels has been demonstrated in several types of neuroglial cells such as astrocytes and Schwann cells. Recently, we reported the occurrence of such Na+ currents in retinal Müller (glial) cells from dog and cat. This paper deals with t...

journal_title：Glia

authors： Chao TI,Skachkov SN,Eberhardt W,Reichenbach A

更新日期：1994-03-01 00:00:00

abstract：:Differentiation of oligodendrocyte precursor cells (OPCs) is the most important event for the myelination of central nervous system (CNS) axons during development and remyelination in demyelinating diseases, while the underlying molecular mechanisms remain largely unknown. Here we show that NMDA receptor (NMDAR) is a ...

journal_title：Glia

authors： Li C,Xiao L,Liu X,Yang W,Shen W,Hu C,Yang G,He C

更新日期：2013-05-01 00:00:00

abstract：:The pro-apoptotic sphingolipid ceramide plays an emergent role in the etiology of Alzheimer's disease (AD), although its function for neurodegeneration is not known. We determined the concentration and composition of ceramide in hippocampal tissue from newborn presenilin 1 (PS1) knock-in (PS1M146V) mice, a mouse model...

journal_title：Glia

authors： Wang G,Silva J,Dasgupta S,Bieberich E

更新日期：2008-03-01 00:00:00

abstract：:The basic helix-loop-helix (bHLH) transcription factor Ascl1 plays crucial roles in both oligodendrocyte development and neuronal development; however, the molecular target of Ascl1 in oligodendrocyte progenitor cells (OPCs) remains elusive. To identify the downstream targets of Ascl1 in OPCs, we performed gene expres...

journal_title：Glia

authors： Ueno T,Ito J,Hoshikawa S,Ohori Y,Fujiwara S,Yamamoto S,Ohtsuka T,Kageyama R,Akai M,Nakamura K,Ogata T

更新日期：2012-10-01 00:00:00

abstract：:Astrocytic glycogen, the only storage form of glucose in the brain, has been shown to play a fundamental role in supporting learning and memory, an effect achieved by providing metabolic support for neurons. We have examined the interplay between glycogenolysis and the bioenergetics of astrocytic Ca(2+) homeostasis, b...

journal_title：Glia

authors： Müller MS,Fox R,Schousboe A,Waagepetersen HS,Bak LK

更新日期：2014-04-01 00:00:00

abstract：:Human glioblastoma is a highly lethal tumor known for its capability of interfering with effective antitumor immune responses. Costimulatory signals are of critical relevance in both the inductive and effector phases of immune responses. Inducible costimulator-ligand (ICOSL), a member of the B7 family of costimulatory...

journal_title：Glia

authors： Schreiner B,Wischhusen J,Mitsdoerffer M,Schneider D,Bornemann A,Melms A,Tolosa E,Weller M,Wiendl H

更新日期：2003-12-01 00:00:00