Plasmacytoid dendritic cells: in vivo regulators of alloimmune reactivity?

Abstract:

:Dendritic cells (DC) exhibit remarkable plasticity in terms of their ability to induce and regulate innate and adaptive immune responses. Human and mouse interferon alpha-producing plasmacytoid (p) DC have been found to regulate allogeneic T cell responses in vitro. Evidence is emerging that pDC may also regulate immune reactivity in vivo, including the responses that underlie graft-versus-host disease and organ transplant rejection. These cells may also offer potential for therapy of adverse immune responses and the promotion of tolerance induction.

journal_name

Transplant Proc

authors

Abe M,Colvin BL,Thomson AW

doi

10.1016/j.transproceed.2005.09.111

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

4119-21

issue

9

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)01062-6

journal_volume

37

pub_type

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