当前位置： SCI文献检索 > CHEMICO-BIOLOGICAL INTERACTIONS期刊下所有文献 > Investigations into the antitumour activity of organotin compounds. I. Diorganotin dihalide and di-pseudohalide complexes.

Investigations into the antitumour activity of organotin compounds. I. Diorganotin dihalide and di-pseudohalide complexes.

Abstract：

:The antitumor activity of a series of diorganotin dihalide and di-pseudohalide complexes, R2SnX2, L2, where R = Methyl (Me), Ethyl (Et), n-Propyl (Pr), n-Butyl (Bu) or Phenyl (Ph); X = F, Cl, Br, I or NCS; and L = O- or N- donor organic ligand, which were modelled on the active platinum complexes, has been investigated. A number of these derivatives exhibit reproducible therapeutic activity in vivo towards P-388 lymphocytic leukaemia in mice, particularly the diethyltin dihalide and dipseudohalide complexes. The possible factors influencing activity are discussed, both in terms of the stereochemistry of the dialkyltin compounds and their structural similarity to the platinum antitumour drugs.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Crowe AJ,Smith PJ,Atassi G

doi

10.1016/0009-2797(80)90075-7

subject

Has Abstract

pub_date

1980-10-01 00:00:00

pages

171-8

issue

1-2

eissn

0009-2797

issn

1872-7786

pii

0009-2797(80)90075-7

journal_volume

32

pub_type

杂志文章

相关文献

CHEMICO-BIOLOGICAL INTERACTIONS文献大全
  • Bioinorganic and bioorganic studies of liver alcohol dehydrogenase.

    abstract：:Liver alcohol dehydrogenase (E.C.1.1.1.1) is an NAD(+)/NADH dependent enzyme with a broad substrate specificity being active on an assortment of primary and secondary alcohols. It catalyzes the reversible oxidation of a wide variety of alcohols to the corresponding aldehydes and ketones as well as the oxidation of cer...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(00)00263-5

    authors： Pocker Y

    更新日期：2001-01-30 00:00:00

  • A specific inhibitor of polo-like kinase 1, GSK461364A, suppresses proliferation of Raji Burkitt's lymphoma cells through mediating cell cycle arrest, DNA damage, and apoptosis.

    abstract：:Polo-like kinase 1 (PLK1) is a prominent mediatory player during the cell cycle, mitosis, and cytokinesis in eukaryotic cells. Besides its physiological roles, PLK1 expression is upregulated in a wide range of human malignant tumors and its overexpression worsens prognosis, therefore, specific inhibition of PLK1 in tu...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2020.109288

    authors： Ergul M,Bakar-Ates F

    更新日期：2020-12-01 00:00:00

  • Glutathione-dependent detoxification of alpha-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitors.

    abstract：:The glyoxalase system is a metabolic pathway that catalyses the detoxification of alpha-oxoaldehydes RCOCHO to corresponding aldonic acids RCH(OH)CO2H. It thereby protects cells from alpha-oxoaldehyde-mediated formation of advanced glycation endproducts (AGEs). It is comprised of two enzymes, glyoxalase I and glyoxala...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章,评审

    doi：10.1016/s0009-2797(97)00157-9

    authors： Thornalley PJ

    更新日期：1998-04-24 00:00:00

  • Cytochrome P450 expression and metabolic activation of cooked food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in MCF10A breast epithelial cells.

    abstract：:The cytochrome P450 expression profile was determined in the MCF10A human breast epithelial cell line, as was the ability of this cell line to catalyze the bioactivation of the cooked food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Using non-quantitative reverse transcription-polymerase chain rea...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2006.01.007

    authors： Thomas RD,Green MR,Wilson C,Weckle AL,Duanmu Z,Kocarek TA,Runge-Morris M

    更新日期：2006-04-15 00:00:00

  • Biologically active aromatic retinoids bearing azido photoaffinity-labeling groups and their binding to cellular retinoic acid-binding protein.

    abstract：:Retinoids bearing azido photoaffinity-labeling groups (azidoretinoids) have potential as probes for investigating the molecular mechanisms of action of all-trans-retinoic acid (RA) as mediated by its cellular retinoic acid-binding protein (CRABP) and nuclear receptor proteins. Two new azidoretinoids, 3-azido-4-[2-(5,6...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(90)90072-u

    authors： Sani BP,Wille JJ Jr,Dawson MI,Hobbs PD,Bupp J,Rhee S,Chao WR,Dorsky A,Morimoto H

    更新日期：1990-01-01 00:00:00

  • Identification of plasma proteins containing sulfite-reactive disulfide bonds.

    abstract：:Plasma protein S-sulfonate compounds (RS-SO-3) have previously been shown to form, presumably by sulfitolysis of disulfide bonds, as a result of exposure to sulfite. In the investigations reported here, we identify two proteins in rabbit plasma, namely albumin and plasma fibronectin, which contain reactive sites for S...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(84)90052-8

    authors： Gregory RE,Gunnison AF

    更新日期：1984-04-01 00:00:00

  • Some mechanisms operative in carcinogenesis a review.

    abstract：:Multiple factors contribute to the development of neoplasia. Sometimes a single agency can bring about a tumour if it has many different effects, but at other times a tumour arises more insidiously due to a succession of events [240,241] which by themselves may be innocent. Alterations in the genome of the cell are at...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章,评审

    doi：10.1016/0009-2797(76)90010-7

    authors： Frei JV

    更新日期：1976-04-01 00:00:00

  • Effects of hypoxia and ethanol on xanthine oxidase of isolated rat hepatocytes: conversion from D to O form and leakage from cells.

    abstract：:The combined effects of ethanol and hypoxia on the conversion of xanthine dehydrogenase (D form) to xanthine oxidase (O form) and on the leakage of the enzyme from isolated rat hepatocytes was studied. Time-dependent death of cells occurred during incubation in hypoxic conditions. Ethanol (40 mM) had only a moderate e...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(92)90093-z

    authors： Battelli MG,Abbondanza A,Stirpe F

    更新日期：1992-06-15 00:00:00

  • Inhibition of human prostatic tumour acid phosphatase by N,N-p-di-2-chloroethylaminophenol, N,N-p-di-2-chloroethylaminophenyl phosphate and other difunctional nitrogen mustards.

    abstract：:Potent inhibition of human prostatic carcinoma tissue acid phosphatase by N,N-d-di-2-chloroethylaminophenol (AMOH) and N,N-p-di-2-chloroethylaminophenyl phosphate (AMPh) is described. Certain other difunctional nitrogen mustards were also inhibitory but N,N-p-di-2hydroxyethylaminophenol, the non-alkylating fully hydro...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(78)90085-6

    authors： Workman P

    更新日期：1978-01-01 00:00:00

  • Benzalkonium chloride and cetylpyridinium chloride induce apoptosis in human lung epithelial cells and alter surface activity of pulmonary surfactant monolayers.

    abstract：:Quaternary ammonium compounds (e.g., benzalkonium chloride (BAC) and cetylpyridinium chloride (CPC)) constitute a group of cationic surfactants are widely used for personal hygiene and medical care despite the potential pulmonary toxicity. To examine whether BAC and CPC aerosols deposited in the alveolar region alter ...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2020.108962

    authors： Kanno S,Hirano S,Kato H,Fukuta M,Mukai T,Aoki Y

    更新日期：2020-02-01 00:00:00

  • Naringenin, a flavanone inhibits the proliferation of cerebrally implanted C6 glioma cells in rats.

    abstract：:Tumor cells are able to survive and proliferate in spite of their increased oxidative stress. This was taken as a hint for the implication of oxidants/antioxidants in the proliferation of glial-tumor cells. In the present study, an anti-proliferative effect of Naringenin, an antioxidant against cerebrally implanted C6...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2010.09.028

    authors： Sabarinathan D,Mahalakshmi P,Vanisree AJ

    更新日期：2011-01-15 00:00:00

  • Inhibition of rat hepatic mixed function oxidases by antimalarial drugs: selectivity for cytochromes P-450 and P-448.

    abstract：:Intraperitoneal administration of chloroquine, primaquine and quinacrine to rats resulted in inhibition of the hepatic microsomal mixed-function oxidases. The N-demethylation of benzphetamine (cytochrome P-450) was inhibited by chloroquine only while the O-deethylation of ethoxyresorufin (cytochrome P-448) was inhibit...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(84)90154-6

    authors： Thabrew MI,Ioannides C

    更新日期：1984-10-01 00:00:00

  • Traces of copper ions deplete glutathione in human hepatoma cell cultures with low cysteine content.

    abstract：BACKGROUND:Cell death induced by intracellular glutathione depletion has been reported to be dependent on the presence of trace amounts of extracellular copper ions. Since little is known about the relationship between glutathione depletion and copper homeostasis, we have in the present study further investigated the r...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2007.01.005

    authors： Hultberg M,Isaksson A,Andersson A,Hultberg B

    更新日期：2007-04-05 00:00:00

  • Gallic acid and ferulic acid protect the liver from thioacetamide-induced fibrosis in rats via differential expression of miR-21, miR-30 and miR-200 and impact on TGF-β1/Smad3 signaling.

    abstract：:This study evaluates the possible protective effects of gallic acid (GaA) and ferulic acid (FeA) against an experimentally induced liver fibrosis by thioacetamide (TAA) in rats. Animals were divided into: Control group, GaA group (20 mg/kg/day, p.o), FeA (20 mg/kg/day, p.o), TAA group (receiving 250 mg/kg twice/week, ...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2020.109098

    authors： Hussein RM,Anwar MM,Farghaly HS,Kandeil MA

    更新日期：2020-06-01 00:00:00

  • Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase.

    abstract：:Butyrylcholinesterase (BChE) has proven to be an effective bioscavenger against nerve agents and organophosphates. Phase I safety trials of human BChE are currently being conducted and large-scale production of recombinant BChE is underway. Information on the real-time distribution of BChE from the injection site has ...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2008.02.011

    authors： Duysen EG,Lockridge O

    更新日期：2008-09-25 00:00:00

  • In vitro cytotoxicity of montelukast in HAPI and SH-SY5Y cells.

    abstract：:Montelukast is a cysteinyl leukotriene (CysLT) receptor antagonist with efficacy against a variety of diseases, including asthma and inflammation-related conditions. However, various neuropsychiatric events (NEs) suspected to be related to montelukast have been reported recently, with limited understanding on their as...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2020.109134

    authors： Tseng YT,Cox TM,Grant GD,Arora D,Hall S,McFarland AJ,Ekberg J,Rudrawar S,Anoopkumar-Dukie S

    更新日期：2020-08-01 00:00:00

  • Effects of arenastatin A and its synthetic analogs on microtubule assembly.

    abstract：:Inhibition of microtubule assembly by arenastatin A (1) and five synthetic analogs (3-7) was examined. Arenastatin A and the triamide 6 showed potent and moderately strong inhibitory activities, respectively (IC50; 2.3 microM for 1, 7.8 microM for 6) and also depolymerized preformed microtubules. The other analogs tes...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(96)03743-x

    authors： Koiso Y,Morita K,Kobayashi M,Wang W,Ohyabu N,Iwasaki S

    更新日期：1996-12-20 00:00:00

  • Role of intracellular reactive oxygen species and mitochondrial dysfunction in evening primrose extract-induced apoptosis in Ehrlich ascites tumor cells.

    abstract：:Herbal medicines are increasingly being utilized to treat a wide variety of disease processes. Evening primrose extract (EPE) is extracted from Oenothera biennis L., one species of evening primroses, which has been shown to have several pharmacological effects. However, anti-tumor activity in the extract of defatted s...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(03)00060-7

    authors： Arimura T,Kojima-Yuasa A,Watanabe S,Suzuki M,Kennedy DO,Matsui-Yuasa I

    更新日期：2003-06-15 00:00:00

  • Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line.

    abstract：:The present study was an attempt to investigate the hepatoprotective and antioxidative property of Phyllanthus amarus (P. amarus) extract and phyllanthin. Phyllanthin, one of the active lignin present in this plant species was isolated from the aerial parts, by silica gel column chromatography employing gradient eluti...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2009.06.014

    authors： Krithika R,Mohankumar R,Verma RJ,Shrivastav PS,Mohamad IL,Gunasekaran P,Narasimhan S

    更新日期：2009-10-30 00:00:00

  • 1H-nuclear magnetic resonance of intercalators and rGCA: a potential mutagenicity probe.

    abstract：:Variable temperature 1H-nuclear magnetic resonance (NMR) has been used to study the interaction of the RNA trimer, GpCpA, with the intercalators ethidium bromide and the acridine derivatives; proflavin, 9-amino-acridine, acridine orange, acridine yellow and acriflavin. The complexes formed were studied at nucleic acid...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(84)90135-2

    authors： Coddington JM,Alkema D,Bell RA,Hughes DW,Neilson T

    更新日期：1984-06-01 00:00:00

  • Biology and function of the reversible sulfation pathway catalysed by human sulfotransferases and sulfatases.

    abstract：:Sulfation and sulfate conjugate hydrolysis play an important role in metabolism, and are catalysed by members of the sulfotransferase and sulfatase enzyme super-families. In general, sulfation is a deactivating, detoxication pathway, but for some chemicals the sulfate conjugates are much more reactive than the parent ...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章,评审

    doi：10.1016/s0009-2797(97)00117-8

    authors： Coughtrie MW,Sharp S,Maxwell K,Innes NP

    更新日期：1998-02-20 00:00:00

  • Human serum paraoxonase (PON1): identification of essential amino acid residues by group-selective labelling and site-directed mutagenesis.

    abstract：:Human serum paraoxonase/arylesterase (PON1, EC 3.1.8.1.) is a calcium-dependent enzyme which hydrolyzes a wide variety of organophosphates, including paraoxon, DFP, sarin and soman. Although the 3-D structure of PON has not yet been determined and its sequence shows no similarity with any other crystallized proteins, ...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/s0009-2797(99)00015-0

    authors： Josse D,Xie W,Masson P,Lockridge O

    更新日期：1999-05-14 00:00:00

  • Cadmium induces the activation of cell wall integrity pathway in budding yeast.

    abstract：:MAP kinases are important signaling molecules regulating cell survival, proliferation and differentiation, and can be activated by cadmium stress. In this study, we demonstrate that cadmium induces phosphorylation of the yeast cell wall integrity (CWI) pathway_MAP kinase Slt2, and this cadmium-induced CWI activation i...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2015.09.007

    authors： Xiong B,Zhang L,Xu H,Yang Y,Jiang L

    更新日期：2015-10-05 00:00:00

  • Time-resolved fluorescence spectroscopy of hematoporphyrin-derivative in human lymphocytes.

    abstract：:This paper reports on time-resolved microfluorimetric measurements on hematoporphyrin-derivative (HpD)-treated lymphocytes. HpD is at present widely used as a tumor-locating and photosensitizing drug. It is therefore of great importance to study the extent to which the HpD uptake process depends on cell functional and...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(84)90090-5

    authors： Docchio F,Ramponi R,Sacchi CA,Bottiroli G,Freitas I

    更新日期：1984-07-01 00:00:00

  • Muscular dystrophy with laminin deficiency decreases acetylcholinesterase activity in thymus of dystrophic Lama2dy mice.

    abstract：:We have studied the effect of muscular dystrophy by merosin deficiency on mouse thymus acetyl- (AChE) and butyrylcholinesterase (BuChE). The organ contains AChE and BuChE activities. Merosin deficiency causes an important decrease (46%) in AChE specific activity. Thymus produces dimers, monomers and tetramers of AChE,...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2005.10.092

    authors： Sánchez del Campo L,Nieto-Cerón S,Muñoz-Delgado E,Vidal CJ,Campoy FJ

    更新日期：2005-12-15 00:00:00

  • Responses of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in MCF-7 cells are culture condition dependent.

    abstract：:To compare the effects of the food toxin 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) and estradiol in hormone-responsive MCF-7 cells, the cells were exposed to different concentrations of either PhIP or estradiol. The effect of various culture conditions (e.g. phenol red, FBS, vehicle (DMSO/EtOH) and seedi...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2009.07.020

    authors： Immonen E,Serpi R,Vähäkangas K,Myllynen P

    更新日期：2009-11-10 00:00:00

  • NADH fluorescence lifetime analysis of the effect of magnesium ions on ALDH2.

    abstract：:Aldehyde dehydrogenase 2 (ALDH2) catalyzes oxidation of toxic aldehydes to carboxylic acids. Physiologic levels of Mg(2+) ions influence ALDH2 activity in part by increasing NADH binding affinity. Traditional fluorescence measurements monitor the blue shift of the NADH fluorescence spectrum to study ALDH2-NADH interac...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2011.01.023

    authors： Gonnella TP,Leedahl TS,Karlstad JP,Picklo MJ

    更新日期：2011-05-30 00:00:00

  • The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism.

    abstract：:In human populations, serum paraoxonase (PON1) exhibits a substrate dependent polymorphism. The Arg192 isoform hydrolyzes paraoxon rapidly but diazoxon, soman and especially sarin slowly. On the other hand, the Gln192 isoform hydrolyzes paraoxon slowly, but diazoxon, soman and sarin more rapidly than the Arg192 isofor...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章,评审

    doi：10.1016/s0009-2797(99)00055-1

    authors： Costa LG,Li WF,Richter RJ,Shih DM,Lusis A,Furlong CE

    更新日期：1999-05-14 00:00:00

  • Overexpression of microRNA-519d-3p suppressed the growth of pancreatic cancer cells by inhibiting ribosomal protein S15A-mediated Wnt/β-catenin signaling.

    abstract：:Ribosomal protein S15A (RPS15A) has emerged as a novel oncogene of various human cancers. However, whether RPS15A is involved in pancreatic cancer remains unclear. In this study, we aimed to investigate the potential relevance of RPS15A in pancreatic cancer and elucidate the underlying regulatory mechanism. We found t...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/j.cbi.2019.02.026

    authors： Liang J,Liu Y,Zhang L,Tan J,Li E,Li F

    更新日期：2019-05-01 00:00:00

  • Characterization of paraoxonase activity in pericardial fluid: usefulness as a marker of coronary disease.

    abstract：:In this study, the presence of paraoxonase activity in pericardial fluid was demonstrated. A comparison of some properties, such as optimum pH, stability versus pH, heat inactivation, effect of inhibitors, isoelectric point and kinetic parameters (Km and Vmax), between plasma and pericardial fluid paraoxonase was made...

    journal_title：Chemico-biological interactions

    pub_type： 杂志文章

    doi：10.1016/0009-2797(93)90039-2

    authors： Hernández AF,Pla A,Valenzuela A,Gil F,Villanueva E

    更新日期：1993-06-01 00:00:00