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Role of intracellular reactive oxygen species and mitochondrial dysfunction in evening primrose extract-induced apoptosis in Ehrlich ascites tumor cells.

Abstract：

:Herbal medicines are increasingly being utilized to treat a wide variety of disease processes. Evening primrose extract (EPE) is extracted from Oenothera biennis L., one species of evening primroses, which has been shown to have several pharmacological effects. However, anti-tumor activity in the extract of defatted seeds of O. biennis L. has not been defined thus far. In this study, we identified the major biochemical changes upon EPE treatment and investigated the functional relationship between these changes. We found that EPE-induced apoptosis in Ehrlich ascites tumor cells as evidenced by morphological changes. Furthermore, our results demonstrated rapid increase of intracellular peroxides levels, loss of mitochondrial membrane potential and the release of cytochrome c from mitochondria to cytosol. These results suggest that the rapid increase of intracellular peroxides levels after addition of EPE triggers off induction of apoptosis.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Arimura T,Kojima-Yuasa A,Watanabe S,Suzuki M,Kennedy DO,Matsui-Yuasa I

doi

10.1016/s0009-2797(03)00060-7

subject

Has Abstract

pub_date

2003-06-15 00:00:00

pages

337-47

issue

3

eissn

0009-2797

issn

1872-7786

pii

S0009279703000607

journal_volume

145

pub_type

杂志文章

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