abstract：:The aberrant expression level of SARS-CoV-2 cell receptor gene ACE2 was reported in lung adenocarcinoma (LUAD) comorbidity of COVID-19. However, the association of ACE2 expression levels with immunosuppression and metabolic reprogramming in LUAD remains lacking. We investigated the expression level of ACE2, an associa...

journal_title：Chemico-biological interactions

authors： Uddin MN,Akter R,Li M,Abdelrahman Z

更新日期：2021-02-01 00:00:00

abstract：:Lactosyl-Sepharose binding proteins (LSBPs) were recently described in human pancreatic ductal adenocarcinoma (PDAC) Suit2-007 cells regarding their lectin-like properties and role in metastasis. This study further investigated how calcium and galactose influence the binding of LSBPs to the lactosyl resin as well as t...

journal_title：Chemico-biological interactions

authors： Sagini MN,Hotz-Wagenblatt A,Berger MR

更新日期：2021-01-25 00:00:00

abstract：:Previous studies revealed that direct contact with graphene oxide (GO) induced cytotoxic effects, but the importance of involvement of metabolic pathways, in particular lipid metabolism pathways, might be overlooked. In this study, human umbilical vein endothelial cells (HUVECs) were exposed to GO with large size (den...

journal_title：Chemico-biological interactions

authors： Luo Y,Wang X,Cao Y

更新日期：2021-01-05 00:00:00

abstract：:HPV infections in the oral cavity that progress to cancer are on the increase in the USA. Model systems to study co-factors for progression of these infections are lacking as HPVs are species-restricted and cannot grow in preclinical animal models. We have recently developed a mouse papillomavirus (MmuPV1) oral mucosa...

journal_title：Chemico-biological interactions

authors： Christensen ND,Chen KM,Hu J,Stairs DB,Sun YW,Aliaga C,Balogh KK,Atkins H,Shearer D,Li J,Brendle SA,Gowda K,Amin S,Walter V,Viscidi R,El-Bayoumy K

更新日期：2021-01-05 00:00:00

abstract：:Nicotine exposure increases the release of glutamate in part through stimulatory effects on pre-synaptic nicotinic acetylcholine receptors (nAChRs). To assess the impact of chronic electronic (e)-cigarette use on these drug dependence pathways, we exposed C57BL/6 mice to three types of inhalant exposures for 3 months;...

journal_title：Chemico-biological interactions

authors： Alasmari F,Crotty Alexander LE,Hammad AM,Horton A,Alhaddad H,Schiefer IT,Shin J,Moshensky A,Sari Y

更新日期：2021-01-05 00:00:00

abstract：:The cytotoxic potential of a naturally occurring indoloquinazoline alkaloid, soyauxinium chloride (SCHL), was determined on a broad panel of animal and human cancer cell lines, including various sensitive and drug-resistant phenotypes. The cytotoxicity, SCHL-induced autophagic, ferroptotic, and necroptotic cell death ...

journal_title：Chemico-biological interactions

authors： Mbaveng AT,Noulala CGT,Samba ARM,Tankeo SB,Abdelfatah S,Fotso GW,Happi EN,Ngadjui BT,Beng VP,Kuete V,Efferth T

更新日期：2021-01-05 00:00:00

abstract：:The on-going pandemic of COVID-19 wreaked by a viral infection of SARS-CoV-2, has generated a catastrophic plight across the globe. Interestingly, one of the hallmarks of COVID-19 is the so-called 'cytokine storm' due to attack of SARS-Cov-2 in the lungs. Considering, mesenchymal stem cells (MSCs) therapy could contri...

journal_title：Chemico-biological interactions

authors： Dubey AK,Singh A,Prakash S,Kumar M,Singh AK

更新日期：2020-12-01 00:00:00

abstract：:Ginsenoside Rb1 (GsRb1) is the best constituent of ginseng and although it shows clinical efficacy as an antineoplastic, antioxidative and antirheumatic agent, its oral bioavailability is poor due to its limited solubility. In this study, the solubility of GsRb1 was improved by encapsulating it in polymeric nanocapsul...

journal_title：Chemico-biological interactions

authors： Liu Y,Zhu H,Zhou W,Ye Q

更新日期：2020-12-01 00:00:00

abstract：:Polo-like kinase 1 (PLK1) is a prominent mediatory player during the cell cycle, mitosis, and cytokinesis in eukaryotic cells. Besides its physiological roles, PLK1 expression is upregulated in a wide range of human malignant tumors and its overexpression worsens prognosis, therefore, specific inhibition of PLK1 in tu...

journal_title：Chemico-biological interactions

authors： Ergul M,Bakar-Ates F

更新日期：2020-12-01 00:00:00

abstract：:The present study aims to explore the effects of astaxanthin on the semen quality of diabetes mellitus (DM) KKAy mice. A total of 60 DM KKAy mice with similar body weights and initial blood glucose and serum lipid levels were assigned to four groups, namely, one control and three astaxanthin treatments (10, 50, or 100...

journal_title：Chemico-biological interactions

authors： Hao Z

更新日期：2020-12-01 00:00:00

abstract：:A cellular model of cardiomyocytes (H9c2 cell line) and mitochondria isolated from mouse liver were used to understand the drug action of BPDZ490 and BPDZ711, two benzopyran analogues of the reference potassium channel opener cromakalim, on mitochondrial respiratory parameters and swelling, by comparing their effects ...

journal_title：Chemico-biological interactions

authors： Mouithys-Mickalad A,Ceusters J,Charif M,El Moualij B,Schoumacher M,Plyte S,Franck T,Bettendorff L,Pirotte B,Serteyn D,de Tullio P

更新日期：2020-11-01 00:00:00

abstract：:Artesunate is a kind of derivative of artemisinin, which possesses potent anti-cancer effect in addition to its anti-malarial property. And autophagy was a highly conserved process, exerting a double-edged effect in cancer cell survival. Besides, apoptosis is a programmed cell death program, crucial to cell homeostasi...

journal_title：Chemico-biological interactions

authors： Zhou X,Chen Y,Wang F,Wu H,Zhang Y,Liu J,Cai Y,Huang S,He N,Hu Z,Jin X

更新日期：2020-11-01 00:00:00

abstract：:Recently, it has been shown that drimane-type sesquiterpenoids isolated from Zygogynum pancheri, a species native to New Caledonia, possessed significant α-amylase inhibitory activities. To further explore their antidiabetic potential, we investigated the effect of 1β-O-(E-cinnamoyl)-6α-hydroxy-9epi-polygodial (D) and...

journal_title：Chemico-biological interactions

authors： Belhadj S,Keskes H,Apel C,Roussi F,Litaudon M,Hentati O,Allouche N

更新日期：2020-10-01 00:00:00

abstract：:Obesity is characterized by the deposition of excessive body fat, and is caused by energy imbalance, especially when consuming fat-rich diets. High fat diet (HFD)-associated obesity is greatly common in patients with non-alcoholic fatty liver disease (NAFLD) that is emerging as one of the most universal causes of live...

journal_title：Chemico-biological interactions

authors： Lian CY,Zhai ZZ,Li ZF,Wang L

更新日期：2020-10-01 00:00:00

abstract：:Two types of cholinesterases (ChEs) are present in mammalian blood and tissues: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). While AChE regulates neurotransmission by hydrolyzing acetylcholine at the postsynaptic membranes and neuromuscular junctions, BChE in plasma has been suggested to be involved i...

journal_title：Chemico-biological interactions

authors： Naik RS,Belinskaya T,Vinayaka CR,Saxena A

更新日期：2020-10-01 00:00:00

abstract：:Cisplatin induces acute renal failure in humans and mice.Tubular apoptosis, necrosis and inflammation are the primary pathogenesis of cisplatin-induced acute kidney injury(AKI). We previously reported that the depletion of Numb from proximal tubules exacerbates tubular cells apoptosis in cisplatin-induced AKI, however...

journal_title：Chemico-biological interactions

authors： Liu Z,Li Z,Chen Z,Li C,Lei L,Wu X,Li Y

更新日期：2020-10-01 00:00:00

abstract：:Tebuconazole (TEB) is a broad-spectrum conazole fungicide that has been used in agriculture in the control of foliar and soil-borne diseases of many crops. The present study has investigated the adverse effects of subchronic exposure to TEB on the kidney of male rats. Animals were divided into four equal groups and tr...

journal_title：Chemico-biological interactions

authors： Othmène YB,Hamdi H,Salem IB,Annabi E,Amara I,Neffati F,Najjar MF,Abid-Essefi S

更新日期：2020-10-01 00:00:00

abstract：:Cigarette smoke is a complex mixture capable of triggering inflammation and oxidative damage in animals at pulmonary and systemic levels. Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl) reduces tissue injury associated with inflammation in vivo by mechanisms that are not completely understood. Here we evaluate...

journal_title：Chemico-biological interactions

authors： Silva DAD,Correia TML,Pereira R,da Silva RAA,Augusto O,Queiroz RF

更新日期：2020-09-25 00:00:00

abstract：:The caseinate and glycated caseinate generated from the transglutaminase-catalyzed reaction of caseinate and oligochitosan were digested using pepsin and trypsin, and the activity of the resultant digests was measured in rat intestinal epithelial cell line (IEC-6) using several biological responses as indicators. Comp...

journal_title：Chemico-biological interactions

authors： Wang XP,Ma CM,Zhao XH

更新日期：2020-09-01 00:00:00

abstract：:Hydroxychloroquine (HCQ) is frequently used medications for many auto-immunity diseases. However, HCQ induced retinal toxicity, which might result in irreversible retinopathy, is one of the most important complications of HCQ. However, the molecular mechanism underlying the HCQ retinal toxicity is still not well known...

journal_title：Chemico-biological interactions

authors： Li JH,Xu ZY,Li MJ,Zheng WL,Huang XM,Xiao F,Cui YH,Pan HW

更新日期：2020-09-01 00:00:00

abstract：:The present study was undertaken to assess the effect of imatinib mesylate; a tyrosine kinase inhibitor and a well-known anticancer with numerous medical benefits on blood sugar levels, insulin, and glucagon secretion in an experimental model of STZ-induced diabetes mellitus. Type 1 diabetes mellitus (T1DM) was induce...

journal_title：Chemico-biological interactions

authors： Samaha MM,Said E,Salem HA

更新日期：2020-09-01 00:00:00

abstract：:Excessive osteoclast leads to the imbalance in bone reconstruction and results in osteolytic diseases, such as osteoporosis and rheumatic arthritis. Integrin αvβ3 abundantly expresses on osteoclast and plays a critical role in the formation and function of osteoclast, therefore, blockage of αvβ3 has become an attracti...

journal_title：Chemico-biological interactions

authors： Zeng Q,Lu W,Deng Z,Wu J,Guo R,Xu X

更新日期：2020-08-25 00:00:00

abstract：:Boldine is the main alkaloid of Peumus boldus Molina, widely used in the traditional medicine for the treatment of digestive disorders. It is a compound with excellent antioxidant and anti-inflammatory properties already described. Despite the widespread use of P. boldus for digestive disorders treatment, the gastropr...

journal_title：Chemico-biological interactions

authors： Boeing T,Mariano LNB,Dos Santos AC,Tolentino B,Vargas AC,de Souza P,Nesello LAN,da Silva LM

更新日期：2020-08-25 00:00:00

abstract：:Scoulerine, an isoquinoline alkaloid isolated from Corydalis plants, has been reported to possess potent anti-proliferative and pro-apoptotic function in cancer cells. However, the effects and underlying mechanisms of scoulerine on colorectal cancer (CRC) progression remain elusive. CCK-8 and LDH assays were used to e...

journal_title：Chemico-biological interactions

authors： Tian J,Mo J,Xu L,Zhang R,Qiao Y,Liu B,Jiang L,Ma S,Shi G

更新日期：2020-08-25 00:00:00

abstract：:The renin-angiotensin-aldosterone system (RAAS) is a hormonal system that has a critical role in maintaining the normotensive state and electrolyte balance of the organism. The RAAS also has an important influence in the development of various pathophysiological conditions especially those concerning the renal system,...

journal_title：Chemico-biological interactions

authors： Alshahrani S

更新日期：2020-08-01 00:00:00

abstract：:Montelukast is a cysteinyl leukotriene (CysLT) receptor antagonist with efficacy against a variety of diseases, including asthma and inflammation-related conditions. However, various neuropsychiatric events (NEs) suspected to be related to montelukast have been reported recently, with limited understanding on their as...

journal_title：Chemico-biological interactions

authors： Tseng YT,Cox TM,Grant GD,Arora D,Hall S,McFarland AJ,Ekberg J,Rudrawar S,Anoopkumar-Dukie S

更新日期：2020-08-01 00:00:00

abstract：:Overactivation of N-methyl-D-aspartate (NMDA) receptors has been associated with neurodegenerative disorders such as Alzheimer's disease (AD), cerebral vascular disorders and amyotrophic lateral sclerosis (ALS). We have previously designed and synthesized a series of memantine nitrate and some of them have shown vesse...

journal_title：Chemico-biological interactions

authors： Liu Z,Qiu X,Mak S,Guo B,Hu S,Wang J,Luo F,Xu D,Sun Y,Zhang G,Cui G,Wang Y,Zhang Z,Han Y

更新日期：2020-07-01 00:00:00

abstract：:UDP-glucuronosyltransferases (UGTs) are a family of phase II drug metabolizing enzymes that catalyze glucuronidation of numerous endogenous and exogenous substrates. Carbon tetrachloride (CCl4) is widely used to develop liver injuries mimicking human liver diseases. However, effects of CCl4 on the expression and activ...

journal_title：Chemico-biological interactions

authors： Xu L,Zheng R,Xie P,Guo Q,Ji H,Li T

更新日期：2020-07-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is conventionally known to play a crucial role in hepatocyte proliferation, liver regeneration and is also associated with hepatocellular carcinogenesis. In addition to these proliferative roles, EGFR has also implicated in apoptotic cell death signaling in various hepatic cells...

journal_title：Chemico-biological interactions

authors： Bhushan B,Michalopoulos GK

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:An imbalance between oxidants and antioxidants in favour of oxidants, potentially leading to damage, is termed oxidative stress. Antioxidants (AO), either enzymatic or non-enzymatic, are the ones that can reduce diverse effects of pro-oxidants such as DNA, proteins and lipids damage. Chalcones (1,3-diaryl-...

journal_title：Chemico-biological interactions

authors： Janković T,Turković N,Kotur-Stevuljević J,Vujić Z,Ivković B

更新日期：2020-06-01 00:00:00

abstract：:This study evaluates the possible protective effects of gallic acid (GaA) and ferulic acid (FeA) against an experimentally induced liver fibrosis by thioacetamide (TAA) in rats. Animals were divided into: Control group, GaA group (20 mg/kg/day, p.o), FeA (20 mg/kg/day, p.o), TAA group (receiving 250 mg/kg twice/week, ...

journal_title：Chemico-biological interactions

authors： Hussein RM,Anwar MM,Farghaly HS,Kandeil MA

更新日期：2020-06-01 00:00:00

abstract：:Osteoarthritis (OA) is one of the most prevalent degenerative joint diseases, and the risk of developing OA significantly increases with age as well as with concomitant diseases, such as diabetes. Advanced glycation end products (AGEs) accumulate in the body over time and are associated with increased expression of va...

journal_title：Chemico-biological interactions

authors： Li H,Chen J,Li B,Fang X

更新日期：2020-05-01 00:00:00

abstract：:Fatty liver is the earliest and most common response of the liver to consumption of excessive alcohol. Steatosis can predispose the fatty liver to develop progressive liver damage. Chief among the many mechanisms involved in development of hepatic steatosis is dysregulation of insulin-mediated adipose tissue metabolis...

journal_title：Chemico-biological interactions

authors： Rasineni K,Kubik JL,Knight KL,Hall L,Casey CA,Kharbanda KK

更新日期：2020-05-01 00:00:00

abstract：:Heart rhythm disturbances have been widely recognized as major triggers of cardiovascular (CV) mortality in chronic kidney disease (CKD) patients. Connexin 43 (Cx43)-composed gap junctions are essential in cardiomyocyte synchronization and may be involved in the pathological response to uremic toxins. Indoxyl sulfate ...

journal_title：Chemico-biological interactions

authors： Changchien CY,Sung MH,Chang HH,Tsai WC,Peng YS,Chen Y

更新日期：2020-03-01 00:00:00

abstract：:Acetylcholinesterase (AChE) terminates cholinergic neurotransmission by hydrolyzing acetylcholine. The collagen-tailed AChE tetramer is a product of 2 genes, ACHE and ColQ. The AChE tetramer consists of 4 identical AChE subunits and one polyproline-rich peptide, whose function is to hold the 4 AChE subunits together. ...

journal_title：Chemico-biological interactions

authors： Toker L,Silman I,Zeev-Ben-Mordehai T,Sussman JL,Schopfer LM,Lockridge O

更新日期：2020-03-01 00:00:00

abstract：:In this study, we assessed the efficacy of the Reactive Skin Decontamination Lotion (RSDL®) Kit against parathion and aldicarb pesticide dermal exposure in a guinea pig model. The pesticides inhibit acetylcholinesterase (AChE) leading to signs and symptoms of hyperactivity of organs due to accumulation of acetylcholin...

journal_title：Chemico-biological interactions

authors： Fentabil M,Gebremedhin M,Barry J,Mikler J,Cochrane L

更新日期：2020-02-25 00:00:00

abstract：:The biotoxin okadaic acid (OA) is a lipophilic secondary metabolite of marine microalgae. Therefore, OA accumulates in the fatty tissue of various shellfish and may thus enter the food chain. The ingestion of OA via contaminated marine species can lead to the diarrhetic shellfish poisoning syndrome characterized by th...

journal_title：Chemico-biological interactions

authors： Dietrich J,Schindler M,Lampen A,Braeuning A,Hessel-Pras S

更新日期：2020-02-01 00:00:00

abstract：:Quaternary ammonium compounds (e.g., benzalkonium chloride (BAC) and cetylpyridinium chloride (CPC)) constitute a group of cationic surfactants are widely used for personal hygiene and medical care despite the potential pulmonary toxicity. To examine whether BAC and CPC aerosols deposited in the alveolar region alter ...

journal_title：Chemico-biological interactions

authors： Kanno S,Hirano S,Kato H,Fukuta M,Mukai T,Aoki Y

更新日期：2020-02-01 00:00:00

abstract：:Endocrine therapies (e.g. tamoxifen and aromatase inhibitors) targeting estrogen action are effective in decreasing mortality of breast cancer. However, their efficacy is limited by intrinsic and acquired resistance. Our previous study demonstrated that overexpression of a histone methyltransferase NSD2 drives tamoxif...

journal_title：Chemico-biological interactions

authors： Wang Q,Zheng J,Zou JX,Xu J,Han F,Xiang S,Liu P,Chen HW,Wang J

更新日期：2020-02-01 00:00:00

abstract：:Fatty liver is the hepatic consequence of chronic insulin resistance (IR) and related syndromes. It is mostly accompanied by inflammatory and oxidative molecules. Increased activity of xanthine oxidase (XO) exerts both inflammatory and oxidative effects and has been implicated in metabolic derangements including non-a...

journal_title：Chemico-biological interactions

authors： Dangana EO,Omolekulo TE,Areola ED,Olaniyi KS,Soladoye AO,Olatunji LA

更新日期：2020-01-25 00:00:00