The effect of D-penicillamine on metallothionein mRNA levels and copper distribution in mouse hepatocytes.

abstract：:Herbal medicines are increasingly being utilized to treat a wide variety of disease processes. Evening primrose extract (EPE) is extracted from Oenothera biennis L., one species of evening primroses, which has been shown to have several pharmacological effects. However, anti-tumor activity in the extract of defatted s...

journal_title：Chemico-biological interactions

authors： Arimura T,Kojima-Yuasa A,Watanabe S,Suzuki M,Kennedy DO,Matsui-Yuasa I

更新日期：2003-06-15 00:00:00

abstract：:A study was conducted to test the hypothesis that repeated low level exposures to 1,3-butadiene (BD), approaching the OSHA occupational threshold for this chemical, produce a significant mutagenic response in mice. Female B6C3F1 mice (4-5 weeks of age) were exposed by inhalation for 2 weeks (6 h/day, 5 days/week) to 0...

journal_title：Chemico-biological interactions

authors： Meng Q,Henderson RF,Long L,Blair L,Walker DM,Upton PB,Swenberg JA,Walker VE

更新日期：2001-06-01 00:00:00

abstract：:Flavonoids are phenolic substances that appear to exert beneficial effects in several chronic diseases, including cancer. Structure-activity relationships of the cytotoxic activity of a series of flavonols and their 3-methyl ether derivatives established that 3'-hydroxy-3,4'-dimethoxyflavone (flavonoid 11) displayed s...

journal_title：Chemico-biological interactions

authors： Estévez-Sarmiento F,Hernández E,Brouard I,León F,García C,Quintana J,Estévez F

更新日期：2018-05-25 00:00:00

abstract：:Prostate (CaP) cancer is the second-leading cause of cancer-related mortality in men in Western societies. Androgen receptor (AR) signaling is a critical survival pathway for prostate cancer cells, and androgen-deprivation therapy (ADT) remains the principal treatment for patients with locally advanced and metastatic ...

journal_title：Chemico-biological interactions

authors： Wadhwa B,Dumbre R

更新日期：2016-12-25 00:00:00

abstract：:The enzymatic oxidation of tetrachloro-1,4-hydroquinone (1,4-TCHQ), resulting in covalent binding to protein of tetrachloro-1,4-benzoquinone (1,4-TCBQ), was investigated, with special attention to the involvement of cytochrome P-450 and reactive oxygen species. 1,4-TCBQ itself reacted very rapidly and extensively with...

journal_title：Chemico-biological interactions

authors： van Ommen B,Voncken JW,Müller F,van Bladeren PJ

更新日期：1988-01-01 00:00:00

abstract：:Many flavonoids have been shown to present good results for the treatment of gastric ulcers. Baicalein, a bioactive flavonoid derived from the Scutellaria baicalensis Georgi root, possesses several biological effects, such as anti-inflammatory and antioxidant. This study was conducted to assess the gastroprotective pr...

journal_title：Chemico-biological interactions

authors： Ribeiro AR,do Nascimento Valença JD,da Silva Santos J,Boeing T,da Silva LM,de Andrade SF,Albuquerque-Júnior RL,Thomazzi SM

更新日期：2016-12-25 00:00:00

abstract：:Genistein (4', 5, 7-trihydroxyisoflavone), a naturally occurring flavonoid characteristic of Leguminoseae plants, is a phyto-oestrogen exerting oestrogenic activity as both an agonist and an antagonist substance. A large body of evidence suggests that genistein possesses many physiological and pharmacological properti...

journal_title：Chemico-biological interactions

authors： Sureda A,Sanches Silva A,Sánchez-Machado DI,López-Cervantes J,Daglia M,Nabavi SF,Nabavi SM

更新日期：2017-04-25 00:00:00

abstract：:Studies were undertaken to investigate the mechanism of bioactivation and covalent binding of TNT. Incubation of [14C]TNT with rat liver microsomes in the presence of an NADPH generating system resulted in metabolism and covalent binding to microsomal proteins. Time-dependence studies showed that TNT was rapidly reduc...

journal_title：Chemico-biological interactions

authors： Leung KH,Yao M,Stearns R,Chiu SH

更新日期：1995-06-30 00:00:00

abstract：:Potent inhibition of human prostatic carcinoma tissue acid phosphatase by N,N-d-di-2-chloroethylaminophenol (AMOH) and N,N-p-di-2-chloroethylaminophenyl phosphate (AMPh) is described. Certain other difunctional nitrogen mustards were also inhibitory but N,N-p-di-2hydroxyethylaminophenol, the non-alkylating fully hydro...

journal_title：Chemico-biological interactions

authors： Workman P

更新日期：1978-01-01 00:00:00

abstract：:We examined radiosensitizing properties of two novel platinum complexes (ethylenediamine(L-malato)platinum(II)), Pt1 and bis(1-ethylimidazole(L-malato)platinum(II)), Pt4. Initial double strand break (DSB) level and DSB rejoining were measured, using pulse field gel electrophoresis (PFGE) in human G1 phase lymphocytes ...

journal_title：Chemico-biological interactions

authors： Gradzka I,Buraczewska I,Kuduk-Jaworska J,Romaniewska A,Szumiel I

更新日期：2003-10-25 00:00:00

abstract：:The cytochrome P450 expression profile was determined in the MCF10A human breast epithelial cell line, as was the ability of this cell line to catalyze the bioactivation of the cooked food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Using non-quantitative reverse transcription-polymerase chain rea...

journal_title：Chemico-biological interactions

authors： Thomas RD,Green MR,Wilson C,Weckle AL,Duanmu Z,Kocarek TA,Runge-Morris M

更新日期：2006-04-15 00:00:00

abstract：:The present study was undertaken to assess the effect of imatinib mesylate; a tyrosine kinase inhibitor and a well-known anticancer with numerous medical benefits on blood sugar levels, insulin, and glucagon secretion in an experimental model of STZ-induced diabetes mellitus. Type 1 diabetes mellitus (T1DM) was induce...

journal_title：Chemico-biological interactions

authors： Samaha MM,Said E,Salem HA

更新日期：2020-09-01 00:00:00

abstract：:Osteoarthritis (OA) is one of the most prevalent degenerative joint diseases, and the risk of developing OA significantly increases with age as well as with concomitant diseases, such as diabetes. Advanced glycation end products (AGEs) accumulate in the body over time and are associated with increased expression of va...

journal_title：Chemico-biological interactions

authors： Li H,Chen J,Li B,Fang X

更新日期：2020-05-01 00:00:00

abstract：:The carcinogenic activity of the synthetic estrogen hexestrol was measured in male Syrian hamsters. Between 90% and 100% of the animals treated with hexestrol or with 3',3",5',5"-tetradeuteriohexestrol, implanted subcutaneously as 25-mg pellets, were found with renal carcinoma after 6-7 months. In vitro hexestrol meta...

journal_title：Chemico-biological interactions

authors： Liehr JG,Ballatore AM,Dague BB,Ulubelen AA

更新日期：1985-10-01 00:00:00

abstract：:Excessive osteoclast leads to the imbalance in bone reconstruction and results in osteolytic diseases, such as osteoporosis and rheumatic arthritis. Integrin αvβ3 abundantly expresses on osteoclast and plays a critical role in the formation and function of osteoclast, therefore, blockage of αvβ3 has become an attracti...

journal_title：Chemico-biological interactions

authors： Zeng Q,Lu W,Deng Z,Wu J,Guo R,Xu X

更新日期：2020-08-25 00:00:00

abstract：:Inflammation and oxidative stress exert important roles in intestinal ischemia-reperfusion injury (IRI). Lycium barbarum polysaccharides (LBPs) have shown effective antioxidative and immunomodulatory functions in different models. The purpose of the present study was to assess the effects and potential mechanisms of L...

journal_title：Chemico-biological interactions

authors： Yang X,Bai H,Cai W,Li J,Zhou Q,Wang Y,Han J,Zhu X,Dong M,Hu D

更新日期：2013-08-25 00:00:00

abstract：:Keratinocytes cultured from human and rat epidermis exhibited strongly divergent sensitivities to toxicity from the heterocyclic amine food mutagen Trp-P-2. To find a biochemical basis for this difference, the cultured cells were compared in their expression of phase 1 and 2 biotransformation activities, mutagenic act...

journal_title：Chemico-biological interactions

authors： Chun HS,Kuzmicky PA,Kado NY,Rice RH

更新日期：2000-07-14 00:00:00

abstract：:The carcinogenic compound 2,4,6-trichlorophenol (2,4,6-TCP) was incubated with rat liver S-9 fraction. Three metabolites were identified: 2,6-dichloro-1,4-hydroquinone (DHQ), and two isomers of hydroxypentachlorodiphenyl ether (OH-Cl5-DPE). The latter are probably products of microsomal .OH radical attack on the trich...

journal_title：Chemico-biological interactions

authors： Juhl U,Blum K,Witte I

更新日期：1989-01-01 00:00:00

abstract：:The effects of benzoflavones on skin tumor initiation by polycyclic hydrocarbons and epidermal aryl hydrocarbon hydroxylase were investigated. 7,8-Benzoflavone (7,8-BF) was found to be a potent inhibitor of the inhibition of skin tumors by 3-methylcholanthrene (MC) as well as 7,12-dimethylbenz(a)anthracene (DMBA). 5,6...

journal_title：Chemico-biological interactions

authors： Slaga TJ,Thompson S,Berry DL,Digiovanni J,Juchau MR,Viaje A

更新日期：1977-06-01 00:00:00

abstract：:Mode of interaction of mercuric mercury and selenite in rabbit blood was investigated in vitro. After the incubation of rabbit blood with 10(-5) M each of 203HgCl2 and Na2(75)SeO3, the amounts of both 203Hg and 75Se incorporated into erythrocytes were markedly larger than the case where the blood was treated separatel...

journal_title：Chemico-biological interactions

authors： Naganuma A,Imura N

更新日期：1983-03-01 00:00:00

abstract：:It was aimed to identify the cytochrome(s) P450 (CYPs) involved in the N-demethylation and N-oxidation of clozapine (CLZ) by various approaches using human liver microsomes or microsomes from human B-lymphoblastoid cell lines. The maximum rates of formation were measured in the microsomal fraction of human livers and ...

journal_title：Chemico-biological interactions

authors： Tugnait M,Hawes EM,McKay G,Eichelbaum M,Midha KK

更新日期：1999-04-01 00:00:00

abstract：:Selenocysteine Se-conjugates (e.g. methylselenocysteine) have been shown to be potent chemopreventive and chemoprotective agents, and inducers of apoptosis. Although the mechanism of action remains to be elucidated, beta-elimination of these compounds by beta-lyase enzymes into corresponding selenols, pyruvate and amm...

journal_title：Chemico-biological interactions

authors： Rooseboom M,Vermeulen NP,Groot EJ,Commandeur JN

更新日期：2002-08-15 00:00:00

abstract：:In a preliminary study screening anti-proliferative natural alkaloids, a very potent benzophenanthridine, chelidonine showed strong cytotoxicity in cancer cells. While several modes of death have been identified, most of anti-cancer attempts have focused on stimulation of cells to undergo apoptosis. Chelidonine seems ...

journal_title：Chemico-biological interactions

authors： Noureini SK,Esmaili H

更新日期：2014-11-05 00:00:00

abstract：:Dietary flavonoid quercetin has been suggested as a cancer chemopreventive agent, but the mechanisms of action remain unclear. This study investigated the influence of quercetin on p38-MAPK and the potential regulation of the nuclear transcription factor erythroid-2p45-related factor (Nrf2) and the cellular antioxidan...

journal_title：Chemico-biological interactions

authors： Granado-Serrano AB,Martín MA,Bravo L,Goya L,Ramos S

更新日期：2012-01-25 00:00:00

abstract：:To evaluate the protective role of cell glutathione (GSH) against the toxicity of cadmium, the effect of GSH depletion on the metal toxicity was investigated and the role of glutathione was compared with that of zinc-induced metallothioneins (MTs). A 6-h incubation of cultured Chinese hamster V79 cells with 0.2 mM L-b...

journal_title：Chemico-biological interactions

authors： Ochi T,Otsuka F,Takahashi K,Ohsawa M

更新日期：1988-01-01 00:00:00

abstract：:Butyrylcholinesterase (BChE) has been associated to body mass index (BMI), weight, cholesterol and triglyceride levels. -116A (rs1126680) and K (A539T, 1615A, rs1803274) BCHE gene variants had previously been associated to BChE activity, weight and BMI variance in adults. The present study examined -116A and K variant...

journal_title：Chemico-biological interactions

authors： Chaves TJ,Leite N,Milano GE,Milano GE,Souza RL,Chautard-Freire-Maia EA,Furtado-Alle L

更新日期：2013-03-25 00:00:00

abstract：:Medium-chain dehydrogenases/reductases (MDR) alcohol dehydrogenases exhibit multiple forms through a number of gene duplications. A crucial duplication was the one leading from the glutathione-dependent formaldehyde dehydrogenase line to the liver alcohol dehydrogenase (ADH) lines of vertebrates, the first duplication...

journal_title：Chemico-biological interactions

authors： Jörnvall H,Shafqat J,Persson B

更新日期：2001-01-30 00:00:00

abstract：:Osteoporosis is accompanied by insufficient osteogenic capacity. Several lines of evidence suggested that solutions to enhance osteoblastogenesis were important strategies for osteoporotic bone defect repair. This study investigated the effect of combined treatment with vitamin K2 and PTH on bone formation in calvaria...

journal_title：Chemico-biological interactions

authors： Weng SJ,Yan DY,Gu LJ,Chen L,Xie ZJ,Wu ZY,Tang JH,Shen ZJ,Li H,Bai BL,Boodhun V,Yang L

更新日期：2019-02-25 00:00:00

abstract：:In this study, the presence of paraoxonase activity in pericardial fluid was demonstrated. A comparison of some properties, such as optimum pH, stability versus pH, heat inactivation, effect of inhibitors, isoelectric point and kinetic parameters (Km and Vmax), between plasma and pericardial fluid paraoxonase was made...

journal_title：Chemico-biological interactions

authors： Hernández AF,Pla A,Valenzuela A,Gil F,Villanueva E

更新日期：1993-06-01 00:00:00

abstract：:2,4,6-Triphenyldioxane-1,3 (TPD) is a highly effective species-specific inducer of CYP2В in rats. Several analogs of TPD were synthesized to verify a hypothesis that minor changes in the inducer structure can cause changes in induction abilities (R=H, cisTPD and transTPD; R=N(CH(3))(2), transpDMA; R=NO(2), transpNO(2)...

journal_title：Chemico-biological interactions

authors： Pustylnyak V,Yarushkin A,Kachaylo E,Slynko N,Lyakhovich V,Gulyaeva L

更新日期：2011-07-15 00:00:00