Abstract:
:The present study was undertaken to assess the effect of imatinib mesylate; a tyrosine kinase inhibitor and a well-known anticancer with numerous medical benefits on blood sugar levels, insulin, and glucagon secretion in an experimental model of STZ-induced diabetes mellitus. Type 1 diabetes mellitus (T1DM) was induced by a single I.P. injection of Streptozotocin (STZ) (50 mg/kg) in male Sprague-Dawley rats. Daily oral imatinib (10 mg/kg) and (20 mg/kg) for 4 weeks induced a significant attenuation in signs of DM in rats reflected in their assessed lab values. Biomarkers of cell injury, tissue necrosis, and apoptosis; caspase-3 were significantly reduced with imatinib treatment. Furthermore, pancreatic antioxidants defenses of which; superoxide dismutase (SOD) and catalase activities, reduced glutathione (GSH) concentration, and total antioxidant capacity have significantly improved with a simultaneous reduction in malondialdehyde (MDA) content. Histopathologically, imatinib treatment was associated with a minimal pancreatic injury and marked restoration of insulin content in β-cells. Moreover, imatinib treatment revealed a significant reduction in the infiltration of macrophages in β-cells. Imatinib's ameliorative impact on DM may be attributed to it's mediated protection and preservation of pancreatic β-cells function and the improvement in serum insulin levels and hence the improvement of blood glucose and overall glycemic control.
journal_name
Chem Biol Interactjournal_title
Chemico-biological interactionsauthors
Samaha MM,Said E,Salem HAdoi
10.1016/j.cbi.2020.109197subject
Has Abstractpub_date
2020-09-01 00:00:00pages
109197eissn
0009-2797issn
1872-7786pii
S0009-2797(20)30728-6journal_volume
328pub_type
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journal_title:Chemico-biological interactions
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journal_title:Chemico-biological interactions
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