Abstract：
:Structure-uncoupling activity relationship of seven anthraquinone derivatives were investigated using rat liver mitochondria. Three compounds bearing the free hydroxyl group at the beta-position of their anthraquinone nucleus (1,3,6,8-tetrahydroxyanthraquinone, 1-acetyl-2,4,5,7-tetrahydroxy-9,10-anthracenedione and skyrin) exhibited uncoupling effect. Rugulosin, rugulin and physcion (all lacking the hydroxyl at the beta-position) were ineffective. Erythroglaucin, a derivative of physcion with the free hydroxyl group at the gamma-position, exhibited the highest uncoupling activity in the series tested. In addition, erythroglaucin abolished the energy dependent Ca2+ retention in mitochondria and induced Ca2+ leak. It also prevented the energization of mitochondrial membrane by ATP and induced a loss of the ATP induced membrane potential similarly as did carbonylcyanamide-3-chlorophenyl hydrazone (CCCP). The data show that the free hydroxyl group at either the gamma-position or the beta-position of anthraquinone nucleus is a prerequisite of the uncoupling activity of hydroxyanthraquinones.
journal_name
Chem Biol Interactjournal_title
Chemico-biological interactionsauthors
Betina V,Kuzela Sdoi
10.1016/0009-2797(87)90089-5subject
Has Abstractpub_date
1987-01-01 00:00:00pages
179-89issue
2eissn
0009-2797issn
1872-7786pii
0009-2797(87)90089-5journal_volume
62pub_type
杂志文章abstract：:2-Nitropropane (2-NP) is a genotoxicant and hepatocarcinogen in rodents. Conversion to propane 2-nitronate (P2N), the anion of the tautomeric aci form of 2-NP, seems to be a pivotal part of the mechanism by which 2-NP causes its toxicity. We tested the hypothesis that the tautomeric equilibrium is influenced by enzyme...
journal_title：Chemico-biological interactions
pub_type： 杂志文章
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journal_title：Chemico-biological interactions
pub_type： 杂志文章
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journal_title：Chemico-biological interactions
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doi：10.1016/0009-2797(94)90020-5
更新日期：1994-12-01 00:00:00
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journal_title：Chemico-biological interactions
pub_type： 杂志文章
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更新日期：2011-05-30 00:00:00
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journal_title：Chemico-biological interactions
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更新日期：2010-03-19 00:00:00
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journal_title：Chemico-biological interactions
pub_type： 杂志文章,评审
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journal_title：Chemico-biological interactions
pub_type： 杂志文章
doi：10.1016/0009-2797(95)03618-v
更新日期：1995-08-18 00:00:00
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journal_title：Chemico-biological interactions
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doi：10.1016/j.cbi.2008.05.016
更新日期：2008-07-30 00:00:00
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journal_title：Chemico-biological interactions
pub_type： 杂志文章
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更新日期：1984-06-01 00:00:00
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journal_title：Chemico-biological interactions
pub_type： 杂志文章
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更新日期：2008-09-25 00:00:00
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journal_title：Chemico-biological interactions
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更新日期：2005-12-15 00:00:00
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journal_title：Chemico-biological interactions
pub_type： 杂志文章
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更新日期：1992-01-01 00:00:00
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journal_title：Chemico-biological interactions
pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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journal_title：Chemico-biological interactions
pub_type： 杂志文章
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更新日期：1978-01-01 00:00:00
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journal_title：Chemico-biological interactions
pub_type： 杂志文章
doi：10.1016/j.cbi.2016.09.010
更新日期：2016-10-25 00:00:00
abstract：:Rat hepatic hydroxysteroid sulfotransferase with sulfoconjugates androsterone (androsterone-sulfating sulfotransferase) is an oligomer consisting of several subunits with distinct pI values but with the same molecular mass (pI variants). N-terminal amino acid sequences of the pI variants are all identical. The enzyme ...
journal_title：Chemico-biological interactions
pub_type： 杂志文章
doi：10.1016/0009-2797(94)90049-3
更新日期：1994-06-01 00:00:00
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journal_title：Chemico-biological interactions
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更新日期：2015-10-05 00:00:00
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journal_title：Chemico-biological interactions
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更新日期：2010-10-06 00:00:00
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journal_title：Chemico-biological interactions
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更新日期：2009-01-15 00:00:00
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journal_title：Chemico-biological interactions
pub_type： 杂志文章
doi：10.1016/0009-2797(91)90057-e
更新日期：1991-01-01 00:00:00
abstract：:Human serum paraoxonase/arylesterase (PON1, EC 3.1.8.1.) is a calcium-dependent enzyme which hydrolyzes a wide variety of organophosphates, including paraoxon, DFP, sarin and soman. Although the 3-D structure of PON has not yet been determined and its sequence shows no similarity with any other crystallized proteins, ...
journal_title：Chemico-biological interactions
pub_type： 杂志文章
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更新日期：1999-05-14 00:00:00
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journal_title：Chemico-biological interactions
pub_type： 杂志文章
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更新日期：1976-07-01 00:00:00
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journal_title：Chemico-biological interactions
pub_type： 杂志文章
doi：10.1016/j.cbi.2008.05.014
更新日期：2008-08-11 00:00:00
abstract：:Epigallocatechin-3-gallate (EGCG), a tea polyphenol, inhibits the proliferation of many cancer cell lines; however, the antiproliferative mechanism(s) are not well-characterized. The objective of this study is to identify the cellular signaling mechanism(s) responsible for the antiproliferative effects of EGCG in the ...
journal_title：Chemico-biological interactions
pub_type： 杂志文章
doi：10.1016/j.cbi.2007.09.001
更新日期：2008-01-10 00:00:00
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journal_title：Chemico-biological interactions
pub_type： 杂志文章,评审
doi：10.1016/j.cbi.2019.108917
更新日期：2020-01-25 00:00:00
abstract：:Tumor angiogenesis and PI3K/Akt/mTOR pathway are two major molecular objectives for the treatment and management of breast cancer. Here we first time report the molecular mechanism of a marine sponge alkaloid derivative 4-chloro fascapysin (4-CF) for its anticancer and antiangiogenesis potential. It simultaneously tar...
journal_title：Chemico-biological interactions
pub_type： 杂志文章
doi：10.1016/j.cbi.2017.07.017
更新日期：2017-09-25 00:00:00
abstract：:Formic acid is a common organic acid used in many industrial processes. There is a paucity of research on the direct toxicity of formic acid and how it might affect the cardiovascular system. This study aimed to understand the effect of formic acid on vascular tension in an animal model and the underlying mechanism. R...
journal_title：Chemico-biological interactions
pub_type： 杂志文章
doi：10.1016/j.cbi.2019.06.023
更新日期：2019-08-25 00:00:00
abstract：:The enzymatic oxidation of tetrachloro-1,4-hydroquinone (1,4-TCHQ), resulting in covalent binding to protein of tetrachloro-1,4-benzoquinone (1,4-TCBQ), was investigated, with special attention to the involvement of cytochrome P-450 and reactive oxygen species. 1,4-TCBQ itself reacted very rapidly and extensively with...
journal_title：Chemico-biological interactions
pub_type： 杂志文章
doi：10.1016/0009-2797(88)90110-x
更新日期：1988-01-01 00:00:00
abstract：:Sophoricoside (SOPH) is an isoflavone glycoside isolated from the fruits of Sophora japonica. Since its first isolation in 1961, there are rare findings about the effects of SOPH on reproductive system. In the present study, the pregnant mice administrated by different doses of SOPH were used to explore the effect of ...
journal_title：Chemico-biological interactions
pub_type： 杂志文章
doi：10.1016/j.cbi.2014.05.009
更新日期：2014-08-05 00:00:00
