Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions.


:Risperidone has been used in some stress disorders and may be potentially protective against stress-induced gastric lesions. Thus, the aim of the present study is to investigate, whether risperidone, a D(2) receptor and 5-HT(2A) receptor antagonist, would be able to result in gastroprotective effect in stress-induced lesions and also explore the possible mechanism of action behind its gastroprotective activity. Gastroprotective activity of risperidone was evaluated both by single treatment and 21 days repeated (0.03, 0.1, 0.3 and 1mg/kg, p.o.) treatment in the cold restraint stress (CRS) model and 21 days repeated treatment in the pyloric ligation (PL) model and compared with that of sulpiride (D(2) receptor antagonist) and ketanserin (5-HT(2) receptor antagonist) as standard. Histopathological assessment was done to evaluate the gastroprotective activity of risperidone in CRS model. The roles of nitric oxide (NO), sulfhydryl (SH) group, ATP-sensitive K(+) channels (K(ATP) channels) and prostaglandins (PGs) in the gastroprotective effect of risperidone against CRS were also investigated. PGE(2), hexosamine as a marker of mucus barrier and microvascular permeability were also estimated. Results show that repeated treatment of risperidone, sulpiride and ketanserin exhibited a gastroprotective effect against CRS-induced lesions while single administration of risperidone was found to be ineffective. Moreover, repeated treatment of risperidone and ketanserin was found to be ineffective in case of PL in contrast to sulpiride. Risperidone pretreatment reverses the stress induced alteration in hexosamine, PGE(2) and microvascular permeability. Pretreatment with l-NAME, NEM, glibenclamide and indomethacin reversed the gastroprotective effect of risperidone. The results suggest that risperidone has significant gastroprotective effects in CRS-induced gastric lesions models, which appears to be mediated by endogenous NO, SH, PGs and K(ATP) channel opening.


Chem Biol Interact


Saxena B,Krishnamurthy S,Singh S




Has Abstract


2011-04-25 00:00:00














  • The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase.

    abstract::The anticancer prodrug CPT-11 is a highly effective camptothecin analog that has been approved for the treatment of colon cancer. The 2.6 angstroms resolution crystal structure of its complex with Torpedo californica acetylcholinesterase (TcAChE) demonstrates that CPT-11 binds to TcAChE and spans its gorge similarly t...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Harel M,Hyatt JL,Brumshtein B,Morton CL,Wadkins RM,Silman I,Sussman JL,Potter PM

    更新日期:2005-12-15 00:00:00

  • Excretion of copper complexed with thiomolybdate into the bile and blood in LEC rats.

    abstract::Copper (Cu) accumulating in a form bound to metallothionein (MT) in the liver of Long-Evans rats with a cinnamon-like coat color (LEC rats), an animal model of Wilson disease, was removed with ammonium tetrathiomolybdate (TTM), and the fate of the Cu complexed with TTM and mobilized from the liver was determined. TTM ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Komatsu Y,Sadakata I,Ogra Y,Suzuki KT

    更新日期:2000-02-01 00:00:00

  • Inhibition of human prostatic tumour acid phosphatase by N,N-p-di-2-chloroethylaminophenol, N,N-p-di-2-chloroethylaminophenyl phosphate and other difunctional nitrogen mustards.

    abstract::Potent inhibition of human prostatic carcinoma tissue acid phosphatase by N,N-d-di-2-chloroethylaminophenol (AMOH) and N,N-p-di-2-chloroethylaminophenyl phosphate (AMPh) is described. Certain other difunctional nitrogen mustards were also inhibitory but N,N-p-di-2hydroxyethylaminophenol, the non-alkylating fully hydro...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Workman P

    更新日期:1978-01-01 00:00:00

  • The diversity of microbial aldo/keto reductases from Escherichia coli K12.

    abstract::The genome of Escherichia coli K12 contains 9 open reading frames encoding aldo/keto reductases (AKRs) that are differentially regulated and sequence diverse. A significant amount of data is available for the E. coli AKRs through the availability of gene knockouts and gene expression studies, which adds to the biochem...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Lapthorn AJ,Zhu X,Ellis EM

    更新日期:2013-02-25 00:00:00

  • Anti-cocaine antibody and butyrylcholinesterase-derived cocaine hydrolase exert cooperative effects on cocaine pharmacokinetics and cocaine-induced locomotor activity in mice.

    abstract::We are investigating treatments for cocaine abuse based on viral gene transfer of a cocaine hydrolase (CocH) derived from human butyrylcholinesterase, which can reduce cocaine-stimulated locomotion and cocaine-primed reinstatement of drug-seeking behavior in rats for many months. Here, in mice, we explored the possibi...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Brimijoin S,Orson F,Kosten TR,Kinsey B,Shen XY,White SJ,Gao Y

    更新日期:2013-03-25 00:00:00

  • Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehyde.

    abstract::NADP(H)-dependent cytosolic aldo-keto reductases (AKR) are mostly monomeric enzymes which fold into a typical (α/β)(8)-barrel structure. Substrate specificity and inhibitor selectivity are determined by interaction with residues located in three highly variable loops (A, B, and C). Based on sequence identity, AKR have...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Ruiz FX,Moro A,Gallego O,Ardèvol A,Rovira C,Petrash JM,Parés X,Farrés J

    更新日期:2011-05-30 00:00:00

  • A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters.

    abstract::Wild-type human butyrylcholinesterase (BuChE) has proven to be an efficient bioscavenger for protection against nerve agent toxicity. Human acetylcholinesterase (AChE) has a similar potential. A limitation to their usefulness is that both cholinesterases (ChEs) react stoichiometrically with organophosphosphorus (OP) e...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Masson P,Nachon F,Broomfield CA,Lenz DE,Verdier L,Schopfer LM,Lockridge O

    更新日期:2008-09-25 00:00:00

  • Mitochondrial involvement in genetically determined transition metal toxicity II. Copper toxicity.

    abstract::Copper, like iron, is an essential transition metal ion in which its redox reactivity, whilst essential for the activity of mitochondrial enzymes, can also be a source of harmful reactive oxygen species if not chelated to biomolecules. Therefore, both metals are sequestered by protein chaperones and moved across membr...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审


    authors: Mehta R,Templeton DM,O'brien PJ

    更新日期:2006-10-27 00:00:00

  • Prevention of prostate cancer through custom tailoring of chemopreventive regimen.

    abstract::One practical way to control cancer is through chemoprevention, which refers to the administration of synthetic or naturally occurring agents to block, reverse or delay the process of carcinogenesis. For a variety of reasons, the most important of which is human acceptance, for chemopreventive intervention naturally o...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审


    authors: Siddiqui IA,Afaq F,Adhami VM,Mukhtar H

    更新日期:2008-01-30 00:00:00

  • The in vitro interaction with DNA of several hypoxic radiosensitizers.

    abstract::The five 5-nitroimidazole derivatives and the four glyoxylic compounds tested in this paper for their interaction with DNA with and without irradiation had previously been reported to act as radiosensitizers at a cellular level. Our aim was to find if the radiosensitizing activity of these products could be due to the...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Santos Peinado L,Cornago Ramirez P,Lopez Zumel C

    更新日期:1989-01-01 00:00:00

  • Involvement of PI3K/Akt/GSK-3β signaling pathway in the antidepressant-like and neuroprotective effects of Morus nigra and its major phenolic, syringic acid.

    abstract::Depression is a common neuropsychiatric disorder whose pathophysiology has been associated with glutamatergic excitotoxicity. Thus, the research for new antidepressant strategies with the ability to mitigate glutamate toxicity has received growing attention. Given this background, the present study sought to investiga...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Dalmagro AP,Camargo A,Severo Rodrigues AL,Zeni ALB

    更新日期:2019-12-01 00:00:00

  • Trikatu, an herbal compound ameliorates rheumatoid arthritis by the suppression of inflammatory immune responses in rats with adjuvant-induced arthritis and on cultured fibroblast like synoviocytes via the inhibition of the NFκB signaling pathway.

    abstract::The present study was designed to investigate the potential therapeutic effect of trikatu, an herbal compound and its underlying molecular mechanism in rats with adjuvant-induced arthritis (AIA). Our results indicate that trikatu (1000 mg/kg/b.wt. oral) administration suppressed the production of pro-inflammatory cyto...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Doss HM,Ganesan R,Rasool M

    更新日期:2016-10-25 00:00:00

  • Ghrelin regulates adipose tissue metabolism: Role in hepatic steatosis.

    abstract::Fatty liver is the earliest and most common response of the liver to consumption of excessive alcohol. Steatosis can predispose the fatty liver to develop progressive liver damage. Chief among the many mechanisms involved in development of hepatic steatosis is dysregulation of insulin-mediated adipose tissue metabolis...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Rasineni K,Kubik JL,Knight KL,Hall L,Casey CA,Kharbanda KK

    更新日期:2020-05-01 00:00:00

  • Mechanism of apicidin-induced cell cycle arrest and apoptosis in Ishikawa human endometrial cancer cells.

    abstract::Histone deacetylase (HDAC) inhibitors are a promising new class of anticancer agents that act by inhibiting cell proliferation and inducing apoptosis in a variety of cancer cells. Although apicidin acts as a potent HDAC inhibitor, the precise mechanism for its anti-tumor activity in human endometrial cancer cells is n...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Ahn MY,Lee J,Na YJ,Choi WS,Lee BM,Kang KW,Kim HS

    更新日期:2009-05-15 00:00:00

  • Combined effect of vanadium(V) and chromium(III) on lipid peroxidation in liver and kidney of rats.

    abstract::Since chromium(III) was demonstrated to have antioxidative action, we have decided to study the effect of this element on V-induced LPO in liver and kidney of rats. Outbred 2-month-old, albino male Wistar rats received daily, for a period of 12 weeks: group I (control), deionized water to drink; group II, sodium metav...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Scibior A,Zaporowska H,Ostrowski J,Banach A

    更新日期:2006-02-25 00:00:00

  • Inhibitory effect of mabuterol on proliferation of rat ASMCs induced by PDGF-BB via regulating [Ca2+]i and mitochondrial fission/fusion.

    abstract::This study is aimed to investigate whether Mabuterol (Mab) inhibits proliferation of airway smooth muscle cells (ASMCs) induced by platelet-derived growth factor BB (PDGF-BB) and how far it is related to mitochondrial fission/fusion and intracellular calcium if it comes into play. To explore the mechanism of Mab's ant...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Gu Y,Yu X,Li X,Wang X,Gao X,Wang M,Wang S,Li X,Zhang Y

    更新日期:2019-07-01 00:00:00

  • Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes.

    abstract::Dioxinodehydroeckol (DHE) isolated from Ecklonia cava, has previously been investigated for its inhibition of the differentiation of 3T3-L1 preadipocytes into adipocytes. Levels of lipid accumulation were measured, along with changes in the expression of genes and proteins associated with adipogenesis and lipolysis. C...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Kim SK,Kong CS

    更新日期:2010-06-07 00:00:00

  • iTRAQ-based quantitative proteomics discovering potential serum biomarkers in locoweed poisoned rabbits.

    abstract::Locoism threatens the sustainable development of animal husbandry in areas around the world with intensified desertification, especially in the western United States, western China, Canada, and Mexico, among other countries. This study was conducted to discover potential serum biomarkers in locoweed-poisoned rabbits a...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Jiao J,Wang S,Zhang R,Ma Z,Du G,Chen X,Tao D,Zhao J

    更新日期:2017-04-25 00:00:00

  • Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38.

    abstract::Dietary flavonoid quercetin has been suggested as a cancer chemopreventive agent, but the mechanisms of action remain unclear. This study investigated the influence of quercetin on p38-MAPK and the potential regulation of the nuclear transcription factor erythroid-2p45-related factor (Nrf2) and the cellular antioxidan...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Granado-Serrano AB,Martín MA,Bravo L,Goya L,Ramos S

    更新日期:2012-01-25 00:00:00

  • HTLV-1 Tax: Linking transformation, DNA damage and apoptotic T-cell death.

    abstract::The human T-cell leukemia virus type I (HTLV-1) is the causative agent of adult T-cell leukemia (ATL), an aggressive CD4-positive T-cell neoplasia. The HTLV-1 proto-oncogene Tax, a potent transcriptional activator of cellular and viral genes, is thought to play a pivotal role in the transforming properties of the viru...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审


    authors: Chlichlia K,Khazaie K

    更新日期:2010-11-05 00:00:00

  • Aliskiren - A promising antioxidant agent beyond hypertension reduction.

    abstract::The renin-angiotensin-aldosterone system (RAAS) is a hormonal system that has a critical role in maintaining the normotensive state and electrolyte balance of the organism. The RAAS also has an important influence in the development of various pathophysiological conditions especially those concerning the renal system,...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审


    authors: Alshahrani S

    更新日期:2020-08-01 00:00:00

  • Biochemical changes after hepatic injury by allyl alcohol and N-hydroxy-2-acetylaminofluorene.

    abstract::Administration of hepatotoxic doses of allyl alcohol and N-hydroxy-2-acetylaminofluorene (N-OH-AAF) TO adult male rats produced periportal necrosis and functional derangement of the hepatic endoplasmic reticulum within 24 h. The rates of N-demethylation of ethylmorphine and p-hydroxylation of aniline were decreased 6 ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Thorgeirsson SS,Mitchell JR,Sasame HA,Potter WZ

    更新日期:1976-10-02 00:00:00

  • In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications.

    abstract::Catalytic scavengers of organophosphates (OPs) are considered very promising antidote candidates for preventing the adverse effects of OP intoxication as stand alone treatments. This study aimed at correlating the in-vivo catalytic efficiency ((kcat/KM)[Enzyme]pl), established prior to the OP challenge, with the sever...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Ashani Y,Leader H,Aggarwal N,Silman I,Worek F,Sussman JL,Goldsmith M

    更新日期:2016-11-25 00:00:00

  • Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress.

    abstract::Malignant gliomas are the most common primary brain tumors, and novel ways of treating gliomas are urgently needed. Ursolic acid (UA), a pentacyclic triterpenoid, has been reported to exhibit promising antitumor activity. Here, we evaluated the effects of UA on U87MG cells and explored the underlying molecular mechani...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Shen S,Zhang Y,Zhang R,Tu X,Gong X

    更新日期:2014-07-25 00:00:00

  • Peroxisome proliferator-activated receptor alpha agonist, clofibrate, has profound influence on myocardial fatty acid composition.

    abstract::The hypolipidemic fibrates have been identified as agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha), which plays a critical role in the regulation of cardiac fatty acid metabolism. Despite the widespread clinical use of fibrates, their role in myocardial oxidative stress and fatty acid comp...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Tian Q,Grzemski FA,Panagiotopoulos S,Ahokas JT

    更新日期:2006-04-15 00:00:00

  • Spectral interactions of tetrachlorobiphenyls with hepatic microsomal cytochrome p450 enzymes.

    abstract::This study investigated the spectral interactions of hepatic microsomal cytochrome p450 (CYP) enzymes with four symmetrical polychlorinated biphenyls (PCBs): 2,2',4,4'-tetrachlorobiphenyl (PCB 47); 2,2',5,5'-tetrachlorobiphenyl (PCB 52); 2,2',6,6'-tetrachlorobiphenyl (PCB 54); and 3,3',4,4'-tetrachlorobiphenyl (PCB 77...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Hrycay EG,Bandiera SM

    更新日期:2003-12-15 00:00:00

  • Human serum paraoxonase (PON1): identification of essential amino acid residues by group-selective labelling and site-directed mutagenesis.

    abstract::Human serum paraoxonase/arylesterase (PON1, EC is a calcium-dependent enzyme which hydrolyzes a wide variety of organophosphates, including paraoxon, DFP, sarin and soman. Although the 3-D structure of PON has not yet been determined and its sequence shows no similarity with any other crystallized proteins, ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Josse D,Xie W,Masson P,Lockridge O

    更新日期:1999-05-14 00:00:00

  • Melatonin exerts a more potent effect than S-adenosyl-l-methionine against iron metabolism disturbances, oxidative stress and tissue injury induced by obstructive jaundice in rats.

    abstract::Melatonin and S-adenosyl-l-methionine (SAMe) prevent oxidative stress and tissue dysfunction in obstructive jaundice (OJ). Lipid peroxidation is exacerbated in the presence of trace amounts of iron (Fe). The study investigated the regulation by melatonin and SAMe the induction of oxidative stress, iron metabolism dist...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Muñoz-Castañeda JR,Túnez I,Herencia C,Ranchal I,González R,Ramírez LM,Arjona A,Barcos M,Espejo I,Cruz A,Montilla P,Padillo FJ,Muntané J

    更新日期:2008-07-30 00:00:00

  • Biological and toxicological consequences of quinone methide formation.

    abstract::Quinone methides are a class of reactive, electrophilic compounds which are capable of alkylating cellular macromolecules. They are formed during xenobiotic biotransformation reactions and are hypothesized to mediate the toxicity of a large number of quinone antitumor drugs as well as several alkylphenols. In addition...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审


    authors: Thompson DC,Thompson JA,Sugumaran M,Moldéus P

    更新日期:1993-02-01 00:00:00

  • Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2.

    abstract::Monomeric carbonyl reductase 1 (CBR1, SDR21C1) is a member of the short-chain dehydrogenase/reductase superfamily and is involved in the metabolism of anthracycline anti-cancer drugs, prostaglandins, and isatin, which is an endogenous inhibitor of monoamine oxidases. Additionally, cancer progression may be partly regu...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Miura T,Taketomi A,Nishinaka T,Terada T

    更新日期:2013-02-25 00:00:00