Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions.


:Risperidone has been used in some stress disorders and may be potentially protective against stress-induced gastric lesions. Thus, the aim of the present study is to investigate, whether risperidone, a D(2) receptor and 5-HT(2A) receptor antagonist, would be able to result in gastroprotective effect in stress-induced lesions and also explore the possible mechanism of action behind its gastroprotective activity. Gastroprotective activity of risperidone was evaluated both by single treatment and 21 days repeated (0.03, 0.1, 0.3 and 1mg/kg, p.o.) treatment in the cold restraint stress (CRS) model and 21 days repeated treatment in the pyloric ligation (PL) model and compared with that of sulpiride (D(2) receptor antagonist) and ketanserin (5-HT(2) receptor antagonist) as standard. Histopathological assessment was done to evaluate the gastroprotective activity of risperidone in CRS model. The roles of nitric oxide (NO), sulfhydryl (SH) group, ATP-sensitive K(+) channels (K(ATP) channels) and prostaglandins (PGs) in the gastroprotective effect of risperidone against CRS were also investigated. PGE(2), hexosamine as a marker of mucus barrier and microvascular permeability were also estimated. Results show that repeated treatment of risperidone, sulpiride and ketanserin exhibited a gastroprotective effect against CRS-induced lesions while single administration of risperidone was found to be ineffective. Moreover, repeated treatment of risperidone and ketanserin was found to be ineffective in case of PL in contrast to sulpiride. Risperidone pretreatment reverses the stress induced alteration in hexosamine, PGE(2) and microvascular permeability. Pretreatment with l-NAME, NEM, glibenclamide and indomethacin reversed the gastroprotective effect of risperidone. The results suggest that risperidone has significant gastroprotective effects in CRS-induced gastric lesions models, which appears to be mediated by endogenous NO, SH, PGs and K(ATP) channel opening.


Chem Biol Interact


Saxena B,Krishnamurthy S,Singh S




Has Abstract


2011-04-25 00:00:00














  • Biochemical changes after hepatic injury by allyl alcohol and N-hydroxy-2-acetylaminofluorene.

    abstract::Administration of hepatotoxic doses of allyl alcohol and N-hydroxy-2-acetylaminofluorene (N-OH-AAF) TO adult male rats produced periportal necrosis and functional derangement of the hepatic endoplasmic reticulum within 24 h. The rates of N-demethylation of ethylmorphine and p-hydroxylation of aniline were decreased 6 ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Thorgeirsson SS,Mitchell JR,Sasame HA,Potter WZ

    更新日期:1976-10-02 00:00:00

  • Lack of effect of glutathione depletion on cytotoxicity, mutagenicity and DNA damage produced by doxorubicin in cultured cells.

    abstract::Since endogenous glutathione (GSH), the main non-protein intracellular thiol compound, is known to provide protection against reactive radical species, its depletion by diethylmaleate (DEM) was used to assess the role of free radical formation mediated by doxorubicin in DNA damage, cytotoxicity and mutagenicity of the...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Capranico G,Babudri N,Casciarri G,Dolzani L,Gambetta RA,Longoni E,Pani B,Soranzo C,Zunino F

    更新日期:1986-02-01 00:00:00

  • Influence of toluene co-exposure on the metabolism and genotoxicity of benzene in mice using continuous and intermittent exposures.

    abstract::Benzene exposure in occupational settings often occurs with concurrent exposure to toluene, the methyl-substituted derivative of benzene. Toluene is also readily metabolized by CYP450 isozymes although oxidation primarily occurs in the methyl group. While earlier mouse studies addressing co-exposure to benzene and tol...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Bird MG,Wetmore BA,Letinski DJ,Nicolich M,Chen M,Schnatter AR,Whitman FT

    更新日期:2010-03-19 00:00:00

  • Interactions between selenium and mercury in mice: marked retention in the lung after inhalation of metallic mercury.

    abstract::The distribution of 203Hg after inhalation of radioactive metallic mercury (4.3 mumol 203Hg0/kg body wt. for 1 h) was studied in saline (control) and selenite (10 mumol/kg body wt. intraperitoneally, i.p.) pretreated male C57BL mice by means of whole-body autoradiography and scintillation counting. Selenite pretreatme...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Khayat A,Dencker L

    更新日期:1983-09-15 00:00:00

  • iTRAQ-based quantitative proteomics discovering potential serum biomarkers in locoweed poisoned rabbits.

    abstract::Locoism threatens the sustainable development of animal husbandry in areas around the world with intensified desertification, especially in the western United States, western China, Canada, and Mexico, among other countries. This study was conducted to discover potential serum biomarkers in locoweed-poisoned rabbits a...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Jiao J,Wang S,Zhang R,Ma Z,Du G,Chen X,Tao D,Zhao J

    更新日期:2017-04-25 00:00:00

  • Interaction of DNA with water soluble complex of Nickle and formation of DNA cross-links.

    abstract::Interaction of double stranded DNA with bulky and hydrophobic Salen type Schiff base complex: [N, N' Bis [3- tert-butyl-5-[triphenyl-phosphonium - methyl] - salicylidene] 1,2 ethylene-diamine nickel(III) acetate (refer to Ni Salen complex) was extensively investigated using the spectroscopic techniques and gel electro...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Nejat Dehkordi M,Akerman B

    更新日期:2018-02-25 00:00:00

  • An evaluation of the CYP1A induction potential of pantoprazole in primary rat hepatocytes: a comparison with other proton pump inhibitors.

    abstract::The ability of pantoprazole to affect the induction of cytochrome P450 (CYP) 1A subfamily was evaluated and compared with two other proton pump inhibitors, omeprazole and lansoprazole, in primary cultured hepatocytes from female Sprague-Dawley rats. The hepatocytes were cultured for 2 days, followed by treatment for 2...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Masubuchi N,Okazaki O

    更新日期:1997-11-06 00:00:00

  • The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism.

    abstract::In human populations, serum paraoxonase (PON1) exhibits a substrate dependent polymorphism. The Arg192 isoform hydrolyzes paraoxon rapidly but diazoxon, soman and especially sarin slowly. On the other hand, the Gln192 isoform hydrolyzes paraoxon slowly, but diazoxon, soman and sarin more rapidly than the Arg192 isofor...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审


    authors: Costa LG,Li WF,Richter RJ,Shih DM,Lusis A,Furlong CE

    更新日期:1999-05-14 00:00:00

  • Iron-mediated effect of alcohol on hepatocyte differentiation in HepaRG cells.

    abstract::The development of alcoholic liver diseases depends on the ability of hepatocyte to proliferate and differentiate in the case of alcohol-induced injury. Our previous work showed an inhibitory effect of alcohol on hepatocyte proliferation. However, the effect of alcohol on hepatocyte differentiation has not yet been pr...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Do TH,Gaboriau F,Cannie I,Batusanski F,Ropert M,Moirand R,Brissot P,Loreal O,Lescoat G

    更新日期:2013-11-25 00:00:00

  • Mechanism of unbalanced growth-induced cell damage. I. A probable role for hydrolytic enzymes synthesis.

    abstract::This study examines the relationship between cell progress into the state of unbalanced growth, hydrolytic enzyme activities and cell survival during the exposure of L5178Y cells to hydroxyurea (HU), excess thymidine (dThR), hydroxyurea with excess of four deoxyribonucleosides (dNR) or excess dTHR with deoxycytidine (...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Malec J,Przybyszewski WM,Grabarczyk M,Sitarska E,Czartoryska B

    更新日期:1986-03-01 00:00:00

  • Inducibility of drug-metabolizing enzymes in the rat skin.

    abstract::The influence of systemic application of chemically unrelated drugs and xenobiotics (phenobarbital (PB), rifampicin (Rifa), pregnenolone-16 alpha-carbonitrile (PCN) and 3-methylcholanthrene (MC) on drug metabolizing enzymes was investigated in the skin of rats of both sexes. The results were compared with those obtain...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Vizethum W,Ruzicka T,Goerz G

    更新日期:1980-08-01 00:00:00

  • Novel and existing data for a future physiological toxicokinetic model of ethylene and its metabolite ethylene oxide in mouse, rat, and human.

    abstract::The olefin ethylene is a ubiquitously found gas. It originates predominantly from plants, combustion processes and industrial sources. In mammals, inhaled ethylene is metabolized by cytochrome P450-dependent monooxygenases, particularly by cytochrome P450 2E1, to ethylene oxide, an epoxide that directly alkylates prot...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Filser JG,Artati A,Li Q,Pütz C,Semder B,Klein D,Kessler W

    更新日期:2015-11-05 00:00:00

  • NADH fluorescence lifetime analysis of the effect of magnesium ions on ALDH2.

    abstract::Aldehyde dehydrogenase 2 (ALDH2) catalyzes oxidation of toxic aldehydes to carboxylic acids. Physiologic levels of Mg(2+) ions influence ALDH2 activity in part by increasing NADH binding affinity. Traditional fluorescence measurements monitor the blue shift of the NADH fluorescence spectrum to study ALDH2-NADH interac...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Gonnella TP,Leedahl TS,Karlstad JP,Picklo MJ

    更新日期:2011-05-30 00:00:00

  • Muscular dystrophy with laminin deficiency decreases acetylcholinesterase activity in thymus of dystrophic Lama2dy mice.

    abstract::We have studied the effect of muscular dystrophy by merosin deficiency on mouse thymus acetyl- (AChE) and butyrylcholinesterase (BuChE). The organ contains AChE and BuChE activities. Merosin deficiency causes an important decrease (46%) in AChE specific activity. Thymus produces dimers, monomers and tetramers of AChE,...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Sánchez del Campo L,Nieto-Cerón S,Muñoz-Delgado E,Vidal CJ,Campoy FJ

    更新日期:2005-12-15 00:00:00

  • Protective effect of fosfomycin on gentamicin-induced lipid peroxidation of rat renal tissue.

    abstract::Fosfomycin is clinically recognized to reduce the aminoglycoside antibiotics-induced nephrotoxicity. However, little has been clarified why fosfomycin protects the kidney from the aminoglycosides-induced nephrotoxicity. Gentamicin, a typical aminoglycoside, is reported to cause lipid peroxidation. We focused on lipid ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Yanagida C,Ito K,Komiya I,Horie T

    更新日期:2004-07-20 00:00:00

  • Therapeutic efficacy of green tea polyphenols on cellular thiols in 4-Nitroquinoline 1-oxide-induced oral carcinogenesis.

    abstract::In cancer, a high flux of oxidants not only depletes the cellular thiols, but damages the whole cell as well. Epidemiological studies suggest green tea may mitigate cancers in human and animal models for which several mechanisms have been proposed. In the present investigation, the levels of cellular thiols such as re...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Srinivasan P,Sabitha KE,Shyamaladevi CS

    更新日期:2004-10-15 00:00:00

  • Selective protection by stably transfected human ALDH3A1 (but not human ALDH1A1) against toxicity of aliphatic aldehydes in V79 cells.

    abstract::Toxic medium chain length alkanals, alkenals, and 4-hydroxyalkenals that are generated during lipid peroxidation are potential substrates for aldehyde dehydrogenase (ALDH) isoforms. We have developed transgenic cell lines to examine the potential for either human ALDH1A1 or ALDH3A1 to protect against damage mediated b...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Townsend AJ,Leone-Kabler S,Haynes RL,Wu Y,Szweda L,Bunting KD

    更新日期:2001-01-30 00:00:00

  • Interactions of safrole and isosafrole and their metabolites with cytochromes P-450.

    abstract::The structural features which determine interaction of safrole and related methylenedioxyphenyl compounds with cytochromes P-450 or P-448, and determine the induction of these two classes of the cytochrome, have been studied. All methylenedioxyphenyl compounds studied interact with both cytochromes P-450 and P-448 eli...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Ioannides C,Delaforge M,Parke DV

    更新日期:1985-05-01 00:00:00

  • Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase.

    abstract::Anthracyclines (ANTs) are widely used in the treatment of various forms of cancer. Although their usage contributes to an improvement in life expectancy, it is limited by severe adverse effects-acute and chronic cardiotoxicity. Several enzymes from both AKR and SDR superfamilies have been reported as participants in t...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Skarka A,Skarydová L,Stambergová H,Wsól V

    更新日期:2011-05-30 00:00:00

  • Trialkyl phosphorothioates and glutathione S-transferases.

    abstract::Using a rat liver cytosol source of enzyme trialkyl phosphorothioates have been shown to be substrates of glutathione S-transferases. Using OSS-trimethyl phosphorodithioate (OSS-Me(O] and OOS-trimethyl phosphorothioate (OOS-Me(O] the methyl transferred to the sulphydryl of glutathione is that attached to phosphorus vi...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Aldridge WN,Grasdalen H,Aarstad K,Street BW,Norkov T

    更新日期:1985-07-01 00:00:00

  • Punarnavine, an alkaloid from Boerhaavia diffusa exhibits anti-angiogenic activity via downregulation of VEGF in vitro and in vivo.

    abstract::Punarnavine, a quinolizidine alkaloid isolated from Boerhaavia diffusa is known to possess analgesic, anti-inflammatory, hepato-protective, immunomodulatory and anti-proliferative properties. However, its roles in tumor angiogenesis and the involved molecular mechanism are still unknown. Therefore, we examined its ant...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Saraswati S,Alhaider AA,Agrawal SS

    更新日期:2013-11-25 00:00:00

  • Induction by butylated hydroxytoluene of rat liver gamma-glutamyl transpeptidase activity in comparison to expression in carcinogen-induced altered lesions.

    abstract::Butylated hydroxytoluene (BHT) at concentrations of 300-6000 ppm in the diet caused a dose-dependent increase in gamma-glutamyl transpeptidase (GGT) activity in normal F344 male rat liver at 18 weeks. However, the activities of glutathione S-transferases (GSTs) of rat liver cytosol were enhanced only at concentrations...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Furukawa K,Maeura Y,Furukawa NT,Williams GM

    更新日期:1984-01-01 00:00:00

  • Structural characterization of the major covalent adduct formed in vitro between acetaminophen and bovine serum albumin.

    abstract::The structure of the covalent adduct formed in vitro between [14C]-acetaminophen ([14C]APAP) and bovine serum albumin (BSA) has been investigated with the aid of new analytical methodology. The APAP-BSA adduct, isolated from mouse liver microsomal incubations to which the radiolabeled drug and BSA had been added, was ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Hoffmann KJ,Streeter AJ,Axworthy DB,Baillie TA

    更新日期:1985-02-01 00:00:00

  • A review of the epidemiology of 1,3-butadiene and chloroprene.

    abstract::Butadiene epidemiologic research has focused primarily on one cohort of workers in the North American styrene-butadiene rubber (SBR) industry and on the largest cohort of workers in the United States butadiene monomer industry. The most recent studies of these populations are characterized by carefully enumerated stud...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章,评审


    authors: Acquavella JF,Leonard RC

    更新日期:2001-06-01 00:00:00

  • Benzene, the exposome and future investigations of leukemia etiology.

    abstract::Benzene exposure is associated with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and probably lymphoma and childhood leukemia. Biological plausibility for a causal role of benzene in these diseases comes from its toxicity to hematopoietic stem cells (HSC) or progenitor cells, from which all leukemias...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Smith MT,Zhang L,McHale CM,Skibola CF,Rappaport SM

    更新日期:2011-06-30 00:00:00

  • Screening of O-ethyl O-4-nitrophenyl phosphoramidate (ENPP) for delayed neuropathic potential.

    abstract::O-Ethyl-O-4-nitrophenylphosphoramidate is a short-acting anticholinesterase and a possible candidate for a prophylactic agent against nerve agents since human acetylcholinesterase inhibited by this agent undergoes rapid spontaneous reactivation which can be accelerated further, if necessary, by treatment with oximes. ...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Johnson MK,Read DJ

    更新日期:1993-06-01 00:00:00

  • 1H-nuclear magnetic resonance of intercalators and rGCA: a potential mutagenicity probe.

    abstract::Variable temperature 1H-nuclear magnetic resonance (NMR) has been used to study the interaction of the RNA trimer, GpCpA, with the intercalators ethidium bromide and the acridine derivatives; proflavin, 9-amino-acridine, acridine orange, acridine yellow and acriflavin. The complexes formed were studied at nucleic acid...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Coddington JM,Alkema D,Bell RA,Hughes DW,Neilson T

    更新日期:1984-06-01 00:00:00

  • Signal transduction mechanism in response to aflatoxin B1 exposure: protein kinase C activity.

    abstract::A single dose of the carcinogen aflatoxin B1 (7 mg/kg body weight) to male Wistar rats significantly enhanced the hepatic activity of protein kinase C in the particulate and nuclear fractions. The particulate fraction showed stimulation at 4 and 7 h, while the nuclear activity was increased at 17 h following administr...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Mistry KJ,Krishna M,Pasupathy K,Murthy V,Bhattacharya RK

    更新日期:1996-03-25 00:00:00

  • Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure.

    abstract::Methylene diphenyl diisocyanate (MDI) is among the leading chemical causes of occupational asthma world-wide, however, the mechanisms of disease pathogenesis remain unclear. This study tests the hypothesis that glutathione (GSH) reacts with MDI to form quasi-stable conjugates, capable of mediating the formation of MDI...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Wisnewski AV,Liu J,Redlich CA

    更新日期:2013-09-05 00:00:00

  • Biopolymer metal catalysts for the hydrolysis of nerve gases.

    abstract::Glucosamine oligomers--monomer through tetramer--form complexes with Cu2+ that catalyse the hydrolysis of the 'nerve gas' 1,2,2-trimethylpropyl- methylphosphonofluroidate (soman) by cleaving the P-F bond. A 1/1 glucosamine/Cu2+ ratio whether as glucosamine or glucosamine units, gives the highest hydrolytic rate over t...

    journal_title:Chemico-biological interactions

    pub_type: 杂志文章


    authors: Hoskin FC,Rajan KS,Remy D,Walker JE

    更新日期:1993-06-01 00:00:00