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Effect of methylglyoxal on Bufo bufo embryo development: morphological and biochemical aspects.

Abstract：

:Methylglyoxal (2-oxopropanal) is a cytotoxic compound that can be formed endogenously as a by-product of glycolytic pathway; so its concentration is expected to increase when glycolysis activity increases such as during embryo development. In this work we study the effect of exogenous methylglyoxal on development and embryo viability during Bufo Bufo development and on the enzymes and cofactors involved in its detoxication process (glyoxalase I and II, reduced glutathione and glyceraldehyde 3-phosphate dehydrogenase). The results show that exogenous methylglyoxal does not affect the enzymatic pattern until stage 20, while it induces a significant activity decrease of the tested enzymes at stage 25. On the contrary methylglyoxal positively influences the reduced glutathione concentration at all the considered stages. At morphological and histological levels methylglyoxal causes a strong retardation of cell division in the early stages, that results in various abnormalities in the late development. In conclusion, methylglyoxal enters the embryo and is antiproliferative and teratogenic: the data further supports the hypothesis of the importance of the glyoxalase system in the process of cell growth and division.

journal_name

Chem Biol Interact

journal_title

Chemico-biological interactions

authors

Amicarelli F,Bonfigli A,Colafarina S,Bucciarelli T,Principato G,Ragnelli AM,Di Ilio C,Miranda M

doi

10.1016/s0009-2797(98)00048-9

subject

Has Abstract

pub_date

1998-07-24 00:00:00

pages

177-89

issue

3

eissn

0009-2797

issn

1872-7786

pii

S0009279798000489

journal_volume

114

pub_type

杂志文章

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