Inhibitory effect of hemin on mutagenicity of the electrophilic sulfuric acid ester of 6-hydroxymethylbenzo[a]pyrene.

abstract：:4-Trifluoromethylphenol (4-TFMP) was cytotoxic to precision-cut rat liver slices as indicated by loss of intracellular potassium. Intracellular glutathione levels decreased and fluoride ion levels increased in a time and concentration-dependent manner. The cytotoxicity of 4-TFMP did not appear to be due to the release...

journal_title：Chemico-biological interactions

authors： Thompson DC,Perera K,London R

更新日期：2000-04-14 00:00:00

abstract：:Interaction of double stranded DNA with bulky and hydrophobic Salen type Schiff base complex: [N, N' Bis [3- tert-butyl-5-[triphenyl-phosphonium - methyl] - salicylidene] 1,2 ethylene-diamine nickel(III) acetate (refer to Ni Salen complex) was extensively investigated using the spectroscopic techniques and gel electro...

journal_title：Chemico-biological interactions

authors： Nejat Dehkordi M,Akerman B

更新日期：2018-02-25 00:00:00

abstract：:Caffeine was found to potentiate the cytotoxic effect of misonidazole (1-(2-nitroimidazol-1-yl)-3-methoxy-2-propanol) towards mammalian cells in vitro. This enhancement of toxicity is shown to occur under both aerobic and hypoxic conditions. Split dose experiments indicate that the general shape of the hypoxic surviva...

journal_title：Chemico-biological interactions

authors： Horsman MR,Stratford IJ

更新日期：1982-08-01 00:00:00

abstract：:Pelargonidin (PEL) is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. Here, we tested the possible use of PEL in the treatment of lipopolysaccharide (LPS)-mediated vascular inflammatory responses. The anti-infla...

journal_title：Chemico-biological interactions

authors： Lee BS,Lee C,Yang S,Park EK,Ku SK,Bae JS

更新日期：2019-04-01 00:00:00

abstract：:At pH 7.35, N-(2-oxopropyl)-N-nitrosourea (OPNU) reacted with calf thymus DNA to yield O6-methylguanine, 7-methylguanine and 3-methyladenine. Kinetic measurements of the base catalyzed decomposition of OPNU and the extent of methylation of DNA by OPNU suggested that methylnitrosourea is not formed as an intermediate p...

journal_title：Chemico-biological interactions

authors： Leung KH,Archer MC

更新日期：1984-02-01 00:00:00

abstract：:Styrene oxide was reacted with deoxynucleosides and DNA in aqueous buffer at pH 7.4. The products were purified by HPLC, characterized by UV spectroscopy and by chemical ionization mass spectrometry. The main products identified were 7-alkyl-, N2-alkyl- and O6-alkyldeoxyguanosine, 1-alkyl-, and N6-alkyldeoxyadenosine,...

journal_title：Chemico-biological interactions

authors： Savela K,Hesso A,Hemminki K

更新日期：1986-12-01 00:00:00

abstract：:Retinoids bearing azido photoaffinity-labeling groups (azidoretinoids) have potential as probes for investigating the molecular mechanisms of action of all-trans-retinoic acid (RA) as mediated by its cellular retinoic acid-binding protein (CRABP) and nuclear receptor proteins. Two new azidoretinoids, 3-azido-4-[2-(5,6...

journal_title：Chemico-biological interactions

authors： Sani BP,Wille JJ Jr,Dawson MI,Hobbs PD,Bupp J,Rhee S,Chao WR,Dorsky A,Morimoto H

更新日期：1990-01-01 00:00:00

abstract：:The biological and physicochemical effects of reacting bacteriophages R17 and T7 with acetoxy-dimethylnitrosamine (ADMN) have been studied. The rate-determining step in the reactions appeared to be the loss of the acetoxy group by hydrolysis, the hydroxymethyl-methylnitrosamine generated decomposing rapidly to give a ...

journal_title：Chemico-biological interactions

authors： Shooter KV,Wiessler M

更新日期：1976-07-01 00:00:00

abstract：:Tiaprofenic acid is a widely used anti-inflammatory drug; however, the reductive metabolism of tiaprofenic acid is not yet well understood. Here, we compared the reduction of tiaprofenic acid in microsomes and cytosol from the human liver. The microsomes exhibited lower Km value toward tiaprofenic acid than the cytoso...

journal_title：Chemico-biological interactions

authors： Malátková P,Skarka A,Musilová K,Wsól V

更新日期：2017-10-01 00:00:00

abstract：:Using a rat liver cytosol source of enzyme trialkyl phosphorothioates have been shown to be substrates of glutathione S-transferases. Using OSS-trimethyl phosphorodithioate (OSS-Me(O] and OOS-trimethyl phosphorothioate (OOS-Me(O] the methyl transferred to the sulphydryl of glutathione is that attached to phosphorus vi...

journal_title：Chemico-biological interactions

authors： Aldridge WN,Grasdalen H,Aarstad K,Street BW,Norkov T

更新日期：1985-07-01 00:00:00

abstract：:S1 nuclease hydrolysis and benzoylated naphthoylated DEAE cellulose (BND-cellulose) chromatography have been used to study the effect of riboflavin and visible light on DNA. Native calf thymus DNA was incubated with riboflavin in the presence of fluorescent light for various time periods and subjected to S1 nuclease h...

journal_title：Chemico-biological interactions

authors： Alvi NK,Ahmad NS,Ahmad S,Hadi SM

更新日期：1984-03-01 00:00:00

abstract：:Dietary flavonoid quercetin has been suggested as a cancer chemopreventive agent, but the mechanisms of action remain unclear. This study investigated the influence of quercetin on p38-MAPK and the potential regulation of the nuclear transcription factor erythroid-2p45-related factor (Nrf2) and the cellular antioxidan...

journal_title：Chemico-biological interactions

authors： Granado-Serrano AB,Martín MA,Bravo L,Goya L,Ramos S

更新日期：2012-01-25 00:00:00

abstract：:Colorectal cancer is the third most common cancer in the world. Cromolyn is a mast cell stabilizer and was proposed as an anticancer agent; however its high polarity limits its bioavailability by rapid washing from the body. We formulated 10 cromolyn chitosan nanoparticles (CCSNPs)1 following ionic gelation technique ...

journal_title：Chemico-biological interactions

authors： Motawi TK,El-Maraghy SA,ElMeshad AN,Nady OM,Hammam OA

更新日期：2017-09-25 00:00:00

abstract：BACKGROUND:Mild hyperhomocysteinemia is associated with premature vascular disease. The mechanism behind the vascular injuries is, however, still unknown. Homocysteine may be catabolized in the trans-sulfuration pathway to cysteine. Cystathionine beta-synthase, which catalyses the first step in the trans-sulfuration pa...

journal_title：Chemico-biological interactions

authors： Hultberg M,Hultberg B

更新日期：2007-01-05 00:00:00

abstract：:4-Methylcyclophosphamide, an analogue of the antitumour agent cyclophosphamide, exists in cis and trans forms, each of which comprises a pair of optical isomers. The extents of metabolism by rat liver microsomes during 20 min were compared for the four steroisomers incubated separately, and for the racemic cis and tra...

journal_title：Chemico-biological interactions

authors： Farmer PB,Jarman M,Facchinetti T,Pankiewicz K,Stec WJ

更新日期：1977-07-01 00:00:00

abstract：:Drug induced liver injury (DILI), a major cause of pre- and post-approval failure, is challenging to predict pre-clinically due to varied underlying direct and indirect mechanisms. Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) and Ritonavir, a protease inhibitor, are antiviral drugs that cause c...

journal_title：Chemico-biological interactions

authors： Terelius Y,Figler RA,Marukian S,Collado MS,Lawson MJ,Mackey AJ,Manka D,Qualls CW Jr,Blackman BR,Wamhoff BR,Dash A

更新日期：2016-08-05 00:00:00

abstract：:Administration of a single oral dose of dieldrin (20 mg/kg body wt.) to rhesus monkeys considerably elevated the uptake of glucose and the activities of brush border sucrase, lactase, maltase and alkaline phosphatase in intestine compared to control animals. Leucine uptake and leucine amino peptidase activity was sign...

journal_title：Chemico-biological interactions

authors： Mahmood A,Agarwal N,Sanyal S,Dudeja PK,Subrahmanyam D

更新日期：1981-10-01 00:00:00

abstract：:Treatment of a lysosome-rich fraction from liver with 2-chloroethylethyl sulfide resulted in a dose-dependent release of arylsulfatase. The inclusion of Ca2+ enhanced the enzyme release by approximately 2.3-fold. The enhancing effect of Ca2+, showing an EC50 value of 30 mM, was mimicked by neither Mg2+ nor Mn2+. Studi...

journal_title：Chemico-biological interactions

authors： Shin S,Choi DS,Kim YB,Cha SH,Sok DE

更新日期：1995-08-18 00:00:00

abstract：:Chronic exposure of humans to benzene causes severe bone marrow cell depression leading to aplastic anemia. Marrow stromal macrophage dysfunction and deficient interleukin-1 production has been reported for patients with severe aplastic anemia. The stromal macrophage, a target of benzene toxicity, is involved in hemat...

journal_title：Chemico-biological interactions

authors： Niculescu R,Bradford HN,Colman RW,Kalf GF

更新日期：1995-12-22 00:00:00

abstract：:Repair synthesis has been followed in P388F cell DNA following treatment with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) using 5-iodo-deoxyuridine (IUdR) and [3H] thymidine combination. A pattern of repair synthesis was obtained, similar in its timing to the initial and medial stages of single-strand break formation ...

journal_title：Chemico-biological interactions

authors： Nikaido O,Fox BW

更新日期：1976-07-01 00:00:00

abstract：:Lanthanides (Ln) were known to induce cell apoptosis, which might be the results of their effects on mitochondria (MT). This study was trying to clarify the role of MT and reactive oxygen species (ROS) in Ln-induced apoptosis. We found that micromolar or lower concentration of La(3+), Gd(3+) and Yb(3+) bound to MT and...

journal_title：Chemico-biological interactions

authors： Liu H,Yuan L,Yang X,Wang K

更新日期：2003-07-25 00:00:00

abstract：:The interaction of the potent tumor-promoting agent phorbol myristate acetate (PMA) with purified rat liver plasma membranes suspended in phosphate-buffered saline (PBS), pH 7.4, was studied by fluorescence spectrophotometry. Exposure of membranes to PMA caused up to 21% decrease of the native membrane emission, i.e. ...

journal_title：Chemico-biological interactions

authors： van Duuren BL,Banerjee S,Witz G

更新日期：1976-11-01 00:00:00

abstract：:tert-Butylhydroquinone (BHQ), an antioxidant used as a food additive, exhibits an anticancer effect at low doses, but is carcinogenic in rodents at high doses. BHQ is metabolized into cytotoxic tert-butylquinone (TBQ), which is further converted to 6-tert-butyl-2,3-epoxy-4-hydroxy-5-cyclohexen-1-one (TBEH) through 6-t...

journal_title：Chemico-biological interactions

authors： Endo S,Nishiyama A,Suyama M,Takemura M,Soda M,Chen H,Tajima K,El-Kabbani O,Bunai Y,Hara A,Matsunaga T,Ikari A

更新日期：2015-06-05 00:00:00

abstract：:Penicillamine (I) and certain related compounds are known to reduce the skin tensile strength (sts) of rat dorsal skin when they are given in the diet. This effect seems significant to studies of the biochemistry of collagen and of diseases of collagen, perhaps including the arthritides. The reduction of sts appears t...

journal_title：Chemico-biological interactions

authors： Hanley WS,Snyder ME,Field L,Gallo AA

更新日期：1978-06-01 00:00:00

abstract：:Fosfomycin is clinically recognized to reduce the aminoglycoside antibiotics-induced nephrotoxicity. However, little has been clarified why fosfomycin protects the kidney from the aminoglycosides-induced nephrotoxicity. Gentamicin, a typical aminoglycoside, is reported to cause lipid peroxidation. We focused on lipid ...

journal_title：Chemico-biological interactions

authors： Yanagida C,Ito K,Komiya I,Horie T

更新日期：2004-07-20 00:00:00

abstract：:Quantum dots (QDs) are highly promising nanomaterials in bioimaging system because of their bright fluorescence, broad UV excitation, narrow emission band, and high photostability. Recently, there is a great activity on Ag2S quantum dots for both imaging and drug/gene delivery due to the potential of having a better c...

journal_title：Chemico-biological interactions

authors： Ozkan Vardar D,Aydin S,Hocaoglu I,Yagci Acar FH,Basaran N

更新日期：2018-08-01 00:00:00

abstract：:Effects of hepatocarcinogens dimethylnitrosamine (DMN) and diethylnitrosamine (DEN) on the sedimentation pattern of rat liver DNA in alkaline sucrose gradients were studied with regard to time and dose dependency. Both DMN (10 mg/kg body weight) and den (13.4 or 134 mg/kg) induced appreciably decreased DNA sedimentati...

journal_title：Chemico-biological interactions

authors： Den Engelse L,Philippus EJ

更新日期：1977-10-01 00:00:00

abstract：:Avermectin (AVM) is a macrocyclic lactone agent widely used as a nematicide, acaricide and insecticide in veterinary medicine and plant protection. P-glycoprotein (P-gp) is an ATP-dependent drug efflux pump for xenobiotic compounds, and is involved in multidrug resistance. To understand the development of AVM resistan...

journal_title：Chemico-biological interactions

authors： Luo L,Sun YJ,Yang L,Huang S,Wu YJ

更新日期：2013-04-25 00:00:00

abstract：:The AH receptor (AHR) mediates toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as well as induction of three cytochrome P450 enzymes and certain Phase II enzymes. In laboratory animals, genetic variations in the AHR lead to substantial differences in sensitivity to biochemical and toxic effects of TCDD and rela...

journal_title：Chemico-biological interactions

authors： Harper PA,Wong Jm,Lam MS,Okey AB

更新日期：2002-09-20 00:00:00

abstract：:The administration of the placental hormone human chorionic gonadotrophin (HCG) to 50-day-old virgin Sprague--Dawley rats has been shown to reduce the incidence of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary cancer. We now report from studies using rat mammary epithelial cells in culture that the anti-carcin...

journal_title：Chemico-biological interactions

authors： Tay LK,Russo J

更新日期：1985-10-01 00:00:00